Kindler Syndrome

About the Disease
Kindler Syndrome, also known as poikiloderma of kindler, is related to urethral stricture and epidermolysis bullosa, and has symptoms including grooving of nail An important gene associated with Kindler Syndrome is FERMT1 (FERM Domain Containing Kindlin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Progesterone and Mifepristone have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are ichthyosis and telangiectasia of the skin

Common Targets
USB1 | FAM111B | FERMT1

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