Cataract

About the Disease
Cataract, also known as cataracts, is related to senile cataract and cataract 1, multiple types. An important gene associated with Cataract is CRYBB3 (Crystallin Beta B3), and among its related pathways/superpathways is 1q21.1 copy number variation syndrome. The drugs Cyclopentolate and Atropine have been mentioned in the context of this disorder. Affiliated tissues include Eye, endothelial and cortex, and related phenotype is vision/eye.

Common Targets
Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | Proteasome Complex | LIM2 | PITX3 | G6647 | GJB2 | MIP | XRCC1 | GJA3 | EZR | TAPT1 | PSEN1 | m-Calpain | G472 | G3576 | KDR | TTR | FANCD2 | Calpain (nonspecified subtype) | XPC | CRBN | GSR | GSTM3 | RRAGA | CAMK1 | NEIL2 | F13A1 | ERCC6 | G3620 | FGFR2 | GFER | CHMP4B | OPRM1 | NHS | FTL | ABHD16A | GSTO1 | CHRM1 | CTSL | PPARA | Alpha-crystallin | CDK6 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | ALDH2 | ZNF350 | NF-kappaB (NFkB) | G5133 | G4780 | CDK4 | COMT | HSF4 | WRN | GJA8 | OGG1 | MAP2K1 | Chaperone (nonspecified subtype) | TGM2 | BRD4 | SOD2 | AGK | HSD11B1 | KLC1 | GSTO2 | G142 | C1orf167 | G581 | BLM | AKR1B1 | MAF | ALDH1A1 | GALK1 | CRYAA | OPRD1 | POLG | PPARG | SOD3 | CAPN1 | NTRK1 | CRYGC | GSTT1 | CRYAB | CRYGD | CAPN15 | OSBP | SLC11A2 | CRYBA1 | ERCC2 | G3630 | SOX9 | GYS1 | CRYBA4 | LMNA | TGFB2 | UCHL1 | CRYBB1 | TDO2 | APEX1 | PAX6 | CRYBB2 | EPHA2 | PDCD1LG2 | G4318 | Gamma Crystallin (nonspecified subtype) | G7157 | NR3C1 | COL11A1 | FASLG | HSD17B1 | APP | CTSB | SMUG1 | SLCO1B1 | G1786 | BRIP1 | GCNT2 | AGER | ITGB4 | PARP2 | MBD4 | Tubulin | FAS | FOXC1 | BFSP2 | G672 | FTO | NQO1 | TRPA1 | IFNG | FYCO1 | beta-Crystallin | GSTM1 | HRH4 | Glutathione peroxidase (nonspecified subtype) | mu-Calpain (calpain 1) | NEIL3 | Soluble guanylyl cyclase | VHL | CAPN2 | KCNAB1 | MTHFR | HSD17B3 | PITX2 | G7124

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