Chronic Lymphocytic Leukemia

About the Disease
Leukemia, Chronic Lymphocytic 2, also known as leukemia, chronic lymphocytic, susceptibility to, 2, is related to chronic lymphocytic leukemia/small lymphocytic lymphoma and chromosomal triplication, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Lymphocytic 2 is CLLS2 (Disrupted In B-Cell Neoplasia), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Interleukin-4 and Interleukin-13 signaling. The drugs Valganciclovir and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and b cells, and related phenotypes are chronic lymphatic leukemia and immune system

Common Targets
DESI1 | DUOXA1 | CHEK2 | MSH2 | TNFRSF10B | MED12 | IL2RB | PUS10 | KLRC1 | PLCG2 | HYMAI | PTPN6 | ITGA6 | CRBN | PIK3CG | OR52K2 | HTRA4 | BBS9 | PRDM8 | TUBGCP2 | PLCXD3 | KDR | FBXW7 | HLA-DQB1 | TOMM34 | SELE | CXCR5 | YES1 | IDUA | FCGR2B | WNT5A | XRCC1 | PVT1 | AP2A2 | G6714 | BRME1 | FUBP1 | MYNN | COL12A1 | CAT | EMC10 | HCK | DNA Methyltransferase (DNMT) (nonspecified subtype) | TEC | MAP1A | CSNK1E | HS3ST6 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | MIR1306 | KCNH2 | AURKA | G472 | SPEN | MAP3K12 | TRIM72 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | ERCC5 | MST1R | UFD1 | OR4A5 | TERF2IP | SLC28A2 | CD74 | DNA-Directed DNA Polymerase Complex | G1956 | FGR | ABL1 | NAP1L5 | MICAL2 | Cyclin B (nonspecified subtype) | G3576 | LPL | NBN | STN1 | ZBTB38 | RAI14 | PRDM9 | IL6ST | LRFN4 | THTPA | NRIP1 | FADD | COLEC10 | CSMD3 | CDK4/Cyclin D1 | JAK2 | G3845 | LRRD1 | PUS7L | KIAA1549L | SERPINB6 | MGC12916 | WDR55 | MIR150 | CUL5 | MIR2110 | PSMB5 | MESTIT1 | VSIG8 | LDLR | TCEA2 | GTF2H1 | POLI | MIR2053 | IL1B | UBXN6 | MALT1 | Protein Phosphatase 2A | TPM4 | XPC | CDH13 | HLA-E | MIR323B | SCN10A | RHOBTB2 | PIGP | SLC28A3 | MIR943 | ASXL2 | FAP | ANKRD53 | GSTM3 | CGREF1 | FBXL16 | MIR1282 | MAGEC3 | TNFRSF1B | PREP | MYH9 | ORC3 | MIR106B | AKAP9 | AVPR1A | CD177 | IGF2R | SREBF2 | G6774 | MAP2 | CDK2 | G3569 | SMAD5-AS1 | G7015 | MYD88 | SOX14 | KIAA1217 | THBS1 | UBR5 | CASP5 | HLA-DMB | TNRC6A | CCR6 | IL1RN | LCN8 | CSK | KCNN3 | JAKMIP1 | MIR449B | NLRP11 | CNOT1 | ABHD13 | MIR1178 | NCOA2 | LRRK2 | NLRP13 | RAPGEF1 | SOCS6 | HFE | MARK4 | DHX9 | CASP1P2 | RMDN3 | SLC28A1 | SLC22A1 | CARD17P | HDAC6 | CFAP91 | BTK | UNKL | ME1 | PRKCZ | LINC00528 | HDAC2 | NFATC1 | ZNF668 | IPCEF1 | CCNH | TRAF3 | MYO9B | MIR23A | TNFRSF10A | NLRP8 | G3620 | SELL | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Cyclin-dependent kinase (nonspecified subtype) | ERCC6 | NAXD | TMEM139-AS1 | AMP-activated protein kinase (AMPK) | LGALS3 | C8orf82 | SNU13 | CTC1 | MIR548H3 | Heat shock protein 90 (nonspecified subtype) | CYP2C19 | LEF1 | FANK1 | NEURL3 | DSG4 | CDK5/p25 | DND1 | NAE1 | CCND2 | PCDHGC4 | MORC1 | TP53I3 | RANBP10 | ADRA2B | CDC73 | BUB1B | WNT9A | G3BP1 | MIR34A | ECHDC2 | G595 | FGF4 | CDC25C | RWDD2A | KMT2C | NLRP5 | DNLZ | FAT1 | GALNT10 | ESCO1 | TSPAN33 | G1/S-specific cyclin-E (nonspecified subtype) | ELANE | OPRM1 | MIEF1 | SMAD5 | OAS3 | CHAD | PTPN12 | MIR155 | ENTPD1-AS1 | DUSP22 | IL2RA | SPAM1 | EPHX2 | TNFSF12 | GPR18 | CDK6 | AVPR1B | ADCY3 | CHEK1 | HSP90AB1 | XRCC2 | PLEKHG4 | ALLC | ITGA2B | MIR577 | NPM1 | CHAC2 | ATP5MK | NAT2 | FAN1 | NRAS | NXF1 | STARD8 | MIR492 | HS3ST3A1 | NF-kappaB (NFkB) | G207 | MIR3151 | EMC7 | IGDCC3 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | RANBP6 | AURKB | AXL | STRIP2 | IL3 | Ephrin Receptor (nonspecified subtype) | LTA | CUTALP | CASP10 | RAB37 | CCR7 | Ribonucleoside-diphosphate reductase | MIR585 | EHMT1 | LIN7A | BMX | LAG3 | CARD11 | CENPB | CELF6 | IRF3 | Protein kinase C (nonspecified subtype) | LCK | LPP | G7099 | DROSHA | ZEB2 | SP140 | SPPL2A | CDX4 | APBA3 | PSMB10 | GEMIN4 | PLS3 | BAK1 | HLA class II histocompatibility antigen DR (HLA-DR) | G598 | CD3 Complex (T Cell Receptor Complex) | TYK2 | G5133 | POLE | CPEB1-AS1 | NBR2 | CSF1R | GEMIN5 | GBGT1 | MIR3184 | LOC102724428 | MIR595 | NID1 | G1950 | TUBA4A | PLAC9 | STRN4 | ADCK1 | CHD2 | CIRBP | CILP2 | TMPRSS6 | G842 | CHTOP | REV1 | TEX13B | TNFSF13B | IL12RB1 | BST1 | G7295 | XRCC6 | MIR1255B1 | RTKN | ZNF513 | ITGA3 | MIR142 | MRPL50 | CDK4 | CDK5 | HTR4 | KIT | EXO1 | IL1RL1 | IKZF1 | G29126 | DDX19B | IL4R | MIR16-1 | ZMYND8 | VPS9D1-AS1 | GSTA2 | HLA-G | G5728 | CFAP92 | ZNF557 | GATA6-AS1 | TAAR6 | CPT1B | PMS2 | S1PR4 | IGLL5 | TEX12 | C7orf13 | ZNF597 | MIR34B | ANKRD23 | SF3B1 | TFAP2A-AS1 | NAV1 | DSEL | IDH1 | G4780 | PCDH8 | FLJ30679 | MCF2L | HLA-B | KEAP1 | HSF1 | SLC46A1 | CDK9/Cyclin T1 | TCP11 | HNRNPUL2 | G7852 | GP5 | DLC1 | GSTA4 | FAT3 | E2F2 | EGR2 | CHPF2 | CD86 | CEACAM1 | G4851 | PIK3CB | MAP3K6 | WBP2NL | MIR24-2 | DDR2 | PLAGL1 | GNAQ | NAT1 | CENPF | BRCA2 | C9orf152 | MIR604 | MDC1 | NOD2 | KCNJ2 | PEG10 | CCDC183 | ZBTB42 | RNF17 | BCR | CYP1A1 | CAPN3 | KLLN | SH2D3C | CIT | ICAM1 | HEPH | IL-2 receptor | MIR25 | MAB21L1 | CD200 | DPP7 | HLA-DRB1 | TNFRSF10A-DT | AMDHD2 | BRD4 | TSSK3 | MBD1 | PIK3CD | XIAP | TIAM1 | NAV2 | VCAM1 | FZD7 | HDLBP | WIF1 | ADSS1 | CYP2C8 | SLFN5 | DNA Topoisomerase II (nonspecified subtype) | SLC44A2 | DCAF12L2 | EXOC6B | ESRP2 | MTRNR2L8 | HAS1 | PTPN13 | RAD23B | Adenosine deaminase (nonspecified subtype) | FREM1 | MIR605 | MLX | TGFB1I1 | TMEM185B | KRT19P2 | WSCD1 | OBSL1 | PFKFB4 | DPP8 | MIR23AHG | CDK9 | FCMR | CAAP1 | ADAM20 | CCN2 | G673 | MTRR | ADA | IRF4 | CHD7 | REV3L | SMAD7 | SPIDR | PDPK1 | CD44 | DGCR8 | CD40 | ZBTB7C | MIR423 | MAP3K13 | CD52 | POLQ | HELQ | Chaperone (nonspecified subtype) | B3GNTL1 | MIR26A1 | NPM2 | CD38 | RBBP6 | SIRPA | XPO1 | DNPEP | FUOM | ZNF875 | SLC29A3 | DDX20 | SELP | MSI1 | ZAP70 | ANGPT2 | PLXNA4 | CD22 | MUC15 | PIK3C2B | RPS15 | SOD2 | CPNE2 | NRGN | LOC286059 | G1029 | PEX11G | ABCC2 | ACO2 | HLA-DRA | ADCY6 | HSPA6 | G142 | ITGA4 | NSD1 | SYK | MIR34C | PDGFRB | POLL | SYNGR1 | ITK | CASP2 | PTPRK | DPP4 | SH3YL1 | ARL10 | Pim Kinase (nonspecified subtype) | NFATC4 | MGA | C10orf88 | BCL2L13 | ACOT4 | CDK4/Cyclin D | LOXL1 | ORC4 | AKAP1 | BIN1 | G581 | SIGIRR | SCT | HDAC1 | PLPPR4 | MIR612 | NFKBIE | JMJD8 | Reverse transcriptase (Telomerase) | G4170 | CCNT1 | CYP3A7 | SUMO3 | FCGR3A | ORC5 | LRRC23 | GBX2 | REPIN1 | LELP1 | CEP152 | PPP1R13B | SND1-IT1 | PTCH1 | NLRP9 | CCR8 | PKD1L1 | STIM1 | FABP5 | G4609 | POT1 | PLG | DHDH | KLF2 | SH3RF1 | CSRNP1 | ZNF280D | PAX5 | QPCT | SOCS3 | SIRPB1 | NEDD8-activating enzyme E1 | NLRP14 | IL11RA | AMZ1 | MRE11 | RUFY1 | LHX6 | LOC284191 | POSTN | LOC107984179 | MIR372 | H3C4 | CASP8 | APAF1 | BLTP1 | BIRC3 | WDR49 | WFS1 | DGKZ | HLA-A | AIF1 | TRIM59 | HYLS1 | PRG4 | EYS | PDE12 | ARHGEF18 | G9429 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | MS4A1 | RAD1 | BCL2A1 | Cyclin D (nonspecified subtype) | RNF186 | MTA2 | KRTAP13-2 | GATA5 | MEN1 | G2475 | SCOC-AS1 | BCL2L11 | INMT | RHOU | UBALD1 | RBM46 | MTTP | CLUAP1 | G9734 | SELPLG | MIR618 | TNFAIP3 | DICER1 | RTEL1 | ACKR3 | CDK1/Cyclin B | TLR2 | PNP | GSTT1 | CXCL12 | DAPK1 | NEURL1 | ZFYVE28 | ACKR2 | GOLT1A | MEIG1 | YIPF3 | PRKDC | LRP12 | RAN | CD1D | XPO5 | LOC107984390 | KCNQ1OT1 | CNOT6 | BOLA1 | CAMK2D | FCRLB | G3630 | KCTD8 | EPHB6 | COTL1 | CCL27 | TTC22 | ANKS1B | LRRC4 | PRUNE2 | OR4D5 | UGT8 | PLCG1 | TNFRSF11A | ACOXL | HCG9 | BRWD1 | SETD2 | CD33 | MYH4 | BCOR | PTPRT | IKZF3 | A4GNT | MIR499B | RCAN3AS | KIR2DL1 | MIR27A | ERCC2 | KMT2A | WAPL | RCAN3 | EDN1 | MRI1 | NPRL2 | PLEKHH1 | TDRD6 | RTL6 | ZNF331 | CD80 | USP34 | SAMHD1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | BFSP1 | MLL/SET1 Complex | SERPINB2 | FRK | RAD51 | G836 | AMT | DIPK1C | ACBD7 | KLRG1 | PPP2R5E | CD3E | MPDU1 | HLA-DRB3 | RARB | HSF5 | S100A11 | NELFA | PDE2A | TESMIN | CARD16 | CDK2/Cyclin A | NAP1L3 | PLEK2 | GSTZ1 | RUSC2 | PTPRN2 | TNFRSF13C | ZBTB46 | BLK | TLL1 | G4318 | G7157 | ROR1 | CCNE1 | BCL2L2 | LRRIQ3 | IL5RA | SLC34A1 | Ikzf1 | NR3C1 | NLRP2 | ARFGEF1 | GRAMD1B | MIR216A | FOXRED2 | PROM1 | ABR | EHMT2 | CSNK2B | TDO2 | FASN | CDC20B | MCM4 | GPRC6A | CLPTM1L | AP-1 Transcription Factor Complex | B3GALT6 | GLIPR1L2 | SIK2 | B2M | USH2A | HERC6 | MYCL-AS1 | KIR2DL2 | MIR29A | DDR1 | AGO2 | CDX1 | GPR158 | Janus Kinase (nonspecified subtype) | NARS1 | IL1RL2 | CNGB1 | SIM1 | MDGA2 | PIM1 | PTPN22 | FAM174C | IL12A-AS1 | IL1A | PAX6 | SERF2 | BMF | BCKDK | IRF8 | RBL2 | IL16 | NLRP4 | CTSO | ESCO2 | G4193 | FCGR2A | DHX40 | PIWIL1 | IL12A | CYP2C9 | XRCC4 | FARP2 | BRD3 | PON1 | FEM1A | HLA-DRB4 | FASTK | ACD | PKD2L2 | POLA1 | DIRAS3 | PPP1R9A | TMEM167A | SLMAP | GMNN | GC | IKBIP | IRF7 | SLC5A1 | ISYNA1 | NLRP1 | MAU2 | NPTXR | ATL3 | SLC8A2 | CLDN14 | CXCR2 | DCAF8L1 | MCTS2 | ACYP2 | HOXC5 | Tubulin | MIR93 | CDK2/Cyclin E | LYN | PDILT | ERCC4 | SCARF1 | CAPN9 | ITGAE | ILRUN | CYP2B6 | TST | TNRC18 | CFAP251 | LDHC | PDE5A | ZMYM3 | GANC | SPDEF | GLDN | C1R | WSCD2 | RAVER1 | CPEB1 | PCED1A | BMP5 | KIR2DL3 | MIR656 | GLB1L | SIK1 | HLA-DPB1 | N4BP3 | CD79B | RAG1 | ODF3B | CASP1 | TLR9 | MIR1265 | TDRD12 | SLCO1B1 | ZNF793 | C4BPA | PMAIP1 | Cyclin A (nonspecified subtype) | ITPKB | DCLRE1C | CCNI2 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | VDR | H4C4 | TOLLIP-DT | TNFRSF10C | NAMPT | CRACD | SLC7A4 | MIR146A | MCM7 | MEST | LACTB2 | PRKD2 | DNAJA4 | ALPK2 | CTLA4 | NCAPG2 | G4233 | SETD1B | CADM1 | PARP2 | FAS | NOS2 | XRCC5 | HLA-DRB5 | RIPK3 | HOXC10 | MAGEE1 | RCAN1 | WT1 | TNRC6B | PIK3CA | LRP1B | MIR1302-4 | CD47 | ZNF479 | IFNG | KCP | CNOT2 | GATA3 | IRAK1 | NT5DC2 | P2RX7 | SMCHD1 | PEX3 | SND1 | MAPK7 | CD28 | ITGB4 | CD37 | MCCC1 | MAML3 | HCN1 | BID | ADRA1B | G7124 | CDC6 | PRAMEF12 | G672 | MIR29B2 | IL1RAPL2 | KBTBD7 | MAP1LC3A | DEGS1 | U2AF2 | DTX1 | LINC02913 | COL21A1 | FAM217B | DDX3X | MMP14 | KMT2D | C5orf22 | MRPL28 | CYP1B1 | NQO1 | CNOT3 | SMIM11 | GNAS | CCDC186 | FLT3 | FYN | L3MBTL1 | PKN2 | CCDC168 | ARF6 | METTL15 | H4C6 | PEX7 | LMF2 | BIRC5 | RAP1GAP | COL6A3 | ERAL1 | MYH7B | CCL2 | DPY19L3 | CNOT4 | PDGFRA | DPP9 | RARG | HSPA2 | TCL1A | MYO1H | GSTM1 | NMUR2 | HOXA4 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | ZPBP2 | IL10 | ZNF132 | TEAD4 | CDK12 | CFLAR | MTHFR | NPR2 | TNFRSF13B | AGO1 | ATR | PPP1R3D | TDP1 | HRH4 | VHL | LRRIQ1 | CHCHD5 | ZNF354C | CEACAM19 | Proteasome Complex | SLIT3 | MIR196A2 | IL17RB | PRKG1 | AKR7A3 | MIR1185-1 | SLC8A1 | TAP2 | ARID1A | PER3 | FAM50A | PPARGC1A | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | CYP2C18 | G2146 | CD5 | ENOX2 | Histone deacetylase (nonspecified subtype) | ZNF135 | G5243 | MBOAT1 | SVIL | TP53BP1 | OPLAH | MIR1206 | ARFIP1 | CDK1 | DNA-Dependent Protein Kinase (DNA-PK) | CDHR4 | GABRG1 | PML | MIR29C | PACSIN1 | KCNN2 | TRPC3 | ZNF292 | FOXJ2 | CD19 | EFNB2 | LYPD5 | MIR499A | ZBBX | BANK1 | DPH3P1 | CDK7 | HOXA5 | PTPRO | CYP19A1 | LTF | DNAH9 | CAPN2 | SIT1 | KLHL6 | IL13 | GLI1 | ZSCAN18 | RNF227 | TACC2 | C2 | G7422 | MIR300 | MIR1307 | ADAR | CTBP2 | JAK3 | PRIMPOL | G238 | KBTBD6 | IL18 | FCER2 | HLA-C | RARRES1 | TMEM139 | DGKQ | MCCD1 | OR8K3 | SSH3 | LRRTM3 | CNTD1 | TNFRSF9 | JAK1 | NSRP1 | SHPRH | MIR1294 | GSTP1 | MSH6 | G596 | DCC | LIG4 | LINC00336 | INPP5F | CARD8 | BAG6 | TLR7

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Spondylolisthesis | Hypercholesterolemia | Desmosterolosis | Hypotrichosis Simplex | Prolidase Deficiency | Focal Segmental Glomerulosclerosis | Chorea | Vertebrobasilar Insufficiency | Bronchiolitis | Hyperparathyroidism, Secondary | Von Willebrand Disease | Pancytopenia | Megaloblastic Anemia | Hyperparathyroidism | Marshall-Smith Syndrome | Mucormycosis | Renal Medullary Carcinoma | Hereditary Neuropathy With Liability To Pressure Palsies | Congenital Hereditary Endothelial Dystrophy Type II | Craniometaphyseal Dysplasia | Farber Disease | Spondyloarthritis | Gerstmann-Straussler-Scheinker Syndrome | Leber Congenital Amaurosis | Skin Papilloma | Sarcoidosis, Pulmonary | Sarcoma | Argininosuccinic Aciduria | Colon Adenoma | Epidermolysis Bullosa Acquisita | Familial Hyperaldosteronism | Primary Ovarian Insufficiency | Nanophthalmos | Muscle Wasting | Autoimmune Polyendocrinopathy Syndrome Type I | Inflammatory Myopathy | Lymphedema | Granular Corneal Dystrophy Type 1 | Juvenile Hyaline Fibromatosis | Schistosomiasis Mansoni | Martsolf Syndrome | Menetrier Disease | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Leishmaniasis, Cutaneous | Cirrhosis | Amelanotic Melanoma | Trichothiodystrophy | Borderline Personality Disorder | Thyroid Dysgenesis | Osteomyelitis | Seborrheic Dermatitis | Autosomal Recessive Congenital Ichthyosis | Oligodendroglioma | Duodenal Atresia | Bainbridge-Ropers Syndrome | Feingold Syndrome | Arteriosclerosis | Lipid Storage Myopathy | Tenosynovial Giant Cell Tumor | Ataxia-ocular Apraxia 2 | Episodic Ataxia Type 1 | Tay-Sachs Disease | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hereditary Pyropoikilocytosis | Cardiofaciocutaneous Syndrome | Reticular Dysgenesis | Evans Syndrome | Delirium | Hennekam Lymphangiectasia-lymphedema Syndrome | Meleda Disease | Spondyloperipheral Dysplasia | Hypermethioninemia | Infectious Diarrhea | Proteus Syndrome | Diabetes Mellitus, Transient Neonatal | Granular Corneal Dystrophy | Adrenomyeloneuropathy | Acute Tubular Necrosis | Sulfite Oxidase Deficiency | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Sleep Disorder | Cardiac Sarcoidosis | Amyloidosis | Kabuki Syndrome 2 | Conjunctivitis | Sclerocornea | AIDS Dementia Complex | Neuroleptic Malignant Syndrome | Multiple Sclerosis, Primary Progressive | Scoliosis | Usher Syndrome | WAGR Syndrome | Mabry Syndrome | Periventricular Nodular Heterotopia | Colitis, Collagenous | Hypotonia-cystinuria Syndrome | Hermansky-Pudlak Syndrome | MELAS Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Congenital Lipoid Adrenal Hyperplasia | Mesothelioma, Malignant | Hyperacusis | Peutz-Jeghers Syndrome | Rheumatoid Arthritis | Adenylosuccinate Lyase Deficiency | Acne | Congenital Disorders Of Glycosylation | Lentigo | Hydrocephalus, Normal Pressure | Endocarditis | Autosomal Recessive Spastic Paraplegia Type 75 | Gray Platelet Syndrome | Joubert Syndrome | Bare Lymphocyte Syndrome | Niemann-Pick Disease | Papillorenal Syndrome | VACTERL/VATER Association | Cataract | Papillon-Lefevre Syndrome | Hemorrhagic Disorders | Dermatofibrosarcoma | Hyperglycemia | Endometritis | Ameloblastic Carcinoma | Cryopyrin-associated Periodic Syndromes | Cholecystitis | Bullous Pemphigoid | Keratoconus | Myelofibrosis | Hyperostosis | Proopiomelanocortin Deficiency | Myelodysplasia | Skin Carcinoma