Platelet Disorders

About the Disease
Blood Platelet Disease, also known as platelet disorder, is related to platelet disorder, familial, with associated myeloid malignancy and bernard-soulier syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Blood Platelet Disease is RUNX1 (RUNX Family Transcription Factor 1), and among its related pathways/superpathways are Disease and Response to elevated platelet cytosolic Ca2+. The drugs Ticagrelor and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lung and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Common Targets
EPHB2 | ITGA2 | PTPN1 | G7157 | ANO6 | SLFN14 | GP1BB | GATA2 | GP9 | P2RY12 | FLI1 | MPIG6B | RASGRP2 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | ITGB3 | RUNX1 | AMP-activated protein kinase (AMPK) | PLA2G2D | GP6 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | Cyclin-dependent kinase inhibitor (nonspecified subtype) | TBXA2R | PEAR1 | LDLR | THBD | Tubulin | GPBAR1 | CYP2C19 | GAS6 | PLA2G2A | ACHE | PTGS1 | G3630 | MYH9 | VWF | NBEAL2

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