Hereditary Spastic Paraplegia

About the Disease
Hereditary Spastic Paraplegia, also known as hereditary spastic paraparesis, is related to spastic paraplegia 10, autosomal dominant and spastic paraplegia 2, x-linked, and has symptoms including leg cramps, pain in lower limb and urgency of micturition. An important gene associated with Hereditary Spastic Paraplegia is SPAST (Spastin). The drugs Acetylcholine and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, retina and brain, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
LRRK2 | IGSF10 | TUBB4A | FARS2 | AP5Z1 | LYST | GBA1 | SPG11 | GCH1 | CPT1C | MIR33A | PLSCR4 | KLC4 | C9orf72 | DDHD2 | ATP1A1 | PRKCG | DYNC1H1 | ZFYVE26 | RTRAF | SERAC1 | NFU1 | GPT | ATP13A2 | PLP1 | DNAJA3 | SELENOI | SLC33A1 | IMPA1 | AP4B1 | HSPD1 | DDHD1 | NIPA1 | VPS37A | NUTM1 | SPTSSA | ALDH18A1 | SPG21 | MTRFR | PCYT2 | VPS53 | B4GALNT4 | ATAD3A | SARS1 | PNPLA6 | B4GALNT1 | AP4S1 | MFSD1 | SPTAN1 | KIF5A | BSCL2 | DNAH1 | RTN2 | CYP7B1 | UBAP1 | ISCA2 | EXOSC3 | SPAST | PLA2G6 | KIF1C | MTHFR | TMEM63C | ALS2 | WWTR1 | POLG | CAPN1 | SPG7 | PFN2 | SACS | G3845 | OTOGL | MARS1 | IFIH1 | VCP | CYP2U1 | SLC2A1 | TH | ATP6 | AP4M1 | REEP1 | MAGEL2 | SVBP | ENTPD1 | TECPR2 | FUT10 | REEP2 | ERLIN2 | SPART | GBA2 | OPA1 | FA2H | ZNF735 | ARMC12 | WASHC5 | NEFL | POLR3A | RNASEH2B | KIF1A | VEPH1 | ATP2B4 | ABCD1 | CRISP2 | AFG3L2 | COQ4 | RNF170 | AP4E1 | ATL1 | GRIK4 | TFG | C19orf12 | ARMC10 | NT5C2 | NMD3

Note: If you'd like to get a target analysis report for Hereditary Spastic Paraplegia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hereditary Spastic Paraplegia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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