Precocious Puberty

About the Disease
Precocious Puberty, also known as cryptogenic sexual precocity, is related to central precocious puberty and idiopathic central precocious puberty. An important gene associated with Precocious Puberty is LOC100507346 (Uncharacterized LOC100507346), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Megestrol acetate and Leuprolide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testis, and related phenotypes are growth/size/body region and renal/urinary system

Common Targets
TACR3 | KISS1 | AKR1C2 | PRKCA | CYP17A1 | PAPSS2 | LIN28B | MECP2 | SHBG | DLK1 | G2099 | POU1F1 | LHCGR | NR0B1 | GNRHR | AKR1C3 | G367 | VDR | NPFFR1 | VHL | CYP19A1 | MKRN3 | PLCB1 | CRBN | HSD17B3 | ITPR1 | KISS1R

Note: If you'd like to get a target analysis report for Precocious Puberty, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Precocious Puberty at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Epidermolysis Bullosa Acquisita | Multisystemic Smooth Muscle Dysfunction Syndrome | Charcot-Marie-Tooth Disease, Type 2A | Hemophilia | Hypoproteinemia, Hypercatabolic | Sensorineural Hearing Loss | Calcium Pyrophosphate Deposition Disease | Genee-Wiedemann Syndrome | Relapsing Polychondritis | Chediak-Higashi Syndrome | Prolactinoma | Colitis | Hereditary Inclusion Body Myopathy | Monilethrix | Congenital Bilateral Absence Of Vas Deferens | Fibrodysplasia Ossificans Progressiva | Porphyria | Asthma, Nocturnal | Atrioventricular Septal Defect | Actinomycetoma | Perivascular Epithelioid Cell Tumor | Goiter | Spinocerebellar Ataxia Type 23 | Chanarin-Dorfman Syndrome | Osteoporosis-pseudoglioma Syndrome | Osteoporosis | Arteriovenous Malformations | Lamellar Ichthyosis | Diabetes Insipidus, Nephrogenic | Hypervalinemia | Waardenburg Syndrome Type 2 | IgA Nephropathy | Osteogenesis Imperfecta Type IV | Methylmalonic Aciduria And Homocystinuria, CblC Type | Paraplegia | Hemimegalencephaly | Hoyeraal-Hreidarsson Syndrome | Echinococcosis | Hypertension, Essential | DNA Ligase IV Deficiency | Gitelman Syndrome | Ichthyosis | Diarrhea | Specific Granule Deficiency | Skin Carcinoma | Carbonic Anhydrase VA Deficiency | HANAC Syndrome | Niemann-Pick Disease, Type A | Autonomic Nervous System Disorders | Lewy Body Dementia | Carcinoma, Small Cell | Pain | Diabetes | Osteoporosis, Postmenopausal | VACTERL Association | Skin Fragility-woolly Hair Syndrome | Saethre-Chotzen Syndrome | Neuroectodermal Tumors, Primitive | Neurocysticercosis | Benign Familial Neonatal Convulsions | Congenital Dysfibrinogenemia | Fundus Albipunctatus | Sensory Neuropathy | Polyneuropathy | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Pleurisy | Neonatal Progeroid Syndrome | Bare Lymphocyte Syndrome | Peripheral Neuropathy | Colitis, Lymphocytic | Congenital Hypofibrinogenemia | Nephrosclerosis | Meningitis | FG Syndrome | Congenital Bile Acid Synthesis Defect | Ependymoma | Pontocerebellar Hypoplasia | Short-chain Acyl-CoA Dehydrogenase Deficiency | Retinal Degeneration | Bethlem Myopathy | Situs Inversus | Kernicterus | Uremia | Malaria, Cerebral | Myositis | Spondylocostal Dysostosis | Cantu Syndrome | Atelosteogenesis Type 2 | Hypobetalipoproteinemias | Vitamin D Deficiency | Ameloblastoma | Hyperglycemia | Crimean-Congo Hemorrhagic Fever | Astrocytoma, Anaplastic | Torticollis | Cholesteryl Ester Storage Disease | Vertebrobasilar Insufficiency | Early Infantile Epileptic Encephalopathy 13 | Pitt-Hopkins Syndrome | Pneumoconiosis | Dysplastic Nevus | McCune-Albright Syndrome | Metachromatic Leukodystrophy | Scabies | Viral Meningitis | Lassa Fever | Epidermal Nevus Syndrome | Lichen Planus | Sarcosinemia | Familial Exudative Vitreoretinopathy | Mastitis | Nemaline Myopathy 10 | Tetanus | Bronchitis | Spondyloepiphyseal Dysplasia Tarda, X-linked | Hyperlipidemia | Pfeiffer Syndrome | Varices | Lymphangioma | Smith-Kingsmore Syndrome | Cholecystitis | Tangier Disease | Hyperhomocysteinemia | Cat Eye Syndrome | Myosin Storage Myopathy | Neuromyotonia | Progressive Familial Intrahepatic Cholestasis Type 1 | Sleep Apnea, Central | Retinal Telangiectasia | Cone Dystrophy | Dubin-Johnson Syndrome | Pearson Syndrome | Juvenile Myelomonocytic Leukemia | Lafora Disease | Cholestasis | Congenital Torticollis | Vitiligo | Epithelioid Hemangioma | Meningococcal Meningitis | Cannabis Abuse | Mucormycosis | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Renal Tubular Dysgenesis | Niemann-Pick Disease, Type C | Cartilage Disorders | Cardiospondylocarpofacial Syndrome | Ovarian Sex Cord-stromal Tumor | Schnitzler Syndrome | Kaposiform Hemangioendothelioma | Asthma, Exercise-induced | Subacute Sclerosing Panencephalitis | Olmsted Syndrome | Coffin-Lowry Syndrome | Heavy Chain Disease | Chronic Mucocutaneous Candidiasis | Cancer, Lung | Galactosialidosis | Postaxial Polydactyly | Kaposi Sarcoma | Heterotopic Ossification | Pheochromocytoma | Amelogenesis Imperfecta | Fragile X Syndrome | Nemaline Myopathy 8 | Onchocerciasis | Microphthalmia, Syndromic 7 | Ectopia Lentis, Isolated, Autosomal Recessive | Arthritis, Psoriatic | Progressive Osseous Heteroplasia | Waardenburg Syndrome Type 1 | Hennekam Lymphangiectasia-lymphedema Syndrome | Medulloblastoma | Empyema | Corneal Neovascularization | Prader-Willi Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Hyperlipidemia, Familial Combined | Nephrocalcinosis | Schizencephaly | Abetalipoproteinemia | Acute Kidney Injury | Pneumothorax | Nephrotic Syndrome | Homocystinuria | Synovitis | Charcot-Marie-Tooth Disease | Turner's Syndrome | Salla Disease | Cirrhosis | Hypophosphatasia | Frank-ter Haar Syndrome | Polycythemia Vera | Colitis, Collagenous | Johanson-Blizzard Syndrome | Eosinophilic Asthma | Thanatophoric Dysplasia Type 1 | Pseudohypoparathyroidism Type 1C | Alopecia Totalis | Neutropenia | Acrodysostosis | Pneumonia, Mycoplasma | Primary Hyperoxaluria | Wolff-Parkinson-White Syndrome | Macular Corneal Dystrophy | Thrombotic Microangiopathy | Congenital Lipoid Adrenal Hyperplasia | Pyelonephritis | Recurrent Respiratory Papillomatosis | Protein C Deficiency | Tendinopathy | Hypokalemic Periodic Paralysis | Brenner Tumor | Malignant Peripheral Nerve Sheath Tumor | Keratosis, Actinic | Hemophagocytic Lymphohistiocytosis | Benign Familial Pemphigus | Usher Syndrome Type I | Schizophrenia | Osteosclerosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Small Lymphocytic Lymphoma | Hepatoblastoma | Thanatophoric Dysplasia | Charcot-Marie-Tooth Disease, Type 1A | Large Granular Lymphocytic Leukemia | Papillon-Lefevre Syndrome | Methemoglobinemia | Granular Corneal Dystrophy Type 1 | Congenital Hereditary Endothelial Dystrophy Type I | Diabetes Type 1 | Congenital Hemolytic Anemia | Myopia | Ehlers-Danlos Syndrome | Rothmund-Thomson Syndrome | Keratosis | Brugada Syndrome 1 | Anovulation | Ventricular Septal Defect | Pituitary Disorders | Spinal And Bulbar Muscular Atrophy | Apparent Mineralocorticoid Excess Syndrome | Systemic Lupus Erythematosus | Cystitis, Interstitial | Hypertension | Kindler Syndrome | Limb Girdle Muscular Dystrophy | Basan Syndrome | Cavitary Optic Disc Anomalies | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Enterocolitis, Necrotizing | Pompe Disease | Gliosarcoma | Optic Neuropathy | Chronic Myeloid Leukemia | Hypohidrotic Ectodermal Dysplasia, X-linked | Epilepsy, Generalized | Prostatitis | Wiedemann-Steiner Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Insulinoma | Autosomal Recessive Spastic Paraplegia Type 75 | Multicentric Carpotarsal Osteolysis Syndrome | Adenosine Deaminase Deficiency | Eczema | Dermatofibrosarcoma | Achondrogenesis | Impetigo | Polycystic Kidney, Autosomal Dominant | Vaginitis | Syndactyly | Hypertension, Renal | Oligospermia | Lymphomatoid Granulomatosis | Retinal Coloboma | Neuronal Ceroid Lipofuscinosis | Pantothenate Kinase-associated Neurodegeneration | Chromosome 5q Deletion Syndrome | Charcot-Marie-Tooth Disease Type 4B1 | Osteoglophonic Dysplasia | Cryptococcal Meningitis | Sleep Apnea | Cousin Syndrome | Autoimmune Autonomic Ganglionopathy | Kallmann Syndrome | Schuurs-Hoeijmakers Syndrome | Paternal Uniparental Disomy Of Chromosome 14 | Hepatitis E | Histiocytosis | Fraser Syndrome | Leukoplakia | Heimler Syndrome | Arrhythmogenic Right Ventricular Cardiomyopathy | Metabolic Diseases | Hemorrhoids | Leri Pleonosteosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Anti-glomerular Basement Membrane Disease | Extramammary Paget's Disease | Preaxial Polydactyly | Mumps | Neurofibroma | X-linked Creatine Transporter Deficiency | Heterotaxy | Placenta Previa | Macrophage Activation Syndrome | Inflammatory Myofibroblastic Tumor | Antithrombin III Deficiency | Polyarteritis Nodosa | Borjeson-Forssman-Lehmann Syndrome | Birk-Barel Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Anorchia | Spinocerebellar Ataxia Type 15 | Urofacial Syndrome | Adenomyosis | Exfoliative Dermatitis | NGLY1 Deficiency | Intracranial Hypertension | Dementia, Vascular | Retinal Detachment | Leishmaniasis, Cutaneous | Speech Disorders | Encephalitis | Waldenstrom Macroglobulinemia | Plasmacytoma | Pseudo-pseudohypoparathyroidism | Dystonia | Down Syndrome | Reticular Dysgenesis | Williams Syndrome | Joubert Syndrome 2 | Adrenomyeloneuropathy | Cerebral Amyloid Angiopathy | Encephalocele | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Sepiapterin Reductase Deficiency | Trimethylaminuria | Axenfeld-Rieger Syndrome | Autoimmune Disease | Oculocutaneous Albinism Type 1 | Primary Erythromelalgia | Riboflavin Transporter Deficiency Neuronopathy | Spinocerebellar Ataxia Type 2 | Trichotillomania | Primary Familial Brain Calcification | Spinocerebellar Ataxia Type 12 | Glycogen Storage Disease | Bartter Syndrome | Agnathia-Otocephaly Complex | Pierre Robin Syndrome | Sporadic Inclusion Body Myositis | Adenocarcinoma | X-linked Charcot-Marie-Tooth Disease | Takayasu's Arteritis | Agoraphobia | MIRAGE Syndrome | Paracoccidioidomycosis | Camurati-Engelmann Disease | Myopathy | Hypercalciuria | Postpartum Depression | Rhabdomyosarcoma, Alveolar | Keratocystic Odontogenic Tumor | Primary Biliary Cholangitis | Congenital Heart Defects | Hydrocephalus, Normal Pressure | Osteopathia Striata With Cranial Sclerosis | Walker-Warburg Syndrome | Sclerosteosis 2 | Focal Dermal Hypoplasia | Keratitis-ichthyosis-deafness Syndrome | Hemochromatosis Type 1 | Migraine | Spinal Muscular Atrophy Type 3 | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Thrombasthenia | Charcot-Marie-Tooth Disease, Type 6 | Cholelithiasis | Hereditary Hemorrhagic Telangiectasia | Ichthyosis Bullosa Of Siemens | Hypospadias | Ileitis | Carbohydrate Metabolism Disorders | Spinocerebellar Ataxia Type 20 | Polymyalgia Rheumatica | Acne | Blau Syndrome | Peroxisomal Disorder | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Pyruvate Decarboxylase Deficiency | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Dental Caries | Common Variable Immunodeficiency | Campomelic Dysplasia | Anxiety Disorders | Glomerulonephritis, Membranoproliferative | Bipolar Disorder | Intestinal Obstruction | Leukemia | Zimmermann-Laband Syndrome