Brain Cancer

About the Disease
Brain Cancer, also known as malignant neoplasm of brain, is related to li-fraumeni syndrome and lung cancer, and has symptoms including back pain, headache and pain. An important gene associated with Brain Cancer is MIR142 (MicroRNA 142), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Fentanyl and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
DYNC2I2 | G6774 | Protein farnesyltransferase | MIRLET7G | TH2LCRR | LDLR | BDKRB2 | MIR20A | SLC5A2 | FAP | BICRA | SNCA | CCDC26 | HDAC2 | IL12B | GSR | G3620 | ZEB1 | ERCC1 | TSC1 | HDAC6 | BTK | FGFR2 | PTPN2 | CREM | KIT | HIF1A | G595 | TFRC | gamma-Secretase | LRRK2 | Tyrosine-Protein Kinases Src (nonspecified subtype) | PREP | Integrin alphavbeta3 (vitronectin) receptor | G29126 | HFE | KCNA3 | CDK6 | NF-kappaB (NFkB) | CTAG1A | AMP-activated protein kinase (AMPK) | IL13RA2 | CD3 Complex (T Cell Receptor Complex) | Ribonucleoside-diphosphate reductase | G5728 | PRMT5 | NOS1 | TOP1 | G673 | XRCC2 | CDK4 | Folate Receptor (nonspecified subtype) | VIM | G7295 | CNR2 | POLE | LINC00632 | Protein kinase C (nonspecified subtype) | Thyroid hormone receptor (nonspecified subtype) | MYL12A | G842 | G7852 | TNC | IDH1 | SIGMAR1 | CTSS | BMX | G1029 | G4780 | mTOR complex 1 | FGFR3 | BRD2 | IL4R | DNA Topoisomerase II (nonspecified subtype) | PMS2 | Lipoxygenase (nonspecified subtype) | C11orf65 | CYP1A1 | EXO1 | XRCC6 | MAOA | G142 | BRD4 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | GRM2 | VAMP5 | ROS1 | HDAC1 | CDKN2B-AS1 | CNR1 | Neurotrophic Factor (nonspecified subtype) | NADH dehydrogenase (Complex I) | MTRR | ANGPT2 | DPP7 | TK1 | G4609 | ABCA1 | G2475 | CYP2E1 | G7157 | RAD23B | DYRK1A | NTRK3 | CHAF1A | CASP8 | DPP8 | Reverse transcriptase (Telomerase) | Histone acetyltransferase (HAT) (nonspecified subtype) | BCHE | Chaperone (nonspecified subtype) | DPP4 | SELP | PTGS1 | STAT5 (nonspecified subtype) | NTRK1 | XRCC3 | PTPN1 | KLC3 | ZGPAT | OLIG2 | G3480 | ELAVL1 | DICER1 | ERCC2 | CDKN2A-DT | Tubulin | EBP | FGFR1 | GSDMB | ACVR1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | RTEL1 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | Pyruvate dehydrogenase kinase (nonspecified subtype) | PRKDC | Mitogen-Activated Protein Kinase (nonspecified subtype) | FOLH1 | CBS | RAF1 | G6PC1 | G4318 | KIF11 | FGFR4 | KDM1A | WRAP53 | AKR1C3 | RB1 | BLK | G4193 | G4233 | IKZF3 | CCNE1 | G2064 | PIK3CA | EPHA2 | GPC2 | PIM1 | AP-1 Transcription Factor Complex | FASN | ZBTB46 | G5743 | FLT3 | XRCC4 | Janus Kinase (nonspecified subtype) | BRD3 | CTAG1B | TMEM97 | ADGRE5 | MMP2 | IL12A | G367 | G5243 | G1786 | PDGFRA | CDK8 | EME1 | Calcium-activated chloride channel regulators (nonspecified subtype) | SLC5A1 | VRK2 | MGMT | CD47 | TOP2A | LIG1 | NMDA receptor | IL10 | TACR1 | KDR | BIRC5 | MTHFR | SMARCB1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | XRCC5 | G1956 | G3146 | Arginase (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | Proteasome Complex | PTPN11 | PDGFA | CTDSP1 | CCL2 | Retinoid RXR receptor (nonspecified subtype) | ATR | G3845 | APC | MTR | ALOX5 | DPP9 | NLRP3 Inflammasome | ENOX2 | CHEK2 | MAGEA1 | XRCC1 | CYP19A1 | PLAUR | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | ZPBP2 | G472 | RTEL1-TNFRSF6B | MAOB | ABL1 | IL13 | ODC1 | G7015 | DNA Methyltransferase (DNMT) (nonspecified subtype) | G114548 | LIG4 | DNA-Directed DNA Polymerase Complex | NTRK2 | FASTKD3 | MAGEA3 | POLD1

Note: If you'd like to get a target analysis report for Brain Cancer, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Brain Cancer at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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