Coronary Heart Disease

About the Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

Common Targets
LPL | G2335 | L-type voltage-dependent calcium channel complex | CCDC26 | DYSF | NDUFA10 | DCAF13 | COL18A1 | HLA-DQA1 | TOP1 | LOC105377329 | BUD13 | PPARG | FADS2 | HOXD4 | HRG | SLC9A1 | CYP2D6 | AKAP9 | TOMM40 | FOXO1 | NGFR | G59272 | ESR2 | CNR1 | NR1H2 | ABHD18 | SLC6A2 | ANGPTL4 | SREBF2 | GRB10 | LTA | NANOG | ZPR1 | PNPLA3 | HP | CTNNA3 | ORC6 | PRKCA | Lipoxygenase (nonspecified subtype) | ADRA2B | MADD | GNB3 | MIR451A | AGT | PAFAH1B2 | GJA4 | TRIB1 | CDKN2B | GLIS3 | TAS2R42 | WARS1 | ADIPOQ | PTGS1 | CARNMT1 | Estrogen receptor (nonspecified subtype) | MAP3K5 | G2099 | G6PC2 | MRPS7 | CERT1 | STX8 | NOS1AP | SELL | LAG3 | SH2B1 | HMGCR | RAD52 | APOA5 | Glycogen phosphorylase (nonspecified subtype) | MTHFR | ITGA2 | KDM4C | NPC1L1 | COL4A1 | G23411 | G5743 | SCNN1A | Phospholipase A2 (nonspecified subtype) | ACHE | APLNR | MAP3K20 | G5243 | NR1H3 | GCK | ANKS1A | GP1BA | CDKAL1 | THBS2 | PIK3R1 | EDEM2 | HSD11B1 | TNFSF11 | LRFN2 | G1956 | DNLZ | HLA-G | SLC22A3 | ENG | SPOCK3 | CDKN2B-AS1 | PROCR | NOTCH4 | ADTRP | EBI3 | G4318 | SCARB1 | MIR206 | CCR2 | KCTD21 | LOC101927947 | SNRPD2 | SYK | F2 | DPP4 | ABCA1 | ABCG1 | CASQ2 | G3605 | SOD2 | IL1RL1 | CD40 | VDR | MLXIPL | FRY | KCNJ1 | CACNA1C | MIS12 | DOCK6 | PCSK9 | VANGL1 | GABARAPL2 | CORO1A | GUCY1A2 | MMAB | BCHE | SHBG | FPGT-TNNI3K | NIPSNAP2 | OR51B5 | NOS3 | KDR | Oxysterols receptor LXR (nonspecified subtype) | WEE1 | GALNT2 | TAS2R31 | SERPINE1 | SELP | LIPA | MTNR1B | APOC3 | IL10 | DACH1 | LDLRAD1 | TOMM5 | TCF21 | ELP1 | SELENOS | TIAM1 | Histone acetyltransferase (HAT) (nonspecified subtype) | CKAP2L | CES1 | SMARCA4 | LINC01122 | PRKAG2 | SNX30 | GIPR | GCKR | CLEC2D | CLEC1B | IL1B | PLEKHA7 | TAS2R19 | PSRC1 | MVK | PLG | MLX | PENK | G3569 | ANXA4 | ARAP1 | ANGPTL8 | SLCO1B7 | CXCL12 | Na+/K+-ATPase (nonspecified subtype) | G7422 | PDE5A | CELSR2 | PZP | CYP3A5 | ADCY5 | IL1A | PRF1 | LRRC31 | ABCC8 | S100A8 | PCSK7 | QPCTL | G6PC1 | P2RY12 | FGB | AGXT2 | PIK3C2G | ACVRL1 | LRP1 | TFAP2B | DDR1 | LRRC23 | MRFAP1 | RPS19 | LINC01399 | LOC105371642 | IL17F | CYP1A2 | CPB2 | ADIPOR1 | APOA1-AS | AGTR1 | G7015 | USP1 | SLC23A1 | AP-1 Transcription Factor Complex | FASLG | JAK2 | TRIM46 | BICD1 | PLCG1 | ROCK2 | TRPC4AP | L-Type calcium channel (nonspecified subtype) | BCL2L14 | CDKN1B | NF-kappaB (NFkB) | EDN1 | MOGS | Janus Kinase (nonspecified subtype) | JAK3 | TXNRD1 | GLT6D1 | JAK1 | PDX1 | MIR499B | HTR3B | WDR12 | CHI3L1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G1786 | MIR146A | GC | PON1 | SLCO1B1 | IL12A | GCLM | ARL15 | G7124 | CA9 | THBS4 | APOE | IL16 | AMT | NRXN2 | APOA1 | NAMPT | ITGB3 | DAB2IP | C3 | F11 | SERPINB2 | CYP19A1 | MC4R | SMAD3 | PLAU | AGER | ZDHHC20 | CFH | CYP2B6 | CCT6B | Nitric oxide synthase (NOS) (nonspecified subtype) | RDH10 | TSSC4 | IL6R | LOC101929710 | F2RL3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CCL2 | SLC15A5 | FTO | GP6 | NARS1 | ZDHHC5 | DCHS2 | APOB | GLP1R | BORCS5 | ATXN1 | PLA2G7 | A1CF | Myosin (nonspecified subtype) | TGFB1 | SLC2A9 | MAS1 | TLR6 | MCM6 | G7099 | SH2B3 | KIF6 | F7 | CYP11B2 | G673 | MIR196A2 | TAPBPL | HMOX1 | CRP | MEST | G5133 | PRB4 | PROX1 | PEAR1 | IGF2BP2 | SLC2A2 | LPA | TCF7L2 | LOC105376659 | ND5 | TSBP1 | CHRM2 | NLRX1 | SLC30A8 | TRNL1 | MYH7B | NPC1 | LOC107985393 | NTRK2 | AHSG | MRAS | EPAS1 | OR51Q1 | LOC105370050 | PPARGC1A | OR51I1 | MPO | CXCL16 | SLCO1B3 | DMD | HNF4G | CMA1 | LINC02627 | MIR499A | CHCHD1 | PON2 | LOC105379030 | MIA3 | TAP2 | PRH1 | G29126 | LIPG | TERC | LINC01725 | BDNF | CYP3A4 | HAUS3 | G595 | ACE | HLA-DRB1 | TRNL2 | GCGR | G1029 | ATF7IP | SELE | CYBA | NODAL | IL1RN | SLCO1C1 | PLPP3 | CST3 | LDLR | SLC5A2 | TNFSF4 | ND6 | PKD1L3 | LCAT | PRH2 | MAP2K5 | SLC22A11 | ZNF648 | LINGO2 | VAMP1 | PVT1 | MIR149 | RNLS | TNFRSF11B | CYP2C19 | SREBF1 | RBP5 | CETP | HFE | HLF | EWSR1 | THBS1 | ADAL | PPARA | STN1 | WDTC1 | PHACTR1

Note: If you'd like to get a target analysis report for Coronary Heart Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Coronary Heart Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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