Epilepsy, Generalized

About the Disease
Epilepsy, Idiopathic Generalized, also known as idiopathic generalized epilepsy, is related to epilepsy, idiopathic generalized 5 and generalized epilepsy with febrile seizures plus, type 7, and has symptoms including seizures, non-epileptic convulsion and absence seizures. An important gene associated with Epilepsy, Idiopathic Generalized is GABRA1 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1), and among its related pathways/superpathways are "Celecoxib Pathway, Pharmacodynamics" and "Benzodiazepine Pathway, Pharmacodynamics". The drugs Levetiracetam and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotypes are eeg with spike-wave complexes (>3.5 hz) and bilateral tonic-clonic seizure

Common Targets
CHRNB3 | LGI1 | CACNA1B | EPM2A | PADI4 | OPRM1 | CACNA2D2 | SLC25A22 | HPS4 | GRIK1 | HLA-DRB1 | LGI4 | EFHC1 | TPP1 | T-Type Calcium Channel | SCN3A | ME2 | HTR1A | KCNQ3 | GABRG2 | PCDH19 | PADI6 | CASR | ZEB2 | CACNA1G | CPA6 | CHD2 | SCN8A | PRRT2 | ARX | TBC1D24 | LIAS | CHRNA7 | ABCC2 | TSC2 | HNRNPU | Voltage-Gated Sodium Channel Complex | CHRNA2 | SZT2 | GJA8 | SPTAN1 | JRK | CSMD1 | UBE3A | ADGRV1 | G5243 | GRIN2A | Sodium channel (nonspecified subtype) | RYR2 | GABRB3 | CLCN1 | GABRA1 | POLG | ANKRD11 | PNKP | NRXN1 | NDE1 | PRICKLE1 | CLCN2 | FOLR1 | SCN1A | SCN9A | HTR2A | ERBB4 | SYNGAP1 | SLC2A1 | KCNMA1 | CNTNAP2 | HTR1B | IL1B | CYP2C9 | SLC6A1 | GABRD | CACNA1A | EFHC2 | SCN1B | FA2H | CACNB4 | CHRNA4 | GRM4 | HCN1 | KCNJ10 | ALDH7A1 | GATM | DOCK7 | CHRNB2 | MFSD8 | KCNA2 | GMPPB | SCN5A | STXBP1 | IQSEC2 | KCNQ2 | Glutamate Receptor Ionotropic AMPA Receptor | SPECC1 | SCN2A | SV2A | CACNA1H

Note: If you'd like to get a target analysis report for Epilepsy, Generalized, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Epilepsy, Generalized at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Focal Facial Dermal Dysplasia | Localized Scleroderma | Nestor-Guillermo Progeria Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Meningococcal Meningitis | Myocardial Infarction | Hashimoto Thyroiditis | Nephronophthisis | Asthma, Exercise-induced | Angiosarcoma | Silver-Russell Syndrome | Patent Foramen Ovale | Hemorrhagic Disorders | Hereditary Mixed Polyposis Syndrome | Renal Oncocytoma | Acne | Ellis-Van Creveld Syndrome | Congenital Absence Of Vas Deferens | Rhabdomyosarcoma | 3-methylglutaconic Aciduria | Arts Syndrome | Kleine-Levin Syndrome | Androgenic Alopecia | Dystrophy, Cone-rod | Kawasaki Disease | Apraxia | Gyrate Atrophy Of The Choroid And Retina | Alopecia Totalis | Familial Exudative Vitreoretinopathy | Early Infantile Epileptic Encephalopathy 1 | Kaposi Sarcoma | Charcot-Marie-Tooth Disease, Type 2 | Mucolipidosis Type III | Carpenter Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Conduct Disorder | Oligoastrocytoma | Optic Neuritis | Schwannoma | Mucolipidosis Type IV | Long QT Syndrome Type 1 | Hypertelorism | Pneumoconiosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Joubert Syndrome 2 | Angiodysplasia | Temporal Lobe Epilepsy | Lung Diseases | Niemann-Pick Disease, Type B | Endometritis | Bare Lymphocyte Syndrome | Periodontitis | Encephalitis, Tick-borne | Rhabdomyosarcoma, Alveolar | Microcephaly, Seizures, And Developmental Delay | Pleomorphic Xanthoastrocytoma | Dystonia | Anorectal Fistula | Leukodystrophies | Atelosteogenesis Type 2 | Pompe Disease | Chronic Idiopathic Myelofibrosis | Persistent Fetal Circulation | Cholecystitis | Cryptosporidiosis | Tumoral Calcinosis | Carey-Fineman-Ziter Syndrome | Transient Bullous Dermolysis Of The Newborn | Genitopatellar Syndrome | Myasthenia | Diabetes Mellitus, Transient Neonatal | Rubeosis Iridis | Cutaneous Angiosarcoma | WAGR Syndrome | Bacterial Meningitis | Infectious Diarrhea | Ovarian Sex Cord-stromal Tumor | Hereditary Folate Malabsorption | Speech Disorders | Familial Episodic Pain Syndrome | Progressive Myoclonic Epilepsy | Multiple Epiphyseal Dysplasia | GAPO Syndrome | Colitis, Lymphocytic | Erdheim-Chester Disease | T-cell Lymphoma, Subcutaneous Panniculitis-like | Myeloid Leukemia | Hernia, Inguinal | Carcinoma, Transitional Cell | Acute Anterior Uveitis | Mumps | Spinal Muscular Atrophy | Johanson-Blizzard Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Fanconi Syndrome | Asphyxia Neonatorum | Barrett Esophagus | Progressive Familial Intrahepatic Cholestasis Type 1 | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Esthesioneuroblastoma | Neuromyotonia | Gigantism | Chronic Myeloid Leukemia | Juvenile Xanthogranuloma | Campomelic Dysplasia | Pleurisy | Carcinoma, Merkel Cell | Basal Cell Nevus Syndrome | Dysplastic Nevus | Hereditary Hemorrhagic Telangiectasia | Succinic Semialdehyde Dehydrogenase Deficiency | Congenital Hereditary Endothelial Dystrophy Type I | Hyperandrogenemia | Pearson Syndrome | Thyroiditis, Autoimmune | Granuloma Annulare | Ichthyosis Hystrix, Curth-Macklin Type | Familial Pheochromocytoma-paraganglioma | Congenital Central Hypoventilation Syndrome | Hypersensitivity Pneumonitis | Rothmund-Thomson Syndrome | 3-methylglutaconic Aciduria Type I | Waardenburg Syndrome Type 2E | Periventricular Nodular Heterotopia | Carcinoma, Small Cell | 3C Syndrome | Macrophage Activation Syndrome | Spinal And Bulbar Muscular Atrophy | Platelet Disorders | Joubert Syndrome | Toxoplasmosis | Spinocerebellar Ataxia Type 31 | Hypermetropia | Allergic Contact Dermatitis | Paronychia | Apparent Mineralocorticoid Excess Syndrome | Postpoliomyelitis Syndrome | Torticollis | McKusick Type Metaphyseal Chondrodysplasia | Chediak-Higashi Syndrome | Congenital Disorders Of Glycosylation Type II | Niemann-Pick Disease | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Esophageal Motility Disorders | Noonan Syndrome-like Disorder With Loose Anagen Hair | Cardiofaciocutaneous Syndrome | Eosinophilic Asthma | Glycogen Storage Disease Type 1a | Phenylketonuria | Anorchia | Renal Medullary Carcinoma | Alzheimer Disease, Late Onset | Trigonocephaly | Bladder Exstrophy | Retinal Vasculitis | Hypothyroidism | Oral Lichen Planus | Usher Syndrome Type I | Subcortical Band Heterotopia | Bronchitis | Spinocerebellar Ataxia Type 28 | Plasma Cell Dyscrasia | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 38 | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Thanatophoric Dysplasia | Anovulation | Harlequin Ichthyosis | Glycogen Storage Disease | Peroxisomal Disorder | Dermatofibrosarcoma | Tyrosinemia Type 2 | DNA Ligase IV Deficiency | Aceruloplasminemia | Adrenal Insufficiency | Stevens-Johnson Syndrome | Waardenburg Syndrome Type 4 | Tenosynovial Giant Cell Tumor | Combined Deficiency Of Factor V And Factor VIII | Acute Lymphocytic Leukemia | Kallmann Syndrome | Maple Syrup Urine Disease | Sengers Syndrome | Psoriasis | Myelitis, Transverse | Retinal Coloboma | Charcot-Marie-Tooth Disease Type 4B1 | Extramammary Paget's Disease | Sick Sinus Syndrome 1 | Osteogenesis Imperfecta Type V | Sjogren Syndrome | Leishmaniasis, Visceral | Myopia | Gangliosidosis | Inflammatory Bowel Disease | Thromboembolism | Porphyria | Cole-Carpenter Syndrome | Addison Disease | Hermansky-Pudlak Syndrome | Thrombocytopenia | Thrombotic Microangiopathy | Trichotillomania | Hypoalbuminemia | Adenoid Cystic Carcinoma | Cyclic Vomiting Syndrome | Ghosal Syndrome | Spondylosis | Cryoglobulinemia | Mandibuloacral Dysplasia With Type A Lipodystrophy | Spinocerebellar Ataxia Type 3 | Roberts Syndrome | Monilethrix | Cabezas Syndrome | Familial Hyperaldosteronism | Sarcoma, Endometrial Stromal | Iron Overload | Tatton-Brown-Rahman Syndrome | LEOPARD Syndrome | Spinocerebellar Ataxia Type 27 | Schwannomatosis | Palmoplantar Keratoderma | Glycogen Storage Disease Type 0 | Nemaline Myopathy 10 | Prostatitis | Sponastrime Dysplasia | Connective Tissue Disorders | Nephrocalcinosis | Cancer, Bladder | Dent Disease | Chylothorax, Congenital | Common Cold | Barakat Syndrome | Iron Deficiency Anemia | Specific Granule Deficiency | Azoospermia | Cerebrotendinous Xanthomatosis | T-cell Leukemia | Aspartylglycosaminuria | Acute Chest Syndrome | Focal Cortical Dysplasia Type 2 | Stroke, Hemorrhagic | Rash | Diabetes Insipidus, Nephrogenic | Hereditary Elliptocytosis | Cartilage Disorders | Charcot-Marie-Tooth Disease Axonal Type 2N | Hepatorenal Syndrome | Primary Aldosteronism | Endometrial Hyperplasia | Neovascular Glaucoma | Exotropia | Congenital Myasthenic Syndrome | Stroke, Ischemic | Tularemia | Esotropia | Neurofibromatosis-Noonan Syndrome | Large Granular Lymphocytic Leukemia | Adenomatoid Tumor | Tetraplegia | Hyperkalemic Periodic Paralysis | Epidermolysis Bullosa Simplex, Generalized | Nail-Patella Syndrome | Beta-Propeller Protein-associated Neurodegeneration | Varices | Avellino Corneal Dystrophy | Pain | Hypopigmentation | Cancer, Skin | Fabry's Disease | Ocular Surface Squamous Neoplasia | Pseudohypoparathyroidism Type 1B | Progressive Familial Intrahepatic Cholestasis | Chorea-acanthocytosis | Systemic Lupus Erythematosus | Charcot-Marie-Tooth Disease Type 3 | Syndactyly | Seminoma | Pregnancy, Ectopic | Marinesco-Sjogren Syndrome | Rheumatoid Arthritis | Congenital Primary Aphakia | Corneal Dystrophy | Currarino Syndrome | Opisthorchiasis | Bursitis | Osteoglophonic Dysplasia | Paget's Disease Of The Breast | Dementia, Vascular | Veno-occlusive Disease | Congenital Sodium Diarrhea | Epidermolytic Hyperkeratosis | Botulism | Cancer, Brain | X-linked Acrogigantism | Guillain-Barre Syndrome | Retinal Degeneration | Ovarian Hyperstimulation Syndrome | Fuchs Dystrophy | Chiari Malformation Type I | Aldosteronism | Early Infantile Epileptic Encephalopathy 4 | Budd-Chiari Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Tricho-hepato-enteric Syndrome | Polyomavirus Nephropathy | Alstrom Syndrome | Diffuse Intrinsic Pontine Glioma | Hemophagocytic Lymphohistiocytosis | Aneurysm, Thoracic Aortic | Carbamoyl Phosphate Synthetase I Deficiency | Familial Advanced Sleep Phase Syndrome | Familial Isolated Hyperparathyroidism | Sialidosis Type I | Hemolytic Anemia | Lymphoma Lymphoblastic | Crohn's Disease | Glioblastoma | Thrombophlebitis | Hidradenitis | Arterial Tortuosity Syndrome | Supravalvular Aortic Stenosis | Benign Recurrent Intrahepatic Cholestasis 1 | Pituitary Dwarfism | Oligodendroglioma | Dowling-Degos Disease | Renal Failure | D-2-Hydroxyglutaric Aciduria | Schnyder Crystalline Corneal Dystrophy | Microphthalmia, Syndromic 7 | Hereditary Coproporphyria | Van Der Knaap Disease | Intestinal Tuberculosis | Phosphoglycerate Dehydrogenase Deficiency | Ectodermal Dysplasia | Galactosialidosis | Cardiac Sarcoidosis | Acanthosis Nigricans | Osteogenesis Imperfecta Type II | Fragile X Syndrome | Erythrokeratodermia Variabilis | Myasthenia Gravis | Benign Familial Neonatal Convulsions | MIRAGE Syndrome | Muir-Torre Syndrome | Pemphigus Vulgaris | Venous Insufficiency | Hereditary Multiple Exostoses | Hypercalciuria | Hemophilia | Pemphigus | Coronary Artery Disease | Primary Cutaneous Amyloidosis | Intermittent Explosive Disorder | Whipple's Disease | Influenza | Pericarditis | Central Core Disease | Gnathodiaphyseal Dysplasia | Blepharophimosis Syndrome | Hepatoblastoma | Cleidocranial Dysplasia | Odonto-onycho-dermal Dysplasia | Optic Neuropathy, Anterior Ischemic | Rhizomelic Chondrodysplasia Punctata | Charcot-Marie-Tooth Disease | Macular Corneal Dystrophy Type 1 | Silicosis | Astrocytoma, Anaplastic | Pyruvate Kinase Deficiency | IMAGe Syndrome | Gastrointestinal Disorders | Colitis, Microscopic | Insulin Resistance | Aicardi-Goutieres Syndrome | Dyslipidemia | McCune-Albright Syndrome | Globozoospermia | Glutathione Synthetase Deficiency | Saethre-Chotzen Syndrome | Anal Fissure | Cholera | Corneal Dystrophy And Perceptive Deafness | Diabetes Type 2 | Melanocytic Nevus | Proximal Symphalangism | Chronic Periodontitis | Adenoma, Pleomorphic | Rubinstein-Taybi Syndrome | Kashin-Beck Disease | Renal-hepatic-pancreatic Dysplasia | Motor Neuron Diseases | VEXAS Syndrome | Disseminated Superficial Actinic Porokeratosis | Autoimmune Polyendocrine Syndrome | Liebenberg Syndrome | Mast Cell Leukemia | Amenorrhea | Leri Pleonosteosis | Peritonitis