Disease

Restless Legs Syndrome

About the Disease
Restless Legs Syndrome, also known as restless leg syndrome, is related to restless legs syndrome 7 and restless legs syndrome 6, and has symptoms including back pain, headache and pain. An important gene associated with Restless Legs Syndrome is RLS4 (Restless Legs Syndrome 4), and among its related pathways/superpathways are Alpha-synuclein signaling and "Methylphenidate Pathway, Pharmacodynamics". The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spinal cord.

Common Targets
Sodium channel (nonspecified subtype) | IL1B | CACNA2D2 | TOX3 | GABRA4 | PDE8A | CTNNA3 | HTR2B | C9orf72 | GABRG2 | TRPV2 | PKMYT1 | LOC107986816 | HMOX2 | ADORA2A | PCDHA3 | MBIP | RNF115 | G3605 | BAZ1A | HPD | Glutamate Transporter (nonspecified subtype) | alpha-Adrenoceptor (nonspecified subtype) | SLC6A4 | Opioid receptor (nonspecified subtype) | NFKBIA | SERGEF | MIA2 | FLNA | DRD5 | Nicotinic alpha4beta2 receptor | FXN | FAT2 | LOC100130207 | ADH1B | TRAPPC6B | GLO1 | TRPA1 | KCNC3 | DRD1 | STK32B | XKR6 | LINGO1 | GABRB3 | LOC105374107 | BRD1 | FOXA1 | SLC4A5 | L-Type calcium channel (nonspecified subtype) | GABRR1 | SKOR1 | HTR1B | LOC101929452 | Dopamine receptor (nonspecified subtype) | CCDC148 | HTR2C | GABRA5 | GABRQ | WWC2 | GPR55 | EAPP | CNOT6 | DRD3 | SLC6A3 | SLC34A1 | LINC02086 | MAOB | GABRR2 | DET1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | HMOX1 | NPAS2 | OPRM1 | SSTR1 | MEIS1 | PRKN | BTBD9 | CHRNB2 | PPARGC1A | ATRN | GABRE | DRD2 | MC1R | SLC1A2 | HTR1D | Calcium channel (nonspecified subtype) | LILRB5 | MIS18BP1 | RASGRP4 | LRRK2 | SNCA | CLOCK | COMT | LOC107986023 | PDE7A | TRPM8 | TRPV1 | GABRR3 | L-type voltage-dependent calcium channel complex | TOGARAM1 | CASC16 | DDC | MAP2K5 | USP46 | SLC6A2 | CACNA2D1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | PTPRD | VDR | PAX9 | PNN | Voltage-Gated Sodium Channel Complex | NOS1

疾病靶点研报
Restless Legs Syndrome

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