Wilson's Disease

About the Disease
Wilson Disease, also known as hepatolenticular degeneration, is related to disorder of copper metabolism and choreatic disease, and has symptoms including abdominal pain, back pain and constipation. An important gene associated with Wilson Disease is ATP7B (ATPase Copper Transporting Beta), and among its related pathways/superpathways are Ferroptosis and Detoxification of Reactive Oxygen Species. The drugs Zinc cation and Choline have been mentioned in the context of this disorder. Affiliated tissues include Liver, eye and brain, and related phenotypes are intellectual disability and failure to thrive

Common Targets
PRDX1 | PNPLA3 | YKT6 | MGST1 | ICAM1 | MGST3 | G3480 | MINK1 | NF-kappaB (NFkB) | TAB1 | MYT1L | PTPN1 | G7015 | PRKCZ | MYO18B | ZNF750 | CACNB1 | GSTM5 | WNT11 | Integrin alpha4beta7 (LPAM-1) receptor | Reverse transcriptase (Telomerase) | ZNF644 | HDAC5 | FBN2 | MLXIPL | GSTP1 | TPSG1 | SEPTIN9 | KDSR | KDELR2 | PKHD1 | NF1 | TXN2 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | B4GALNT4 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | JAG1 | MT1X | CFTR | HLCS | CCDC115 | CEBPB | ATP7B | LONRF2 | SLCO1B1 | APP | COMMD1 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | AGER | TH | FHL3 | AFAP1 | FGFR2 | AFF3 | HDAC6 | SLC25A13 | GSTZ1 | TRIM11 | G6647 | TMEM184A | FGF2 | ELFN1 | PPCDC | ALKBH5 | GRID2IP | GMPR | SIM2 | SLC31A1 | PSAPL1 | CACNA1H | HFE | CAMK2B | MAP2K1 | NIBAN2 | Integrin alpha4beta1 (VLA-4) receptor | SH3PXD2A | GSTM2 | MAD1L1 | MYO15A

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