Generalized Epidermolysis Bullosa Simplex

About the Disease
Epidermolysis Bullosa Simplex Generalized Type, also known as epidermolysis bullosa simplex, koebner type, is related to epidermolysis bullosa simplex 1b, generalized intermediate and epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive. An important gene associated with Epidermolysis Bullosa Simplex Generalized Type is KRT14 (Keratin 14), and among its related pathways/superpathways are Collagen chain trimerization and Extracellular matrix organization. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is integument.

Common Targets
KRT5 | LAMB3 | KRT14

Note: If you'd like to get a target analysis report for Generalized Epidermolysis Bullosa Simplex, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Generalized Epidermolysis Bullosa Simplex at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinocerebellar Ataxia Type 2 | Idiopathic Pulmonary Fibrosis | Cockayne Syndrome | Bursitis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Cornelia De Lange Syndrome | Tyrosinemia Type 1 | Renal Tubular Acidosis | Burn-McKeown Syndrome | Scapuloperoneal Myopathy, X-linked Dominant | Diabetes Mellitus, Transient Neonatal | Glycogen Storage Disease Type 0 | Mucolipidosis Type IV | Hashimoto Thyroiditis | Rotor Syndrome | Spinocerebellar Ataxia Type 1 | Angiodysplasia | Lesch-Nyhan Syndrome | Tyrosinemia | Congenital Lipoid Adrenal Hyperplasia | Facioscapulohumeral Muscular Dystrophy Type 2 | Charcot-Marie-Tooth Disease Axonal Type 2N | Cutaneous Angiosarcoma | Congenital Diaphragmatic Hernia | Cole-Carpenter Syndrome | Johanson-Blizzard Syndrome | Retinitis Pigmentosa 3 | Allan-Herndon-Dudley Syndrome | Cerebrovascular Disorders | Hypolipoproteinemia | Echinococcosis | T-cell Chronic Lymphocytic Leukemia | Primary Progressive Aphasia | Vestibular Disease | Encephalopathy, Glycine | Mandibuloacral Dysplasia With Type A Lipodystrophy | Histoplasmosis | Schamberg Disease | Acute Generalized Exanthematous Pustulosis | Bladder Exstrophy | Anorectal Malformations | Lactose Intolerance | Wolman Disease | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Pitt-Hopkins Syndrome | Keratoconus | Craniolenticulosutural Dysplasia | Amish Infantile Epilepsy Syndrome | Porphyria, Variegate | Fibronectin Glomerulopathy | Disseminated Intravascular Coagulation | Familial Episodic Pain Syndrome | GATA2 Deficiency | Hoyeraal-Hreidarsson Syndrome | Diastrophic Dysplasia | Androgen Insensitivity | Keratitis-ichthyosis-deafness Syndrome | Neovascular Glaucoma | Malaria, Cerebral | Adenoid Cystic Carcinoma | Hepatic Veno-occlusive Disease | Antiphospholipid Syndrome | Sertoli Cell-only Syndrome | Hypoparathyroidism | Paraganglioma | Orthostatic Intolerance | Subacute Sclerosing Panencephalitis | Lassa Fever | Restrictive Dermopathy | McCune-Albright Syndrome | Fibromyalgia | Glycogen Storage Disease | Trichorhinophalangeal Syndrome | Meningeal Melanocytoma | Peeling Skin Syndrome Type B | Hemimegalencephaly | Osteonecrosis | Oligodendroglioma | Kohlschutter-Tonz Syndrome | Cardiofaciocutaneous Syndrome | Leber Hereditary Optic Neuropathy | Phosphoglycerate Dehydrogenase Deficiency | Osteoporosis-pseudoglioma Syndrome | Chronic Kidney Disease | Hypertrophy | Familial Glucocorticoid Deficiency | Vasculitis | Facioscapulohumeral Muscular Dystrophy Type 1 | Adenomyosis | Cholangiocarcinoma | Progressive Myoclonic Epilepsy | Inflammatory Joint Disease | Language Disorders | Dementia | Polycythemia | Multiple Sclerosis | Cryopyrin-associated Periodic Syndromes | Primary Erythromelalgia | Chondrodysplasia Punctata 1, X-linked Recessive | Fibromuscular Dysplasia | Early Infantile Epileptic Encephalopathy 4 | Precocious Puberty | Lupus Erythematosus | Nemaline Myopathy | Hepatitis B, Chronic | Glanzmann Thrombasthenia | Chitayat Syndrome | Chronic Beryllium Disease | Megalencephaly | Cousin Syndrome | Esophageal Adenocarcinoma | Glutaric Aciduria Type 2 | Basal Ganglia Disease | C3 Glomerulonephritis | Spondylolisthesis | Muckle-Wells Syndrome | Amyotrophic Lateral Sclerosis | Thrombasthenia | Persistent Truncus Arteriosus | Aromatic L-amino Acid Decarboxylase Deficiency | Auriculocondylar Syndrome | Opisthorchiasis | Synpolydactyly | Placenta Previa | Spinocerebellar Ataxia Type 8 | Wolcott-Rallison Syndrome | Neuropathy | Cervicitis | Larsen Syndrome | Ghosal Syndrome | Myocardial Infarction | Hypercholesterolemia, Familial | Primary Ovarian Insufficiency | Rheumatoid Arthritis | Rolandic Epilepsy | Rickets | Waardenburg Syndrome Type 4 | Spasticity | Walker-Warburg Syndrome | Lymphedema-distichiasis Syndrome | Hereditary Sensory And Autonomic Neuropathy | Infantile Neuroaxonal Dystrophy | Reticular Dysgenesis | Inborn Errors Of Metabolism | Tularemia | Small Lymphocytic Lymphoma | Meckel-Gruber Syndrome | Combined Deficiency Of Factor V And Factor VIII | Congenital Aniridia | Dupuytren Disease | Spinocerebellar Ataxia Type 21 | Pterygium | Retinal Degeneration | Hereditary Spherocytosis | Erdheim-Chester Disease | Coronary Artery Disease | X-linked Creatine Transporter Deficiency | Ocular Hypertension | Mevalonate Kinase Deficiency | Spondylosis | Hairy Cell Leukemia | Gardner Syndrome | Glaucoma | Situs Inversus | Ornithine Transcarbamylase Deficiency | Migraine | Intermittent Explosive Disorder | Fontaine Progeroid Syndrome | Sialidosis | Pyelonephritis | Hemolytic Uremic Syndrome | Meier-Gorlin Syndrome | Sezary Syndrome | Trigonocephaly | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Ganglioneuroma | Oculocutaneous Albinism Type 4 | Enhanced S-cone Syndrome | Osteoglophonic Dysplasia | Gastritis, Atrophic | Cholera | Herpes Genitalis | Congenital Heart Defects | Amenorrhea | Periodic Limb Movement Disorder | Methylmalonic Aciduria And Homocystinuria, CblC Type | Hyper IgE Syndrome | Triphalangeal Thumb-polysyndactyly Syndrome | Dengue Hemorrhagic Fever | Goiter | GNE Myopathy | Vascular Cognitive Impairment | Autonomic Neuropathy | Fatty Aldehyde Dehydrogenase Deficiency | Pheochromocytoma | Hemosiderosis | Myelofibrosis | Cholestasis | Rhabdoid Tumor | Veno-occlusive Disease | Bicuspid Aortic Valve | Malignant Peripheral Nerve Sheath Tumor | Fukuyama Congenital Muscular Dystrophy | Incontinentia Pigmenti | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | T-cell Leukemia | Thrombophlebitis | ADNP Syndrome | Ovarian Sex Cord-stromal Tumor | Distal Myopathy 2 | Hypereosinophilic Syndrome | Congenital Hemolytic Anemia | Cryptorchidism | Polycystic Liver | Juvenile Polyposis | Non-epidermolytic Palmoplantar Keratoderma | Congenital Generalized Lipodystrophy | Extramammary Paget's Disease | Filariasis | Sarcoma | Benign Familial Pemphigus | Chronic Idiopathic Myelofibrosis | Birt-Hogg-Dube Syndrome | Traboulsi Syndrome | Nance-Horan Syndrome | Carcinoma, Squamous Cell | Fuchs Dystrophy | Cardiomyopathy, Restrictive | Non-Langerhans Cell Histiocytosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Viral Meningitis | Biotinidase Deficiency | Galactosialidosis | Prostatitis | Acromegaly | Lymphoma, B-cell | Chondromyxoid Fibroma | Potocki-Shaffer Syndrome | Pulmonary Stenosis | Pseudohypoparathyroidism Type 1A | Corneal Edema | Muscle Wasting | Poikiloderma With Neutropenia | Ganglioglioma | Infantile Spasm | Bare Lymphocyte Syndrome | B-cell Chronic Lymphocytic Leukemia | Leukemia | Pouchitis | Ureteropelvic Junction Obstruction | Uveitis, Anterior | Heterotaxy | Primary Lateral Sclerosis | Richter's Syndrome | Smoldering Myeloma | Hypercalcemia | Conduct Disorder | Crigler-Najjar Syndrome | Personality Disorders | Bronchiectasis | Atrioventricular Septal Defect | Asperger Syndrome | Diabetes Gestational | Vertigo | Neurodermatitis | Intermittent Claudication | Congenital Adrenal Hyperplasia | Primary Aldosteronism | Coronary Restenosis | Cancer, Prostate | Hypobetalipoproteinemias | Okihiro Syndrome | T-cell Prolymphocytic Leukemia | Blepharospasm | Congenital Hereditary Endothelial Dystrophy Type II | Goldenhar Syndrome | Hypopituitarism | Partington Syndrome | Cerebellofaciodental Syndrome | Primary Pigmented Nodular Adrenocortical Disease | Cranioectodermal Dysplasia | Blepharoconjunctivitis | Succinic Semialdehyde Dehydrogenase Deficiency | Hyperkalemic Periodic Paralysis | Tic Disorder | Obsessive-compulsive Disorder | Sleep Apnea, Obstructive | Dengue Shock Syndrome | Kallmann Syndrome | Hidradenitis Suppurativa | Nicotine Dependence | Dysequilibrium Syndrome | Low Phospholipid Associated Cholelithiasis | Lung Diseases | Acute Kidney Injury | Dystonia | Endocarditis | Disseminated Superficial Actinic Porokeratosis | Niemann-Pick Disease | Periodontitis | Leber Congenital Amaurosis | Nephrocalcinosis | Arteriovenous Malformations | Spinocerebellar Ataxia Type 20 | Ischemia | Cryoglobulinemia | Tendinopathy | C3 Glomerulopathy | 3-methylglutaconic Aciduria | Anti-NMDA Receptor Encephalitis | Multisystemic Smooth Muscle Dysfunction Syndrome | Glycogen Storage Disease Type 0, Muscle | Myoclonus | Smith-Lemli-Opitz Syndrome | Epithelioid Hemangioma | Wagner Disease | Schuurs-Hoeijmakers Syndrome | Lymphoma, AIDS-related | Analgesia | Charcot-Marie-Tooth Disease, Type 1A | Donnai-Barrow Syndrome | Schaaf-Yang Syndrome | Kashin-Beck Disease | Meniere's Disease | Stiff-man Syndrome | CHOPS Syndrome | Spinocerebellar Ataxia Type 6 | Onchocerciasis | Chordoid Glioma | Lymphoproliferative Disease, X-linked | Hereditary Folate Malabsorption | Peutz-Jeghers Syndrome | Vici Syndrome | Pendred Syndrome | Porphyria | Thrombotic Microangiopathy | Congenital Nephrotic Syndrome | Adenoma, Pituitary | Celiac Disease | Hyperprolactinemia | Hypokalemic Periodic Paralysis | Turner's Syndrome | Seminoma | Avellino Corneal Dystrophy | Autosomal Recessive Bestrophinopathy | Sclerosing Cholangitis | Sitosterolemia | Juvenile Myelomonocytic Leukemia | Lipid Storage Diseases | Cohen Syndrome | Schizencephaly | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Growth Hormone Excess | Ocular Albinism Type 1 | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Leukoencephalopathy, Progressive Multifocal | Congestive Heart Failure | Major Depression | Nijmegen Breakage Syndrome | Myofibrillar Myopathy | Van Der Knaap Disease | Spinocerebellar Ataxia | Subcortical Band Heterotopia | Sengers Syndrome | Anosmia, Congenital | Hydrops Fetalis | Arts Syndrome | Spinocerebellar Ataxia Type 23 | Encephalitis, Tick-borne | Vitreoretinopathy, Proliferative | Central Retinal Artery Occlusion | Methemoglobinemia | Branchiootorenal Syndrome | Hypophosphatasia | Rhinitis | Glutathione Synthetase Deficiency | Epilepsy Of Infancy With Migrating Focal Seizures | Infertility | Charcot-Marie-Tooth Disease | Hypertension, Renovascular | Cutaneous Lupus Erythematosus | Hemolytic Anemia | Pyruvate Carboxylase Deficiency Disease | Absence Epilepsy | Dental Caries | Progressive Familial Intrahepatic Cholestasis Type 2 | Olmsted Syndrome | Tinea Versicolor | Carcinoma In Situ | Antisocial Personality Disorder | Frontometaphyseal Dysplasia | Pyruvate Dehydrogenase Deficiency | Brenner Tumor | Wiedemann-Steiner Syndrome | Myoclonic Atonic Epilepsy | Urea Cycle Disorder | Lymphangioma | Cannabis Abuse | Intestinal Obstruction | Keratocystic Odontogenic Tumor