Macrophage Activation Syndrome

About the Disease
Macrophage Activation Syndrome is related to hemophagocytic lymphohistiocytosis, familial, 1 and griscelli syndrome, type 2. An important gene associated with Macrophage Activation Syndrome is PRF1 (Perforin 1), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and bone, and related phenotypes are fever and anemia

Common Targets
NF-kappaB (NFkB) | IL1RN | LYST | AP3B1 | IL2RA | IL-1 Receptor (nonspecified subtype) | UNC13D | G2475 | ITK | G7124 | PRF1 | NLRC4 | DOCK8 | ALB | IL18 | STXBP2

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