Jacobsen Syndrome

About the Disease
Jacobsen Syndrome, also known as jacobsen distal 11q deletion syndrome, is related to johanson-blizzard syndrome and hypoplastic left heart syndrome, and has symptoms including muscle spasticity An important gene associated with Jacobsen Syndrome is JBS (Jacobsen Syndrome). The drugs Metformin and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and kidney, and related phenotypes are intellectual disability and global developmental delay

Common Targets
CDC42

Note: If you'd like to get a target analysis report for Jacobsen Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Jacobsen Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Myoclonic Atonic Epilepsy | Familial Hyperaldosteronism | Neuronal Ceroid Lipofuscinosis | Greig Cephalopolysyndactyly Syndrome | McCune-Albright Syndrome | Pulmonary Capillary Hemangiomatosis | Hyperandrogenemia | Delayed Sleep Phase Syndrome | Pneumoconiosis | Vitiligo | Osteitis | Tibial Muscular Dystrophy | Interstitial Lung Diseases | Holt-Oram Syndrome | Strabismus | Non-small Cell Lung Cancer | Cholecystitis | Postaxial Polydactyly | Incontinentia Pigmenti | Guanidinoacetate Methyltransferase Deficiency | Eclampsia | Otitis Media | Diverticulitis | Precocious Puberty | Spinal Muscular Atrophy | Cryptosporidiosis | Fascioliasis | Epidermolysis Bullosa Simplex, Generalized | Common Variable Immunodeficiency | Hypobetalipoproteinemias | Neurocutaneous Melanocytosis | Thalassemia | Lymphoma, AIDS-related | Juvenile Hyaline Fibromatosis | Papillon-Lefevre Syndrome | Bacterial Meningitis | Sarcoidosis | Glycogen Storage Disease Type 6 | Retinoschisis | Nemaline Myopathy 10 | Tenosynovial Giant Cell Tumor | Congenital Hypofibrinogenemia | Spinocerebellar Ataxia Type 28 | Lupus Erythematosus | Hemorrhagic Disorders | Metabolic Syndrome | Asthma, Exercise-induced | Meningioma, Benign | Ornithine Transcarbamylase Deficiency | Scapuloperoneal Spinal Muscular Atrophy | Cole-Carpenter Syndrome | Porphyria Cutanea Tarda | Hyperkeratosis | Schistosomiasis Mansoni | Rift Valley Fever | Gliosarcoma | Hereditary Folate Malabsorption | Vulvovaginitis | Follicular Dendritic Cell Sarcoma | Hemophilia | Dystonia | Epithelioid Hemangioma | Fabry's Disease | Mucolipidosis | Holoprosencephaly | Tangier Disease | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Acquired Partial Lipodystrophy | Charcot-Marie-Tooth Disease, Type 6 | Hereditary Inclusion Body Myopathy | Spinocerebellar Ataxia Type 13 | Esophagitis | Liver Failure | Cancer, Bladder | Mesothelioma, Malignant | Oligoasthenoteratozoospermia | Absence Epilepsy | Osteochondroma | Hereditary Multiple Exostoses | Phosphoglycerate Dehydrogenase Deficiency | Hyperprolactinemia | Non-bullous Congenital Ichthyosiform Erythroderma | Primary Sclerosing Cholangitis | Charcot-Marie-Tooth Disease Type 3 | Hypervalinemia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Hypersensitivity Pneumonitis | Blastoma, Pleuropulmonary | Spinocerebellar Ataxia Type 23 | Hypodontia | Ulcerative Colitis | Tuberculous Meningitis | Pancytopenia | Pneumothorax | Spinocerebellar Ataxia Type 3 | Lennox-Gastaut Syndrome | Early Infantile Epileptic Encephalopathy 13 | Overactive Bladder | Restrictive Dermopathy | Hyperparathyroidism, Primary | Thyroiditis | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Peters-plus Syndrome | Nijmegen Breakage Syndrome | Hepatoblastoma | Renal Tubular Dysgenesis | Kabuki Syndrome | Phenylketonuria | Keratopathy | Hydronephrosis | Neuroectodermal Tumors, Primitive | Multiple Sclerosis, Primary Progressive | Diabetes Insipidus | Osteoporosis | Hemangioendothelioma | Charcot-Marie-Tooth Disease, Type 2 | Adenoma, Pituitary | Obesity, Morbid | Unverricht-Lundborg Syndrome | Lattice Corneal Dystrophy | Central Pain Syndrome | Premature Ejaculation | Polycystic Kidney, Autosomal Recessive | Anorchia | Hypospadias | Xeroderma Pigmentosum Variant Type | Spinocerebellar Ataxia Type 38 | Leishmaniasis, Cutaneous | Systemic Mastocytosis | Spinal Muscular Atrophy Type 3 | Motor Neuron Diseases | Harlequin Ichthyosis | Arts Syndrome | Colon Adenoma | Nemaline Myopathy | Hepatic Steatosis | Cancer, Prostate | Anti-glomerular Basement Membrane Disease | Gerstmann-Straussler-Scheinker Syndrome | Open-angle Glaucoma | Adenomyosis | Rhabdomyosarcoma, Alveolar | Babesiosis | Metachondromatosis | Epilepsy, Generalized | Ureteropelvic Junction Obstruction | Cardiomyopathy, Restrictive | Periventricular Nodular Heterotopia | Methemoglobinemia Type IV | Spastic Paraplegia Type 7 | Hyperbilirubinemia | Fetal And Neonatal Alloimmune Thrombocytopenia | Retinoblastoma | Bernard-Soulier Syndrome | Transcobalamin Deficiency | Brachydactyly | Hepatitis, Chronic | Tatton-Brown-Rahman Syndrome | Hyperparathyroidism, Secondary | Echinococcosis | Wolfram Syndrome | Autism Spectrum Disorders | Proteus Syndrome | Basal Ganglia Cerebrovascular Disease | Peutz-Jeghers Syndrome | Vitelliform Macular Dystrophy | Behavioral Variant Of Frontotemporal Dementia | Lung Diseases | Iron Metabolism Disorders | Cancer, Kidney | GLUT1 Deficiency Syndrome | Macrophage Activation Syndrome | Nicotine Dependence | Marfan Syndrome | Stroke, Ischemic | Infantile Neuroaxonal Dystrophy | Gynecomastia | Localized Scleroderma | Exocrine Pancreatic Insufficiency | Malaria | Usher Syndrome | Wolfram Syndrome 2 | Apert Syndrome | Chanarin-Dorfman Syndrome | Rash | Dermatofibrosarcoma | Aarskog-Scott Syndrome | Diastrophic Dysplasia | Acne | Transient Bullous Dermolysis Of The Newborn | Alexander Disease | Meesmann Corneal Dystrophy | Chitayat Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Anodontia | Coenzyme Q10 Deficiency | Porphyria | Hereditary Xerocytosis | Congenital Stromal Corneal Dystrophy | Diabetes Insipidus, Nephrogenic | Smith-Magenis Syndrome | Retinopathy Of Prematurity | Dupuytren Disease | Wolff-Parkinson-White Syndrome | Epilepsy | Eczema | Blastomycosis | Facioscapulohumeral Muscular Dystrophy Type 2 | Diabetes Gestational | Congenital Nystagmus | WAGR Syndrome | 3-methylcrotonyl-CoA Carboxylase Deficiency | Lymphomatoid Granulomatosis | Atelosteogenesis Type 1 | Takayasu's Arteritis | Diffuse Intrinsic Pontine Glioma | Adult Polyglucosan Body Disease | Charcot-Marie-Tooth Disease Type 4E | Hennekam Lymphangiectasia-lymphedema Syndrome | Pemphigoid | Low Phospholipid Associated Cholelithiasis | Hereditary Elliptocytosis | Cri-du-chat Syndrome | Hydrocephalus, Normal Pressure | Intestinal Obstruction | Hypopigmentation | Pyruvate Carboxylase Deficiency Disease | Scleroderma | Dementia, Vascular | Congenital Heart Block | Hepatitis C, Chronic | Werner's Syndrome | Leigh Syndrome | Encephalitis, Tick-borne | Ophthalmoplegia | Leukoencephalopathy, Progressive Multifocal | N-acetylglutamate Synthase Deficiency | Tay-Sachs Disease | Acute Anterior Uveitis | Heimler Syndrome | Lymphoma, Follicular | Dent Disease | Costello Syndrome | Glutaric Aciduria Type 3 | Progressive Osseous Heteroplasia | Lichen Sclerosus | Lymphangioleiomyomatosis | Oculocutaneous Albinism Type 4 | Sarcomatoid Carcinoma Of The Lung | Muscle Wasting | Rolandic Epilepsy | Treacher Collins Syndrome | Ocular Surface Squamous Neoplasia | Osteopathia Striata With Cranial Sclerosis | Pelvic Inflammatory Disease | Polycystic Liver | Ganglioneuroma | Melanoma, Malignant | Galactosemia | Gastroschisis | Camptocormia | Seborrheic Dermatitis | Hyperekplexia | Keratocystic Odontogenic Tumor | Cardiac Sarcoidosis | Communication Disorders | Acrodysostosis | Bladder Exstrophy | Primary Hyperoxaluria | Benign Familial Pemphigus | Trichorhinophalangeal Syndrome | Epidermal Nevus Syndrome | Heavy Chain Disease | Diamond-Blackfan Anemia | Hereditary Spherocytosis | Alopecia Areata | Esophagitis, Eosinophilic | Hepatitis | Dubin-Johnson Syndrome | CHOPS Syndrome | Schnitzler Syndrome | Prurigo Nodularis | Cancer, Breast | Epicondylitis | Malignant Fibrous Histiocytoma | Primary Familial Brain Calcification | Meningococcal Meningitis | Goiter | C3 Glomerulonephritis | Avian Influenza | TARP Syndrome | Neurofibromatosis | Preaxial Polydactyly | Histiocytic Sarcoma | Von Hippel-Lindau Disease | Saethre-Chotzen Syndrome | Spinocerebellar Ataxia Type 8 | Rotor Syndrome | Orotic Aciduria | Autism | Christianson Syndrome | Chronic Thromboembolic Pulmonary Hypertension | Lassa Fever | Hypertelorism | Dwarfism | Acrodermatitis | Synovitis | GAPO Syndrome | Papillorenal Syndrome | Stuve-Wiedemann Syndrome | Hypersomnia | Chorea | Dengue Shock Syndrome | Cerebrovascular Disorders | Saul-Wilson Syndrome | Epiphyseal Chondrodysplasia, Miura Type | Anal Fissure | Pituitary Disorders | Prolidase Deficiency | Blue Rubber Bleb Nevus Syndrome | Neural Tube Defect | Duane Retraction Syndrome | Microcephalic Primordial Dwarfism | Bulimia Nervosa | Rickets | Wilson's Disease | Hypertension, Essential | Pelizaeus-Merzbacher Disease | Heterotopic Ossification | Chronic Enteropathy Associated With SLCO2A1 Gene | 3-hydroxy-3-methylglutaric Aciduria | Acromegaly | Camurati-Engelmann Disease | Wiskott-Aldrich Syndrome | Hyperglycemia | Osteoporosis, Postmenopausal | Agranulocytosis | Guillain-Barre Syndrome | Meningeal Melanocytoma | Hernia, Inguinal | Rubinstein-Taybi Syndrome | Hypoparathyroidism | Hypercalcemia | Clouston Hidrotic Ectodermal Dysplasia | Sengers Syndrome | Astrocytoma | D-2-Hydroxyglutaric Aciduria | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Hypotrichosis | Diabetic Nephropathy | Congenital Adrenal Hyperplasia 1 | Familial Dysautonomia | Birt-Hogg-Dube Syndrome | Onchocerciasis | Retinitis Pigmentosa 3 | Hypocalcemia | Pulmonary Vein Stenosis | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Corneal Dystrophy | Metatropic Dysplasia | Barakat Syndrome | Whipple's Disease | Prediabetes | Intestinal Tuberculosis | Infantile Nephropathic Cystinosis | Renal Medullary Carcinoma | Chronic Periodontitis | Hyperbilirubinemia, Neonatal | Pituitary Dwarfism | Mood Disorder | CDKL5 Deficiency Disorder | Nicotine Addiction | Tinea | Sturge-Weber Syndrome | Hypersensitivity | Myoclonus-dystonia Syndrome | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Antisocial Personality Disorder | Sensory Neuropathy | Multiple Sclerosis, Secondary Progressive | 3-methylglutaconic Aciduria Type I | Distal Myopathy | Pregnancy, Ectopic | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Isobutyryl-CoA Dehydrogenase Deficiency | Borjeson-Forssman-Lehmann Syndrome | Nasodigitoacoustic Syndrome | Knobloch Syndrome | Aneurysm, Abdominal Aortic | Bethlem Myopathy | Thyroid Dyshormonogenesis | DOCK8 Immunodeficiency Syndrome | Infertility, Male | Autosomal Recessive Spastic Paraplegia Type 35 | Peeling Skin Syndrome, Acral Type | Chronic Kidney Disease | Rett Syndrome | Uremia | Lymphedema-distichiasis Syndrome | Osteopetrosis