Toxic Epidermal Necrolysis

About the Disease
Severe Cutaneous Adverse Reaction, also known as stevens-johnson syndrome, is related to sjogren syndrome and viral infectious disease. An important gene associated with Severe Cutaneous Adverse Reaction is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and salivary gland, and related phenotypes are nausea and vomiting and dysphagia

Common Targets
G7124 | HLA-B | CYP2C19 | TRAF3IP2-AS1 | PTGER3 | DDX39B | HLA-A | GSTT1 | G5243 | IL10 | Retinoid acid receptor (nonspecified subtype) | CYP3A5 | PSORS1C1 | IFNG | SCN1A | CYP2C9 | GSTM1 | CYP2B6 | EPHX1 | IL13 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | ABCC10 | TRAF3IP2 | CYP3A4 | GNLY | BAG6

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