Waardenburg Syndrome Type 4A

About the Disease
Waardenburg Syndrome, Type 4a, also known as waardenburg syndrome type 4a, is related to peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease and waardenburg syndrome, type 4c. An important gene associated with Waardenburg Syndrome, Type 4a is EDNRB (Endothelin Receptor Type B), and among its related pathways/superpathways are Neural crest differentiation and Melanocyte Development and Pigmentation. Affiliated tissues include skin, eye and brain, and related phenotypes are constipation and hearing impairment

Common Targets
EDNRB

Note: If you'd like to get a target analysis report for Waardenburg Syndrome Type 4A, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Waardenburg Syndrome Type 4A at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Blastoma, Pleuropulmonary | Limb Girdle Muscular Dystrophy | Corticobasal Syndrome | Blood Protein Disorders | Lennox-Gastaut Syndrome | Retinitis Pigmentosa 3 | Hemophagocytic Lymphohistiocytosis | Cyclic Vomiting Syndrome | Triphalangeal Thumb-polysyndactyly Syndrome | Leiomyoma | Leber Congenital Amaurosis | Brachydactyly | Lewy Body Dementia | CREST Syndrome | Familial Episodic Pain Syndrome | Pancreatitis | Transient Bullous Dermolysis Of The Newborn | Hypercholesterolemia, Familial | Miyoshi Myopathy | Renal Failure | Spinocerebellar Ataxia Type 16 | Pulmonary Sclerosing Hemangioma | Multiple Sclerosis | Progressive Myoclonic Epilepsy | Melanoma | Dementia | Follicular Dendritic Cell Sarcoma | Atopic Dermatitis | Congenital Sodium Diarrhea | Pemphigus Foliaceus | Orotic Aciduria | Galactosialidosis | Corneal Edema | Combined Deficiency Of Factor V And Factor VIII | Tyrosine Hydroxylase Deficiency | Lissencephaly 2 | Spinocerebellar Ataxia Type 23 | Mitochondrial DNA Depletion Syndrome 13 | Arthritis, Gouty | Cancer, Brain | 5-oxoprolinase Deficiency | Myoclonic Atonic Epilepsy | Chanarin-Dorfman Syndrome | Stroke, Hemorrhagic | Epidermolysis Bullosa Simplex | Osteochondroma | Dystonia Musculorum Deformans | Atopy | Mood Disorder | Neonatal Progeroid Syndrome | Papillon-Lefevre Syndrome | Fibronectin Glomerulopathy | Hereditary Coproporphyria | Papilloma | Sarcomatoid Carcinoma Of The Lung | Discoid Lupus Erythematosus | Acral Lentiginous Melanoma | Cardiofaciocutaneous Syndrome | Large Granular Lymphocytic Leukemia | Hemochromatosis | Schaaf-Yang Syndrome | Jaundice, Obstructive | Muscle Wasting | Macrophage Activation Syndrome | Robinow Syndrome | Delirium | Adult Polyglucosan Body Disease | Amblyopia | Parkinson's Disease | Sleep Apnea | Chronic Beryllium Disease | Hemochromatosis Type 2 | Wilson's Disease | DOCK8 Immunodeficiency Syndrome | Blepharospasm | CHOPS Syndrome | Shprintzen-Goldberg Syndrome | Myocarditis | Meleda Disease | Trichuriasis | Cataplexy | Coenzyme Q10 Deficiency | Charcot-Marie-Tooth Disease Type 3 | Rash | Pain | Hyperparathyroidism, Secondary | Corneal Dystrophy | Rift Valley Fever | Pneumococcal Meningitis | Cold-induced Sweating Syndrome | Thalassemia | Sengers Syndrome | Thrombasthenia | Inflammatory Myofibroblastic Tumor | Paronychia | Gastroenteritis | Pierre Robin Syndrome | Reticular Dysgenesis | Precocious Puberty | Metachondromatosis | Wolfram Syndrome 2 | Metabolic Syndrome | Kaposiform Hemangioendothelioma | Batten Disease | X-linked Sideroblastic Anemia | Vici Syndrome | Acute Leukemia | Veno-occlusive Disease | Granular Corneal Dystrophy | Bladder Exstrophy | Tietze Syndrome | Primary Carnitine Deficiency | Epicondylitis | Nail-Patella Syndrome | Epidermolysis Bullosa Dystrophica | Spinocerebellar Ataxia Type 7 | Autoimmune Polyendocrinopathy Syndrome Type I | Aicardi-Goutieres Syndrome | Anorexia Nervosa | Lamellar Ichthyosis | Spinocerebellar Ataxia Type 31 | Familial Hypobetalipoproteinemia | Carey-Fineman-Ziter Syndrome | Compartment Syndrome | Neurodermatitis | Heroin Dependence | Optic Neuritis | Chromosome 16p11.2 Deletion Syndrome | Congenital Adrenal Hyperplasia | Combined Malonic And Methylmalonic Acidemia | Primary Progressive Nonfluent Aphasia | Progressive Osseous Heteroplasia | Light Chain Amyloidosis | Agoraphobia | Diffuse Palmoplantar Keratoderma | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Wagner Disease | Osteopathia Striata With Cranial Sclerosis | Cancer, Breast | Papulopustular Rosacea | Gingivitis | Marfan Syndrome | Aldosterone Synthase Deficiency | Ectrodactyly | Neurofibromatosis Type 2 | Postpartum Depression | Loeys-Dietz Syndrome Type 4 | Cheilitis | Alopecia Totalis | Neurocysticercosis | Hyper IgE Syndrome | Distal Spinal Muscular Atrophy | Netherton Syndrome | Hereditary Xerocytosis | Birk-Barel Syndrome | Pulmonary Alveolar Proteinosis | Antithrombin III Deficiency | Encephalitis | Nijmegen Breakage Syndrome | Colitis, Collagenous | Congenital Bilateral Absence Of Vas Deferens | TARP Syndrome | Salla Disease | Progressive Familial Intrahepatic Cholestasis Type 3 | Yellow Fever | Heart Septal Defects | Sezary Syndrome | Odonto-onycho-dermal Dysplasia | Eating Disorder | Inborn Errors Of Metabolism | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Pneumonia, Mycoplasma | Metachromatic Leukodystrophy | Stuve-Wiedemann Syndrome | Persistent Hyperplastic Primary Vitreous | Restrictive Dermopathy | Still Disease | Charcot-Marie-Tooth Disease Type 4E | Medulloblastoma | Allergic Contact Dermatitis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Benign Familial Pemphigus | Epidermolytic Ichthyosis, Annular | Split Hand-foot Malformation | Alexander Disease | Narcolepsy | Porphyria | H Syndrome | Dermatitis | Retinopathy, Diabetic | Gardner Syndrome | Vertebrobasilar Insufficiency | Dysthymia | Pituitary Stalk Interruption Syndrome | Prostatitis | Intestinal Hypomagnesemia 1 | Progressive Encephalopathy-optic Atrophy Syndrome | Takayasu's Arteritis | Duchenne Muscular Dystrophy | Multisystemic Smooth Muscle Dysfunction Syndrome | Chondrodysplasia Punctata | Alveolar Capillary Dysplasia | Methylmalonic Acidemia | Creatine Deficiency Syndrome Due To AGAT Deficiency | Pulmonary Vein Stenosis | Spinocerebellar Ataxia Type 27 | Adrenal Insufficiency | Meningioma, Benign | Danon Disease | Seminoma | Majeed Syndrome | Pregnancy, Ectopic | Asthma | Pseudomyxoma Peritonei | Stroke | Migraine | Osteogenesis Imperfecta Type III | Waardenburg Syndrome Type 1 | Takenouchi-Kosaki Syndrome | Inflammatory Bowel Disease | Learning Disability | Ichthyosis Hystrix, Curth-Macklin Type | Kabuki Syndrome 2 | Congenital Poikiloderma | Proctitis | Myelomeningocele | Smith-Lemli-Opitz Syndrome | Sick Sinus Syndrome 1 | Evans Syndrome | Stiff-man Syndrome | CDKL5 Deficiency Disorder | Rolandic Epilepsy | Genee-Wiedemann Syndrome | Anosmia, Congenital | Werner's Syndrome | Cocaine-Related Disorders | Chorioretinitis | Spinocerebellar Ataxia | Brenner Tumor | Dowling-Degos Disease | Sarcoma | Paroxysmal Nocturnal Hemoglobinuria | Hyperinsulinism-hyperammonemia Syndrome | Pulmonary Veno-occlusive Disease | Polymicrogyria | Carcinoma, Small Cell | Thyroid Dyshormonogenesis | MELAS Syndrome | Osteochondrosis | Best Macular Dystrophy | Microphthalmia | Diabetic Nephropathy | Urolithiasis | Endocarditis | Maple Syrup Urine Disease | Headache | AIDS | L-2-Hydroxyglutaric Aciduria | Pfeiffer Syndrome | Polyneuropathy | Beckwith-Wiedemann Syndrome | Leprosy | Keratopathy | Angioimmunoblastic T-cell Lymphoma | Spondyloarthritis | Nutrition Disorders | Opisthorchiasis | 3-hydroxy-3-methylglutaric Aciduria | Creutzfeldt-Jakob Disease | Trigonocephaly | Mucormycosis | Cerebrovascular Disorders | Optic Atrophy 2 | Hyperlipidemia Type V | Chondrodysplasia Punctata 1, X-linked Recessive | Fibromyalgia | PASLI Disease | Schnitzler Syndrome | Gastritis | Craniolenticulosutural Dysplasia | Osmotic Demyelination Syndrome | Persistent Fetal Circulation | Paternal Uniparental Disomy Of Chromosome 14 | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Hypersensitivity Pneumonitis | Infantile Nephropathic Cystinosis | Nance-Horan Syndrome | Endometriosis | Pulmonary Alveolar Microlithiasis | Aneurysm, Thoracic Aortic | Charcot-Marie-Tooth Disease Axonal Type 2N | Papilledema | Neuromyotonia | Keratosis, Actinic | Thin Basement Membrane Disease | Giant Cell Arteritis | Heavy Chain Disease | Chronic Granulomatous Disease | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Spinocerebellar Ataxia Type 14 | Cystinuria | Ventricular Septal Defect | Gerodermia Osteodysplastica | Amyloidosis | Cardiomyopathy, Restrictive | Polycystic Ovary Syndrome | Arthritis | Glycogen Storage Disease Type 5 | DRESS Syndrome | Pontocerebellar Hypoplasia | Primary Cutaneous Amyloidosis | Long QT Syndrome Type 1 | Leukoplakia, Oral | Chronic Thromboembolic Pulmonary Hypertension | Chorea-acanthocytosis | Peripheral T-cell Lymphoma | Sporadic Inclusion Body Myositis | Hyperthyroidism | Essential Fructosuria | Otosclerosis | Idiopathic Pulmonary Fibrosis | Osteogenesis Imperfecta Type IV | Pneumothorax | DNA Ligase IV Deficiency | Takotsubo Cardiomyopathy | Costello Syndrome | Hennekam Lymphangiectasia-lymphedema Syndrome | Hypertensive Nephropathy | Cutaneous Lupus Erythematosus | Pneumoconiosis | Androgenic Alopecia | Retinal Degeneration | Neurofibroma, Plexiform | Aneurysm, Abdominal Aortic | Gynecomastia | Hypopigmentation | Erythema Multiforme | Extramammary Paget's Disease | Anorchia | Tinea | Non-bullous Congenital Ichthyosiform Erythroderma | Autosomal Recessive Congenital Ichthyosis | Genitopatellar Syndrome | Lateral Meningocele Syndrome | Primary Ovarian Insufficiency | GM2-gangliosidosis AB Variant | Joubert Syndrome 2 | Mast Cell Leukemia | Heimler Syndrome | Charcot-Marie-Tooth Disease | Osteosarcoma | Actinomycetoma | Binge Eating Disorder | Multicystic Renal Dysplasia | Snyder-Robinson Syndrome | Tetraplegia | Glaucoma, Congenital | Bronchiolitis | Epilepsy | Schizoaffective Disorder | Pyloric Stenosis, Infantile Hypertrophic | Tularemia | Lymphoma, AIDS-related | Isobutyryl-CoA Dehydrogenase Deficiency | Azoospermia | Tuberculosis | Chronic Lymphocytic Leukemia | Colitis, Lymphocytic | Pemphigus Vulgaris | Von Hippel-Lindau Disease | Carbohydrate Metabolism Disorders | Primary Pigmented Nodular Adrenocortical Disease | Pheochromocytoma | Riboflavin Transporter Deficiency Neuronopathy | Trichotillomania | Enlarged Vestibular Aqueduct | Occipital Neuralgia | Lichen Planus | Blastomycosis | Stevens-Johnson Syndrome | Hepatitis, Autoimmune | Hypodontia | IgA Deficiency | Histiocytosis | Hyperhomocysteinemia | Familial Hemiplegic Migraine | Polycythemia Vera | Multifocal Motor Neuropathy | Jacobsen Syndrome | Gout | Obesity | Carney Triad | Periventricular Leukomalacia | Charcot-Marie-Tooth Disease Type 2T | Alopecia Areata | Non-proliferative Diabetic Retinopathy | Arthritis, Reactive | VEXAS Syndrome | Glomerulonephritis | Pneumonia, Viral