Pitt-Hopkins Syndrome

About the Disease
Pitt-Hopkins Syndrome, also known as pths, is related to pitt-hopkins-like syndrome 2 and pitt-hopkins-like syndrome 1, and has symptoms including constipation, seizures and nasal flaring. An important gene associated with Pitt-Hopkins Syndrome is TCF4 (Transcription Factor 4), and among its related pathways/superpathways are Neurogenesis regulation in the olfactory epithelium and MECP2 and associated Rett syndrome. The drugs Sodium citrate and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and skin, and related phenotypes are failure to thrive and constipation

Common Targets
KCND3 | TCF4 | MECP2 | FOXG1 | Calcium channel (nonspecified subtype) | KCND2

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