Tay-Sachs Disease

About the Disease
Tay-Sachs Disease, also known as hexosaminidase a deficiency, is related to gm2-gangliosidosis, ab variant and gm1-gangliosidosis, type i, and has symptoms including back pain, headache and pain. An important gene associated with Tay-Sachs Disease is HEXA (Hexosaminidase Subunit Alpha), and among its related pathways/superpathways are Metabolism and Sphingolipid metabolism. The drugs Miglustat and Anti-HIV Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, spinal cord and brain, and related phenotypes are progressive spasticity and abnormal enzyme/coenzyme activity

Common Targets
GBA1 | UGCG | G6774 | HEXA | Chaperone (nonspecified subtype) | SLC5A4 | HEXB | OGA | beta-Hexosaminidase Complex | GM2A | GBA2

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