Generalized Epilepsy

About the Disease
Epilepsy, Idiopathic Generalized, also known as idiopathic generalized epilepsy, is related to epilepsy, idiopathic generalized 5 and generalized epilepsy with febrile seizures plus, type 7, and has symptoms including seizures, non-epileptic convulsion and absence seizures. An important gene associated with Epilepsy, Idiopathic Generalized is GABRA1 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1), and among its related pathways/superpathways are "Celecoxib Pathway, Pharmacodynamics" and "Benzodiazepine Pathway, Pharmacodynamics". The drugs Levetiracetam and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotypes are eeg with spike-wave complexes (>3.5 hz) and bilateral tonic-clonic seizure

Common Targets
CHRNB3 | LGI1 | CACNA1B | EPM2A | PADI4 | OPRM1 | CACNA2D2 | SLC25A22 | HPS4 | GRIK1 | HLA-DRB1 | LGI4 | EFHC1 | TPP1 | T-Type Calcium Channel | SCN3A | ME2 | HTR1A | KCNQ3 | GABRG2 | PCDH19 | PADI6 | CASR | ZEB2 | CACNA1G | CPA6 | CHD2 | SCN8A | PRRT2 | ARX | TBC1D24 | LIAS | CHRNA7 | ABCC2 | TSC2 | HNRNPU | Voltage-Gated Sodium Channel Complex | CHRNA2 | SZT2 | GJA8 | SPTAN1 | JRK | CSMD1 | UBE3A | ADGRV1 | G5243 | GRIN2A | Sodium channel (nonspecified subtype) | RYR2 | GABRB3 | CLCN1 | GABRA1 | POLG | ANKRD11 | PNKP | NRXN1 | NDE1 | PRICKLE1 | CLCN2 | FOLR1 | SCN1A | SCN9A | HTR2A | ERBB4 | SYNGAP1 | SLC2A1 | KCNMA1 | CNTNAP2 | HTR1B | IL1B | CYP2C9 | SLC6A1 | GABRD | CACNA1A | EFHC2 | SCN1B | FA2H | CACNB4 | CHRNA4 | GRM4 | HCN1 | KCNJ10 | ALDH7A1 | GATM | DOCK7 | CHRNB2 | MFSD8 | KCNA2 | GMPPB | SCN5A | STXBP1 | IQSEC2 | KCNQ2 | Glutamate Receptor Ionotropic AMPA Receptor | SPECC1 | SCN2A | SV2A | CACNA1H

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