Paraganglioma

About the Disease
Hereditary Paraganglioma-Pheochromocytoma Syndromes, also known as hereditary pheochromocytoma-paraganglioma, is related to paragangliomas 1 and sporadic pheochromocytoma/secreting paraganglioma, and has symptoms including aphonia An important gene associated with Hereditary Paraganglioma-Pheochromocytoma Syndromes is MAX (MYC Associated Factor X), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Doxazosin and Phenoxybenzamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, thyroid and kidney, and related phenotypes are extraadrenal pheochromocytoma and adrenal pheochromocytoma

Common Targets
PGAP1 | DYSF | BICRA | MDH2 | ADGB | EXT1 | GBA1 | TTC27 | KMT2C | KIAA1549L | IL1F10 | SPG11 | SLC6A2 | INTS6L | ATRX | XIRP1 | MAX | FAT4 | FAM218A | FH | MUC16 | MITF | NLRP8 | ADAMTS8 | TEX29 | CSPG4 | MNDA | GCNA | FLT4 | ARMC9 | PROK2 | FGFR1 | ESCO1 | IRX5 | GLMN | FLT1 | MTRR | EIF4H | NXF1 | ABCA1 | MOCS1 | MEI1 | ABHD14B | RANBP6 | HEPACAM2 | MAP3K8 | NUDCD1 | APBA3 | RAB11FIP3 | SDHB | RAD54B | MCM3AP | SORCS1 | ANO8 | NRCAM | PCDH8 | KDR | MEF2A | CCDC62 | CIT | DNMT3B | CAST | OR5H6 | EIF2AK4 | SLC6A4 | CATSPER4 | MEN1 | RTN1 | ZNF681 | HRNR | ADGRG4 | SPIDR | RARB | FGFR4 | NPM2 | RET | LINC03034 | CMYA5 | ADCY4 | IMPDH2 | PCLO | SDHC | H2BC12 | BLTP1 | VCL | TSHB | STS | UBP1 | G7015 | LTBP1 | NF1 | OXLD1 | ITGA7 | ADRA1D | ZFP37 | SOAT1 | G672 | CYP2J2 | MYH14 | UCN2 | RBM33 | DNAH17 | VHL | TTN | MYBBP1A | SDK2 | MYOCD | CEP20 | ABCC6 | PPME1 | TMEM127 | ARHGEF5 | DSC1 | F11 | TOP2A | NUMA1 | CRISPLD2 | SDHD | NAP1L3 | AP1G1 | FANCA | MUC4 | NPAS2 | CNGB1 | DTHD1 | WNT10A | ARID1A | GPR158 | KIT | EGLN1 | AHNAK2 | PATJ | APOB | KIF25 | FBXL17 | RDH8 | OSMR | TRMT2A | SEMA3A | SMARCAD1 | ZSWIM6 | SDHA | RASSF1 | VPS50 | MYCN | PLEKHG1 | RXFP4 | MYH7 | SCRN1 | ZNF462 | PI3 | EPAS1 | MYO5A | SLC37A3 | FOXC1 | NNMT | RUVBL2 | GALNT9 | RHOD | MED12 | MIA3 | WDR20 | SDHAF2 | MYO5B | PDHA2 | DNA Methyltransferase (DNMT) (nonspecified subtype) | CDH4 | G1029 | RASSF5 | HEXD | ALDH3B2 | ZNF28 | ITGB7 | ZNF283 | TUBB3 | HRAS | LIX1 | PDGFRB | KRT33A

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