Alcoholism

About the Disease
Alcohol Dependence, also known as alcoholism, is related to alcohol use disorder and personality disorder. An important gene associated with Alcohol Dependence is GABRA2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Metapathway biotransformation Phase I and II. The drugs Lenograstim and Alogliptin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and prefrontal cortex, and related phenotypes are alcoholism and no effect

Common Targets
LINC01238 | AP2A2 | PNPLA3 | PCED1B | PM20D1 | SLC6A7 | DTX2 | LINC02774 | SNORD72 | Nicotinic alpha4beta2alpha5 Receptor | RALYL | MXRA7 | FCHO1 | GABRG2 | CASR | GPR88 | BICRA | CCR6 | LMF1 | NF-kappaB (NFkB) | NOS3 | ASAP2 | DHODH | PHGDH | UMODL1 | Microtubule-Associated Protein (nonspecified subtype) | SEC14L1 | GRIK1 | FARS2 | T-Type Calcium Channel | NBPF6 | DIO1 | LOC105375204 | SLC26A1 | B4GALNT2 | CYP1A1 | ECI2-DT | RRAGC | THUMPD1 | PDE10A | SERINC2 | MMP17 | NTPCR | RPL13AP17 | DIO2 | ZNF576 | TMEM9 | CTNNA1 | PRMT8 | G7015 | TRIM29 | IFITM4P | SLC6A4 | PAH | B3GNT7 | ATG7 | SLC35E2A | NFATC1 | MYT1L | GABRB2 | CCDC154 | GRAMD4 | G836 | LINC01606 | HTR2A | OVGP1 | AVPR1B | CHRNA7 | LRRC14B | SLC19A3 | FGF22 | MAP2 | AKR1B1 | NAALADL2-AS3 | Nicotinic (alpha4beta2)2alpha4 receptor | PRKCZ | SLC17A6 | SCD | IRX2-DT | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | LINC03021 | HTR4 | ITIH3 | PSMD13 | GAS5 | NPSR1 | MYOM2 | GREB1 | MYH10 | Nicotinic (alpha4beta2)2beta2 receptor | CHST8 | SNORD78 | PIP5K1C | LINC00648 | WDR41 | HSP90AA4P | SFTA2 | ACSF3 | BATF | LOC349160 | DHX9 | LGSN | ANKK1 | GALNT1 | HNRNPA1 | CLSTN2 | DUSP5 | RXFP3 | SEPTIN7P9 | SNORD22 | alpha-Adrenoceptor (nonspecified subtype) | CACNA1C | PCSK9 | KCNH5 | DBH | NOTCH4 | DHX16 | OR12D3 | LINC00298 | OPRD1 | POMC | PTPRZ1 | NMDA receptor | HCRTR1 | RFLNB | SHMT2 | RASGRP1 | GLRX3 | Opioid receptor (nonspecified subtype) | THBS2 | SLC7A11 | PDGFRA | HS6ST1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | OXT | RYR2 | FAM120B | SLC25A46 | SEC24D | UBA3 | DAP | NOX4 | FHIT | CDK18 | RFTN1 | LRRK1 | PTPRN2-AS1 | LOC101927896 | POU2F2 | LINC01115 | REEP3 | SRPK3 | CEP170B | GRK3 | GEMIN4 | BAK1 | Nicotinic alpha4beta2 receptor | GRIN2A | KHK | SYNE3 | G4137 | TPO | PFDN4 | KLHL35 | ACSS2 | HHLA2 | SDHB | NPY2R | TOLLIP | RASGRF2 | SMAD6 | TP63 | CES1 | JPH3 | G1385 | SLC6A9 | TRPA1 | GET1 | Nicotinic alpha3beta4 Receptor | FAAH | MYEOV | NOS2 | SPAG16 | ZNF57 | MIR584 | G7099 | RAX2 | PGRMC2 | HLA-DRA | G114548 | IRGQ | DYNC2I1 | ABLIM3 | KAT6A | MIR591 | SLC1A5 | OPRL1 | ADGRA1 | GIPR | REL | SNORA58 | LOC105377864 | ADH1B | VHL | DRD1 | RNF216 | LINC00029 | IAPP | XXYLT1 | TIAL1 | TM9SF1 | CDC5L | CPAMD8 | PRPF8 | EYA4 | WDR27 | PKHD1 | CHRNA9 | ATXN7L1 | HCG4 | CHPT1 | CXADRP3 | NRDC | PRSS23 | THSD7B | CCDC166 | GLO1 | NLGN4X | CRHBP | NUDT1 | TMEM100 | HRH1 | FKBP5 | GGCT | HLA-DPA1 | EDDM3A | SCN11A | Amylin receptor | GABRA1 | BHLHA9 | GABRB3 | PRKCD | GABRG3 | Neuropeptide FF Receptor (nonspecified subtype) | TAS1R2 | HTATIP2 | HLA-J | AHSP | LINC01310 | HSPG2 | P2RX4 | AGPAT1 | HLA-K | HDAC4 | HLA-L | RHPN1 | MT2A | NPY | PLXNC1 | RGPD5 | HCRTR2 | MICALL2 | FSCN2 | SPATC1L | PRKCH | CRPPA | SCN1A | L-Type calcium channel (nonspecified subtype) | CA2 | AACSP1 | LOC100507053 | SPATA18 | G1786 | DOCK5 | CAMK2A | SMYD2 | RGPD6 | HLA-DQB1 | ADH4 | RNU6ATAC | CYP7B1 | TACR1 | G9734 | NUP58 | ALDH1A1 | NCOA5 | COX4I1 | TLCD4-RWDD3 | UGDH-AS1 | CRHR1 | SLC6A11 | SPAST | LINC02210-CRHR1 | EYS | alpha1-Adrenoceptor (nonspecified subtype) | NTSR1 | SDHAF3 | CHRNA3 | JDP2 | BDNF-AS | GRM8 | Nitric oxide synthase (NOS) (nonspecified subtype) | HTR2C | TPH2 | Dopamine receptor (nonspecified subtype) | Potassium Channels (nonspecified subtype) | ZBP1 | MIF | HTR1B | TRNA | HMGCS1 | SERPINA9 | HTR6 | SCN4B | TPD52L1 | PTPN5 | ATPSCKMT | LOC286083 | NINJ2-AS1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | SLC6A3 | PHC1 | GBX2 | ADCY8 | LOC100129534 | DGKZ | DRD3 | FTO | GRAMD1C | MIR186 | TTLL13 | MIR346 | LOC101927040 | RN7SK | PLEKHS1 | HCAR1 | SULF2 | SKP2 | AMZ1 | NBPF22P | GABRA5 | TMEM97 | G2475 | OR2L13 | B4GALT6 | PDYN-AS1 | SPRY1 | SPTBN4 | ANKS3 | MUC2 | OPRM1 | MS4A4A | STARD7-AS1 | RAB20 | URAD | LOC286177 | ASTN1 | ZNF365 | LINC01126 | HTR3B | GRM3 | AOX1 | TRIM31 | ARID3A | ANKS1B | ADH7 | LINC02544 | ALDH1L2 | CAPN8 | STAM2 | HIPK2 | EAPP | SSTR5 | ZFP57 | DYNC2H1 | FEM1B | HCG9 | KCNMA1 | B3GALT1 | TAS2R60 | ELOVL5 | ASIC1 | FANCA | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | ZNF699 | SLC6A1 | CHRM5 | OXTR | GUCY2C | CNR2 | ADH5 | MIR633 | GABRD | GRIN2B | ZDHHC19 | GSDME | MIR3663 | LRRC20 | COL6A2 | PDE11A | SDCBP2 | KRT82 | IRF8 | SNORA70 | B2M | POU2AF3 | FLJ37201 | MTHFR | SMLR1 | HOOK2 | MACC1 | G595 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | OCA2 | GABRA2 | PER1 | MIR544A | DGKA | PKNOX2 | CNTN4 | G7124 | GOSR2 | DIPK1C | ABR | BRMS1 | MS4A14 | PPARG | SEMA3A | ADH1A | TSPAN10 | AGO2 | HSP90B3P | Nicotinic alpha4beta4 receptor | CADM4 | BAHD1 | CHRM2 | SLC6A13 | DRD2 | ATP1A4 | LOC154449 | UBTD1 | TLR6 | IFT43 | RPL37 | MIR548O2 | G3620 | GHRHR | PRXL2B | AKR7A2 | STK25 | CHRNB2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | LAMA3 | HERC6 | NR3C1 | HLA-DRB4 | TSPAN5 | TRA2B | MAPK8IP1P2 | OPRK1 | TMEM176B | EXD3 | EPHA10 | alpha-6 beta-2 Nicotinic receptor | INS-IGF2 | SDK1 | PRKCE | BDNF | SLC43A1 | ACOT1 | Glutamate Receptor Ionotropic AMPA Receptor | ATP5MC1 | PPP1R16B | MRGPRX2 | G3569 | CFAP46 | Nicotinic alpha9alpha10 Receptor | CBX7 | MRTO4 | PPARGC1A | HRH3 | CNR1 | G5743 | Glutathione S-Transferase (GST) (nonspecified subtype) | ABAT | KIAA0319 | Calcium channel (nonspecified subtype) | ATG10 | KCNK17 | XRCC5 | MIR4645 | KCNJ9 | CYB561 | LINC00642 | LINC01060 | ACP4 | SORL1 | TRPV1 | GDAP1 | HLA-DRB5 | HTR7 | SLC1A2 | UBL4B | ACSS3 | CRHR2 | INPP1 | GRK2 | HERC2P2 | IRS1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | NKX1-2 | Tubulin | PDGFA | COMT | KCNN1 | PCSK6 | SNORD47 | HERPUD1 | G142 | SOX11 | GABRA6 | ATCAY | KIF26B | PLEKHG4B | MSRA | CTAGE10P | RAB9BP1 | MYBPC1 | MIR4785 | MIR519A2 | Neuronal acetylcholine receptor alpha2beta2 receptor | ACHE | NDFIP1 | DYRK2 | CAPS2 | SNORD58C | PITX1-AS1 | SNCA | CFAP161 | ALDH1B1 | GCG | GNPTAB | EGLN2 | INPP5A | LRAT | BOC | Neuronal acetylcholine receptor alpha2beta2 receptor | G3630 | SLC6A2 | SNHG1 | RNU6-1 | PROX1-AS1 | HDAC1 | HOMER2 | ESM1 | DPF3 | CAT | TMEM165 | NR3C2 | GALNT9 | HTR1A | ARHGAP33 | TERC | GABRA3 | AUTS2 | G4089 | TRIML2 | GDAP2 | LINC01512 | LINC01363 | ZNF583 | KIAA0040 | HECW2 | GABA(A) receptor | MAOA | MGC15885 | MTLN | TRPC2 | RP1L1 | CHRNA5 | KCNN2 | DLGAP2 | HOMER1 | Imidazoline receptor (nonspecified subtype) | MIR129-1 | CACNA1B | GHSR | SLC2A4RG | IL1B | L-type voltage-dependent calcium channel complex | SLIT3 | LHX8 | NEGR1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | TVP23A | KATNIP | SLC6A5 | HLA-DRB6 | ARHGAP22 | SERPINA13P | TACR3 | ADH1C | BRDT | SV2A | AHRR | AGO1 | TUBAL3 | ZNF607 | Sodium channel (nonspecified subtype) | LRRN4 | GABRG1 | CDH4 | Voltage-Gated Sodium Channel Complex | MAP3K21 | KLF4 | HLA-DQA1 | CYBRD1 | Uncharacterized LOC107986115 | CSNK1E | NAALADL2 | MDGA1 | PNLIPRP2 | LOC101928618 | GRM5 | FMN2 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | MAP2K3 | C14orf132 | LINC00221 | SLC12A8 | AGBL4 | ZRANB2-AS1 | CACNA2D1 | BRAP | DGKH | G4851 | FAM86C2P | ATP11A | STK40 | TSPAN18 | PCGF3 | KCND2 | C1orf109 | NCR2 | ADRA1A | DCAF13P3 | UMODL1-AS1 | PCSK1 | SOX1-OT | BIRC2 | SLC39A8 | CCDC57 | Aldehyde Dehydrogenase (nonspecified subtype) | PEX14 | ALDH2 | HAAO | PDYN | RNLS | SIGMAR1 | GYPA | MBD5 | Kainate Receptor (GluR) (nonspecified subtype) | RASA3 | FTCD | HTR3A | CLEC4F | GH1 | SKAP2 | PPM1G | G367 | GAREM2 | Gamma-Aminobutyric acid type B receptor | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | KCNN3 | G3845 | MORN5 | PGR | MIR300 | LOC100507443 | MAD1L1 | GATA4 | MBL1P | MIR4786 | MICAL3 | PYROXD1 | C4orf50 | MYO15A | GABBR1 | mTOR complex 1 | TCF3 | VTRNA2-1 | AVP | HTR2B | ADORA2A | DRD4 | CACNA2D2 | FADS3 | GAPDH

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