Bipolar Disorder

About the Disease
Bipolar Disorder, also known as depression, bipolar, is related to bipolar i disorder and schizophrenia. An important gene associated with Bipolar Disorder is MAFD1 (Major Affective Disorder 1), and among its related pathways/superpathways are Neurotransmitter clearance and "Methylphenidate Pathway, Pharmacodynamics". The drugs Coal tar and Eleuthero have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
CNTN5 | RORA-AS1 | KDM5B | BAHCC1 | GPR139 | SELENOH | LRRC7 | CHRNB3 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | BDNF | AMP-activated protein kinase (AMPK) | TACR3 | COX2 | LRRTM4 | MRC2 | ADCYAP1 | ITIH1 | CACNA1B | PRKAR1A | TCF3 | ADGB | MIR137HG | MAD1L1 | GPR88 | CDC42BPB | NCAN | MIP | CACNA2D1 | LOC105375284 | LOC107986626 | G207 | FADS2 | G7099 | VWF | BHLHE40-AS1 | TACR2 | KCNC1 | ADAMTSL3 | GRAMD1A | RPS6KA2 | DIO2 | RBFOX1 | SP4 | Kainate Receptor (GluR) (nonspecified subtype) | RPGRIP1L | CCND2 | GRM5 | PTPN7 | GCH1 | TTC12 | LOC105375451 | AEBP2 | Serine/Threonine Kinase (nonspecified subtype) | L-type voltage-dependent calcium channel complex | CRY2 | YY1 | OPRK1 | LOC105375452 | NR2E1 | BMAL1 | SMG6 | STIP1 | RGS12 | IL2RA | Protein kinase C (nonspecified subtype) | NOS1 | CHRNB4 | Rho GTPase (nonspecified subtype) | DAO | MTNR1A | GRIN2C | PRKCZ | CHRM4 | PPM1M | MSX1 | ITIH3 | GRIN1 | PKHD1L1 | CNR2 | C3orf49 | SNORD86 | XPNPEP1 | OXCT1 | SRR | TBC1D22A | LOC105370841 | DRD4 | LOC105370842 | LOC105370843 | GPR52 | LOC105370844 | LOC107986983 | KCTD12 | PLET1 | CYB5D2 | CADM2 | POLE | LOC105370845 | EPHX2 | LOC105370878 | G5594 | G598 | ROCK1 | VAV2 | NCAM1 | DRD2 | DAOA | IDH1 | LAMP3 | MGLL | Calcium channel (nonspecified subtype) | SCN3A | ZNF710 | SIGMAR1 | SHMT2 | PLCH2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | LMX1A | DDR2 | C11orf80 | IDH2-DT | LOC105375629 | NRG1 | AVPR1B | KCNQ3 | GRIA1 | LOC105369166 | COMT | GALNT10 | MAGI1-AS1 | CDK5 | TRPC5 | MUTYH | ZHX2 | FAN1 | GABRB2 | ZEB2 | SHANK2 | CHRM1 | PTPN12 | LINC00499 | UTP14C | MPPE1 | G7157 | IMMP2L | G142 | UBE2E2 | PLEC | LOC105373657 | IPO11 | PGR | HMGCR | KCTD16 | HTR1A | KCNC2 | PIK3R1 | LOC105373659 | JAZF1-AS1 | HDAC5 | SNX8 | PDE10A | IMPA1 | TCF20 | FES | ANKK1 | HDAC1 | TCF4 | TRPM1 | PRKD1 | TUBBP5 | SLC6A2 | SSTR3 | GRIK2 | IMPA2 | PRSS35 | DISC1 | YWHAQ | KCNK2 | DAOA-AS1 | PACS1 | HCRTR1 | SNORA51 | NOTCH4 | GRIN2D | CNR1 | CACNB2 | RCOR1 | MIR29B2CHG | TUFT1 | PDE9A | GRM2 | PTPRG | GADL1 | G1385 | Glutamate Transporter (nonspecified subtype) | TAGLN | NFATC2 | MTRR | AKAP13 | HTR2B | GSDMA | DNAJC15 | TMTC1 | WDR27 | CACNA1C | GABA(A) receptor | POLR3H | PLEKHA5 | ZCCHC2 | TRANK1 | ADCY2 | SLC6A9 | NFKBIA | SOD2 | KDM3B | TPTEP2-CSNK1E | CUL4A | VCAM1 | CHRNA7 | CERS6 | LOC100652768 | PTGIS | CYRIB | LINC00400 | TIMELESS | G2099 | GID4 | GRM7 | NRN1 | G7124 | MTNR1B | SLC4A10 | BCHE | Nicotinic alpha4beta2 receptor | ADSS1 | HTR5A | Casein kinase II (CKII) | CENPM | PTPN1 | CARMAL | ACHE | SESTD1 | NFIA | BRD1 | ZNF92 | AKT2 | GSK3B | Voltage-Gated Sodium Channel Complex | PKP4-AS1 | OSBPL2 | DNAH1 | PLXNA4 | NFATC3 | CES1 | AAK1 | ACO2 | LOC105371427 | MKLN1 | NRGN | CACNB3 | OPRL1 | VAC14 | LOC105376014 | Pim Kinase (nonspecified subtype) | CSMD1 | CELSR2 | NR3C1 | LINC02988 | RORA | KCNQ Channels (K(v) 7) (nonspecified subtype) | FKBP5 | G2309 | PC | LOC100507053 | CCNC | LOC105376107 | MPG | TLR2 | JADE2 | ZSCAN2 | LOC107984113 | G836 | DPP10 | G4318 | BORCS7-ASMT | GRIN2A | Orexin receptor (nonspecified subtype) | SSTR4 | LOC102724790 | ZBED4 | NAB2 | TMX2-CTNND1 | LOC102724802 | TSPO | ZBED3-AS1 | ZNF804A | PLA2G6 | MEF2C-AS1 | KRT75 | BTN2A1 | JAZF1 | PCLO | G367 | SNORD114-7 | CUL3 | BUB1B-PAK6 | sigma Receptor (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | HCRTR2 | Sodium channel (nonspecified subtype) | DRD1 | VIPR2 | BDNF-AS | GPX3 | VAPA | IDH2 | TPH2 | IGSF9B | CBS | ATP2A2 | TRPC4AP | GABBR2 | CACNA1D | SORCS2 | QSOX1 | SLC17A1 | NRXN1 | NDE1 | RGS6 | PTPRT | DTNBP1 | COA8 | ACTN3 | FABP7 | LINC01470 | ACOXL | DDR1 | CHRNA3 | DOCK2 | NOS3 | BCL11B | LINC02210-CRHR1 | LOC105374524 | SRPK2 | MTHFR | MMP2 | EPOR | APEX1 | RASIP1 | PDE2A | PRKCB | SLC6A4 | NFIX | GRM3 | CLCN3 | Dopamine receptor (nonspecified subtype) | TRPM2 | MRPL13 | RORB | IL10 | CRHR1 | GSDME | TXNRD1 | RASSF10 | LINC01539 | GPM6A | TRAIP | HTR6 | SLC1A1 | CYP26B1 | L-Type calcium channel (nonspecified subtype) | STK4 | CA2 | PPP2R5E | ACO1 | FKBP2 | ST6GALNAC1 | ZFYVE21 | GRAMD1B | SCN9A | UNC45B | FRMD3 | ROCK2 | LOC107984782 | ALG10B | NEIL1 | GABRA5 | IDH3A | NMDA receptor | NOX3 | EP300-AS1 | LOC105372131 | CNTN4 | TMEM131L | ITGB3 | PAX8 | MAPK10 | KCTD13-DT | HTR1B | HTR2A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | ATP6 | LMAN2L | AS3MT | LINC00939 | LOC105372213 | HRH1 | CACNA1A | PBRM1 | SDCCAG8 | FURIN | CD47 | G7422 | VHL | Histone deacetylase (nonspecified subtype) | TACR1 | CSRNP2 | IDH3B | VRK2 | DAGLA | PPP3CB | SYNE1 | LINC02551 | LOC105376559 | MAN2A1 | PPP1R16B | SLCO1B1 | MAGI1 | PTPN11 | SSBP2 | FYN | STAG1 | alpha1-Adrenoceptor (nonspecified subtype) | GAD1 | DGKI | HNF4A | GABRA2 | NR1D1 | AKT3 | CAND2 | PHF3 | P2RX7 | INPP1 | PALS2 | LOC105378800 | NADPH Oxidase Complex | LINC02694 | SSTR1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | CCL2 | HCAR2 | SATB2 | TENM4 | FOXO6 | DNAJB4 | HTR2C | FER1L6 | NR4A2 | ETF1 | GRM4 | LOC105372505 | DRD3 | MMP14 | MSRA | STEAP3 | ANK3 | LOC105378867 | IRAK1 | ACSBG1 | LOC105372507 | HCN1 | IL1B | CSNK1D | ALOX5 | SLC30A8 | MTR | KIF26B | STARD9 | G3569 | KCNN1 | ASAP1 | CDK1 | RBPJL | XRCC1 | TMEM165 | G596 | GRN | HOMER2 | EGR3 | MIR29B2 | SLC25A17 | PTPRC | Potassium Channels (nonspecified subtype) | MALL | MAOB | OPCML | THOC7 | C12orf42 | SLC6A3 | LINC02057 | SIVA1 | ABAT | KIF26A | MIR1292 | CHRNB2 | GRIN3A | LOC101928516 | DAGLB | CDKN1C | SLC1A2 | MCHR1 | DIDO1 | NADPH Oxidase (nonspecified subtype) | TAAR1 | DAXX | NALCN | PER3 | KCNH7 | SLC18A1 | THRA | MMP10 | NT5DC1 | IP6K1 | GPR17 | CHRM2 | NGF | CNNM2 | RELN | GRIN2B | NOP56 | MIR29C | NTRK2 | CLOCK | KCNB1 | DPYD | KDM5A | AURKA | ADD3-AS1 | Glutathione peroxidase (nonspecified subtype) | THSD7A | MPHOSPH9 | PAK6 | NCKAP5 | KCNQ2 | CAMKK2 | ZMIZ1 | AOAH | TSNARE1 | GPR143 | CHRNA5 | DGKH | G6774 | ASMT | RPL23P8 | NEK5 | XBP1 | GABRB1 | SOX2-OT | Monoamine oxidase (MAO) (nonspecified subtype) | AADAT | RIGI | GIGYF2 | APEH | GPM6B | HSP90B1 | GRIK4 | HSD52 | ST8SIA2 | PDE4D | PDYN | HTR7 | KDM5A-GATAD1-EMSY chromatin complex | NKAIN2 | KMO | FASTKD3 | DCAF5 | HLF | PVT1 | MACROD2 | PDLIM5 | SCN2A | Glutamate Receptor Ionotropic AMPA Receptor | PER2 | ZNF536 | SV2A | NRXN3 | SH3PXD2A | CSNK1E | XIRP2 | ABCA13 | GRIK5 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype)

Note: If you'd like to get a target analysis report for Bipolar Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Bipolar Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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