Hereditary Sensory Neuropathy Type 1

About the Disease
Neuropathy, Hereditary Sensory, Type Ie, also known as hsn ie, is related to neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux and neuropathy, hereditary sensory and autonomic, type ia. An important gene associated with Neuropathy, Hereditary Sensory, Type Ie is DNMT1 (DNA Methyltransferase 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and One-carbon metabolism and related pathways. The drug Serine has been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and brain, and related phenotypes are sensorineural hearing impairment and irritability

Common Targets
RETREG1 | SPTLC2 | NTRK1 | MPZ | LOC100287329 | EGR2 | NDRG1 | WNK1 | SPTLC1 | NFKBIL1 | G1786 | MARS1 | ATL3 | GDAP1 | KIF1A | ATL1 | TFG

Note: If you'd like to get a target analysis report for Hereditary Sensory Neuropathy Type 1, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hereditary Sensory Neuropathy Type 1 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Zollinger-Ellison Syndrome | Scapuloperoneal Myopathy, X-linked Dominant | NDH Syndrome | Hodgkin Lymphoma | Malonyl-CoA Decarboxylase Deficiency | Familial Male-limited Precocious Puberty | Herpes Genitalis | Tic Disorder | Oral Lichen Planus | Hereditary Xerocytosis | Ataxia-ocular Apraxia 2 | Bartter Syndrome | Autoimmune Autonomic Ganglionopathy | Congenital Bile Acid Synthesis Defect | Spinal Muscular Atrophy | Lymphomatoid Granulomatosis | Diabetic Macular Edema | Pseudohypoparathyroidism Type 2 | Craniofacial Dysostosis | Fahr Disease | Oculocutaneous Albinism Type 1 | Kindler Syndrome | Pontocerebellar Hypoplasia Type 7 | Hemochromatosis Type 2 | Multicentric Carpotarsal Osteolysis Syndrome | Pulmonary Vein Stenosis | Pseudohypoparathyroidism Type 1C | Acne | Plasmacytoma | Hemophilia | Thrombophilia | Chronic Inflammatory Demyelinating Polyneuropathy | Prader-Willi Syndrome | Amyloidosis | Malaria, Cerebral | Familial Hyperaldosteronism | Congenital Lipoid Adrenal Hyperplasia | Nemaline Myopathy 10 | Frontotemporal Dementia | POEMS Syndrome | Filariasis | Alpha-thalassemia Myelodysplasia Syndrome | Peripheral Neuropathy | Mumps | Hereditary Hemorrhagic Telangiectasia Type 2 | Primary Hyperoxaluria Type 3 | Hypertension, Essential | Congenital Dyserythropoietic Anemia | Dyslexia | Splenomegaly | Tyrosine Hydroxylase Deficiency | Rheumatic Heart Disease | Ectodermal Dysplasia | Long QT Syndrome Type 2 | Creatine Deficiency Syndrome | Stargardt Disease | Bursitis | Schamberg Disease | Melnick-Needles Syndrome | Cryoglobulinemia | Hyperekplexia | Crisponi Syndrome | Waardenburg Syndrome Type 4A | Peeling Skin Syndrome Type B | Acute Chest Syndrome | Hemangioma | Vogt-Koyanagi-Harada Syndrome | Traboulsi Syndrome | Hereditary Sensory And Autonomic Neuropathy | Mitochondrial Encephalomyopathy | Tetraplegia | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Temporal Lobe Epilepsy | Cerebellar Ataxia, Cayman Type | Placenta Previa | Haim-Munk Syndrome | Adenoid Cystic Carcinoma | Aspergillosis | Asperger Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Kidney Stones | Globozoospermia | Adenoma, Villous | Basal Cell Nevus Syndrome | Adenylosuccinate Lyase Deficiency | Krabbe Disease | Cardiomyopathy, Hypertrophic | Presbyopia | Emery-Dreifuss Muscular Dystrophy | Neutrophilia | Cardiomyopathy, Dilated, 1L | Becker Muscular Dystrophy | Chromosome 5q Deletion Syndrome | Familial Exudative Vitreoretinopathy | Conn Syndrome | Methylmalonic Acidemia | Hypercholesterolemia | Spinocerebellar Ataxia Type 3 | PHARC Syndrome | Periodic Limb Movement Disorder | Niemann-Pick Disease | Motor Neuron Diseases | H Syndrome | Anorectal Fistula | Keratitis | Galactosialidosis | Tricho-hepato-enteric Syndrome | Raynaud Phenomenon | Hereditary Neuropathy With Liability To Pressure Palsies | Rhabdomyosarcoma, Alveolar | Lichen Sclerosus | Cluster Headache | Microcephalic Primordial Dwarfism | Oculopharyngeal Muscular Dystrophy | Intermittent Explosive Disorder | Plasma Cell Leukemia | Neurodevelopmental Disorders | Pterygium | Myotonia | Papulopustular Rosacea | Open-angle Glaucoma | Pneumoconiosis | Hyperbilirubinemia, Neonatal | Uveitis, Anterior | Porphyria | Familial Isolated Hyperparathyroidism | Pompe Disease | Hyperparathyroidism-jaw Tumor Syndrome | Thyroiditis | Hemochromatosis | Primary Torsion Dystonia | Intestinal Tuberculosis | Recurrent Respiratory Papillomatosis | Maple Syrup Urine Disease | Osteomalacia | Jawad Syndrome | Kearns-Sayre Syndrome | Dyslipidemia | Enhanced S-cone Syndrome | Specific Granule Deficiency | Sarcoma, Alveolar Soft Part | Gastritis | Lateral Meningocele Syndrome | Glycogen Storage Disease Type 6 | Eiken Syndrome | Urticaria | Glycogen Storage Disease Type 9 | Camptocormia | Rheumatoid Arthritis | Retinitis Pigmentosa 3 | Avian Influenza | Persistent Fetal Circulation | Leukocyte Adhesion Deficiency | Peters-plus Syndrome | Acne Vulgaris | Primary Progressive Aphasia | Pontocerebellar Hypoplasia Type 2 | Polycystic Kidney, Autosomal Dominant | Brachydactyly | Bietti Crystalline Dystrophy | Chorea-acanthocytosis | Shprintzen-Goldberg Syndrome | Lesch-Nyhan Syndrome | Ligneous Conjunctivitis | Potocki-Shaffer Syndrome | Diabetes Type 1 | Renal Failure | Hypoproteinemia, Hypercatabolic | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Hypokalemia | Neuromyotonia | Pituitary Disorders | Glycogen Storage Disease Type 1b | Renpenning Syndrome | Diabetic Nephropathy | Prolidase Deficiency | Schindler Disease | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Hypertension, Renovascular | Hemoglobinopathies | Pierson Syndrome | Myocardial Infarction | Osteogenesis Imperfecta Type V | Hepatitis B, Chronic | Pyoderma Gangrenosum | Urofacial Syndrome | Jacobsen Syndrome | Rotor Syndrome | Renal Medullary Carcinoma | Congenital Hypofibrinogenemia | Granular Corneal Dystrophy Type 1 | Obesity | Nasodigitoacoustic Syndrome | Early Infantile Epileptic Encephalopathy 28 | Hyperacusis | Tonsillitis | Chronic Periodontitis | Esotropia | Infantile Neuroaxonal Dystrophy | Multifocal Motor Neuropathy | Autonomic Nervous System Disorders | Charcot-Marie-Tooth Disease | Non-Langerhans Cell Histiocytosis | Cystinuria | Crigler-Najjar Syndrome | Hypolipoproteinemia | Zygomycosis | Nestor-Guillermo Progeria Syndrome | Sitosterolemia | COACH Syndrome | Encephalitis | Autoimmune Polyendocrinopathy Syndrome Type I | Pemphigus Vulgaris | Trichuriasis | Hypertension, Pulmonary | 3-methylglutaconic Aciduria Type I | Familial Episodic Pain Syndrome | Periodontitis | Glycogen Storage Disease Type 0 | Periventricular Leukomalacia | Polyomavirus Nephropathy | Galloway-Mowat Syndrome | T-cell Lymphoma, Subcutaneous Panniculitis-like | Carbonic Anhydrase VA Deficiency | Immunoproliferative Disorders | Exocrine Pancreatic Insufficiency | Hyperlipidemia, Familial Combined | Venous Insufficiency | Fibromuscular Dysplasia | Pre-eclampsia | Takayasu's Arteritis | Cardiac Arrest | Disseminated Intravascular Coagulation | Desbuquois Syndrome | Microcephaly | Choroiditis | Menkes Disease | Glanzmann Thrombasthenia | Hypertriglyceridemia | Pituitary Dwarfism | Superficial Spreading Melanoma | Blepharophimosis Syndrome | Nicolaides-Baraitser Syndrome | Kashin-Beck Disease | Cerebral Amyloid Angiopathy | Oculocutaneous Albinism Type 4 | Angelman Syndrome | CDKL5 Deficiency Disorder | Pneumonia, Mycoplasma | Erythropoietic Protoporphyria | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Cousin Syndrome | Hepatitis A | Lentigo | Hypersomnia | McLeod Syndrome | Arteriovenous Malformations | Coffin-Siris Syndrome | Dyggve-Melchior-Clausen Disease | Delayed Sleep Phase Syndrome | Panuveitis | Vascular Calcification | Turner's Syndrome | Keratopathy | Cockayne Syndrome | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Generalized Epilepsy With Febrile Seizures Plus | Cholelithiasis | Distal Myopathy | Bicuspid Aortic Valve | Hermansky-Pudlak Syndrome | Huntington's Disease-like 2 | Ulcerative Colitis | Acute Kidney Injury | Peroxisomal Disorder | Retinitis | Loeys-Dietz Syndrome | Trichothiodystrophy | Congenital Dyserythropoietic Anemia Type 1 | Dementia, Vascular | Gray Platelet Syndrome | Astrocytoma, Anaplastic | Antenatal Bartter Syndrome Type 1 | Schizoaffective Disorder | Hypokalemic Periodic Paralysis | Fibronectin Glomerulopathy | X-linked Myotubular Myopathy | Leukocyte Adhesion Deficiency Type 1 | GAPO Syndrome | Thrombophlebitis | Gliosarcoma | Corneal Dystrophies, Hereditary | Idiopathic Pulmonary Fibrosis | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Tinea Versicolor | McCune-Albright Syndrome | Glutaric Aciduria Type 2 | Myofibromatosis | Osteogenesis Imperfecta Type IV | Micropenis | Trigonocephaly | Pyruvate Carboxylase Deficiency Disease | Gangliosidosis | Cramp Fasciculation Syndrome | Spondylolisthesis | Thyroid Dyshormonogenesis | Spinocerebellar Ataxia Type 14 | Rickets | Arthritis, Reactive | Aarskog-Scott Syndrome | Glycogen Storage Disease | Brenner Tumor | Juvenile Hyaline Fibromatosis | Lymphoma, B-cell | Cancer, Lung | Isobutyryl-CoA Dehydrogenase Deficiency | Hemosiderosis | Hyperoxaluria | Pachyonychia Congenita | Metatropic Dysplasia | Sengers Syndrome | Metachromatic Leukodystrophy | Hemorrhagic Disorders | Chronic Myelomonocytic Leukemia | Meesmann Corneal Dystrophy | Histoplasmosis | Leukodystrophies | Purpura, Thrombotic Thrombocytopenic | Goiter | Rett Syndrome | Trimethylaminuria | Van Der Knaap Disease | Photosensitivity | Meniere's Disease | Craniopharyngioma | Batten Disease | DRESS Syndrome | Acute Generalized Exanthematous Pustulosis | Hashimoto Thyroiditis | Craniometaphyseal Dysplasia | Chronic Mucocutaneous Candidiasis | Mesothelioma, Malignant | Encephalopathy | Fanconi Anemia | Myopathy | Benign Familial Pemphigus | Gastrointestinal Disorders | Panic Disorder | Acral Lentiginous Melanoma | Uremic Pruritus | Giant Axonal Neuropathy | Multiple System Atrophy | Heavy Chain Disease | Keratoacanthoma | Hereditary Sensory Neuropathy Type 1 | Erectile Dysfunction | Cancer, Colon | Congenital Ichthyosiform Erythroderma | Costello Syndrome | Gitelman Syndrome | Weill-Marchesani Syndrome | Retinal Vasculitis | Jaundice, Obstructive | Parkinson's Disease | Corticobasal Syndrome | Nutrition Disorders | Spondylosis | Synpolydactyly | Progressive Myoclonic Epilepsy | Gaucher Disease | Syncope | Non-epidermolytic Palmoplantar Keratoderma | Thrombasthenia | Diamond-Blackfan Anemia | Adams-Oliver Syndrome | Optic Nerve Hypoplasia, Bilateral | Histiocytic Sarcoma | Hyperammonemia | Esophagitis | Chronic Kidney Disease | Evans Syndrome | Goiter, Nodular | Hyperferritinemia-cataract Syndrome | Multiple Sclerosis, Chronic Progressive | Ocular Albinism Type 1 | Isovaleric Acidemia | Cranial Nerve Disease | Spinocerebellar Ataxia Type 15 | Fabry's Disease | Irritable Bowel Syndrome | Sickle Cell Anemia | Heart Septal Defects | Diabetes Insipidus | C3 Glomerulopathy | Ureteropelvic Junction Obstruction | Motion Sickness | Blue Rubber Bleb Nevus Syndrome | Localized Scleroderma | Connective Tissue Disorders | Porphyria, Variegate