Cherubism
Cherubism
About the Disease
Cherubism, also known as crbm, is related to giant cell reparative granuloma and bone resorption disease. An important gene associated with Cherubism is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are Signal Transduction and PIP3 activates AKT signaling. Affiliated tissues include bone, lymph node and skin, and related phenotypes are full cheeks and bone cyst
Common Targets
NF1 | SH3BP2 | SOS1
Note: If you'd like to get a target analysis report for Cherubism, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cherubism at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.
Other Diseases
Chondrosarcoma | Epithelioid Hemangioma | Rubinstein-Taybi Syndrome | Autosomal Recessive Congenital Ichthyosis | Cancer, Brain | Cysticercosis | Ocular Albinism Type 1 | Chronic Kidney Disease | Epidermolytic Ichthyosis, Annular | Chronic Lymphocytic Leukemia | Babesiosis | Primary Sclerosing Cholangitis | Anuria | Vogt-Koyanagi-Harada Syndrome | Neuropathy | Stroke | Tinea Versicolor | Lymphoma, B-cell | Shprintzen-Goldberg Syndrome | Schnitzler Syndrome | Transthyretin-related Amyloidosis | Diabetic Nephropathy | Bernard-Soulier Syndrome | Cholecystitis | L-2-Hydroxyglutaric Aciduria | Retinoschisis | Ectopia Lentis, Isolated, Autosomal Recessive | Chromosome 9q34.3 Deletion Syndrome | Whipple's Disease | Localized Scleroderma | Craniopharyngioma | Trichuriasis | Acquired Partial Lipodystrophy | Eclampsia | Myasthenia Gravis | Syphilis | Trismus-pseudocamptodactyly Syndrome | Benign Hereditary Chorea | Angiosarcoma | Schwartz-Jampel-Aberfeld Syndrome | Melanoma | Wiskott-Aldrich Syndrome | 3-hydroxy-3-methylglutaric Aciduria | Osteomyelitis | Dental Caries | Teratozoospermia | Adrenomyeloneuropathy | Panic Disorder | Stroke, Ischemic | Basal Ganglia Cerebrovascular Disease | Arthritis, Psoriatic | Pycnodysostosis | Ghosal Syndrome | Urolithiasis | Aplasia Cutis Congenita | Tonsillitis | Spondylocarpotarsal Synostosis Syndrome | Pseudohypoparathyroidism Type 1A | Raine Syndrome | KBG Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Scleroderma | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Epidermolysis Bullosa Simplex, Localized | Mixed Connective Tissue Disease | Corneal Neovascularization | Antisocial Personality Disorder | Myoclonic Epilepsy With Ragged Red Fibers | Oligoasthenoteratozoospermia | Hypohidrotic Ectodermal Dysplasia | Seasonal Mood Disorder | IgA Deficiency | Myasthenia | AIDS Dementia Complex | Meier-Gorlin Syndrome | Amelanotic Melanoma | Creatine Deficiency Syndrome Due To AGAT Deficiency | Bronchiectasis | Inflammatory Bowel Disease | Pseudoachondroplasia | Hereditary Elliptocytosis | Hyperlipidemia, Familial Combined | Pneumothorax | Bullous Pemphigoid | Spinocerebellar Ataxia Type 3 | Congenital Fiber-type Disproportion Myopathy | Plasmacytoma | Thanatophoric Dysplasia Type 1 | Focal Dermal Hypoplasia | Spinal And Bulbar Muscular Atrophy | Neurotoxicity | Acne Vulgaris | Lyme Disease | Autonomic Nervous System Disorders | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Mohr-Tranebjaerg Syndrome | Primary Cutaneous Amyloidosis | Hyperinsulinism-hyperammonemia Syndrome | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Cardiomyopathy, Dilated, 1L | Familial Hyperaldosteronism | Keratitis | Purpura, Thrombotic Thrombocytopenic | Familial Exudative Vitreoretinopathy | Epithelial-myoepithelial Carcinoma | Osteogenesis Imperfecta | Mucolipidosis Type IV | Pneumonia, Mycoplasma | Supravalvular Aortic Stenosis | Communication Disorders | Spinocerebellar Ataxia Type 1 | Sclerosteosis | Anemia | Schamberg Disease | Mucolipidosis | Traboulsi Syndrome | Bipolar Disorder | Pathological Gambling | Eosinophilic Asthma | Leigh Syndrome | Mosaic Variegated Aneuploidy Syndrome 2 | Diabetes Type 1 | Glutaric Aciduria Type 2 | Waardenburg Syndrome Type 2E | Bronchitis, Chronic | Spinocerebellar Ataxia Type 6 | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Megaloblastic Anemia | Kaposi Sarcoma | Shwachman-Bodian-Diamond Syndrome | Alkaptonuria | Obesity | Polycythemia Vera | Williams Syndrome | LEOPARD Syndrome | Autism | FG Syndrome | Spinocerebellar Ataxia Type 16 | Kohlschutter-Tonz Syndrome | Polycystic Kidney, Autosomal Recessive | Nephrocalcinosis | Myopia | Myelodysplasia | Carbohydrate Metabolism Disorders | Motor Neuron Diseases | Achromatopsia | Strabismus | Tatton-Brown-Rahman Syndrome | Muckle-Wells Syndrome | Splenomegaly | Familial Thoracic Aortic Aneurysm | Paronychia | Marfan Syndrome | Gastrointestinal Disorders | Multiple Sclerosis | Hypertension, Essential | Metachondromatosis | Cohen Syndrome | Adenoid Cystic Carcinoma | Acrodysostosis | Neurocutaneous Melanocytosis | Bacterial Meningitis | Exotropia | Schuurs-Hoeijmakers Syndrome | Pulmonary Sclerosing Hemangioma | Hereditary Coproporphyria | Hepatitis, Chronic | Adrenal Insufficiency | Gerstmann-Straussler-Scheinker Syndrome | Cataract | Erythematotelangiectatic Rosacea | Lymphoproliferative Disorders | Hypertensive Retinopathy | Papillon-Lefevre Syndrome | Pregnancy, Ectopic | ACTH-independent Macronodular Adrenal Hyperplasia | Chanarin-Dorfman Syndrome | Kashin-Beck Disease | Hydronephrosis | Heart Block | Erythropoietic Protoporphyria | Chylomicron Retention Disease | Guttate Psoriasis | Alopecia | Cole-Carpenter Syndrome | Autoimmune Hemolytic Anemia | Fibrosarcoma | Spinal Cord Diseases | Leri Pleonosteosis | Paraganglioma, Carotid Body | Craniofrontonasal Syndrome | Giant Cell Arteritis | Borderline Personality Disorder | Macular Degeneration | Choroideremia | Kabuki Syndrome 2 | Hyperuricemia | Schizophrenia, Paranoid | Neovascular Glaucoma | Hereditary Hemorrhagic Telangiectasia | Sarcoma, Alveolar Soft Part | Sarcoidosis | Conn Syndrome | Pituitary Stalk Interruption Syndrome | Dyskeratosis Congenita | Johanson-Blizzard Syndrome | Onchocerciasis | Melanoma, Malignant | Achondrogenesis | Giant Cell Glioblastoma | Sialidosis | Familial Partial Lipodystrophy | Poretti-Boltshauser Syndrome | Retinal Telangiectasia | Glioblastoma | Corneal Dystrophy And Perceptive Deafness | Brenner Tumor | Peroxisomal Disorder | Chitayat Syndrome | Congenital Hypofibrinogenemia | CHOPS Syndrome | Dysmorphophobia | Cannabis Abuse | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Endometritis | Diarrhea | Pyruvate Kinase Deficiency | Lichen Sclerosus | Pearson Syndrome | Fibrodysplasia Ossificans Progressiva | Pituitary Dwarfism | Familial Glucocorticoid Deficiency | Polymyositis | Spinocerebellar Ataxia Type 31 | Bone Marrow Necrosis | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Prune Belly Syndrome | Anencephaly | Sjogren Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Schistosomiasis Mansoni | Crigler-Najjar Syndrome | Bare Lymphocyte Syndrome | Necrotizing Autoimmune Myopathy | Asthma, Exercise-induced | Scapuloperoneal Myopathy, X-linked Dominant | Epidermolysis Bullosa Simplex, Generalized | Multicystic Renal Dysplasia | Auriculocondylar Syndrome | Azoospermia | Diffuse Intrinsic Pontine Glioma | Glycogen Storage Disease Type 4 | Choroiditis | Dyslexia | Botulism | Fibrillation, Atrial | Atrioventricular Septal Defect | Measles | Spinocerebellar Ataxia Type 17 | Scapuloperoneal Spinal Muscular Atrophy | Bulimia Nervosa | Sarcoma, Ewing | Spinocerebellar Ataxia Type 42 | Mitochondrial Myopathy | Acute Myeloid Leukemia | Progressive Osseous Heteroplasia | Encephalocele | Hypothalamic Obesity | Corneal Dystrophy | Frank-ter Haar Syndrome | Endophthalmitis | Silver-Russell Syndrome | Hemolytic Anemia | Alzheimer Disease, Late Onset | Renal-hepatic-pancreatic Dysplasia | Still Disease | Geleophysic Dysplasia | Chronic Enteropathy Associated With SLCO2A1 Gene | Hypoplastic Left Heart Syndrome | Vitamin D Deficiency | Proopiomelanocortin Deficiency | Cardiomyopathy, Peripartum | Parkinsonism | Oculocutaneous Albinism Type 1 | Myositis | Chronic Granulomatous Disease | Congenital Adrenal Hyperplasia | Colitis | Episodic Ataxia Type 2 | Premenstrual Syndrome | Osteosclerosis | Twin-to-twin Transfusion Syndrome | Niemann-Pick Disease, Type B | 3-methylcrotonyl-CoA Carboxylase Deficiency | Graft-versus-host Disease | Neonatal Progeroid Syndrome | Retinal Degeneration | Diabetic Encephalopathy | Juvenile Hyaline Fibromatosis | Hereditary Mixed Polyposis Syndrome | Retinal Dystrophy, Early-onset Severe | Salla Disease | Non-bullous Congenital Ichthyosiform Erythroderma | Arthropathy | Leukoplakia | Microtia | Primary Lateral Sclerosis | Postpartum Depression | Pulmonary Capillary Hemangiomatosis | Charcot-Marie-Tooth Disease Type 4 | Corneal Dystrophies, Hereditary | Presbyopia | Hyperlipidemia Type V | Leber Congenital Amaurosis | Gangliosidosis, GM1 | Castleman Disease | Dysfibrinogenemia | Familial Hemiplegic Migraine | Angelman Syndrome | Systemic Lupus Erythematosus | Spondyloperipheral Dysplasia | Focal Cortical Dysplasia Type 2 | Corticobasal Syndrome | Amenorrhea | Chudley-McCullough Syndrome | Centronuclear Myopathy | Lymphoma | Delirium | Preaxial Polydactyly | Infectious Diarrhea | Asplenia | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Agammaglobulinemia | Papilledema | Leprosy | Isovaleric Acidemia | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Hennekam Lymphangiectasia-lymphedema Syndrome | WAGR Syndrome | Thyroiditis | Hepatitis | Schwannoma | Nail-Patella Syndrome | Acrocallosal Syndrome | Neural Tube Defect | Autoimmune Polyendocrinopathy Syndrome Type I | Schizotypal Personality Disorder | Carcinoma, Merkel Cell | Apparent Mineralocorticoid Excess Syndrome | Methemoglobinemia Type IV | Erythema Nodosum | Retinitis Pigmentosa | Pancytopenia | Cancer, Skin | Paternal Uniparental Disomy Of Chromosome 14 | Meniere's Disease | Spinocerebellar Ataxia Type 38 | Muir-Torre Syndrome | Hypertension, Renovascular | Osteopetrosis | Myotonia | Fibronectin Glomerulopathy | Subacute Sclerosing Panencephalitis | Tremor | Acromegaly | Distal Myopathy 2 | Aneurysm, Abdominal Aortic | Pneumonia, Bacterial | Intracerebral Hemorrhage | Isobutyryl-CoA Dehydrogenase Deficiency | Angioedema, Acquired | Myocardial Infarction | Hypersomnia | Chronic Periodontitis | Hypertrophy | Transcobalamin Deficiency | Meningococcal Infections | Keratopathy | Congenital Ichthyosiform Erythroderma | Glycogen Storage Disease Type 5 | Renal Oncocytoma | Protein C Deficiency | Cramp Fasciculation Syndrome | Pain | Gout | Colitis, Collagenous | Renal Failure | Costello Syndrome | Wieacker-Wolff Syndrome | Jaundice, Obstructive | Trimethylaminuria | Multisystemic Smooth Muscle Dysfunction Syndrome | Immunoproliferative Disorders | Bursitis | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Bethlem Myopathy | Cystinosis | Zimmermann-Laband Syndrome | Beckwith-Wiedemann Syndrome | Cushing Syndrome