Bipolar Disorder

About the Disease
Bipolar Disorder, also known as depression, bipolar, is related to bipolar i disorder and schizophrenia. An important gene associated with Bipolar Disorder is MAFD1 (Major Affective Disorder 1), and among its related pathways/superpathways are Neurotransmitter clearance and "Methylphenidate Pathway, Pharmacodynamics". The drugs Coal tar and Eleuthero have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
CNTN5 | RORA-AS1 | KDM5B | BAHCC1 | GPR139 | SELENOH | LRRC7 | CHRNB3 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | BDNF | AMP-activated protein kinase (AMPK) | TACR3 | COX2 | LRRTM4 | MRC2 | ADCYAP1 | ITIH1 | CACNA1B | PRKAR1A | TCF3 | ADGB | MIR137HG | MAD1L1 | GPR88 | CDC42BPB | NCAN | MIP | CACNA2D1 | LOC105375284 | LOC107986626 | G207 | FADS2 | G7099 | VWF | BHLHE40-AS1 | TACR2 | KCNC1 | ADAMTSL3 | GRAMD1A | RPS6KA2 | DIO2 | RBFOX1 | SP4 | Kainate Receptor (GluR) (nonspecified subtype) | RPGRIP1L | CCND2 | GRM5 | PTPN7 | GCH1 | TTC12 | LOC105375451 | AEBP2 | Serine/Threonine Kinase (nonspecified subtype) | L-type voltage-dependent calcium channel complex | CRY2 | YY1 | OPRK1 | LOC105375452 | NR2E1 | BMAL1 | SMG6 | STIP1 | RGS12 | IL2RA | Protein kinase C (nonspecified subtype) | NOS1 | CHRNB4 | Rho GTPase (nonspecified subtype) | DAO | MTNR1A | GRIN2C | PRKCZ | CHRM4 | PPM1M | MSX1 | ITIH3 | GRIN1 | PKHD1L1 | CNR2 | C3orf49 | SNORD86 | XPNPEP1 | OXCT1 | SRR | TBC1D22A | LOC105370841 | DRD4 | LOC105370842 | LOC105370843 | GPR52 | LOC105370844 | LOC107986983 | KCTD12 | PLET1 | CYB5D2 | CADM2 | POLE | LOC105370845 | EPHX2 | LOC105370878 | G5594 | G598 | ROCK1 | VAV2 | NCAM1 | DRD2 | DAOA | IDH1 | LAMP3 | MGLL | Calcium channel (nonspecified subtype) | SCN3A | ZNF710 | SIGMAR1 | SHMT2 | PLCH2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | LMX1A | DDR2 | C11orf80 | IDH2-DT | LOC105375629 | NRG1 | AVPR1B | KCNQ3 | GRIA1 | LOC105369166 | COMT | GALNT10 | MAGI1-AS1 | CDK5 | TRPC5 | MUTYH | ZHX2 | FAN1 | GABRB2 | ZEB2 | SHANK2 | CHRM1 | PTPN12 | LINC00499 | UTP14C | MPPE1 | G7157 | IMMP2L | G142 | UBE2E2 | PLEC | LOC105373657 | IPO11 | PGR | HMGCR | KCTD16 | HTR1A | KCNC2 | PIK3R1 | LOC105373659 | JAZF1-AS1 | HDAC5 | SNX8 | PDE10A | IMPA1 | TCF20 | FES | ANKK1 | HDAC1 | TCF4 | TRPM1 | PRKD1 | TUBBP5 | SLC6A2 | SSTR3 | GRIK2 | IMPA2 | PRSS35 | DISC1 | YWHAQ | KCNK2 | DAOA-AS1 | PACS1 | HCRTR1 | SNORA51 | NOTCH4 | GRIN2D | CNR1 | CACNB2 | RCOR1 | MIR29B2CHG | TUFT1 | PDE9A | GRM2 | PTPRG | GADL1 | G1385 | Glutamate Transporter (nonspecified subtype) | TAGLN | NFATC2 | MTRR | AKAP13 | HTR2B | GSDMA | DNAJC15 | TMTC1 | WDR27 | CACNA1C | GABA(A) receptor | POLR3H | PLEKHA5 | ZCCHC2 | TRANK1 | ADCY2 | SLC6A9 | NFKBIA | SOD2 | KDM3B | TPTEP2-CSNK1E | CUL4A | VCAM1 | CHRNA7 | CERS6 | LOC100652768 | PTGIS | CYRIB | LINC00400 | TIMELESS | G2099 | GID4 | GRM7 | NRN1 | G7124 | MTNR1B | SLC4A10 | BCHE | Nicotinic alpha4beta2 receptor | ADSS1 | HTR5A | Casein kinase II (CKII) | CENPM | PTPN1 | CARMAL | ACHE | SESTD1 | NFIA | BRD1 | ZNF92 | AKT2 | GSK3B | Voltage-Gated Sodium Channel Complex | PKP4-AS1 | OSBPL2 | DNAH1 | PLXNA4 | NFATC3 | CES1 | AAK1 | ACO2 | LOC105371427 | MKLN1 | NRGN | CACNB3 | OPRL1 | VAC14 | LOC105376014 | Pim Kinase (nonspecified subtype) | CSMD1 | CELSR2 | NR3C1 | LINC02988 | RORA | KCNQ Channels (K(v) 7) (nonspecified subtype) | FKBP5 | G2309 | PC | LOC100507053 | CCNC | LOC105376107 | MPG | TLR2 | JADE2 | ZSCAN2 | LOC107984113 | G836 | DPP10 | G4318 | BORCS7-ASMT | GRIN2A | Orexin receptor (nonspecified subtype) | SSTR4 | LOC102724790 | ZBED4 | NAB2 | TMX2-CTNND1 | LOC102724802 | TSPO | ZBED3-AS1 | ZNF804A | PLA2G6 | MEF2C-AS1 | KRT75 | BTN2A1 | JAZF1 | PCLO | G367 | SNORD114-7 | CUL3 | BUB1B-PAK6 | sigma Receptor (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | HCRTR2 | Sodium channel (nonspecified subtype) | DRD1 | VIPR2 | BDNF-AS | GPX3 | VAPA | IDH2 | TPH2 | IGSF9B | CBS | ATP2A2 | TRPC4AP | GABBR2 | CACNA1D | SORCS2 | QSOX1 | SLC17A1 | NRXN1 | NDE1 | RGS6 | PTPRT | DTNBP1 | COA8 | ACTN3 | FABP7 | LINC01470 | ACOXL | DDR1 | CHRNA3 | DOCK2 | NOS3 | BCL11B | LINC02210-CRHR1 | LOC105374524 | SRPK2 | MTHFR | MMP2 | EPOR | APEX1 | RASIP1 | PDE2A | PRKCB | SLC6A4 | NFIX | GRM3 | CLCN3 | Dopamine receptor (nonspecified subtype) | TRPM2 | MRPL13 | RORB | IL10 | CRHR1 | GSDME | TXNRD1 | RASSF10 | LINC01539 | GPM6A | TRAIP | HTR6 | SLC1A1 | CYP26B1 | L-Type calcium channel (nonspecified subtype) | STK4 | CA2 | PPP2R5E | ACO1 | FKBP2 | ST6GALNAC1 | ZFYVE21 | GRAMD1B | SCN9A | UNC45B | FRMD3 | ROCK2 | LOC107984782 | ALG10B | NEIL1 | GABRA5 | IDH3A | NMDA receptor | NOX3 | EP300-AS1 | LOC105372131 | CNTN4 | TMEM131L | ITGB3 | PAX8 | MAPK10 | KCTD13-DT | HTR1B | HTR2A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | ATP6 | LMAN2L | AS3MT | LINC00939 | LOC105372213 | HRH1 | CACNA1A | PBRM1 | SDCCAG8 | FURIN | CD47 | G7422 | VHL | Histone deacetylase (nonspecified subtype) | TACR1 | CSRNP2 | IDH3B | VRK2 | DAGLA | PPP3CB | SYNE1 | LINC02551 | LOC105376559 | MAN2A1 | PPP1R16B | SLCO1B1 | MAGI1 | PTPN11 | SSBP2 | FYN | STAG1 | alpha1-Adrenoceptor (nonspecified subtype) | GAD1 | DGKI | HNF4A | GABRA2 | NR1D1 | AKT3 | CAND2 | PHF3 | P2RX7 | INPP1 | PALS2 | LOC105378800 | NADPH Oxidase Complex | LINC02694 | SSTR1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | CCL2 | HCAR2 | SATB2 | TENM4 | FOXO6 | DNAJB4 | HTR2C | FER1L6 | NR4A2 | ETF1 | GRM4 | LOC105372505 | DRD3 | MMP14 | MSRA | STEAP3 | ANK3 | LOC105378867 | IRAK1 | ACSBG1 | LOC105372507 | HCN1 | IL1B | CSNK1D | ALOX5 | SLC30A8 | MTR | KIF26B | STARD9 | G3569 | KCNN1 | ASAP1 | CDK1 | RBPJL | XRCC1 | TMEM165 | G596 | GRN | HOMER2 | EGR3 | MIR29B2 | SLC25A17 | PTPRC | Potassium Channels (nonspecified subtype) | MALL | MAOB | OPCML | THOC7 | C12orf42 | SLC6A3 | LINC02057 | SIVA1 | ABAT | KIF26A | MIR1292 | CHRNB2 | GRIN3A | LOC101928516 | DAGLB | CDKN1C | SLC1A2 | MCHR1 | DIDO1 | NADPH Oxidase (nonspecified subtype) | TAAR1 | DAXX | NALCN | PER3 | KCNH7 | SLC18A1 | THRA | MMP10 | NT5DC1 | IP6K1 | GPR17 | CHRM2 | NGF | CNNM2 | RELN | GRIN2B | NOP56 | MIR29C | NTRK2 | CLOCK | KCNB1 | DPYD | KDM5A | AURKA | ADD3-AS1 | Glutathione peroxidase (nonspecified subtype) | THSD7A | MPHOSPH9 | PAK6 | NCKAP5 | KCNQ2 | CAMKK2 | ZMIZ1 | AOAH | TSNARE1 | GPR143 | CHRNA5 | DGKH | G6774 | ASMT | RPL23P8 | NEK5 | XBP1 | GABRB1 | SOX2-OT | Monoamine oxidase (MAO) (nonspecified subtype) | AADAT | RIGI | GIGYF2 | APEH | GPM6B | HSP90B1 | GRIK4 | HSD52 | ST8SIA2 | PDE4D | PDYN | HTR7 | KDM5A-GATAD1-EMSY chromatin complex | NKAIN2 | KMO | FASTKD3 | DCAF5 | HLF | PVT1 | MACROD2 | PDLIM5 | SCN2A | Glutamate Receptor Ionotropic AMPA Receptor | PER2 | ZNF536 | SV2A | NRXN3 | SH3PXD2A | CSNK1E | XIRP2 | ABCA13 | GRIK5 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype)

Note: If you'd like to get a target analysis report for Bipolar Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Bipolar Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pyruvate Dehydrogenase Deficiency | Exfoliative Dermatitis | Primary Ovarian Insufficiency | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Nephrosclerosis | Chronic Myelomonocytic Leukemia | Myofibrillar Myopathy | Dysthymia | Ophthalmia, Sympathetic | Hydrolethalus Syndrome | Brenner Tumor | Trichorhinophalangeal Syndrome | Long QT Syndrome Type 3 | Corneal Neovascularization | Poirier-Bienvenu Neurodevelopmental Syndrome | Norrie Disease | Epidermolytic Ichthyosis, Annular | Periventricular Nodular Heterotopia | Loeys-Dietz Syndrome | Autism Spectrum Disorders | Angioimmunoblastic T-cell Lymphoma | Priapism | Hyperammonemia | Megalencephaly | Vertebrobasilar Insufficiency | Hepatitis B, Chronic | Hypertension, Renal | Pulmonary Sclerosing Hemangioma | Hoyeraal-Hreidarsson Syndrome | Congenital Adrenal Hyperplasia 1 | Alopecia | Tuberculous Meningitis | Schnyder Crystalline Corneal Dystrophy | Granular Corneal Dystrophy | Retinoblastoma | Chordoma | PHARC Syndrome | Agnathia-Otocephaly Complex | Primary Progressive Nonfluent Aphasia | Schizotypal Personality Disorder | Ichthyosis Bullosa Of Siemens | Hypotension, Orthostatic | Hereditary Folate Malabsorption | Proteasome-associated Autoinflammatory Syndrome 2 | Chorioretinitis | Glaucoma | Hyperlipidemia Type V | Open-angle Glaucoma | Renal Hypouricemia | Congenital Diaphragmatic Hernia | Intestinal Hypomagnesemia 1 | Chronic Neutrophilic Leukemia | Blepharoconjunctivitis | Nijmegen Breakage Syndrome | Conjunctivitis, Allergic | Allergic Contact Dermatitis | Lichen Sclerosus | Pilomatrix Carcinoma | Bartsocas-Papas Syndrome | Rotor Syndrome | Menkes Disease | Greig Cephalopolysyndactyly Syndrome | Pompe Disease | Gallstones | Acute Chest Syndrome | Thrombotic Microangiopathy | Rhabdoid Tumor | Allan-Herndon-Dudley Syndrome | Pachyonychia Congenita | Short-chain Acyl-CoA Dehydrogenase Deficiency | Pseudohermaphroditism | Epilepsy | Wiskott-Aldrich Syndrome | Metanephric Adenoma | Joubert Syndrome 2 | Agammaglobulinemia | Hereditary Pyropoikilocytosis | Jacobsen Syndrome | Pure Red Cell Aplasia | Idiopathic Multicentric Castleman Disease | Microvillus Inclusion Disease | Hypohidrotic Ectodermal Dysplasia | Sporadic Hemiplegic Migraine | Tyrosinemia | Partington Syndrome | Leukodystrophies | Hepatitis C, Chronic | Congenital Absence Of Vas Deferens | Intellectual Disability, Autosomal Dominant 5 | Lymphoma, AIDS-related | Trichothiodystrophy | Cancer, Breast | Cavitary Optic Disc Anomalies | Craniofrontonasal Syndrome | Leiomyoma | Maternally Inherited Diabetes And Deafness | Primary Torsion Dystonia | Spinocerebellar Ataxia Type 3 | PASLI Disease | Rhinitis | Chondroma | Localized Scleroderma | HUPRA Syndrome | Arthritis | Subacute Sclerosing Panencephalitis | Maple Syrup Urine Disease | Urolithiasis | Major Depression | Basan Syndrome | Lipodystrophy | Juvenile Hyaline Fibromatosis | Gastroenteritis | Anal Fissure | Persistent Fetal Circulation | Sialidosis | Tremor | Adenoma, Pituitary | Osteoporosis-pseudoglioma Syndrome | Pancytopenia | Hereditary Hemorrhagic Telangiectasia | Walker-Warburg Syndrome | Nemaline Myopathy | Takenouchi-Kosaki Syndrome | Wolfram Syndrome 2 | Benign Familial Infantile Seizures | Sensorineural Hearing Loss | Cold-induced Sweating Syndrome | Spinal Muscular Atrophy | Palmoplantar Keratoderma | Aspergillosis | Charcot-Marie-Tooth Disease, Type 2A | Tay-Sachs Disease | Fahr Disease | Periventricular Leukomalacia | Facioscapulohumeral Muscular Dystrophy | Spinocerebellar Ataxia Type 14 | Alexander Disease | Spinocerebellar Ataxia Type 17 | Familial Thoracic Aortic Aneurysm | Leukoplakia, Oral | Bietti Crystalline Dystrophy | Hepatic Veno-occlusive Disease | Herpes Genitalis | Hyperkalemic Periodic Paralysis | Batten Disease | Bullous Pemphigoid | Intracranial Hypertension | Vaginitis | Cholangiocarcinoma | Pulmonary Vein Stenosis | Schaaf-Yang Syndrome | Myoclonic Epilepsy With Ragged Red Fibers | Ovarian Hyperstimulation Syndrome | Cherubism | Ureteropelvic Junction Obstruction | Retinal Degeneration | Fibrodysplasia Ossificans Progressiva | Glaucomatocyclitic Crisis | Neuromyotonia | Dyslipidemia | Cutaneous Angiosarcoma | Generalized Epilepsy And Paroxysmal Dyskinesia | Pseudoexfoliation Syndrome | Spondylolisthesis | Pemphigus Foliaceus | Platelet Disorders | Gerodermia Osteodysplastica | Vitamin B12 Deficiency | Congenital Disorders Of Glycosylation Type II | Spinocerebellar Ataxia Type 2 | Mucolipidosis Type IV | Inflammatory Joint Disease | Scleroderma, Diffuse | Diabetes Insipidus | Congenital Sodium Diarrhea | Rickets | Specific Granule Deficiency | Myofibromatosis | Mucolipidosis Type III | Esophageal Carcinoma | Hereditary Spastic Paraplegia | Amebiasis | Hereditary Xerocytosis | MELAS Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Sarcoma, Ewing | Infantile Spasm | Nephropathy | Carcinoma, Squamous Cell | Goiter | Hypoglycemia | Blepharospasm | NGLY1 Deficiency | Hyperbilirubinemia | Lymphoproliferative Disorders | Adenosine Deaminase 2 Deficiency | Ocular Surface Squamous Neoplasia | Retinal Dystrophy | Jaundice, Obstructive | Pseudoachondroplasia | Uterine Leiomyoma | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Ulcerative Colitis | Oligospermia | Hypereosinophilic Syndrome | Nance-Horan Syndrome | Vitiligo | Polyarteritis Nodosa | Thrombocythemia, Essential | Tracheal Disorders | Lactose Intolerance | Nephroblastoma | Polymyalgia Rheumatica | Seminoma | Focal Cortical Dysplasia Type 2 | Acromesomelic Dysplasia | Hyperphenylalaninemia | Sickle Cell Disease | Eosinophilic Asthma | Poretti-Boltshauser Syndrome | Sertoli Cell-only Syndrome | Rubinstein-Taybi Syndrome | Sotos Syndrome | Adenomatoid Tumor | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Synovitis | Werner's Syndrome | Raine Syndrome | Silver-Russell Syndrome | Pneumonia, Bacterial | Familial Isolated Hyperparathyroidism | Spinocerebellar Ataxia Type 38 | Cholangitis | Glycogen Storage Disease Type 4 | Sezary Syndrome | Panuveitis | Anencephaly | HIBCH Deficiency | Parkinson's Disease | T-cell Lymphoma, Subcutaneous Panniculitis-like | Lymphoproliferative Disease, X-linked | Low Tension Glaucoma | Diabetic Macular Edema | Congenital Bilateral Absence Of Vas Deferens | Barrett Esophagus | Gitelman Syndrome | Apraxia | Charcot-Marie-Tooth Disease Type 2T | Shock, Cardiogenic | Myosin Storage Myopathy | Renal Dysplasia | Charcot-Marie-Tooth Disease Type 2E | Chronic Leukemia | 3-hydroxy-3-methylglutaric Aciduria | Hypotonia-cystinuria Syndrome | Corneal Dystrophies, Hereditary | Sitosterolemia | Basal Ganglia Disease, Biotin-responsive | Isovaleric Acidemia | Holoprosencephaly | Epicondylitis | Gardner Syndrome | Atrial Septal Defect | Spinocerebellar Ataxia Type 6 | Aneurysm, Abdominal Aortic | Liver Failure | ACTH-independent Macronodular Adrenal Hyperplasia | Endophthalmitis | Pyelonephritis | Hypodontia | Wolfram Syndrome | Cryopyrin-associated Periodic Syndromes | Multiple System Atrophy | Pontocerebellar Hypoplasia Type 2 | Asphyxia Neonatorum | Dementia | Rothmund-Thomson Syndrome | Tetraplegia | Vitamin D Deficiency | Hodgkin Lymphoma | Epithelial-myoepithelial Carcinoma | Bronchiectasis | Spinocerebellar Ataxia Type 8 | Sweet Syndrome | Autoimmune Polyendocrine Syndrome | Rhabdomyosarcoma | Scoliosis | Hypophosphatasia | Angiomyolipoma | Sarcosinemia | Birt-Hogg-Dube Syndrome | Colitis | Renal Failure | Woodhouse-Sakati Syndrome | Hypogonadism | Sarcomatoid Carcinoma Of The Lung | Retinitis Pigmentosa | Transient Bullous Dermolysis Of The Newborn | Hypogammaglobulinemia | Angiosarcoma | Dwarfism | Heroin Dependence | DICER1 Syndrome | Microtia | Frontometaphyseal Dysplasia | T-cell Prolymphocytic Leukemia | Dermatomyositis | Retinal Coloboma | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Neurodegeneration With Brain Iron Accumulation | Congenital Tufting Enteropathy | Hidradenitis | Glucagonoma | Schizophrenia | Meningococcal Meningitis | Early Infantile Epileptic Encephalopathy | Chronic Periodontitis | Dermatitis Herpetiformis | Dermatofibrosarcoma | Irritable Bowel Syndrome | Macular Corneal Dystrophy | Gangliosidosis, GM1 | Snyder-Robinson Syndrome | Hyperekplexia | Macular Corneal Dystrophy Type 1 | Ganglioneuroma | Long QT Syndrome Type 2 | Hepatitis E | NDH Syndrome | Double Outlet Right Ventricle | Primary Erythromelalgia | Succinic Semialdehyde Dehydrogenase Deficiency | LRBA Deficiency | Enlarged Vestibular Aqueduct | Myoclonus-dystonia Syndrome | Iron Metabolism Disorders | Sarcoma, Endometrial Stromal | Proximal Symphalangism | Non-epidermolytic Palmoplantar Keratoderma | Scleritis | Pontocerebellar Hypoplasia Type 7 | Addison Disease | Kernicterus | Nephrotic Syndrome | Chronic Kidney Disease | Hereditary Sensory And Autonomic Neuropathy | Familial Episodic Pain Syndrome | Granuloma Annulare | Hepatic Steatosis | Pneumoconiosis | Giant Cell Arteritis | Neurodermatitis | Varices | Cholelithiasis | Spinocerebellar Ataxia Type 42 | Liebenberg Syndrome | Withdrawal Syndrome | Systemic Mastocytosis | Low Phospholipid Associated Cholelithiasis | Huntington's Disease-like 2 | Depression | Pterygium | Waardenburg Syndrome Type 2A | Gastroenteritis, Eosinophilic | Lymphangiomatosis | Achromatopsia | Cystinuria | Tricho-hepato-enteric Syndrome | Dental Caries | Glomerulonephritis | Preaxial Polydactyly | Dysmorphophobia | Fabry's Disease | Osteochondroma | Methylmalonic Aciduria And Homocystinuria, CblC Type | Infantile Neuroaxonal Dystrophy | Occipital Neuralgia | CHOPS Syndrome | DiGeorge Syndrome | Sclerosing Cholangitis | Pemphigus | Palsy, Cerebral | Acute Lymphocytic Leukemia | Bare Lymphocyte Syndrome | Esophageal Motility Disorders | Cramp Fasciculation Syndrome | Familial Pheochromocytoma-paraganglioma | Lamellar Ichthyosis | Spondylo-ocular Syndrome | ICF Syndrome | Primary Carnitine Deficiency | Hamartoma | Barakat Syndrome | Hereditary Elliptocytosis | Emery-Dreifuss Muscular Dystrophy | Trimethylaminuria | Usher Syndrome Type II | Primrose Syndrome | Familial Glucocorticoid Deficiency | Mountain Sickness