Coffin-Lowry Syndrome

About the Disease
Coffin-Lowry Syndrome, also known as cls, is related to intellectual developmental disorder, x-linked 19 and coffin syndrome 1, and has symptoms including seizures An important gene associated with Coffin-Lowry Syndrome is RPS6KA3 (Ribosomal Protein S6 Kinase A3), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include bone, kidney and heart, and related phenotypes are intellectual disability and frontal bossing

Common Targets
ARID1B | ATRX | RPS6KA3 | SMC1A | RNU4ATAC | SMARCA4 | SMARCB1

Note: If you'd like to get a target analysis report for Coffin-Lowry Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Coffin-Lowry Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hyperbilirubinemia | Cirrhosis | Woodhouse-Sakati Syndrome | Vulvovaginitis | Acne Vulgaris | Episodic Ataxia | Adult Polyglucosan Body Disease | 3-methylcrotonyl-CoA Carboxylase Deficiency | Pulmonary Stenosis | Spasticity | Leukemia-lymphoma, Adult T-cell | Exostoses | Carbamoyl Phosphate Synthetase I Deficiency | Renal-hepatic-pancreatic Dysplasia | Hepatitis, Alcoholic | Partington Syndrome | Peutz-Jeghers Syndrome | Keratopathy | Sweet Syndrome | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Schizophrenia, Paranoid | Spondylometaphyseal Dysplasia | REM Sleep Behavior Disorder | Myelomeningocele | 3-methylglutaconic Aciduria Type I | Osteogenesis Imperfecta Type V | Proteus Syndrome | Hereditary Multiple Exostoses | Corneal Neovascularization | Vascular Calcification | Batten Disease | Waardenburg Syndrome Type 1 | Congenital Hemolytic Anemia | Insulin Resistance | Galactosialidosis | Nijmegen Breakage Syndrome | Achromatopsia | Scleroderma, Diffuse | Trichothiodystrophy | Dermatitis Herpetiformis | Bardet-Biedl Syndrome | Celiac Disease | Adenocarcinoma | Menkes Disease | Pathological Gambling | Knobloch Syndrome | Pneumonia, Viral | Hypermetropia | Hyperacusis | Malignant Peripheral Nerve Sheath Tumor | Rothmund-Thomson Syndrome | Priapism | Macrophagic Myofasciitis | Sulfite Oxidase Deficiency | Genee-Wiedemann Syndrome | Waardenburg Syndrome Type 2A | Peripheral Neuropathy | Congenital Sodium Diarrhea | Optic Neuropathy | Acquired Partial Lipodystrophy | Benign Familial Infantile Seizures | Diabetes Mellitus, Transient Neonatal | Stuve-Wiedemann Syndrome | Leukocyte Adhesion Deficiency | Keratitis | Spondylosis | Facioscapulohumeral Muscular Dystrophy Type 1 | Hemorrhoids | Hypospadias | Pyruvate Decarboxylase Deficiency | Myeloid Leukemia | Autoimmune Polyendocrinopathy Syndrome Type I | Hyperthyroidism | Proteasome-associated Autoinflammatory Syndrome 2 | Hepatitis E | Blepharitis | Thrombasthenia | Congenital Heart Defects | Triple A Syndrome | Rickets | Shprintzen-Goldberg Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Best Macular Dystrophy | Hereditary Mixed Polyposis Syndrome | Rubeosis Iridis | Superficial Spreading Melanoma | Osteitis | Presbyopia | Long QT Syndrome Type 1 | Cousin Syndrome | Congenital Tufting Enteropathy | Spinocerebellar Ataxia Type 16 | Klippel-Feil Syndrome | Lattice Corneal Dystrophy Type 1 | Coronary Heart Disease | Persistent Truncus Arteriosus | Kabuki Syndrome 2 | Congenital Absence Of Vas Deferens | Gyrate Atrophy Of The Choroid And Retina | Thanatophoric Dysplasia | Kidney Stones | Congenital Mirror Movements | Autoimmune Polyendocrine Syndrome | LEOPARD Syndrome | Schnyder Crystalline Corneal Dystrophy | Non-proliferative Diabetic Retinopathy | Hypotrichosis | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Spinocerebellar Ataxia Type 12 | Myotonic Disorders | Lung Diseases | Bethlem Myopathy | CHOPS Syndrome | Mucormycosis | Primrose Syndrome | Early Infantile Epileptic Encephalopathy 1 | Opisthorchiasis | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Pelizaeus-Merzbacher Disease | Guttate Psoriasis | Hyperparathyroidism, Secondary | Astrocytoma | Acrodysostosis | VEXAS Syndrome | Venous Insufficiency | Glutaric Aciduria Type 3 | Chronic Enteropathy Associated With SLCO2A1 Gene | Lipoma | Pontocerebellar Hypoplasia Type 7 | Pityriasis Rubra Pilaris | Neurofibroma | Congenital Adrenal Hyperplasia 1 | Neurogenic Bladder | Isobutyryl-CoA Dehydrogenase Deficiency | Silicosis | ICF Syndrome | Hypokalemia | Fabry's Disease | Iron Deficiency Anemia | Myelofibrosis | Cyclic Vomiting Syndrome | Hodgkin Lymphoma | Senior-Loken Syndrome | Pyruvate Dehydrogenase Deficiency | Erectile Dysfunction | Cockayne Syndrome | Addison Disease | Blastomycosis | Influenza | Carbonic Anhydrase VA Deficiency | Pyoderma Gangrenosum | Chiari Malformation Type I | Mabry Syndrome | Hypertelorism | Rhabdoid Tumor | Porencephaly | Blepharoconjunctivitis | Atelosteogenesis Type 1 | Hypersomnia | Congenital Aniridia | Wolfram Syndrome 2 | Chylomicron Retention Disease | Combined Pituitary Hormone Deficiency | Endometrial Hyperplasia | Holt-Oram Syndrome | Neuromyelitis Optica | Lipid Storage Diseases | Schuurs-Hoeijmakers Syndrome | Thrombophilia | Cantu Syndrome | Erythropoietic Protoporphyria | Galactosemia | Amebiasis | Ocular Surface Squamous Neoplasia | Hyperkeratosis | Schizencephaly | Prolymphocytic Leukemia | Cervical Dystonia | Epidermolysis Bullosa Simplex, Generalized | Apparent Mineralocorticoid Excess Syndrome | Meningioma, Benign | Hypolipoproteinemia | Spitz Nevus | Cutis Laxa | Vaginitis | Agnathia-Otocephaly Complex | Hemophilia | Schamberg Disease | Glycogen Storage Disease | Wiedemann-Steiner Syndrome | Varicocele | Scleroderma | GLUT1 Deficiency Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Pheochromocytoma | Cardiac Sarcoidosis | Apraxia | Contact Dermatitis | Familial Retinal Arterial Macroaneurysm | Spinocerebellar Ataxia Type 23 | Glutaric Aciduria Type 1 | Barrett Esophagus | Trichorhinophalangeal Syndrome | Multiple Myeloma | Adenomyosis | Conduct Disorder | Meesmann Corneal Dystrophy | Polyneuropathy | Cartilage Disorders | Hyperthermia, Malignant | Danon Disease | Malaria | Kallmann Syndrome | Pulmonary Sclerosing Hemangioma | Ovarian Sex Cord-stromal Tumor | Agoraphobia | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Polymyositis | Neurofibromatosis-Noonan Syndrome | Choriocarcinoma | Retinal Detachment | Charcot-Marie-Tooth Disease Type 4 | Hyperglycemia | Periventricular Nodular Heterotopia | Cutaneous Angiosarcoma | Aldosteronism | Familial Hypertrophic Cardiomyopathy | Sporadic Hemiplegic Migraine | Vitamin B12 Deficiency | Inflammatory Linear Verrucous Epidermal Nevus | Renal Medullary Carcinoma | Primary Progressive Aphasia | Mandibuloacral Dysplasia With Type A Lipodystrophy | Bartsocas-Papas Syndrome | Trichuriasis | Dementia | Meniere's Disease | Eosinophilic Asthma | Chordoid Glioma | Reticular Dysgenesis | Scapuloperoneal Spinal Muscular Atrophy | Lichen Sclerosus | Familial Hemiplegic Migraine | Gerstmann-Straussler-Scheinker Syndrome | SAPHO Syndrome | Hashimoto Thyroiditis | Neonatal Progeroid Syndrome | Hypercholesterolemia, Familial | Muir-Torre Syndrome | Anorectal Malformations | Cystinosis | Neurofibromatosis Type 1 | McKusick Type Metaphyseal Chondrodysplasia | Okihiro Syndrome | Cutaneous T-cell Lymphoma | Pontocerebellar Hypoplasia | Herpes Simplex Dermatitis | Carcinoma, Signet Ring Cell | Charcot-Marie-Tooth Disease Type 2D | Platelet Disorders | Glioblastoma | Oral Lichen Planus | Vici Syndrome | Li-Fraumeni Syndrome | Lactose Intolerance | Leprosy | Macrodactyly | Dystonia-parkinsonism, X-linked | Takenouchi-Kosaki Syndrome | Glomerulonephritis, Membranous | Ocular Hypertension | Idiopathic Pulmonary Fibrosis | Borjeson-Forssman-Lehmann Syndrome | Polyradiculopathy | Sporadic Inclusion Body Myositis | Adams-Oliver Syndrome | Nephrotic Syndrome | Miyoshi Myopathy | Ectopia Lentis, Isolated, Autosomal Recessive | Hemophagocytic Lymphohistiocytosis | Crouzon Syndrome With Acanthosis Nigricans | Astigmatism | Cushing Syndrome | Wolff-Parkinson-White Syndrome | Craniolenticulosutural Dysplasia | Bone Marrow Necrosis | Glycogen Storage Disease Type 0, Muscle | Spinocerebellar Ataxia Type 13 | D-2-Hydroxyglutaric Aciduria | Congenital Bile Acid Synthesis Defect | Lamellar Ichthyosis | Smith-Lemli-Opitz Syndrome | Down Syndrome | Meckel-Gruber Syndrome | Stiff-man Syndrome | Branchiootorenal Syndrome | Gastric Atrophy | Tylosis With Esophageal Cancer | Absence Epilepsy | Cenani-Lenz Syndactyly Syndrome | Fuchs Heterochromic Iridocyclitis | Tenosynovial Giant Cell Tumor | Porphyria | Sickle Cell Anemia | Dystonia | Lymphoma, B-cell | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Autoimmune Hemolytic Anemia | Torticollis | Extramammary Paget's Disease | VACTERL/VATER Association | Sengers Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Tyrosine Hydroxylase Deficiency | Bernard-Soulier Syndrome | Peyronie's Disease | Sandhoff Disease | Pseudoachondroplasia | Diarrhea | Pain | Pemphigus | Gynecomastia | Hemolytic Uremic Syndrome, Atypical | Riboflavin Transporter Deficiency Neuronopathy | Temtamy Preaxial Brachydactyly Syndrome | Ichthyosis, X-linked | Esthesioneuroblastoma | Tyrosinemia | Sarcoidosis, Pulmonary | Hypereosinophilic Syndrome | Hemolytic Anemia | Androgenic Alopecia | Gastritis | Acute Leukemia | Transient Bullous Dermolysis Of The Newborn | Iron Overload | Cardiomyopathy, Hypertrophic | Microvillus Inclusion Disease | Epithelial-myoepithelial Carcinoma | HANAC Syndrome | Netherton Syndrome | Inborn Errors Of Metabolism | Congenital Heart Block | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | X-linked Acrogigantism | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Retinal Vasculitis | Peritonitis | Cervicitis | Tangier Disease | Sleep Apnea, Obstructive | Shock, Cardiogenic | Multisystemic Smooth Muscle Dysfunction Syndrome | X-linked Myotubular Myopathy | Familial Isolated Hyperparathyroidism | Saethre-Chotzen Syndrome | Blue Nevus | Acute Lymphocytic Leukemia | Pilomatrix Carcinoma | Hypertrophy | Hypertension, Renal | Leukocyte Adhesion Deficiency Type 1 | Familial Cerebral Amyloid Angiopathy | Rett Syndrome | PASLI Disease | Cocaine-Related Disorders | Vitamin K Deficiency | Pulmonary Veno-occlusive Disease | Esophagitis | Rhabdomyosarcoma, Alveolar | Asthma, Exercise-induced | Congenital Nystagmus | Lymphoma Lymphoblastic | Pneumonia, Bacterial | Histoplasmosis | Farber Disease | Glaucoma, Congenital | Mixed Connective Tissue Disease | Goiter | Peeling Skin Syndrome Type B | Arts Syndrome | Fowler's Syndrome | Supravalvular Aortic Stenosis | Hyperuricemic Nephropathy, Familial Juvenile | Granular Corneal Dystrophy | Erythrokeratodermia Variabilis | Hydronephrosis | Osteoglophonic Dysplasia | Hypertension, Renovascular | Skin Carcinoma | Trismus-pseudocamptodactyly Syndrome | Acrocallosal Syndrome | Trigonocephaly | Liddle Syndrome | Kohlschutter-Tonz Syndrome | Smith-Kingsmore Syndrome | Intracranial Hypertension | Pneumothorax | Von Willebrand Disease | Orotic Aciduria