Erdheim-Chester Disease

About the Disease
Erdheim-Chester Disease, also known as polyostotic sclerosing histiocytosis, is related to interstitial lung disease and histiocytosis. An important gene associated with Erdheim-Chester Disease is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Signal Transduction and ERK Signaling. The drugs Lenalidomide and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related phenotypes are hyperhidrosis and polydipsia

Common Targets
G673 | MAP2K1 | G5595 | RAF1 | MAP2K2 | RIPK3

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