Pulmonary Hypertension

About the Disease
Pulmonary Hypertension, also known as primary pulmonary hypertension, is related to pulmonary hypertension, primary, 1 and persistent fetal circulation syndrome, and has symptoms including angina pectoris, chest pain and coughing. An important gene associated with Pulmonary Hypertension is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and miRNAs involved in DNA damage response. The drugs Morphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include Lung, heart and endothelial, and related phenotypes are muscle and cardiovascular system

Common Targets
Calcium channel (nonspecified subtype) | L-type voltage-dependent calcium channel complex | CYSLTR1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | gamma-Secretase | CARM1 | PRMT6 | G59272 | EPHX2 | ESR2 | FKBP1A | HTR1A | m-Calpain | SLC6A2 | ZFC3H1 | PDK1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | MIR224 | ALOX5AP | MIR942 | TYR | G1432 | ROCK1 | ALDH2 | GNB3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | PTGER3 | AIMP1 | PRMT8 | DUSP4 | MAP3K5 | PTGIR | CPS1 | KEAP1 | CASR | MTHFR | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | HMGCR | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | DUSP5 | ADORA1 | DNA Topoisomerase II (nonspecified subtype) | PPP3R2 | HTR2B | APLNR | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | Thyroid hormone receptor (nonspecified subtype) | NFU1 | Chymotrypsin (nonspecified subtype) | ADORA2B | Voltage-Gated Sodium Channel Complex | DUSP6 | MMP12 | IL-1 Receptor (nonspecified subtype) | PDE10A | SSH2 | ANO1 | PPP3CC | SGK1 | LOX | PDE1C | G3630 | DUSP7 | PDK2 | F2 | TGFBR1 | CCR2 | PDE9A | ADORA2A | CCN2 | ARG1 | Sodium channel (nonspecified subtype) | KCNJ1 | TIRAP | PGAM5-KEAP1-NRF2 Complex | NOS3 | DNM1L | Guanylate cyclase (nonspecified subtype) | Raf kinase (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | TGM2 | DUSP16 | ADRB3 | EDNRB | CES1 | CRHBP | VIPR1 | UTS2R | MMP2 | RXFP1 | ADORA3 | MIR145 | PRMT1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | SLC6A4 | TBX4 | HTR2A | DDAH1 | PDE5A | TRPC6 | K(ATP) Channel (nonspecified subtype) | RAF1 | ADRB1 | SMURF1 | PTGDR | MME | CAV1 | CTSA | INHBA | ABCC8 | TLR9 | ABCC9 | Elastase (nonspecified subtype) | NOS2 | ACVRL1 | IFNG | Prostanoid TP receptor (nonspecified subtype) | DHCR24 | DUSP10 | PDGFRA | AGTR1 | VIPR2 | GSTP1 | Pyruvate dehydrogenase kinase (nonspecified subtype) | PNP | FASLG | JAK2 | ACKR3 | CRHR1 | PDE2A | ROCK2 | L-Type calcium channel (nonspecified subtype) | NOX3 | PDE1B | Integrin alphaLbeta2 (LFA-1) receptor | HTR6 | SCN1A | INHBB | VHL | TPH1 | ACVR1B | TXNRD1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | LOXL2 | MYLK | KARS1 | Histone deacetylase (nonspecified subtype) | MIF | PPP3CB | NAMPT | SPHK1 | MEP1A | PPP3R1 | NADPH Oxidase Complex | AGTR2 | ALOX5 | CYSLTR2 | MEP1B | P2RX7 | ECE1 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | Potassium Channels (nonspecified subtype) | NPR1 | G6PD | Arginase (nonspecified subtype) | KCNJ8 | Angiotensin receptor (AT) (nonspecified subtype) | G7099 | Mitochondrial pyruvate carrier complex (MPC) | G673 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | Soluble guanylyl cyclase | OTC | G6774 | ABCA3 | RAPGEF3 | RHOC | DDAH2 | QRFPR | EPAS1 | PI3 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | PDE4D | CTBP1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PTGFR | Collagen (nonspecified subtype) | MPO | AMP-activated protein kinase (AMPK) | CMA1 | HIF1A | ARG2 | Phosphodiesterase (nonspecified subtype) | EDNRA | ACE | PDE3A | Inward Rectifier Potassium Channel (nonspecified subtype) | OPRK1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TBXAS1 | DUSP9 | Protein Phosphatase 2B | IL1RN | ECE2 | DUSP1 | ELANE | SCN2A | G4780 | CAPN2 | KCNJ11 | LRRK2 | MIR130A | BDKRB2 | CACNA1H | BMPR2 | PDE4B | GPR35 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | DUSP2 | KDM5B | G2475 | PDGFRB | PREP | MIR130B | F2RL1 | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | TRPM8

Note: If you'd like to get a target analysis report for Pulmonary Hypertension, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Pulmonary Hypertension at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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