Niemann-Pick Disease, Type C

About the Disease
Niemann-Pick Disease, Type C1, also known as niemann-pick disease, type c, is related to niemann-pick disease type c, juvenile neurologic onset and niemann-pick disease type c, adult neurologic onset, and has symptoms including cerebellar ataxia, muscle spasticity and seizures. An important gene associated with Niemann-Pick Disease, Type C1 is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are Neuroscience and "Plasma lipoprotein assembly, remodeling, and clearance". The drugs Miglustat and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and liver, and related phenotypes are dysphagia and jaundice

Common Targets
Protein kinase C (nonspecified subtype) | gamma-Secretase | HDAC1 | GABA(A) receptor | DYRK1A | UGCG | HDAC3 | Cholesterol esterase (nonspecified subtype) | S1PR4 | CLK4 | TWNK | Chaperone (nonspecified subtype) | S1PR3 | SLC5A4 | Heat shock protein 70 (nonspecified subtype) | GAA | S1PR5 | CLK1 | APOE | MIR4709 | KRR1 | GBA2 | RIPK1 | S1PR1 | NPC1 | HDAC6 | HDAC2 | NPC2 | SNCA

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