Carotid Body Paraganglioma

About the Disease
Paragangliomas 1, also known as carotid body tumor, is related to persistent generalized lymphadenopathy and hereditary paraganglioma-pheochromocytoma syndromes, and has symptoms including aphonia An important gene associated with Paragangliomas 1 is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Doxazosin and Phenoxybenzamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, spinal cord and thyroid, and related phenotypes are extraadrenal pheochromocytoma and adrenal pheochromocytoma

Common Targets
RECQL4 | TEC | SPEN | BCL9L | FOXO1 | ASXL2 | ITGAV | EXT2 | KMT2C | BRCA2 | MUC16 | PRDM16 | NUP214 | G7852 | ALDH2 | TRIP11 | BRD4 | PMS2 | PRDM2 | ARID2 | SDHB | HOXA11 | CDH17 | FHIT | RNF213 | GATA2 | TMPRSS2 | PAX5 | ARHGEF12 | CREB3L1 | BIRC3 | SDHC | NIN | RB1 | BRD3 | PREX2 | STRN | SDHD | MUC4 | NUP98 | SDHA | BRIP1 | APC | ARID1A | ATR | MSH6 | TGFBR2 | TCF7L2 | DCC | SDHAF2 | KIT | LATS2

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