Cerebrovascular Disorders

About the Disease
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

Common Targets
Monoamine oxidase (MAO) (nonspecified subtype) | GRIN2B | CDK1 | APEH | MTHFR | ALOX15 | GPR132 | CYP19A1 | Superoxide dismutase (SOD) (nonspecified subtype) | TBXAS1 | Phosphodiesterase (nonspecified subtype) | SLC5A2 | CACNA1H | Glutamate Receptor Ionotropic AMPA Receptor | CETP | G7422 | Proteasome Complex | PIK3CG | SLC9A1 | DUSP3 | EDNRA | G5243 | HRH3 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | CACNA1B | DCTPP1 | G6647 | MIR153-1 | m-Calpain | Cyclin B (nonspecified subtype) | LDLR | Kainate Receptor (GluR) (nonspecified subtype) | MIR153-2 | Calpain (nonspecified subtype) | TTR | NOTCH3 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | CRBN | FAP | GRIK1 | G7124 | DNA-Directed DNA Polymerase Complex | GRM5 | NR1I3 | Carbonic Anhydrase (nonspecified subtype) | L-type voltage-dependent calcium channel complex | Glycogen phosphorylase (nonspecified subtype) | PRKCZ | PTGER3 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | CDK2 | NOS1 | PTGIR | P2RY2 | CYSLTR1 | LRRK2 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | LGALS3 | ADRA1A | NR3C2 | CDK5/p25 | PRKCG | CYP2C19 | FGFR2 | AMP-activated protein kinase (AMPK) | VKORC1 | PDE4B | Phospholipase A2 (nonspecified subtype) | G3620 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | EPHX2 | P2RY4 | ALOX12 | HIF1A | T-Type Calcium Channel | IL1B | COL4A1 | SCD | CALM1 | Heat shock protein 90 (nonspecified subtype) | CTSS | ROCK1 | Casein kinase I (nonspecified subtype) | CTSL | NR1H3 | SIGMAR1 | ACE | KHK | CASR | Calcium channel (nonspecified subtype) | CNR2 | GRM2 | TGFB1 | CACNA1G | S1PR2 | NFATC2 | PDE10A | TYR | CDK5 | HTRA1 | FKBP8 | SLC6A9 | ESR2 | NR5A2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | ADORA2B | alpha-Adrenoceptor (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | F10 | CDK9/Cyclin T1 | Oxysterols receptor LXR (nonspecified subtype) | Neurotrophic Factor (nonspecified subtype) | ADORA1 | TRPM8 | PCSK9 | Adenylate Cyclase (nonspecified subtype) | MAOA | G4780 | HTR5A | VCAM1 | HMGCR | NF-kappaB (NFkB) | NPPA-AS1 | Sphingomyelin phosphodiesterase (nonspecified subtype) | SMPD2 | NR1I2 | CHRNA7 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | ABCA1 | G4137 | C3AR1 | PGR | BCHE | G7099 | MECOM | BRD4 | Estrogen receptor (nonspecified subtype) | PIK3CD | cAMP-Dependent protein kinase (PKA) | GABA(A) receptor | CNR1 | CDK9 | CCR2 | MAPK9 | HSD11B1 | MAPKAPK2 | ABHD6 | FABP5 | DPP4 | 15-Lipoxygenase (nonspecified subtype) | G142 | PRKCD | HLA-DRB1 | SLC22A18 | K(ATP) Channel (nonspecified subtype) | DDIT3 | CCNT1 | P2RY12 | ADCY8 | ADORA2A | TSPO | F2 | ENO2 | AKR1A1 | COL4A2 | Voltage-Gated Sodium Channel Complex | TRPV1 | SERPINE1 | ADORA3 | sigma Receptor (nonspecified subtype) | G4609 | Prostanoid TP receptor (nonspecified subtype) | CHAT | LRP1 | CAPN1 | PTPN1 | PTGS1 | CDK1/Cyclin B | ACHE | GSK3B | TRPM2 | PRKCI | PPARG | Glycine receptor | NR1H4 | Vasopressin Receptor (nonspecified subtype) | Caspase (nonspecified subtype) | FAAH | G2099 | G3630 | Sodium channel (nonspecified subtype) | PDE2A | HTR6 | SIRT5 | GRM1 | L-Type calcium channel (nonspecified subtype) | CDK2/Cyclin A | Poly [ADP-ribose] polymerase (nonspecified subtype) | SURF4 | FASN | TMEM97 | SPHK1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | MAPK10 | APOA1 | CTSK | ECE1 | AKR1B10 | SLC5A1 | PLA2G7 | AP-1 Transcription Factor Complex | Gastric H+/K+-ATPase | NOS3 | G196 | F11 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | ACLY | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | C5AR1 | LRRC32 | SEMA3A | G7157 | alpha1-Adrenoceptor (nonspecified subtype) | ROCK2 | SMAD3 | F2R | Arginase (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | NR4A2 | PRKCQ | AGTR2 | CTSB | LPA | NMDA receptor | FABP4 | PDE5A | IL2 | CASP1 | TREX1 | APP | Cyclin-dependent kinase inhibitor (nonspecified subtype) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | APOB | AGTR1 | Cyclin A (nonspecified subtype) | NAMPT | NT5E | HPGDS | Nitric oxide synthase (NOS) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | KANK2 | SIRT3 | G367 | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | ALB | CYP11B2 | LGALS1 | REN | CX3CR1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | TRPA1 | NOS2 | CYP46A1 | Tubulin | Potassium Channels (nonspecified subtype) | MIF | ABCC3 | Rho kinase (ROCK) (nonspecified subtype) | ECE2 | HTR1D | G5743 | CCR5 | PDE3A | APOE | TRPM3 | DES | S1PR1 | PTAFR | GLP1R | mu-Calpain (calpain 1) | Soluble guanylyl cyclase | SLC6A3 | CAPN2

Note: If you'd like to get a target analysis report for Cerebrovascular Disorders, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cerebrovascular Disorders at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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