3-methylglutaconic Aciduria Type IV

About the Disease
3-Methylglutaconic Aciduria, Type Iv, also known as 3-methylglutaconic aciduria type 4, is related to 3-methylglutaconic aciduria with deafness, encephalopathy, and leigh-like syndrome and mitochondrial dna depletion syndrome 4a. An important gene associated with 3-Methylglutaconic Aciduria, Type Iv is SERAC1 (Serine Active Site Containing 1), and among its related pathways/superpathways is Amino acid metabolism. Affiliated tissues include eye and liver, and related phenotypes are intellectual disability and spasticity

Common Targets
SERAC1 | CLPB

Note: If you'd like to get a target analysis report for 3-methylglutaconic Aciduria Type IV, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of 3-methylglutaconic Aciduria Type IV at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Primary Progressive Nonfluent Aphasia | Periventricular Nodular Heterotopia | Crimean-Congo Hemorrhagic Fever | Ectodermal Dysplasia | Macular Degeneration | Paroxysmal Nocturnal Hemoglobinuria | Eosinophilia | Schnitzler Syndrome | Extramammary Paget's Disease | Urethritis | Hypoparathyroidism | Spinocerebellar Ataxia Type 1 | Niemann-Pick Disease | PASLI Disease | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Cannabis Abuse | Erdheim-Chester Disease | Neonatal Progeroid Syndrome | Beare-Stevenson Syndrome | Alopecia | Hairy Cell Leukemia | D-2-Hydroxyglutaric Aciduria | Tuberculous Meningitis | Osteoarthritis | Hypophosphatasia | Premature Ejaculation | Cancer, Lung | Fanconi Syndrome | Tinea Versicolor | Aldosterone Synthase Deficiency | Gastroschisis | Juvenile Myelomonocytic Leukemia | Synovitis | Mitochondrial DNA Depletion Syndrome 13 | Hypoglycemia | Asthma, Nocturnal | Renpenning Syndrome | Colitis, Lymphocytic | Ovarian Hyperstimulation Syndrome | Congenital Sodium Diarrhea | Meningitis | Craniosynostosis | Hyperlipidemia | Pyruvate Kinase Deficiency | Congenital Adrenal Hyperplasia 1 | Schistosomiasis Mansoni | Cholelithiasis | Cutaneous Mastocytosis | Persistent Hyperplastic Primary Vitreous | Omenn Syndrome | Cervical Dystonia | Fuchs Dystrophy | Hemangioendothelioma | Polymicrogyria | Otitis Media | Demyelinating Diseases | Multiple Sclerosis, Primary Progressive | Dystonia Musculorum Deformans | Dubin-Johnson Syndrome | GATA2 Deficiency | Acute Anterior Uveitis | Glycogen Storage Disease Type 3 | Chromosome 8q21.11 Deletion Syndrome | 3-methylglutaconic Aciduria | Gestational Trophoblastic Disease | Congenital Lipoid Adrenal Hyperplasia | Hemochromatosis Type 2 | Craniopharyngioma | Anorectal Fistula | Methylmalonic Acidemia | Withdrawal Syndrome | Spinocerebellar Ataxia Type 10 | Schaaf-Yang Syndrome | Papulopustular Rosacea | B-cell Prolymphocytic Leukemia | Angioedema, Acquired | Diabetic Macular Edema | Hypothalamic Obesity | Lattice Corneal Dystrophy | Myelodysplasia | Tyrosinemia Type 1 | Galactosialidosis | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Bethlem Myopathy | Aicardi-Goutieres Syndrome | Pulmonary Stenosis | Kabuki Syndrome | Familial Dysautonomia | Pontocerebellar Hypoplasia | Oculocutaneous Albinism | Leber Hereditary Optic Neuropathy | Primary Sclerosing Cholangitis | Tendinopathy | Wolman Disease | Eczema | Persistent Mullerian Duct Syndrome | Venous Insufficiency | Gastritis, Atrophic | Hyperekplexia | Congenital Myasthenic Syndrome | Esophageal Adenocarcinoma | Hereditary Mixed Polyposis Syndrome | Diabetes Type 1 | Coronary Restenosis | Neurocutaneous Syndromes | C3 Glomerulopathy | Retinal Detachment | Retinopathy, Diabetic | Thanatophoric Dysplasia Type 1 | Cerebellofaciodental Syndrome | Intestinal Obstruction | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Neurofibromatosis-Noonan Syndrome | Glycogen Storage Disease Type 1 | Nutrition Disorders | Peripheral T-cell Lymphoma | Plasmacytoma | Krabbe Disease | Optic Neuropathy | Vitreoretinal Degeneration, Snowflake Type | Weill-Marchesani Syndrome | Pregnancy, Ectopic | Woodhouse-Sakati Syndrome | Oculodentodigital Dysplasia | Prune Belly Syndrome | Sialoadenitis | Early Infantile Epileptic Encephalopathy 13 | Megalencephaly | Alpha-1 Antitrypsin Deficiency | Heterotaxy | Choriocarcinoma | Focal Cortical Dysplasia Type 2 | Celiac Disease | Early Infantile Epileptic Encephalopathy 4 | Primary Aldosteronism | Conjunctivitis | Scabies | Anuria | 3-methylglutaconic Aciduria Type I | Snyder-Robinson Syndrome | N-acetylglutamate Synthase Deficiency | Bronchitis | Amyloidosis | Pseudohypoparathyroidism Type 1B | Strabismus | Familial Exudative Vitreoretinopathy | Agammaglobulinemia | Epidermolysis Bullosa Dystrophica | T-cell Chronic Lymphocytic Leukemia | Hyperinsulinemia | Angiodysplasia | Colitis | Neurofibromatosis Type 1 | Hyperglycemia | Noonan Syndrome | Acute Leukemia | Erythema Nodosum | Multiple Sulfatase Deficiency | Epidermodysplasia Verruciformis | Hemochromatosis Type 1 | Adrenoleukodystrophy, X-linked | Priapism | DiGeorge Syndrome | Amyotrophic Lateral Sclerosis, Juvenile | Glycogen Storage Disease Type 4 | Otosclerosis | T-cell Prolymphocytic Leukemia | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Benign Recurrent Intrahepatic Cholestasis 1 | Gliosarcoma | Hypertelorism | Spondylosis | Fibrillation, Atrial | Precocious Puberty | Feingold Syndrome | Glomerulonephritis, Membranoproliferative | Autoimmune Autonomic Ganglionopathy | Benign Familial Pemphigus | Epilepsy, Generalized | Rubeosis Iridis | Non-Hodgkin Lymphoma | Ornithine Transcarbamylase Deficiency | Primary Erythromelalgia | Cramp Fasciculation Syndrome | Glutaric Aciduria Type 1 | Botulism | Autoimmune Hemolytic Anemia | Spondyloepiphyseal Dysplasia Tarda, X-linked | Liver Diseases | Ichthyosis Hystrix, Curth-Macklin Type | Myhre Syndrome | Ocular Albinism Type 1 | Stuve-Wiedemann Syndrome | Spondyloarthritis | Myasthenia | Chudley-McCullough Syndrome | Alexander Disease | Episodic Ataxia Type 2 | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Leukocyte Adhesion Deficiency Type 1 | Mannosidase Deficiency Diseases | Familial Hyperaldosteronism | Hypertrophy | Multiple Myeloma | Pathological Gambling | Anal Fissure | Osteoglophonic Dysplasia | Phenylketonuria II | GM2-gangliosidosis AB Variant | Dermatitis Herpetiformis | Purpura, Thrombotic Thrombocytopenic | Splenomegaly | Epithelial-myoepithelial Carcinoma | Rett Syndrome | Gerodermia Osteodysplastica | Alagille Syndrome | Norrie Disease | Incontinentia Pigmenti | Waardenburg Syndrome Type 2 | Spinocerebellar Ataxia Type 5 | Lymphoma, AIDS-related | Cleidocranial Dysplasia | Blue Nevus | Crohn's Disease | Pheochromocytoma | Temtamy Preaxial Brachydactyly Syndrome | Epidermolytic Hyperkeratosis | Waardenburg Syndrome Type 4A | Irritable Bowel Syndrome | Gastroenteritis | Myocardial Infarction | Juvenile Xanthogranuloma | Exfoliative Dermatitis | NGLY1 Deficiency | Duchenne Muscular Dystrophy | Rheumatoid Arthritis | Acute Lung Injury | Arrhythmogenic Right Ventricular Cardiomyopathy | Myositis, Focal | Sotos Syndrome | Fascioliasis | Calcium Pyrophosphate Deposition Disease | Avian Influenza | Common Cold | Multifocal Motor Neuropathy | T-cell Lymphoma, Subcutaneous Panniculitis-like | Papillon-Lefevre Syndrome | Enhanced S-cone Syndrome | Carcinoma, Small Cell | Cancer, Brain | Micropenis | Dysgerminoma | Plasma Cell Dyscrasia | Polydactyly | C3 Glomerulonephritis | Sensory Neuropathy | Lymphedema-distichiasis Syndrome | Pseudohypoparathyroidism Type 2 | Persistent Truncus Arteriosus | Periodontitis | Familial Retinal Arterial Macroaneurysm | 3-hydroxy-3-methylglutaric Aciduria | Kearns-Sayre Syndrome | Adenoid Cystic Carcinoma | Kashin-Beck Disease | Hereditary Xerocytosis | Blepharospasm | Corneal Dystrophy | Papillorenal Syndrome | Hypertension, Essential | Esophageal Carcinoma | Multisystemic Smooth Muscle Dysfunction Syndrome | Sitosterolemia | Sponastrime Dysplasia | Pyruvate Dehydrogenase Deficiency | Bronchitis, Chronic | Epidermolysis Bullosa Simplex | Cholestasis | Alveolar Capillary Dysplasia | Multicystic Renal Dysplasia | Retinal Diseases | Hernia, Inguinal | Carpenter Syndrome | Werner's Syndrome | Heterotopic Ossification | Esotropia | Spinocerebellar Ataxia Type 20 | WAGR Syndrome | Inflammatory Bowel Disease | TARP Syndrome | Glanzmann Thrombasthenia | Sarcosinemia | Cyst | Tricho-hepato-enteric Syndrome | Cholera | Angiomyolipoma | Familial Isolated Hyperparathyroidism | Tinea | Spinocerebellar Ataxia Type 13 | Mosaic Variegated Aneuploidy Syndrome 2 | Spinocerebellar Ataxia Type 2 | Borderline Personality Disorder | Persistent Fetal Circulation | Hashimoto Thyroiditis | Meningococcal Infections | Carbonic Anhydrase VA Deficiency | Chronic Enteropathy Associated With SLCO2A1 Gene | Paraplegia | Erysipelas | Pompe Disease | Colorectal Adenoma | Kernicterus | Anemia | Hemangioblastoma | Pituitary Disorders | Tay-Sachs Disease | Leiomyosarcoma | Phenylketonuria | Meleda Disease | Argininosuccinic Aciduria | Neuroblastoma | Senior-Loken Syndrome | Cyclic Vomiting Syndrome | Acute Tubular Necrosis | Dysthymia | Hyperthyroidism | Methemoglobinemia Type IV | Spinocerebellar Ataxia Type 38 | Cryopyrin-associated Periodic Syndromes | Leri-Weill Dyschondrosteosis | Veno-occlusive Disease | Globozoospermia | Chronic Idiopathic Myelofibrosis | Hepatic Veno-occlusive Disease | Pain | Frank-ter Haar Syndrome | Pure Red Cell Aplasia | Neutrophilia | Palsy, Cerebral | Vogt-Koyanagi-Harada Syndrome | Erythema Multiforme | B-cell Chronic Lymphocytic Leukemia | Mitochondrial DNA Depletion Syndrome | Congestive Heart Failure | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Encephalopathy | Cysticercosis | Atelosteogenesis Type 1 | Eating Disorder | Microtia | Brachial Plexus Neuropathy | Constipation | Hyperparathyroidism, Primary | Thrombotic Microangiopathy | GNE Myopathy | Benign Familial Infantile Seizures | Thyroid Dyshormonogenesis | Hypermethioninemia | Graft-versus-host Disease | Yellow Fever | Lateral Meningocele Syndrome | Neurotoxicity | Melanoma, Malignant | Sporadic Hemiplegic Migraine | Glaucomatocyclitic Crisis | Stevens-Johnson Syndrome | Seizures-scoliosis-macrocephaly Syndrome | Sick Sinus Syndrome 1 | Nephrocalcinosis | Multiple Sclerosis, Relapsing-remitting | Eccrine Porocarcinoma | Harlequin Ichthyosis | Congenital Fiber-type Disproportion Myopathy | Osteonecrosis Of The Jaw | Ameloblastoma | Hyperthermia, Malignant | Anosmia, Congenital | Transient Bullous Dermolysis Of The Newborn | Lymphoma, Mantle Cell | Gigantism | Portal Vein Thrombosis | Tyrosinemia | Asperger Syndrome | Pulmonary Veno-occlusive Disease | Isobutyryl-CoA Dehydrogenase Deficiency | Hereditary Neuropathy With Liability To Pressure Palsies | Hypertensive Nephropathy | Pontocerebellar Hypoplasia Type 2 | Primary Pigmented Nodular Adrenocortical Disease | Autonomic Neuropathy | Dental Caries | Menetrier Disease | Succinic Semialdehyde Dehydrogenase Deficiency | Dermatomyositis | Chediak-Higashi Syndrome | Tumoral Calcinosis | Thin Basement Membrane Disease | Gaucher Disease | Adult Polyglucosan Body Disease | Neuronal Ceroid Lipofuscinosis