Rubeosis Iridis

About the Disease
Rubeosis Iridis is related to retinal ischemia and microvascular complications of diabetes 5. An important gene associated with Rubeosis Iridis is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signal Transduction and PI3K-Akt signaling pathway. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Common Targets
Integrin alphavbeta3 (vitronectin) receptor | Integrin alphavbeta5 receptor | Integrin alphavbeta1 | NPC1

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