Loeys-Dietz Syndrome

About the Disease
Loeys-Dietz Syndrome, also known as loeys-dietz aortic aneurysm syndrome, is related to loeys-dietz syndrome 1 and loeys-dietz syndrome 2. An important gene associated with Loeys-Dietz Syndrome is TGFBR2 (Transforming Growth Factor Beta Receptor 2), and among its related pathways/superpathways are Signal Transduction and ERK Signaling. The drugs Heparin, bovine and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and skin, and related phenotypes are high palate and pes planus

Common Targets
TGFBR1 | SMAD2 | TGFB2 | SMAD3 | TGFBR2 | TGFB3 | IPO8 | FBN1

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