Genee-Wiedemann Syndrome

About the Disease
Postaxial Acrofacial Dysostosis, also known as miller syndrome, is related to dysostosis and acrofacial dysostosis. An important gene associated with Postaxial Acrofacial Dysostosis is DHODH (Dihydroorotate Dehydrogenase (Quinone)), and among its related pathways/superpathways are Pyrimidine metabolism and PKMTs methylate histone lysines. The drugs Cimetidine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and heart, and related phenotypes are microtia and micrognathia

Common Targets
DHODH

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