Azoospermia

About the Disease
Spermatogenic Failure, also known as azoospermia, is related to spermatogenic failure 10 and male infertility with azoospermia or oligozoospermia due to single gene mutation. An important gene associated with Spermatogenic Failure is MEIOB (Meiosis Specific With OB-Fold), and among its related pathways/superpathways are Gene Silencing by RNA and Ovarian infertility. The drugs Metformin and Insulin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and testes, and related phenotypes are endocrine/exocrine gland and cellular

Common Targets
KIT | MSH3 | KDM3A | MAEL | DNMT3L | DMRT1 | GCNA | PMS2 | TAF4B | MIR34B | TEX13B | FAM9A | FAM9B | MTRR | KITLG | TEX11 | SELENOS | NR5A1 | HSF2 | YBX2 | SOX8 | MIR34C | INSR | GSTT1 | ZMYND15 | MLH3 | TEX13C | MTHFD1 | CBS | AURKC | ZSWIM7 | G367 | FKBP6 | FASN | NOS3 | FASLG | EPSTI1 | MTHFR | NPAS2 | USP8 | PRM1 | LRRC4C | MEST | PRM2 | MTR | XRCC1 | HSPA2 | MLH1 | H19 | MIR499A | CDR1 | SHMT1 | TAF7L | MYRIP

Note: If you'd like to get a target analysis report for Azoospermia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Azoospermia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Duane Retraction Syndrome | Thin Basement Membrane Disease | Hepatitis, Alcoholic | Zimmermann-Laband Syndrome | Acute Anterior Uveitis | Hyper IgE Syndrome | Immunoproliferative Disorders | Sickle Cell Disease | Usher Syndrome Type II | LRBA Deficiency | Pericarditis | Chloridorrhea, Congenital | Multiple Sclerosis, Primary Progressive | Waardenburg Syndrome Type 2E | Cardiofaciocutaneous Syndrome | Crisponi Syndrome | Granular Corneal Dystrophy | Genitopatellar Syndrome | Ehlers-Danlos Syndrome | Tietze Syndrome | Precocious Puberty | Pyruvate Kinase Deficiency | McLeod Syndrome | Bartter Syndrome | Tyrosinemia Type 1 | Pyelonephritis | Fuchs Heterochromic Iridocyclitis | Metatropic Dysplasia | Hepatitis C, Chronic | Cholestasis, Intrahepatic | Early Infantile Epileptic Encephalopathy 4 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Hereditary Xerocytosis | Lymphoma, AIDS-related | Transcobalamin Deficiency | IgA Deficiency | Hermansky-Pudlak Syndrome | Familial Hyperaldosteronism | Myelitis | Oculocutaneous Albinism Type 2 | Graft-versus-host Disease | Birk-Barel Syndrome | Renal-hepatic-pancreatic Dysplasia | Impetigo | Guillain-Barre Syndrome | Bipolar Disorder | Charcot-Marie-Tooth Disease Type 2D | Adenomyosis | Klippel-Feil Syndrome | Alzheimer Disease, Late Onset | Cysticercosis | Asphyxia Neonatorum | Oligospermia | GM2-gangliosidosis AB Variant | Dentinogenesis Imperfecta | Nutrition Disorders | Optic Neuritis | Aspartylglycosaminuria | H Syndrome | Hypertrophy | Agnathia-Otocephaly Complex | Neurofibroma | Primary Sclerosing Cholangitis | Stiff-man Syndrome | Alopecia Totalis | Antiphospholipid Syndrome | Peripheral Neuropathy | Hyperostosis | Seizures-scoliosis-macrocephaly Syndrome | Poretti-Boltshauser Syndrome | Hyperbilirubinemia, Neonatal | Exotropia | Sweet Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Pleomorphic Xanthoastrocytoma | Pathological Gambling | Angiosarcoma | Bone Giant Cell Tumor | Walker-Warburg Syndrome | Progressive Osseous Heteroplasia | Distal Myopathy 2 | Pigment Dispersion Syndrome | Bulimia Nervosa | B-cell Chronic Lymphocytic Leukemia | Hepatitis B, Chronic | Androgenic Alopecia | Hereditary Folate Malabsorption | Cutaneous Angiosarcoma | Infectious Diarrhea | Blepharoconjunctivitis | Hyperprolactinemia | Restless Legs Syndrome | Raynaud Phenomenon | Atrioventricular Septal Defect | Hypocalcemia | Chorea | Tricho-hepato-enteric Syndrome | Transthyretin-related Amyloidosis | Congenital Sodium Diarrhea | Nager Acrofacial Dysostosis | Vitamin B12 Deficiency | Multiple System Atrophy | Papillon-Lefevre Syndrome | Brooke-Spiegler Syndrome | Cenani-Lenz Syndactyly Syndrome | Myelomeningocele | Epidermolytic Palmoplantar Keratoderma | Pulverulent Zonular Cataract | Liebenberg Syndrome | Chordoma | Shwachman-Bodian-Diamond Syndrome | Pierson Syndrome | Cornelia De Lange Syndrome | Diabetes Type 1 | Sjogren Syndrome | Beare-Stevenson Syndrome | Epidermolysis Bullosa Simplex, Generalized | Omenn Syndrome | Creatine Deficiency Syndrome | Spinocerebellar Ataxia Type 27 | Depression | Enhanced S-cone Syndrome | Localized Scleroderma | Meleda Disease | Lipid Storage Myopathy | Sclerosteosis | Craniopharyngioma | Angiosarcoma Of The Breast | Hereditary Neuropathy With Liability To Pressure Palsies | Kabuki Syndrome | Diabetic Macular Edema | Neurocysticercosis | Ovarian Hyperstimulation Syndrome | Campomelic Dysplasia | Wilson's Disease | Melanoma | Congenital Dyserythropoietic Anemia | Cholera | Myosin Storage Myopathy | Narcolepsy | Pelizaeus-Merzbacher Disease | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Chordoid Glioma | Steel Syndrome | Abetalipoproteinemia | Megaloblastic Anemia | Cancer, Prostate | Cardiospondylocarpofacial Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Diabetic Nephropathy | Gastric Atrophy | Paroxysmal Nocturnal Hemoglobinuria | Hepatitis E | Neurodegeneration With Brain Iron Accumulation | Androgen Insensitivity | Metanephric Adenoma | Pulmonary Capillary Hemangiomatosis | Spinal And Bulbar Muscular Atrophy | Aldosterone Deficiency | Hemolytic Uremic Syndrome, Atypical | Urolithiasis | Chronic Idiopathic Myelofibrosis | Blastomycosis | Methylmalonic Aciduria And Homocystinuria, CblC Type | Crouzon Syndrome With Acanthosis Nigricans | Lipoma | Paraganglioma | Globozoospermia | Pseudo-pseudohypoparathyroidism | Kashin-Beck Disease | Usher Syndrome Type IIC | Anal Fissure | Lipid Metabolism Disorders | Stuve-Wiedemann Syndrome | Myocarditis | Wieacker-Wolff Syndrome | Reflex Epilepsy | Metabolic Syndrome | Encephalopathy, Glycine | Cholelithiasis | Basan Syndrome | Astrocytoma | VACTERL Association | Hyperuricemia | Chronic Granulomatous Disease, X-linked | Keratosis | Lipid Storage Diseases | Hyperlipidemia, Familial Combined | Non-epidermolytic Palmoplantar Keratoderma | Neuroblastoma | Papilledema | Plasma Cell Dyscrasia | Endocarditis | Retinoblastoma | Multiple Myeloma | Kleine-Levin Syndrome | Brugada Syndrome 1 | Colitis, Collagenous | Hypodontia | Kernicterus | Micro Syndrome | Pure Autonomic Failure | Charcot-Marie-Tooth Disease Type 3 | Multiple Sclerosis, Chronic Progressive | Blepharospasm | Carney-Stratakis Syndrome | Renal Oncocytoma | Hypersensitivity | Hemosiderosis | Whipple's Disease | Exocrine Pancreatic Insufficiency | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Ulcerative Colitis | Spondylocostal Dysostosis | Benign Familial Infantile Seizures | Cat Eye Syndrome | Spinocerebellar Ataxia Type 42 | Chediak-Higashi Syndrome | Congenital Mirror Movements | Liver Failure, Acute Infantile | Mesothelioma, Malignant | Melnick-Needles Syndrome | Neonatal Progeroid Syndrome | Spermatocele | B-cell Prolymphocytic Leukemia | Schistosomiasis Mansoni | Vulvovaginitis | Nemaline Myopathy | Colorectal Adenoma | Panniculitis | Homocystinuria | Dementia | Cranial Nerve Disease | Tyrosinemia | Autoimmune Interstitial Lung, Joint, And Kidney Disease | X-linked Charcot-Marie-Tooth Disease | Acute Leukemia | Behavioral Variant Of Frontotemporal Dementia | Atrial Septal Defect | Zellweger Syndrome | Cartilage Disorders | Atopic Dermatitis | Orthostatic Intolerance | Renal Failure | Osteogenesis Imperfecta Type V | Okihiro Syndrome | Best Macular Dystrophy | Osteochondroma | Pilomatrix Carcinoma | Membranous Nephropathy | Pulmonary Alveolar Proteinosis | Premature Ejaculation | Adenocarcinoma | Neurofibrosarcoma | Riboflavin Transporter Deficiency Neuronopathy | MELAS Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | 3-methylglutaconic Aciduria Type IV | Robinow Syndrome | Creutzfeldt-Jakob Disease | Primary Erythromelalgia | Enlarged Vestibular Aqueduct | Kawasaki Disease | Epidermolytic Hyperkeratosis | Addison Disease | Glycogen Storage Disease Type 1 | Molybdenum Cofactor Deficiency | Sclerosteosis 2 | Gingivitis | Schizotypal Personality Disorder | DICER1 Syndrome | Neuromuscular Disorders | Pseudoexfoliation Syndrome | Lymphangioleiomyomatosis | Nicotine Dependence | VEXAS Syndrome | Familial Cerebral Amyloid Angiopathy | Argininosuccinic Aciduria | 3-methylcrotonyl-CoA Carboxylase Deficiency | Myeloid Leukemia | Niemann-Pick Disease | Granuloma Annulare | Corneal Edema | Adenosine Deaminase Deficiency | Loeys-Dietz Syndrome Type 4 | Oligoastrocytoma | Paronychia | Diarrhea | Micropenis | Osteopetrosis | Autosomal Recessive Congenital Ichthyosis | Pneumoconiosis | Hereditary Inclusion Body Myopathy | PASLI Disease | Porphyria | Spondylo-ocular Syndrome | Hemophagocytic Lymphohistiocytosis | Pelvic Inflammatory Disease | Fahr Disease | Pemphigus Vulgaris | Juvenile Hyaline Fibromatosis | Hyperparathyroidism, Primary | Glutaric Aciduria Type 1 | Amenorrhea | Neural Tube Defect | Sensory Neuropathy | Cri-du-chat Syndrome | Spondyloarthritis | Measles | Myofibrillar Myopathy | Congenital Dysfibrinogenemia | Hamartoma | Retinal Telangiectasia | Alexander Disease | Schizophrenia, Paranoid | ACTH-independent Macronodular Adrenal Hyperplasia | Congenital Central Hypoventilation Syndrome | Osteoarthritis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Prostatitis | Hemoglobinopathies | Obesity, Morbid | Charcot-Marie-Tooth Disease Type 4D | Cerebellar Ataxia, Cayman Type | Rett Syndrome | GLUT1 Deficiency Syndrome | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Dementia, Vascular | Central Retinal Artery Occlusion | Danon Disease | Tatton-Brown-Rahman Syndrome | Nijmegen Breakage Syndrome | Fatty Aldehyde Dehydrogenase Deficiency | Asperger Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Synpolydactyly | Gastrointestinal Disorders | Aicardi-Goutieres Syndrome | Papillorenal Syndrome | CEDNIK Syndrome | Bone Marrow Necrosis | Overactive Bladder | Otosclerosis | Infertility, Male | Skin Fragility-woolly Hair Syndrome | Spondylolisthesis | Scleritis | Lymphedema | Corneal Neovascularization | Supravalvular Aortic Stenosis | Hypercholesterolemia, Familial | Protein C Deficiency | Waardenburg Syndrome Type 4 | Glycogen Storage Disease Type 5 | Familial Episodic Pain Syndrome | Coloboma | Cataract | Hypercholesterolemia | Familial Glucocorticoid Deficiency | Corneal Ulcer | Nephronophthisis | Juvenile Xanthogranuloma | Vestibular Disease | Mevalonate Kinase Deficiency | Postpoliomyelitis Syndrome | Familial Hypertrophic Cardiomyopathy | Schwannoma | Seborrheic Dermatitis | Hoyeraal-Hreidarsson Syndrome | COACH Syndrome | Acute Motor Axonal Neuropathy | Trismus-pseudocamptodactyly Syndrome | Thyroiditis, Autoimmune | Malonyl-CoA Decarboxylase Deficiency | Budd-Chiari Syndrome | Hypertension, Renal | Goiter | Carbohydrate Metabolism Disorders | Pfeiffer Syndrome | Gangliosidosis, GM1 | Agammaglobulinemia | Tinea Versicolor | Crimean-Congo Hemorrhagic Fever | Charcot-Marie-Tooth Disease Type 2T | Maternally Inherited Diabetes And Deafness | Macular Degeneration | Skin Carcinoma | Seminoma | Peeling Skin Syndrome, Acral Type | Fuchs Dystrophy | Facioscapulohumeral Muscular Dystrophy | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Sarcomatoid Carcinoma Of The Lung | Pulmonary Stenosis | LEOPARD Syndrome | Pemphigus Foliaceus | Craniofacial Dysostosis | Malnutrition | Charcot-Marie-Tooth Disease, Type 2A | Pseudohermaphroditism