Disease

Osteopetrosis

About the Disease
Osteopetrosis, also known as marble bone disease, is related to osteopetrosis, autosomal recessive 7 and osteopetrosis, autosomal recessive 5. An important gene associated with Osteopetrosis is CLCN7 (Chloride Voltage-Gated Channel 7), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related phenotypes are no effect and no effect

Common Targets
PTGER2 | PLA2G2A | Histone deacetylase (nonspecified subtype) | LEMD3 | cAMP Phosphodiesterase (nonspecified subtype) | JAK3 | GAPDH | G1956 | MIR23A | SOST | G7124 | SNX10 | IFNGR1 | CA1 | G6774 | CA12 | IKBKG | MC2R | CTSL | LRP5 | CASR | PLEKHM1 | TRAF6 | ENG | TNFSF11 | ESR2 | GLO1 | SLC29A3 | CA7 | Estrogen receptor (nonspecified subtype) | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | FERMT3 | ESRRA | ACVRL1 | CSNK1A1 | PTH | TCIRG1 | TNFRSF11A | PTGER4 | MIR214 | SGMS2 | G2099 | CTSK | PLA2G2D | CA9 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | CA2 | G196 | SGMS1 | SLC6A4 | PDE5A | APP | CLCN7 | OSTM1 | P2RX7 | VDR | OSCAR

疾病靶点研报
Osteopetrosis

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