Primary Progressive Nonfluent Aphasia

About the Disease
Progressive Non-Fluent Aphasia, also known as progressive nonfluent aphasia, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and echolalia. An important gene associated with Progressive Non-Fluent Aphasia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Neuroscience and Cytoskeletal Signaling. The drugs Aluminum hydroxide and Corticosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and caudate nucleus, and related phenotypes are thickened nuchal skin fold and memory impairment

Common Targets
G4137 | TREM2 | GRN | APOE | EWSR1

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