Primary Progressive Multiple Sclerosis

About the Disease
Primary Progressive Multiple Sclerosis, also known as multiple sclerosis, primary progressive, is related to relapsing-remitting multiple sclerosis and multiple sclerosis. An important gene associated with Primary Progressive Multiple Sclerosis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dalfampridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are immune system and no phenotypic analysis

Common Targets
Calcium channel (nonspecified subtype) | C5 | FGFR3 | ESR2 | IFNB1 | GABA(A) receptor | HLA-A | CYP1A1 | CD40 | S1PR4 | Tyrosine Kinase (nonspecified subtype) | VDR | MTNR1B | S1PR3 | ARNT | MS4A1 | NPY | G3569 | Interferon alpha/beta Receptor (nonspecified subtype) | EBP | IFNG | CYP1A2 | LILRA3 | G196 | CH25H | NF-kappaB (NFkB) | LYN | S1PR5 | DPP6 | SPHK1 | IL13 | CCL20 | KIT | NQO1 | KRR1 | CYP1B1 | RIPK1 | S1PR1 | RGMA | BTK | AHRR | IL1RN | CSF1R | Interleukin 17 (nonspecified subtype)

Note: If you'd like to get a target analysis report for Primary Progressive Multiple Sclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Progressive Multiple Sclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Nicotine Addiction | Papillon-Lefevre Syndrome | Tinea Versicolor | Lichen Planus | Osteoporosis, Postmenopausal | Ventricular Septal Defect | Macrodactyly | Congenital Adrenal Hyperplasia | Lymphangioma | Corneal Dystrophy And Perceptive Deafness | Kashin-Beck Disease | Strabismus | Autosomal Recessive Spastic Paraplegia Type 35 | Harlequin Ichthyosis | Hypermetropia | Nestor-Guillermo Progeria Syndrome | Multiple Epiphyseal Dysplasia | Twin-to-twin Transfusion Syndrome | Cellulitis | Spinocerebellar Ataxia Type 40 | Cholesteryl Ester Storage Disease | Hypertensive Nephropathy | Heterotaxy | Herpes Simplex Dermatitis | Sleep Apnea, Obstructive | Amelogenesis Imperfecta | Arthropathy | Primary Progressive Aphasia | Bainbridge-Ropers Syndrome | Neurodegeneration With Brain Iron Accumulation | Hyperuricemic Nephropathy, Familial Juvenile | Onchocerciasis | Sarcoma, Alveolar Soft Part | Cranial Nerve Disease | Erythema Nodosum | Gitelman Syndrome | Pouchitis | Chitayat Syndrome | Prurigo Nodularis | Polyomavirus Nephropathy | Ectopia Lentis, Isolated, Autosomal Recessive | Iron Deficiency Anemia | Cryptosporidiosis | Coronary Artery Disease | Polyarteritis Nodosa | Rosacea | Progressive Encephalopathy-optic Atrophy Syndrome | Fetal Akinesia Deformation Sequence | Infertility | Arrhythmogenic Right Ventricular Cardiomyopathy | Mitochondrial Encephalomyopathy | Sarcoidosis | Pemphigus Vulgaris | Vitamin A Deficiency | Histoplasmosis | Pyruvate Kinase Deficiency | Dowling-Degos Disease | Genee-Wiedemann Syndrome | Anorectal Malformations | Granuloma Annulare | Cholestasis | Intestinal Tuberculosis | Pseudo-pseudohypoparathyroidism | Anosmia, Congenital | AIDS Dementia Complex | Congenital Hereditary Endothelial Dystrophy Type II | Basal Ganglia Disease, Biotin-responsive | Trichuriasis | Corneal Neovascularization | Polymyalgia Rheumatica | Conjunctivitis, Allergic | Bernard-Soulier Syndrome | Congenital Nephrotic Syndrome | Exotropia | Pterygium | Ocular Surface Squamous Neoplasia | Congenital Heart Defects | Primrose Syndrome | Aldosterone Deficiency | FG Syndrome | Neurofibroma, Plexiform | Autosomal Recessive Spastic Paraplegia Type 54 | Blepharitis | CEDNIK Syndrome | Hypocalcemia | Crohn's Disease | Granular Corneal Dystrophy Type 1 | Nasodigitoacoustic Syndrome | Heimler Syndrome | Auriculocondylar Syndrome | Hyperparathyroidism, Primary | Lung Diseases | Hyperthyroidism | Schizoaffective Disorder | GATA2 Deficiency | Left Ventricular Noncompaction | Carbonic Anhydrase VA Deficiency | Chronic Neutrophilic Leukemia | Anorexia Nervosa | Optic Nerve Hypoplasia, Bilateral | Hereditary Neuropathy With Liability To Pressure Palsies | Endometriosis | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Batten Disease | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Hermansky-Pudlak Syndrome | Osteomyelitis | Neuroma | Sertoli Cell-only Syndrome | Speech Disorders | Portal Vein Thrombosis | Dyslexia | Isovaleric Acidemia | Herpes Genitalis | Influenza | Eating Disorder | Malignant Peripheral Nerve Sheath Tumor | Hemophagocytic Lymphohistiocytosis | Necrotizing Autoimmune Myopathy | Thromboembolism | Non-Hodgkin Lymphoma | Muscular Dystrophy | Aldosteronism | Diffuse Intrinsic Pontine Glioma | Adrenal Insufficiency | Congenital Hemolytic Anemia | Vogt-Koyanagi-Harada Syndrome | Spondylocarpotarsal Synostosis Syndrome | Norrie Disease | Multifocal Motor Neuropathy | Sepiapterin Reductase Deficiency | Aspergillosis | Analgesia | Hyperhomocysteinemia | ADNP Syndrome | Osteogenesis Imperfecta Type III | Shwachman-Bodian-Diamond Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Gastritis | Skin Fragility-woolly Hair Syndrome | Peeling Skin Syndrome, Acral Type | Aphasia | Pyruvate Dehydrogenase Deficiency | Glycogen Storage Disease Type 0, Muscle | Encephalitis | Hemochromatosis | Colitis | Cervicitis | Oculocutaneous Albinism Type 4 | Obesity, Morbid | Primary Erythromelalgia | Pancreatitis, Chronic | Macular Degeneration | Anodontia | Hepatitis, Alcoholic | Amebiasis | Seizures-scoliosis-macrocephaly Syndrome | Cancer, Kidney | Usher Syndrome Type I | Pyloric Stenosis, Infantile Hypertrophic | Persistent Mullerian Duct Syndrome | Chiari Malformation Type I | Charcot-Marie-Tooth Disease Axonal Type 2N | Hypoplastic Left Heart Syndrome | Paraganglioma, Carotid Body | Chondrodysplasia Punctata 1, X-linked Recessive | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Osteogenesis Imperfecta | Pulmonary Tuberculosis | Wolfram Syndrome 2 | Congenital Hypofibrinogenemia | Alagille Syndrome | Sickle Cell Anemia | Spinal Muscular Atrophy Type 2 | Hypertension, Essential | Spinocerebellar Ataxia Type 38 | Restrictive Dermopathy | 5-oxoprolinase Deficiency | Spinocerebellar Ataxia | Warsaw Breakage Syndrome | Hyperuricemia | Acute Myeloid Leukemia | Sarcoidosis, Pulmonary | Rothmund-Thomson Syndrome | ICF Syndrome | Synpolydactyly | Congenital Tufting Enteropathy | PASLI Disease | Menetrier Disease | Tibial Muscular Dystrophy | Progressive External Ophthalmoplegia | Retinal Detachment | Imerslund-Grasbeck Syndrome | Hydronephrosis | CHARGE Syndrome | Deafness, Dystonia, And Cerebral Hypomyelination | Usher Syndrome Type IIC | Neuroblastoma | Waardenburg Syndrome Type 2A | Okihiro Syndrome | Renal Hypomagnesemia 3 | Raine Syndrome | Mucolipidosis Type IV | C3 Glomerulopathy | Spinocerebellar Ataxia Type 7 | Infantile Spasm | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Whipple's Disease | Megaloblastic Anemia | Cone Dystrophy | Supravalvular Aortic Stenosis | Potocki-Shaffer Syndrome | Mesothelioma, Malignant | Relapsing Polychondritis | Chorioretinitis | Ectodermal Dysplasia | Triple A Syndrome | Myoclonus | Congenital Sodium Diarrhea | Panniculitis | Nemaline Myopathy 10 | Brugada Syndrome 1 | Vitelliform Macular Dystrophy | Amyotrophic Lateral Sclerosis | Schindler Disease | H Syndrome | Martsolf Syndrome | Frank-ter Haar Syndrome | Osteochondroma | Kawasaki Disease | Niemann-Pick Disease | Cholelithiasis | Asperger Syndrome | Familial Thoracic Aortic Aneurysm | Venous Insufficiency | Fuchs Dystrophy | Micropenis | Renal Failure | Pseudohypoparathyroidism Type 1B | Non-proliferative Diabetic Retinopathy | Cataract | Mucolipidosis Type II | Amenorrhea | Renal-hepatic-pancreatic Dysplasia | Periventricular Nodular Heterotopia | Amish Infantile Epilepsy Syndrome | Hyperinsulinemia | Diabetes Insipidus, Nephrogenic | Acute Tubular Necrosis | Hypohidrotic Ectodermal Dysplasia, X-linked | Dysferlinopathy | Panuveitis | Fibromuscular Dysplasia | Autoimmune Polyendocrine Syndrome | Bone Marrow Necrosis | Cerebrotendinous Xanthomatosis | McKusick Type Metaphyseal Chondrodysplasia | Creatine Deficiency Syndrome Due To AGAT Deficiency | Osteitis | Endometrial Hyperplasia | Oligospermia | Renal Hypouricemia | Pituitary Dwarfism | Epidermolytic Palmoplantar Keratoderma | Mitochondrial Disease | Meier-Gorlin Syndrome | Hepatitis D | Eiken Syndrome | Primary Carnitine Deficiency | Dystonia-parkinsonism, X-linked | Dentinogenesis Imperfecta | Crigler-Najjar Syndrome | Congenital Absence Of Vas Deferens | Ornithine Transcarbamylase Deficiency | Pyelonephritis | Spastic Paraplegia Type 7 | Marshall-Smith Syndrome | Eczema | Carpal Tunnel Syndrome | Cardiomyopathy, Restrictive | Argininosuccinic Aciduria | Necrobiosis Lipoidica | Filariasis | Toxic Epidermal Necrolysis | Fraser Syndrome | Paternal Uniparental Disomy Of Chromosome 14 | Proximal Symphalangism | Lupus Erythematosus | Spinocerebellar Ataxia Type 31 | Fabry's Disease | Chudley-McCullough Syndrome | Autosomal Recessive Congenital Ichthyosis | Hereditary Sensory And Autonomic Neuropathy | Congenital Afibrinogenemia | Charcot-Marie-Tooth Disease | Goiter, Nodular | Hypohidrotic Ectodermal Dysplasia | Benign Familial Neonatal Convulsions | Heavy Chain Disease | Periventricular Leukomalacia | Clouston Hidrotic Ectodermal Dysplasia | N-acetylglutamate Synthase Deficiency | Hemimegalencephaly | Lymphoma, Mantle Cell | Centronuclear Myopathy | Glioblastoma | Hyperoxaluria | Keratopathy | Ischemia | Miyoshi Myopathy | Endophthalmitis | Hereditary Spherocytosis | Cutaneous Mastocytosis | Usher Syndrome Type II | Fukuyama Congenital Muscular Dystrophy | Connective Tissue Disorders | Megalencephaly | Wiedemann-Steiner Syndrome | Oguchi Disease-2 | Tetraplegia | Lymphangioleiomyomatosis | Muscle Wasting | Myofibrillar Myopathy | Hartsfield Syndrome | Retinitis Pigmentosa | Myotonic Disorders | Dysequilibrium Syndrome | Leukodystrophies | Frontotemporal Dementia | Preaxial Polydactyly | Cerebral Cavernous Malformations | Nemaline Myopathy 8 | Atopic Dermatitis | Hypoglycemia | Enterocolitis, Necrotizing | Fucosidosis | Sotos Syndrome | Schwannoma | Optic Neuropathy | Osmotic Demyelination Syndrome | Marinesco-Sjogren Syndrome | Sialidosis | Low Tension Glaucoma | Pontocerebellar Hypoplasia | Peripheral T-cell Lymphoma | Brenner Tumor | D-2-Hydroxyglutaric Aciduria | Lattice Corneal Dystrophy | Autosomal Recessive Spastic Paraplegia Type 75 | Seasonal Mood Disorder | Acne | Ulcerative Colitis | Hereditary Coproporphyria | Pulmonary Stenosis | Ameloblastic Carcinoma | Acquired Partial Lipodystrophy | Lathosterolosis | Renal Tubular Acidosis | Ophthalmoplegia | Transient Bullous Dermolysis Of The Newborn | Erectile Dysfunction | Retinitis Pigmentosa 3 | Esophagitis | Absence Epilepsy | Hidradenitis | Dwarfism | Chronic Inflammatory Demyelinating Polyneuropathy | Mumps | Primary Aldosteronism | Immunoproliferative Disorders | Mabry Syndrome | Trichothiodystrophy | Sick Sinus Syndrome 1 | Asthma | Hemangioma | Adenomyosis | Alopecia | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Albinism | Methemoglobinemia | Epilepsy | Nephronophthisis | Hyperbilirubinemia | Infertility, Male | Familial Hemiplegic Migraine | Hepatitis C, Chronic | Polycythemia Vera | Usher Syndrome | Stroke, Hemorrhagic | Unverricht-Lundborg Syndrome | Adenosine Deaminase 2 Deficiency | Sezary Syndrome | Periodic Limb Movement Disorder | Interstitial Lung Diseases | Precocious Puberty | Malaria, Cerebral | Malnutrition | Infantile Nephropathic Cystinosis | Walker-Warburg Syndrome | Cutaneous Lupus Erythematosus