Coronary Heart Disease

About the Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

Common Targets
LPL | G2335 | L-type voltage-dependent calcium channel complex | CCDC26 | DYSF | NDUFA10 | DCAF13 | COL18A1 | HLA-DQA1 | TOP1 | LOC105377329 | BUD13 | PPARG | FADS2 | HOXD4 | HRG | SLC9A1 | CYP2D6 | AKAP9 | TOMM40 | FOXO1 | NGFR | G59272 | ESR2 | CNR1 | NR1H2 | ABHD18 | SLC6A2 | ANGPTL4 | SREBF2 | GRB10 | LTA | NANOG | ZPR1 | PNPLA3 | HP | CTNNA3 | ORC6 | PRKCA | Lipoxygenase (nonspecified subtype) | ADRA2B | MADD | GNB3 | MIR451A | AGT | PAFAH1B2 | GJA4 | TRIB1 | CDKN2B | GLIS3 | TAS2R42 | WARS1 | ADIPOQ | PTGS1 | CARNMT1 | Estrogen receptor (nonspecified subtype) | MAP3K5 | G2099 | G6PC2 | MRPS7 | CERT1 | STX8 | NOS1AP | SELL | LAG3 | SH2B1 | HMGCR | RAD52 | APOA5 | Glycogen phosphorylase (nonspecified subtype) | MTHFR | ITGA2 | KDM4C | NPC1L1 | COL4A1 | G23411 | G5743 | SCNN1A | Phospholipase A2 (nonspecified subtype) | ACHE | APLNR | MAP3K20 | G5243 | NR1H3 | GCK | ANKS1A | GP1BA | CDKAL1 | THBS2 | PIK3R1 | EDEM2 | HSD11B1 | TNFSF11 | LRFN2 | G1956 | DNLZ | HLA-G | SLC22A3 | ENG | SPOCK3 | CDKN2B-AS1 | PROCR | NOTCH4 | ADTRP | EBI3 | G4318 | SCARB1 | MIR206 | CCR2 | KCTD21 | LOC101927947 | SNRPD2 | SYK | F2 | DPP4 | ABCA1 | ABCG1 | CASQ2 | G3605 | SOD2 | IL1RL1 | CD40 | VDR | MLXIPL | FRY | KCNJ1 | CACNA1C | MIS12 | DOCK6 | PCSK9 | VANGL1 | GABARAPL2 | CORO1A | GUCY1A2 | MMAB | BCHE | SHBG | FPGT-TNNI3K | NIPSNAP2 | OR51B5 | NOS3 | KDR | Oxysterols receptor LXR (nonspecified subtype) | WEE1 | GALNT2 | TAS2R31 | SERPINE1 | SELP | LIPA | MTNR1B | APOC3 | IL10 | DACH1 | LDLRAD1 | TOMM5 | TCF21 | ELP1 | SELENOS | TIAM1 | Histone acetyltransferase (HAT) (nonspecified subtype) | CKAP2L | CES1 | SMARCA4 | LINC01122 | PRKAG2 | SNX30 | GIPR | GCKR | CLEC2D | CLEC1B | IL1B | PLEKHA7 | TAS2R19 | PSRC1 | MVK | PLG | MLX | PENK | G3569 | ANXA4 | ARAP1 | ANGPTL8 | SLCO1B7 | CXCL12 | Na+/K+-ATPase (nonspecified subtype) | G7422 | PDE5A | CELSR2 | PZP | CYP3A5 | ADCY5 | IL1A | PRF1 | LRRC31 | ABCC8 | S100A8 | PCSK7 | QPCTL | G6PC1 | P2RY12 | FGB | AGXT2 | PIK3C2G | ACVRL1 | LRP1 | TFAP2B | DDR1 | LRRC23 | MRFAP1 | RPS19 | LINC01399 | LOC105371642 | IL17F | CYP1A2 | CPB2 | ADIPOR1 | APOA1-AS | AGTR1 | G7015 | USP1 | SLC23A1 | AP-1 Transcription Factor Complex | FASLG | JAK2 | TRIM46 | BICD1 | PLCG1 | ROCK2 | TRPC4AP | L-Type calcium channel (nonspecified subtype) | BCL2L14 | CDKN1B | NF-kappaB (NFkB) | EDN1 | MOGS | Janus Kinase (nonspecified subtype) | JAK3 | TXNRD1 | GLT6D1 | JAK1 | PDX1 | MIR499B | HTR3B | WDR12 | CHI3L1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G1786 | MIR146A | GC | PON1 | SLCO1B1 | IL12A | GCLM | ARL15 | G7124 | CA9 | THBS4 | APOE | IL16 | AMT | NRXN2 | APOA1 | NAMPT | ITGB3 | DAB2IP | C3 | F11 | SERPINB2 | CYP19A1 | MC4R | SMAD3 | PLAU | AGER | ZDHHC20 | CFH | CYP2B6 | CCT6B | Nitric oxide synthase (NOS) (nonspecified subtype) | RDH10 | TSSC4 | IL6R | LOC101929710 | F2RL3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CCL2 | SLC15A5 | FTO | GP6 | NARS1 | ZDHHC5 | DCHS2 | APOB | GLP1R | BORCS5 | ATXN1 | PLA2G7 | A1CF | Myosin (nonspecified subtype) | TGFB1 | SLC2A9 | MAS1 | TLR6 | MCM6 | G7099 | SH2B3 | KIF6 | F7 | CYP11B2 | G673 | MIR196A2 | TAPBPL | HMOX1 | CRP | MEST | G5133 | PRB4 | PROX1 | PEAR1 | IGF2BP2 | SLC2A2 | LPA | TCF7L2 | LOC105376659 | ND5 | TSBP1 | CHRM2 | NLRX1 | SLC30A8 | TRNL1 | MYH7B | NPC1 | LOC107985393 | NTRK2 | AHSG | MRAS | EPAS1 | OR51Q1 | LOC105370050 | PPARGC1A | OR51I1 | MPO | CXCL16 | SLCO1B3 | DMD | HNF4G | CMA1 | LINC02627 | MIR499A | CHCHD1 | PON2 | LOC105379030 | MIA3 | TAP2 | PRH1 | G29126 | LIPG | TERC | LINC01725 | BDNF | CYP3A4 | HAUS3 | G595 | ACE | HLA-DRB1 | TRNL2 | GCGR | G1029 | ATF7IP | SELE | CYBA | NODAL | IL1RN | SLCO1C1 | PLPP3 | CST3 | LDLR | SLC5A2 | TNFSF4 | ND6 | PKD1L3 | LCAT | PRH2 | MAP2K5 | SLC22A11 | ZNF648 | LINGO2 | VAMP1 | PVT1 | MIR149 | RNLS | TNFRSF11B | CYP2C19 | SREBF1 | RBP5 | CETP | HFE | HLF | EWSR1 | THBS1 | ADAL | PPARA | STN1 | WDTC1 | PHACTR1

Note: If you'd like to get a target analysis report for Coronary Heart Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Coronary Heart Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Tardive Dyskinesia | Anosmia, Congenital | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Hyperbilirubinemia, Neonatal | Waardenburg Syndrome Type 4A | Ectrodactyly | X-linked Myotubular Myopathy | Marfan Syndrome | Exostoses | Enterocolitis, Necrotizing | Bicuspid Aortic Valve | Bone Giant Cell Tumor | Spondyloperipheral Dysplasia | Chiari Malformation Type I | Primary Hyperoxaluria Type 1 | Hypoproteinemia, Hypercatabolic | Keratoconjunctivitis | Menkes Disease | Coronary Restenosis | Insulinoma | Wolff-Parkinson-White Syndrome | Amish Infantile Epilepsy Syndrome | Hepatitis C, Chronic | Myasthenia | Ichthyosis Bullosa Of Siemens | Sclerosteosis 2 | Meningeal Melanocytoma | Myopia | Okihiro Syndrome | Congenital Afibrinogenemia | Galactosialidosis | Speech Disorders | Schnyder Crystalline Corneal Dystrophy | Carcinoma, Squamous Cell | Open-angle Glaucoma | Trichotillomania | Retinal Telangiectasia | Splenomegaly | Hypertension, Renal | Diarrhea | Hypoparathyroidism | Non-epidermolytic Palmoplantar Keratoderma | Cancer, Skin | Androgenic Alopecia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hereditary Elliptocytosis | Nemaline Myopathy | Hypotrichosis | Alopecia Areata | Hemangioma | Hereditary Folate Malabsorption | Diffuse Palmoplantar Keratoderma | Skin Papilloma | Neovascular Glaucoma | Botulism | Pycnodysostosis | Melanocytic Nevus | Barakat Syndrome | Glycogen Storage Disease Type 6 | Prolactinoma | Shprintzen-Goldberg Syndrome | Esophageal Motility Disorders | Cardiomyopathy, Hypertrophic | Corneal Dystrophy And Perceptive Deafness | LRBA Deficiency | Riboflavin Transporter Deficiency Neuronopathy | Mitochondrial Cytopathy | Encephalopathy, Hepatic | Asperger Syndrome | Pituitary Stalk Interruption Syndrome | Congenital Adrenal Hyperplasia | Hemorrhoids | Congenital Aniridia | Tatton-Brown-Rahman Syndrome | Patent Foramen Ovale | Fraser Syndrome | Stroke, Ischemic | Carey-Fineman-Ziter Syndrome | Bartsocas-Papas Syndrome | Liver Failure, Acute Infantile | Congenital Stromal Corneal Dystrophy | PHARC Syndrome | Prostatitis | Diabetes | Tuberculosis | Anti-NMDA Receptor Encephalitis | Lupus Erythematosus | Inborn Errors Of Metabolism | Glycogen Storage Disease Type 4 | Histoplasmosis | Toxic Epidermal Necrolysis | Porphyria Cutanea Tarda | Charcot-Marie-Tooth Disease Type 4D | Myositis, Focal | Hyperphenylalaninemia | Neuromyotonia | Microphthalmia | Citrullinemia | Malonyl-CoA Decarboxylase Deficiency | Pemphigus Vulgaris | Epicondylitis | Takotsubo Cardiomyopathy | Delayed Sleep Phase Syndrome | Pseudomyxoma Peritonei | Angina Pectoris | Stuttering | Acanthosis Nigricans | Epidermolysis Bullosa | Myoclonic Atonic Epilepsy | Oligodendroglioma | Crimean-Congo Hemorrhagic Fever | Acute Motor Axonal Neuropathy | Blastomycosis | Charcot-Marie-Tooth Disease Type 3 | Succinic Semialdehyde Dehydrogenase Deficiency | Brachial Plexus Neuropathy | Jacobsen Syndrome | Hyperoxaluria | Progressive Myoclonic Epilepsy | Congenital Stationary Night Blindness | Spondylolisthesis | Cataplexy | Hermansky-Pudlak Syndrome | Myopathy | Meleda Disease | Keratitis | Chronic Neutrophilic Leukemia | Bipolar Disorder | Norrie Disease | Nephrotic Syndrome Type 1 | Hypersensitivity | Multiple Sulfatase Deficiency | Brugada Syndrome 1 | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Niemann-Pick Disease, Type C | Fanconi Anemia | KBG Syndrome | Wagner Disease | Acne | Proteasome-associated Autoinflammatory Syndrome 2 | Spondylometaphyseal Dysplasia | Intestinal Obstruction | Hypoplastic Left Heart Syndrome | Essential Fructosuria | Lattice Corneal Dystrophy Type 1 | Hemolytic Uremic Syndrome | Cancer, Bladder | Idiopathic Multicentric Castleman Disease | Guanidinoacetate Methyltransferase Deficiency | Hemorrhagic Disorders | Neurotoxicity | Hypertension, Renovascular | Takayasu's Arteritis | Martsolf Syndrome | Renpenning Syndrome | Sporadic Inclusion Body Myositis | Sickle Cell Anemia | Globozoospermia | Pneumococcal Meningitis | Arts Syndrome | Dystonia | Fibromyalgia | T-cell Lymphoma, Subcutaneous Panniculitis-like | Charcot-Marie-Tooth Disease Type 4B1 | Ocular Hypertension | Camptocormia | Alcoholism | Spinocerebellar Ataxia Type 12 | Rothmund-Thomson Syndrome | Vulvovaginitis | Carpenter Syndrome | Peroxisomal Disorder | Familial Episodic Pain Syndrome | Osteomyelitis | Episodic Ataxia Type 1 | Chondrodysplasia Punctata 2, X-linked Dominant | Anorexia Nervosa | Subcortical Band Heterotopia | Glucagonoma | Hemangioblastoma | Early Infantile Epileptic Encephalopathy 28 | Hypophosphatasia | Erythromelalgia | Focal Dermal Hypoplasia | Myelofibrosis | Iron Metabolism Disorders | Familial Retinal Arterial Macroaneurysm | Autism Spectrum Disorders | Spinocerebellar Ataxia Type 42 | Basal Ganglia Cerebrovascular Disease | Bacterial Meningitis | Palmoplantar Keratoderma | Enlarged Vestibular Aqueduct | Allan-Herndon-Dudley Syndrome | Multiple Sclerosis, Secondary Progressive | Cyclic Vomiting Syndrome | Retinal Dystrophy, Early-onset Severe | Galactosemia | Adenocarcinoma | Chediak-Higashi Syndrome | Marinesco-Sjogren Syndrome | Sarcoma, Ewing | Alpha-mannosidosis | Mosaic Variegated Aneuploidy Syndrome 2 | Cutaneous Angiosarcoma | Papillorenal Syndrome | Nephrosclerosis | Spinal Muscular Atrophy | Costello Syndrome | Pituitary Dwarfism | Glaucoma | Chorea-acanthocytosis | Sponastrime Dysplasia | Seminoma | Mast Cell Leukemia | Lipid Metabolism Disorders | Auriculocondylar Syndrome | Seborrheic Dermatitis | Multiple Myeloma | Corneal Dystrophy | Sick Sinus Syndrome | Osteoglophonic Dysplasia | Panniculitis | Hypospadias | Sarcoidosis | Pulmonary Alveolar Proteinosis | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Coenzyme Q10 Deficiency | Asthma, Exercise-induced | Dengue Shock Syndrome | Nance-Horan Syndrome | Rolandic Epilepsy | Kidney Stones | Conn Syndrome | Chloridorrhea, Congenital | Senior-Loken Syndrome | Nutrition Disorders | Pouchitis | Milk Allergy | Hereditary Neuropathy With Liability To Pressure Palsies | Headache | Lathosterolosis | Batten Disease | Gaucher Disease | Chromosome 8q21.11 Deletion Syndrome | Porphyria, Variegate | Alexander Disease | Porokeratosis | McKusick Type Metaphyseal Chondrodysplasia | Fetal Alcohol Syndrome | Myotonia | Nestor-Guillermo Progeria Syndrome | Anuria | Alveolar Capillary Dysplasia | Gestational Trophoblastic Disease | Infantile Neuroaxonal Dystrophy | Congenital Absence Of Vas Deferens | Cholesteryl Ester Storage Disease | Nemaline Myopathy 8 | Gastritis | Postaxial Polydactyly | Parkinsonism | Corticobasal Syndrome | VACTERL Association | Colon Adenoma | Hemochromatosis Type 1 | Sleep Disorder | Pneumonia, Bacterial | Thymoma, Malignant | Temtamy Preaxial Brachydactyly Syndrome | Stuve-Wiedemann Syndrome | Hypertelorism | Spondyloarthritis | Hypodontia | Keratitis-ichthyosis-deafness Syndrome | Zollinger-Ellison Syndrome | Autoimmune Polyendocrine Syndrome | Dent Disease | Polycystic Kidney, Autosomal Recessive | Epidermolytic Ichthyosis, Annular | Infantile Spasm | Achondrogenesis | Waardenburg Syndrome Type 2 | Primary Ovarian Insufficiency | Diabetic Macular Edema | Spinocerebellar Ataxia Type 20 | Hypermethioninemia | Retinal Coloboma | Eating Disorder | Desmosterolosis | Myofibrillar Myopathy | Rhinitis | Cocaine-Related Disorders | Hyperkalemic Periodic Paralysis | Schizophrenia | Ovarian Sex Cord-stromal Tumor | Glomerulonephritis | Hypotension, Orthostatic | Retinal Detachment | Myoclonus-dystonia Syndrome | Bronchitis | Osteogenesis Imperfecta Type I | L-2-Hydroxyglutaric Aciduria | Uveitis, Anterior | Liebenberg Syndrome | Restrictive Dermopathy | Aspergillosis | Alkaptonuria | Iron Deficiency Anemia | Osteopetrosis | Antiphospholipid Syndrome | Chitayat Syndrome | Coronary Heart Disease | Premature Ejaculation | Gynecomastia | Wolcott-Rallison Syndrome | Gliosarcoma | Ventricular Septal Defect | Intermittent Claudication | Erectile Dysfunction | Schwannomatosis | Split Hand-foot Malformation | Cerebellar Ataxia, Cayman Type | Primary Torsion Dystonia | Keloid | Orthostatic Intolerance | Mevalonate Kinase Deficiency | Optic Nerve Hypoplasia, Bilateral | Atrial Septal Defect | Hypocalcemia | Pigment Dispersion Syndrome | Fascioliasis | Hyperparathyroidism-jaw Tumor Syndrome | Meesmann Corneal Dystrophy | FG Syndrome | Wolfram Syndrome 2 | Cryopyrin-associated Periodic Syndromes | Macrophage Activation Syndrome | Hydrops Fetalis | MIRAGE Syndrome | Pneumonia, Mycoplasma | Coloboma | Poikiloderma With Neutropenia | WAGR Syndrome | Corneal Neovascularization | Cryptosporidiosis | Microphthalmia, Syndromic 7 | Chromosome 16p11.2 Deletion Syndrome | Pontocerebellar Hypoplasia Type 7 | Carcinoid Syndrome | Autoimmune Hemolytic Anemia | Prolidase Deficiency | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Hepatopulmonary Syndrome | Paronychia | HELLP Syndrome | Chronic Lymphocytic Leukemia | Alazami Syndrome | Osteogenesis Imperfecta Type II | Chronic Myeloid Leukemia | Amebiasis | Maple Syrup Urine Disease | Traboulsi Syndrome | Monilethrix | Bartter Syndrome | Usher Syndrome Type I | Phenylketonuria II | Multifocal Motor Neuropathy | Waardenburg Syndrome | Peritonitis | Renal Tubular Dysgenesis | Pleurisy | Pompe Disease | Hepatitis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Infertility | Acute Chest Syndrome | Protein S Deficiency | Varicocele | Arterial Tortuosity Syndrome | Medulloblastoma | Anorchia | Hyperprolactinemia | McLeod Syndrome | Nicolaides-Baraitser Syndrome | Antisocial Personality Disorder | Spondylocarpotarsal Synostosis Syndrome | Macrodactyly | Enhanced S-cone Syndrome | Inflammatory Joint Disease | Lipid Storage Myopathy | Lysosomal Acid Lipase Deficiency | Osteonecrosis | Oculocutaneous Albinism Type 4 | Erdheim-Chester Disease | Polycystic Liver | Charcot-Marie-Tooth Disease, Type 6 | Sweet Syndrome | Brachydactyly | Optic Neuropathy