Schwannoma

About the Disease
Neurilemmoma, also known as schwannoma, is related to peripheral nerve schwannoma and neurilemmoma of the fifth cranial nerve. An important gene associated with Neurilemmoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Signal Transduction and Malignant pleural mesothelioma. The drugs Lapatinib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and spinal cord, and related phenotypes are abnormal temporal bone morphology and vestibular schwannoma

Common Targets
TAB3 | ARID1B | LATS1 | LIMK1 | HDAC1 | LZTR1 | LIMK2 | TSC2 | HTRA1 | CAST | DGCR8 | G3845 | PYCARD | DDR1 | MIR146A | ARID1A | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | SMARCB1 | MIR196A2 | ALPK2 | SLC26A4 | G673 | DPYD | GNA11 | MIR499A | HDAC2 | TSC1 | MIR149 | NF2

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