Restless Legs Syndrome

About the Disease
Restless Legs Syndrome, also known as restless leg syndrome, is related to restless legs syndrome 7 and restless legs syndrome 6, and has symptoms including back pain, headache and pain. An important gene associated with Restless Legs Syndrome is RLS4 (Restless Legs Syndrome 4), and among its related pathways/superpathways are Alpha-synuclein signaling and "Methylphenidate Pathway, Pharmacodynamics". The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spinal cord.

Common Targets
Sodium channel (nonspecified subtype) | IL1B | CACNA2D2 | TOX3 | GABRA4 | PDE8A | CTNNA3 | HTR2B | C9orf72 | GABRG2 | TRPV2 | PKMYT1 | LOC107986816 | HMOX2 | ADORA2A | PCDHA3 | MBIP | RNF115 | G3605 | BAZ1A | HPD | Glutamate Transporter (nonspecified subtype) | alpha-Adrenoceptor (nonspecified subtype) | SLC6A4 | Opioid receptor (nonspecified subtype) | NFKBIA | SERGEF | MIA2 | FLNA | DRD5 | Nicotinic alpha4beta2 receptor | FXN | FAT2 | LOC100130207 | ADH1B | TRAPPC6B | GLO1 | TRPA1 | KCNC3 | DRD1 | STK32B | XKR6 | LINGO1 | GABRB3 | LOC105374107 | BRD1 | FOXA1 | SLC4A5 | L-Type calcium channel (nonspecified subtype) | GABRR1 | SKOR1 | HTR1B | LOC101929452 | Dopamine receptor (nonspecified subtype) | CCDC148 | HTR2C | GABRA5 | GABRQ | WWC2 | GPR55 | EAPP | CNOT6 | DRD3 | SLC6A3 | SLC34A1 | LINC02086 | MAOB | GABRR2 | DET1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | HMOX1 | NPAS2 | OPRM1 | SSTR1 | MEIS1 | PRKN | BTBD9 | CHRNB2 | PPARGC1A | ATRN | GABRE | DRD2 | MC1R | SLC1A2 | HTR1D | Calcium channel (nonspecified subtype) | LILRB5 | MIS18BP1 | RASGRP4 | LRRK2 | SNCA | CLOCK | COMT | LOC107986023 | PDE7A | TRPM8 | TRPV1 | GABRR3 | L-type voltage-dependent calcium channel complex | TOGARAM1 | CASC16 | DDC | MAP2K5 | USP46 | SLC6A2 | CACNA2D1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | PTPRD | VDR | PAX9 | PNN | Voltage-Gated Sodium Channel Complex | NOS1

Note: If you'd like to get a target analysis report for Restless Legs Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Restless Legs Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Tyrosinemia Type 1 | Communication Disorders | Plasma Cell Leukemia | Congenital Aniridia | Ocular Surface Squamous Neoplasia | Chloridorrhea, Congenital | Mitochondrial Cytopathy | Alazami Syndrome | Fibronectin Glomerulopathy | Primary Ovarian Insufficiency | Kallmann Syndrome | Mycosis Fungoides | Paternal Uniparental Disomy Of Chromosome 14 | Odonto-onycho-dermal Dysplasia | Torticollis | Schistosomiasis Mansoni | Myelodysplasia | Dementia, Vascular | Waardenburg Syndrome Type 4 | Dysmorphophobia | DOCK8 Immunodeficiency Syndrome | Hereditary Sensory Neuropathy Type 1 | Arthrogryposis | Hypohidrotic Ectodermal Dysplasia | Multiple Sclerosis, Relapsing-remitting | Spondylocostal Dysostosis | Tay-Sachs Disease | Acrocallosal Syndrome | Achromatopsia | Agranulocytosis | Stuttering | CHOPS Syndrome | Dermatitis Herpetiformis | IMAGe Syndrome | Hyperuricemia | Amyloidosis | VACTERL Association | Restrictive Dermopathy | Early Infantile Epileptic Encephalopathy 13 | Pneumoconiosis | Spinocerebellar Ataxia Type 40 | Fetal Akinesia Deformation Sequence | Creutzfeldt-Jakob Disease | Juvenile Xanthogranuloma | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Craniosynostosis | Lymphoproliferative Disorders | Anti-NMDA Receptor Encephalitis | Contact Dermatitis | Hemochromatosis | Prune Belly Syndrome | Congenital Bilateral Absence Of Vas Deferens | Moyamoya Disease | Heavy Chain Disease | Hypervalinemia | High Molecular Weight Kininogen Deficiency | Pfeiffer Syndrome | Evans Syndrome | Leukoplakia | Schamberg Disease | Steel Syndrome | Chondroma | Multiple Sclerosis, Secondary Progressive | Sporadic Hemiplegic Migraine | Neuromyotonia | Spinocerebellar Ataxia Type 17 | Barakat Syndrome | Heart Septal Defects | Tendinopathy | Hidradenitis Suppurativa | Cerebral Cavernous Malformations | Omenn Syndrome | Corneal Dystrophy And Perceptive Deafness | Pontocerebellar Hypoplasia | Hypercalcemia | Persistent Truncus Arteriosus | Trichorhinophalangeal Syndrome | Chorioretinitis | Scabies | Hypotonia-cystinuria Syndrome | Heterotopic Ossification | Adrenal Insufficiency | Pemphigoid | Stuve-Wiedemann Syndrome | MELAS Syndrome | Corneal Neovascularization | Renal-hepatic-pancreatic Dysplasia | Lathosterolosis | Transcobalamin Deficiency | Nail Disorder, Nonsyndromic Congenital | Keratoconus | Adenylosuccinate Lyase Deficiency | Lactose Intolerance | Schuurs-Hoeijmakers Syndrome | Hyperkeratosis | Stromal Corneal Dystrophy | HELLP Syndrome | Antenatal Bartter Syndrome Type 1 | Primary Lateral Sclerosis | Tic Disorder | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Krabbe Disease | Pernicious Anemia | Hydronephrosis | Nicotine Addiction | Retinal Detachment | Epidermal Nevus Syndrome | Diabetic Neuropathy | Autonomic Nervous System Disorders | Enlarged Vestibular Aqueduct | Nicotine Dependence | Takotsubo Cardiomyopathy | Arthritis, Reactive | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Paronychia | Glycogen Storage Disease | Lymphoma, Follicular | Withdrawal Syndrome | Osteogenesis Imperfecta Type III | Trichomegaly | Raynaud Phenomenon | Tatton-Brown-Rahman Syndrome | Reflex Epilepsy | Asplenia | Hypertension, Pulmonary | Craniofrontonasal Syndrome | Epidermodysplasia Verruciformis | Saethre-Chotzen Syndrome | Temtamy Preaxial Brachydactyly Syndrome | Cold Agglutinin Disease | Osteochondrosis | ACTH-independent Macronodular Adrenal Hyperplasia | Seizures-scoliosis-macrocephaly Syndrome | Vogt-Koyanagi-Harada Syndrome | Seborrheic Dermatitis | L-2-Hydroxyglutaric Aciduria | Rhabdoid Tumor | Fundus Albipunctatus | Ataxia-ocular Apraxia 2 | Hypobetalipoproteinemias | Dubin-Johnson Syndrome | Meningitis | Adrenomyeloneuropathy | Cancer, Lung | Motion Sickness | Sick Sinus Syndrome | Eating Disorder | Glycogen Storage Disease Type 5 | Microvillus Inclusion Disease | Sarcoma, Ewing | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Lymphoma Lymphoblastic | Desbuquois Syndrome | Thyroid Dyshormonogenesis | Schizotypal Personality Disorder | Spitz Nevus | Metatropic Dysplasia | Osteoporosis-pseudoglioma Syndrome | Pyruvate Dehydrogenase Deficiency | Hypolipoproteinemia | NGLY1 Deficiency | Vitamin B12 Deficiency | Noonan Syndrome-like Disorder With Loose Anagen Hair | Lymphedema-distichiasis Syndrome | Purpura, Thrombotic Thrombocytopenic | Senior-Loken Syndrome | Cervical Dystonia | Pneumonia, Mycoplasma | Glycogen Storage Disease Type 4 | Congenital Adrenal Hyperplasia | Neuroma | Tinea Versicolor | Schnitzler Syndrome | Pemphigus | Microtia | Hypotension, Orthostatic | Malaria, Cerebral | Loeys-Dietz Syndrome | Gray Platelet Syndrome | Giant Cell Glioblastoma | Early Infantile Epileptic Encephalopathy 1 | Congenital Adrenal Hyperplasia 1 | Rhizomelic Chondrodysplasia Punctata | T-cell Lymphoma, Subcutaneous Panniculitis-like | Tonsillitis | Neurogenic Bladder | Ebstein Anomaly | Epidermolytic Hyperkeratosis | Common Cold | Myositis, Focal | Imerslund-Grasbeck Syndrome | Hartsfield Syndrome | Robinow Syndrome | Zollinger-Ellison Syndrome | Anosmia, Congenital | Infantile Nephropathic Cystinosis | Nicolaides-Baraitser Syndrome | Amenorrhea | Pterygium | Acute Generalized Exanthematous Pustulosis | Progressive Familial Intrahepatic Cholestasis | Gastroenteritis, Eosinophilic | Subacute Sclerosing Panencephalitis | Congenital Torticollis | Sweet Syndrome | Pigment Dispersion Syndrome | Pouchitis | Retinal Degeneration | Overactive Bladder | Pompe Disease | Hemorrhage | Hyperinsulinemia | Agammaglobulinemia | Intestinal Obstruction | Colon Adenoma | Netherton Syndrome | Blood Protein Disorders | Acquired Partial Lipodystrophy | Myocardial Infarction | Leukocyte Adhesion Deficiency | Duodenal Atresia | Congenital Muscular Dystrophy | Fascioliasis | Dyslipidemia | Infantile Refsum Disease | Craniolenticulosutural Dysplasia | Gastroenteritis | Congenital Tufting Enteropathy | Gerodermia Osteodysplastica | Chronic Myeloid Leukemia | Cole-Carpenter Syndrome | Cataplexy | Hepatitis | Lymphoma, AIDS-related | Nephrotic Syndrome | WAGR Syndrome | Treacher Collins Syndrome | Behcet's Disease | HANAC Syndrome | Adenoma, Pituitary | Cornelia De Lange Syndrome | Thyrotoxic Periodic Paralysis | Anorchia | Autism | Retinal Telangiectasia | Colitis, Collagenous | Bronchitis | Guillain-Barre Syndrome | Proteus Syndrome | Thrombocytopenia | Asthma | Paracoccidioidomycosis | Glucagonoma | Paroxysmal Kinesigenic Dyskinesia | Congestive Heart Failure | Maternally Inherited Diabetes And Deafness | Huntington's Disease-like 2 | Headache | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Parkinson's Disease | Syphilis | Reye Syndrome | Nail-Patella Syndrome | Periodontitis | Esophagitis | Cartilage Disorders | Meniere's Disease | Meconium Ileus | Preaxial Polydactyly | Chromosome 17q21.31 Deletion Syndrome | Meningioma, Benign | Clouston Hidrotic Ectodermal Dysplasia | Holoprosencephaly | Sleep Apnea, Obstructive | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Gestational Trophoblastic Disease | Generalized Epilepsy With Febrile Seizures Plus | Prediabetes | Lattice Corneal Dystrophy Type 1 | Blepharophimosis Syndrome | Epidermolytic Palmoplantar Keratoderma | Episodic Ataxia | Multiple System Atrophy | Stevens-Johnson Syndrome | Spinocerebellar Ataxia Type 1 | Acrodysostosis | Alzheimer Disease, Late Onset | Nephroblastoma | Aspartylglycosaminuria | Erdheim-Chester Disease | Common Variable Immunodeficiency | Hypercalciuria | Takenouchi-Kosaki Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Amelanotic Melanoma | Isobutyryl-CoA Dehydrogenase Deficiency | Extramammary Paget's Disease | Iron Overload | Panniculitis | Hyperacusis | Long QT Syndrome Type 2 | Marshall-Smith Syndrome | Pupil Disorders | Liver Failure | Castleman Disease | Smith-Magenis Syndrome | Macular Degeneration | Herpes Genitalis | Lymphangioleiomyomatosis | Cheilitis | Turner's Syndrome | Conjunctivitis | Hypokalemic Periodic Paralysis | Porencephaly | Gigantism | Chronic Lymphocytic Leukemia | Cramp Fasciculation Syndrome | Herpes Simplex Dermatitis | Paraganglioma | Hypotrichosis Simplex | Pituitary Disorders | Mitochondrial Disease | Cancer, Prostate | Gastrointestinal Disorders | Cardiac Sarcoidosis | Niemann-Pick Disease, Type A | Cryptosporidiosis | Short-chain Acyl-CoA Dehydrogenase Deficiency | MIRAGE Syndrome | Hartnup Disease | Glycogen Storage Disease Type 1b | Mumps | Muir-Torre Syndrome | Microcephaly | Congenital Dysfibrinogenemia | Oligoasthenoteratozoospermia | Colitis, Microscopic | Acromegaly | Epidermolysis Bullosa Acquisita | Sotos Syndrome | Encephalocele | Tardive Dyskinesia | Kaposiform Hemangioendothelioma | Angioedema, Hereditary | Epidermolysis Bullosa Simplex, Generalized | Meningococcal Meningitis | Zimmermann-Laband Syndrome | Abetalipoproteinemia | Cerebellofaciodental Syndrome | Porphyria Cutanea Tarda | Peripheral Neuropathy | Cherubism | Bartsocas-Papas Syndrome | Uremic Pruritus | Neurofibromatosis-Noonan Syndrome | Pituitary Stalk Interruption Syndrome | Chronic Beryllium Disease | Benign Recurrent Intrahepatic Cholestasis 1 | Histiocytosis | Liver Diseases | Albinism | Myotonia | Disseminated Superficial Actinic Porokeratosis | Lymphangiomatosis | Bulimia Nervosa | Mucolipidosis Type II | Stargardt Disease | Glutaric Aciduria Type 3 | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Babesiosis | Pulmonary Capillary Hemangiomatosis | Vaginitis | Crimean-Congo Hemorrhagic Fever | Scleritis | Alopecia Totalis | Coma | Raine Syndrome | Rubeosis Iridis | Autoimmune Polyendocrine Syndrome | Homocystinuria | Esophageal Carcinoma | Cardiomyopathy, Dilated, 1L | Familial Hypobetalipoproteinemia | Congenital Nephrotic Syndrome | Pycnodysostosis | Silicosis | Smith-Kingsmore Syndrome | Usher Syndrome | Wolfram Syndrome | Cutaneous Mastocytosis | Dupuytren Disease | Melnick-Needles Syndrome | Insulinoma | Sensory Neuropathy | Intestinal Tuberculosis | Polymyositis | Nemaline Myopathy 8 | Retinal Diseases | Lattice Corneal Dystrophy | Waardenburg Syndrome Type 2E