Hyperkalemic Periodic Paralysis

About the Disease
Hyperkalemic Periodic Paralysis, also known as gamstorp disease, is related to myotonia, potassium-aggravated and periodic paralysis, and has symptoms including stridor, muscular stiffness and myalgia. An important gene associated with Hyperkalemic Periodic Paralysis is SCN4A (Sodium Voltage-Gated Channel Alpha Subunit 4), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Cardiac conduction. The drugs Hops and Diclofenamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, heart and tongue, and related phenotypes are emg abnormality and reduced tendon reflexes

Common Targets
Carbonic Anhydrase (nonspecified subtype) | SCN4A

Note: If you'd like to get a target analysis report for Hyperkalemic Periodic Paralysis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hyperkalemic Periodic Paralysis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Congenital Ichthyosiform Erythroderma | Keratoconjunctivitis | Cavitary Optic Disc Anomalies | Hereditary Multiple Exostoses | Rhabdoid Tumor | Choroiditis | Intermittent Explosive Disorder | Localized Scleroderma | Osteoporosis | Cystinosis | Spinocerebellar Ataxia | Hyperkalemic Periodic Paralysis | Hermansky-Pudlak Syndrome | Cardiac Arrest | Twin-to-twin Transfusion Syndrome | Aspartylglycosaminuria | Hyperparathyroidism, Primary | Muckle-Wells Syndrome | Premature Ejaculation | Colorectal Adenoma | Spasticity | Hyperuricemia | Cerebral Cavernous Malformations | Hemorrhoids | Retinal Degeneration | Transient Bullous Dermolysis Of The Newborn | Tatton-Brown-Rahman Syndrome | Hypotonia-cystinuria Syndrome | Glycogen Storage Disease Type 0, Muscle | Beare-Stevenson Syndrome | Cousin Syndrome | Language Disorders | Beckwith-Wiedemann Syndrome | Osteonecrosis Of The Jaw | Pelizaeus-Merzbacher Disease | Craniolenticulosutural Dysplasia | Periventricular Leukomalacia | Spinocerebellar Ataxia Type 13 | Dyskeratosis Congenita | Mosaic Variegated Aneuploidy Syndrome 2 | McLeod Syndrome | Leiomyoma | Lymphomatoid Granulomatosis | Infertility | Benign Hereditary Chorea | Lymphoma, Mantle Cell | Ocular Albinism Type 1 | Cardiofaciocutaneous Syndrome | Phenylketonuria II | Osteochondrosis | Primary Progressive Nonfluent Aphasia | Eosinophilic Asthma | LMNA-related Congenital Muscular Dystrophy | Walker-Warburg Syndrome | Congenital Stromal Corneal Dystrophy | Polyarteritis Nodosa | Gastritis, Atrophic | Choriocarcinoma | Chordoma | Microtia | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Tyrosinemia Type 2 | Autosomal Recessive Spastic Paraplegia Type 54 | Gastric Atrophy | Amebiasis | Arthropathy | Hereditary Inclusion Body Myopathy | Melnick-Needles Syndrome | Sarcoidosis, Pulmonary | Celiac Disease | Spinocerebellar Ataxia Type 8 | Erythromelalgia | Conduct Disorder | Arterial Tortuosity Syndrome | Narcolepsy | Hemophilia | Microcephaly | Hypertension, Portal | Non-Langerhans Cell Histiocytosis | Retinopathy Of Prematurity | Hereditary Coproporphyria | Infectious Diarrhea | Smoldering Myeloma | Multiple Sclerosis | Porphyria, Acute Intermittent | Megalencephaly | Peters-plus Syndrome | Hoyeraal-Hreidarsson Syndrome | Spondyloperipheral Dysplasia | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Spondyloarthritis | Cabezas Syndrome | Apraxia | Pouchitis | Hereditary Elliptocytosis | Neuropathy | Trichomegaly | Primary Hyperoxaluria Type 1 | Thanatophoric Dysplasia | Lichen Planus | Micro Syndrome | Lymphoma | Usher Syndrome Type I | Carcinoma, Squamous Cell | Stargardt Disease | Disseminated Intravascular Coagulation | Cornelia De Lange Syndrome | Traboulsi Syndrome | Hyperbilirubinemia, Neonatal | Endophthalmitis | Hypertension, Essential | WAGR Syndrome | Relapsing Polychondritis | Angiodysplasia | Greig Cephalopolysyndactyly Syndrome | Cri-du-chat Syndrome | Bladder Exstrophy | Distal Myopathy 2 | Juvenile Polyposis | Pemphigus | Recurrent Respiratory Papillomatosis | Tinea | Astigmatism | Pneumonia, Mycoplasma | Vestibular Disease | Methemoglobinemia Type IV | Scoliosis | Arteriovenous Malformations | Multiple Sclerosis, Relapsing-remitting | Mitochondrial Disease | Panniculitis | Cardiomyopathy, Peripartum | Kawasaki Disease | Sclerosteosis 2 | Rash | Hemorrhage | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Pulmonary Veno-occlusive Disease | Scabies | Colitis, Microscopic | Cartilage Disorders | Hepatitis A | Depression | Schistosomiasis Mansoni | Hyperinsulinism-hyperammonemia Syndrome | Alkaptonuria | Congenital Bile Acid Synthesis Defect | High Molecular Weight Kininogen Deficiency | Adenoma, Pituitary | Carpenter Syndrome | Haim-Munk Syndrome | Leishmaniasis, Visceral | Ollier Disease | ACTH-independent Macronodular Adrenal Hyperplasia | Glomerulonephritis | Microcephalic Primordial Dwarfism | Anti-NMDA Receptor Encephalitis | Alpha-thalassemia Myelodysplasia Syndrome | Carney Triad | Epicondylitis | Poirier-Bienvenu Neurodevelopmental Syndrome | Wolcott-Rallison Syndrome | Hypersensitivity | Williams Syndrome | Waardenburg Syndrome Type 4 | Hydronephrosis | Spondylocarpotarsal Synostosis Syndrome | Spinocerebellar Ataxia Type 40 | Usher Syndrome | Congenital Fiber-type Disproportion Myopathy | Aarskog-Scott Syndrome | Dentinogenesis Imperfecta | Necrobiosis Lipoidica | Hemangioma | Vitamin B12 Deficiency | Knobloch Syndrome | Left Ventricular Noncompaction | Sitosterolemia | Duane Retraction Syndrome | Basan Syndrome | Alagille Syndrome | Intermittent Claudication | Familial Exudative Vitreoretinopathy | Pontocerebellar Hypoplasia Type 2 | Leukemia-lymphoma, Adult T-cell | Angioedema | Succinic Semialdehyde Dehydrogenase Deficiency | Pyruvate Carboxylase Deficiency Disease | Glioblastoma Multiforme | Charcot-Marie-Tooth Disease, Type 6 | Alopecia Areata | Brachydactyly | Pure Autonomic Failure | Portal Vein Thrombosis | Gout | Bipolar Disorder | Schizophrenia | Woodhouse-Sakati Syndrome | Pendred Syndrome | Lennox-Gastaut Syndrome | Hyperferritinemia-cataract Syndrome | Keratitis-ichthyosis-deafness Syndrome | Neutrophilia | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Postaxial Polydactyly | Albinism | Giant Axonal Neuropathy | Hyperacusis | Thrombophilia | Sporadic Inclusion Body Myositis | Retinal Vasculitis | Osteoglophonic Dysplasia | Bone Giant Cell Tumor | Hemangioendothelioma | Robinow Syndrome | Thyroid Dyshormonogenesis | Polymyositis | Polymicrogyria | Pfeiffer Syndrome | Pituitary Disorders | Pseudoachondroplasia | Bacterial Meningitis | Patent Ductus Arteriosus | Lateral Meningocele Syndrome | Pseudo-pseudohypoparathyroidism | Osteogenesis Imperfecta Type II | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Motor Neuron Diseases | Lymphedema | Cerebellofaciodental Syndrome | Leukodystrophies | Myocarditis | Iron Overload | Hypertriglyceridemia | Hypophosphatasia | Lathosterolosis | Oguchi Disease-2 | Glycogen Storage Disease | Nanophthalmos | Agranulocytosis | Adenoma, Pleomorphic | Congenital Heart Block | Centronuclear Myopathy | Adams-Oliver Syndrome | Hypopigmentation | Neonatal Progeroid Syndrome | Glutaric Aciduria Type 2 | Maternally Inherited Diabetes And Deafness | Nicolaides-Baraitser Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Paget's Disease Of The Breast | Platelet Disorders | Cranial Nerve Disease | Meier-Gorlin Syndrome | Acute Kidney Injury | Cutaneous T-cell Lymphoma | CREST Syndrome | Aneurysm, Thoracic Aortic | Erythrokeratodermia Variabilis | Hypoparathyroidism | Chloridorrhea, Congenital | Charcot-Marie-Tooth Disease, Type 2 | T-cell Leukemia | Temporal Lobe Epilepsy | Non-bullous Congenital Ichthyosiform Erythroderma | Duchenne Muscular Dystrophy | Gastroenteritis | Cocaine-Related Disorders | Leukoencephalopathy, Progressive Multifocal | Angiosarcoma | Fragile X Syndrome | Chiari Malformation Type I | Sialidosis Type I | Kearns-Sayre Syndrome | Hyperammonemia | Esophageal Adenocarcinoma | Cholesteryl Ester Storage Disease | Inborn Errors Of Metabolism | TARP Syndrome | Dengue Hemorrhagic Fever | Waardenburg Syndrome Type 1 | Bronchiectasis | Pheochromocytoma | Behavioral Variant Of Frontotemporal Dementia | Sialoadenitis | Familial Digital Arthropathy-brachydactyly | Nephropathy | Polycystic Kidney, Autosomal Recessive | Ophthalmoplegia | Bulimia Nervosa | Aceruloplasminemia | Focal Cortical Dysplasia Type 2 | Systemic Lupus Erythematosus | Ehlers-Danlos Syndrome | Angiosarcoma Of The Breast | Mitochondrial DNA Depletion Syndrome | Crisponi Syndrome | Pleomorphic Xanthoastrocytoma | Ganglioneuroma | Angioimmunoblastic T-cell Lymphoma | Nephrotic Syndrome Type 1 | Cryoglobulinemia | Vertebrobasilar Insufficiency | Congenital Dyserythropoietic Anemia | Dyslexia | Pancreatitis | Coronary Heart Disease | Anal Fissure | Autonomic Nervous System Disorders | Supravalvular Aortic Stenosis | Carcinoid Syndrome | Schuurs-Hoeijmakers Syndrome | Mycosis Fungoides | Tic Disorder | Stiff-man Syndrome | Opisthorchiasis | Neurofibromatosis Type 2 | Polycystic Liver | Superficial Spreading Melanoma | Ischemia | Granular Corneal Dystrophy Type 1 | Lissencephaly 2 | Citrullinemia | Primary Progressive Aphasia | Strabismus | Mitochondrial DNA Depletion Syndrome 13 | Renpenning Syndrome | Glutathione Synthetase Deficiency | Familial Thoracic Aortic Aneurysm | Acne Vulgaris | Ophthalmia, Sympathetic | Pulmonary Sclerosing Hemangioma | Glutaric Aciduria Type 1 | Neurocutaneous Melanocytosis | Majeed Syndrome | Anti-glomerular Basement Membrane Disease | Ulcerative Colitis | Rhabdomyosarcoma, Alveolar | Schistosomiasis | Von Hippel-Lindau Disease | Charcot-Marie-Tooth Disease | Arthritis, Reactive | Pleurisy | Smith-Lemli-Opitz Syndrome | SAPHO Syndrome | Ichthyosis, X-linked | Corneal Neovascularization | Salla Disease | Liebenberg Syndrome | Adenoid Cystic Carcinoma | Anemia | Paracoccidioidomycosis | Non-Hodgkin Lymphoma | Cenani-Lenz Syndactyly Syndrome | Trimethylaminuria | Glycogen Storage Disease Type 3 | Spinal Cord Diseases | 3-methylglutaconic Aciduria Type IV | Tuberculosis | Familial Pheochromocytoma-paraganglioma | Arteriosclerosis | CHOPS Syndrome | Benign Familial Pemphigus | POEMS Syndrome | Small Lymphocytic Lymphoma | Chondrodysplasia Punctata 2, X-linked Dominant | Charcot-Marie-Tooth Disease Type 4B1 | Epidermolytic Hyperkeratosis | Familial Partial Lipodystrophy | Fanconi Syndrome | Chronic Kidney Disease | Glycogen Storage Disease Type 9 | Endometriosis | Van Der Knaap Disease | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Chromosome 17q21.31 Deletion Syndrome | Liddle Syndrome | Hypertension, Renal | Diarrhea | Behcet's Disease | Sarcomatoid Carcinoma Of The Lung | Retinal Detachment | Tricho-hepato-enteric Syndrome | Ganglioglioma | Coenzyme Q10 Deficiency | Renal Failure | Autonomic Neuropathy | Episodic Ataxia Type 1 | Chronic Beryllium Disease | Panuveitis | Infantile Refsum Disease | Autoimmune Polyendocrinopathy Syndrome Type I | Intellectual Disability, Autosomal Dominant 5 | Glutaric Aciduria Type 3 | Skin Carcinoma | Coma | Rotor Syndrome | Guillain-Barre Syndrome | Graves Disease | Anthrax