Chronic Idiopathic Myelofibrosis

About the Disease
Myelofibrosis, also known as primary myelofibrosis, is related to acute megakaryocytic leukemia and thrombocytosis. An important gene associated with Myelofibrosis is MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Panobinostat and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and bone, and related phenotypes are fatigue and anemia

Common Targets
G842 | G598 | FLT3 | NTRK1 | G836 | TET2 | JAK2 | JAK1 | CBL | MPL | CSF1R | IRAK1 | BTK | G1956 | SRSF2 | CDK2 | DNA Methyltransferase (DNMT) (nonspecified subtype) | KDR | ASXL1

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