Cyst

About the Disease
Polycystic Liver Disease 1 with or Without Kidney Cysts, also known as polycystic liver disease 1, is related to bile duct cysts and benign teratoma, and has symptoms including hepatosplenomegaly An important gene associated with Polycystic Liver Disease 1 with or Without Kidney Cysts is PRKCSH (Protein Kinase C Substrate 80K-H), and among its related pathways/superpathways are Cytoskeletal Signaling and Bardet-Biedl syndrome. The drugs Silver nitrate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and pancreas, and related phenotypes are elevated circulating alkaline phosphatase concentration and abnormality of the cardiovascular system

Common Targets
TSC1 | FLCN | PLCD1 | G1029 | PTPRD | SUFU | CDKN2B | PTCH1 | G3845 | CDKN1B | ALG9 | ARID1A | G7157 | G5728

Note: If you'd like to get a target analysis report for Cyst, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cyst at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spondylometaphyseal Dysplasia | Duodenal Atresia | Colorectal Adenoma | Beare-Stevenson Syndrome | Genee-Wiedemann Syndrome | Autoimmune Hemolytic Anemia | Paraplegia | Rift Valley Fever | Nicolaides-Baraitser Syndrome | Lymphoma | Branchiootorenal Syndrome | Mycosis Fungoides | Familial Exudative Vitreoretinopathy | Prolactinoma | Hyperkeratosis | Combined Malonic And Methylmalonic Acidemia | Oligoastrocytoma | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Acute Myeloid Leukemia | Hypotrichosis Simplex | Rheumatic Heart Disease | Uremic Pruritus | Angiomyolipoma | Cholera | Retinitis | Progressive Familial Intrahepatic Cholestasis Type 2 | REM Sleep Behavior Disorder | Lactose Intolerance | Familial Partial Lipodystrophy | Encephalopathy, Glycine | Myasthenia Gravis | Peeling Skin Syndrome Type B | Hidradenitis Suppurativa | Colitis, Lymphocytic | Leukodystrophies | Pontocerebellar Hypoplasia | Acute Coronary Syndrome | Tatton-Brown-Rahman Syndrome | Cockayne Syndrome | Blastoma, Pleuropulmonary | Hypobetalipoproteinemias | Down Syndrome | Torticollis | IMAGe Syndrome | Osteogenesis Imperfecta Type I | Microcephaly, Seizures, And Developmental Delay | Lung Diseases | Cerebellar Ataxia, Cayman Type | Keratopathy | Craniolenticulosutural Dysplasia | Noonan Syndrome-like Disorder With Loose Anagen Hair | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Dementia | Hemorrhagic Disorders | Epilepsy | Acne | Spastic Paraplegia Type 7 | Antley-Bixler Syndrome | Omenn Syndrome | T-cell Prolymphocytic Leukemia | Hypogammaglobulinemia | Multiple Sclerosis, Chronic Progressive | PASLI Disease | Endophthalmitis | Temporal Lobe Epilepsy | Hemangioblastoma | Malaria, Cerebral | POEMS Syndrome | Rhabdomyosarcoma | Cranial Nerve Disease | Parapsoriasis | Epiphyseal Chondrodysplasia, Miura Type | Esophageal Adenocarcinoma | Hemochromatosis Type 2 | Ectodermal Dysplasia | Stroke, Ischemic | Huntington's Disease | Metabolic Diseases | Hyperekplexia | Rolandic Epilepsy | Adult Polyglucosan Body Disease | Celiac Disease | Charcot-Marie-Tooth Disease Type 2D | Ophthalmoplegia | Jacobsen Syndrome | Sertoli Cell-only Syndrome | Cholesteryl Ester Storage Disease | Gynecomastia | Meckel-Gruber Syndrome | Adenosine Deaminase 2 Deficiency | Varicocele | Diabetes Insipidus | Osteoporosis-pseudoglioma Syndrome | Benign Recurrent Intrahepatic Cholestasis 1 | Scabies | Heart Failure | Plasmacytoma | Congenital Muscular Dystrophy | Progressive Osseous Heteroplasia | Charcot-Marie-Tooth Disease Type 3 | Sarcoma, Endometrial Stromal | Onchocerciasis | Measles | Pemphigoid | Myopathy | Atherosclerosis | Mucolipidosis | Usher Syndrome Type II | Non-bullous Congenital Ichthyosiform Erythroderma | Pyloric Stenosis, Infantile Hypertrophic | Chronic Leukemia | Motor Neuron Diseases | Multicystic Renal Dysplasia | Wolcott-Rallison Syndrome | Cystitis, Interstitial | Malnutrition | Krabbe Disease | Oguchi Disease-2 | Lymphoproliferative Disorders | Tendinopathy | Campomelic Dysplasia | Carpal Tunnel Syndrome | Lichen Sclerosus | Leishmaniasis, Cutaneous | Chylothorax, Congenital | Cantu Syndrome | Heart Block | Neuromyotonia | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Facioscapulohumeral Muscular Dystrophy | Aldosteronism | Acromesomelic Dysplasia | Metabolic Syndrome | Paroxysmal Kinesigenic Dyskinesia | Pupil Disorders | Esophagitis, Eosinophilic | Zollinger-Ellison Syndrome | Schwannoma | Succinic Semialdehyde Dehydrogenase Deficiency | Brenner Tumor | Raynaud Phenomenon | Peritonitis | Citrullinemia | Arteriovenous Malformations | Fascioliasis | Wiedemann-Steiner Syndrome | Feingold Syndrome | Pulmonary Sclerosing Hemangioma | Liver Failure, Acute Infantile | Progressive Encephalopathy-optic Atrophy Syndrome | C3 Glomerulopathy | Hypodontia | Nevus | Pleurisy | Ghosal Syndrome | Endocarditis | Glucagonoma | Ebstein Anomaly | Asthma, Nocturnal | Tyrosinemia Type 1 | Open-angle Glaucoma | Avian Influenza | Hepatic Adenomatosis | 3-M Syndrome | Influenza | Osteomyelitis | Stomatitis | FG Syndrome | Communication Disorders | Rotor Syndrome | Sitosterolemia | Blepharoconjunctivitis | Neurocutaneous Melanocytosis | Waardenburg Syndrome Type 4 | Familial Isolated Hyperparathyroidism | Megalencephaly | Juvenile Polyposis | Klippel-Feil Syndrome | Esotropia | Myotonic Disorders | Orotic Aciduria | Mucolipidosis Type III | Nemaline Myopathy 8 | Osteoporosis | Thrombasthenia | Lewy Body Dementia | Myofibromatosis | Corneal Edema | Smith-Magenis Syndrome | Amebiasis | Colitis | Globozoospermia | Preaxial Polydactyly | Familial Hyperaldosteronism | Gitelman Syndrome | Brooke-Spiegler Syndrome | Atrioventricular Septal Defect | Neuromuscular Disorders | Desmosterolosis | Low Tension Glaucoma | Palsy, Cerebral | Familial Cerebral Amyloid Angiopathy | Nephrotic Syndrome Type 1 | Pure Autonomic Failure | Extramammary Paget's Disease | Keratosis, Actinic | Optic Nerve Hypoplasia, Bilateral | Trichuriasis | Waardenburg Syndrome Type 2A | Histiocytosis | X-linked Acrogigantism | Hemorrhage | Tyrosine Hydroxylase Deficiency | Neuroleptic Malignant Syndrome | Wilson's Disease | Focal Facial Dermal Dysplasia | Mountain Sickness | Hypercalciuria | Hereditary Sensory Neuropathy Type 1 | Vertebrobasilar Insufficiency | Usher Syndrome Type IIC | Meleda Disease | Marinesco-Sjogren Syndrome | Psoriasis | Cholelithiasis | Leukoplakia, Oral | Infantile Liver Failure Syndrome 1 | Smith-Lemli-Opitz Syndrome | Waardenburg Syndrome Type 2E | MIRAGE Syndrome | Majeed Syndrome | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Xeroderma Pigmentosum Variant Type | Hypoalbuminemia | Basal Ganglia Cerebrovascular Disease | Dysmorphophobia | Muscular Dystrophy | Hemangioendothelioma | Hypothyroidism | Asthma, Exercise-induced | Adenoma, Pituitary | Dystonia Musculorum Deformans | Primary Erythromelalgia | Neurofibrosarcoma | Frontometaphyseal Dysplasia | Non-proliferative Diabetic Retinopathy | Congenital Absence Of Vas Deferens | Renal Oncocytoma | Immunoproliferative Disorders | Impulse Control Disorder | Cryptosporidiosis | Gliosarcoma | Myositis, Focal | Allergic Contact Dermatitis | Distal Spinal Muscular Atrophy | Charcot-Marie-Tooth Disease Type 2T | Fetal Akinesia Deformation Sequence | Anterior Segment Dysgenesis | Cancer, Bladder | Hereditary Coproporphyria | Spermatocele | Hydrocephalus | Kernicterus | Azoospermia | Hepatitis, Chronic | Glioma | Hepatic Veno-occlusive Disease | Corticobasal Syndrome | Erythrokeratodermia Variabilis | Acute Kidney Injury | Pyelonephritis | Hidradenitis | Eiken Syndrome | Adenoma, Villous | Cerebrotendinous Xanthomatosis | Endometriosis | Epidermolytic Hyperkeratosis | Blomstrand Osteochondrodysplasia | Purpura, Thrombotic Thrombocytopenic | Vitamin B12 Deficiency | Mesothelioma, Malignant | Tardive Dyskinesia | Encephalopathy, Ethylmalonic | Ophthalmia, Sympathetic | Polyarteritis Nodosa | GM2-gangliosidosis AB Variant | Potocki-Shaffer Syndrome | Acute Leukemia | Lipid Storage Diseases | Persistent Mullerian Duct Syndrome | Macular Corneal Dystrophy Type 1 | Hemochromatosis | Van Der Knaap Disease | Lymphoma, Mantle Cell | Strabismus | Facioscapulohumeral Muscular Dystrophy Type 2 | Thrombosis | Polycythemia | H Syndrome | Veno-occlusive Disease | Arthritis, Psoriatic | Angioedema | Spina Bifida | Mast Cell Leukemia | Glycogen Storage Disease Type 1b | Diabetes Gestational | Meningitis | Pre-eclampsia | Maternally Inherited Diabetes And Deafness | Schwannomatosis | Acute Generalized Exanthematous Pustulosis | Wagner Disease | Focal Segmental Glomerulosclerosis | Trichotillomania | Arrhythmogenic Right Ventricular Cardiomyopathy | Pyruvate Carboxylase Deficiency Disease | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Paraganglioma, Carotid Body | Poikiloderma With Neutropenia | Nephronophthisis | Ischemia | Gastroenteritis | Lentigo | Hypohidrotic Ectodermal Dysplasia, X-linked | Charcot-Marie-Tooth Disease, Type 2A | DiGeorge Syndrome | Kleine-Levin Syndrome | Chediak-Higashi Syndrome | Thanatophoric Dysplasia Type 1 | Hereditary Xerocytosis | Jawad Syndrome | Spinocerebellar Ataxia Type 12 | Ellis-Van Creveld Syndrome | Myoclonic Epilepsy With Ragged Red Fibers | Colon Adenoma | Leukocyte Adhesion Deficiency Type 1 | Odonto-onycho-dermal Dysplasia | Neurofibroma, Plexiform | Chordoid Glioma | Neovascular Glaucoma | Hypopituitarism | Rothmund-Thomson Syndrome | Cutis Laxa | Hartnup Disease | Focal Dermal Hypoplasia | Sensorineural Hearing Loss | Infertility, Male | Anuria | Disseminated Intravascular Coagulation | Whipple's Disease | Diabetes Type 1 | Rhabdomyosarcoma, Alveolar | Tricho-hepato-enteric Syndrome | Hyperlipidemia, Familial Combined | Steel Syndrome | Exfoliative Dermatitis | Stromal Corneal Dystrophy | Tenosynovial Giant Cell Tumor | Heroin Dependence | Fahr Disease | Reye Syndrome | Duane Retraction Syndrome | Porphyria Cutanea Tarda | Myhre Syndrome | Spondylocarpotarsal Synostosis Syndrome | Epithelioid Hemangioma | Fibrosis | Spinocerebellar Ataxia Type 3 | Atelosteogenesis Type 2 | MELAS Syndrome | Benign Hereditary Chorea | Takayasu's Arteritis | Anorexia Nervosa | Alazami Syndrome | Venous Insufficiency | Sleep Apnea, Central | Ocular Albinism Type 1 | Hyperparathyroidism | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Ornithine Transcarbamylase Deficiency | Hypertensive Nephropathy | GAPO Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Common Cold | Seminoma | Hyperbilirubinemia | Generalized Epilepsy With Febrile Seizures Plus | Netherton Syndrome | Waardenburg Syndrome Type 1 | Aarskog-Scott Syndrome | Fontaine Progeroid Syndrome | Pierpont Syndrome | Loeys-Dietz Syndrome Type 4 | Zimmermann-Laband Syndrome | Esthesioneuroblastoma | Aplasia Cutis Congenita | Paroxysmal Nocturnal Hemoglobinuria | Hemosiderosis | Hypoproteinemia, Hypercatabolic | Anti-NMDA Receptor Encephalitis