Medulloblastoma

About the Disease
Medulloblastoma, also known as mdb, is related to desmoplastic nodular medulloblastoma and childhood medulloblastoma, and has symptoms including headache, vomiting and gait ataxia. An important gene associated with Medulloblastoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Signaling by Hedgehog and Wnt / Hedgehog / Notch. The drugs Etoposide and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include lower part of the brain, brain and cerebellum, and related phenotypes are nausea and vomiting and increased intracranial pressure

Common Targets
MFAP1 | XIRP2 | HPS6 | MSL2 | BCLAF1 | TEKT5 | MAIP1 | CCDC159 | DVL3 | RTF2 | FUT4 | C2orf88 | MTMR4 | RARRES2 | OR2A14 | TMEM37 | G6774 | CLSTN3 | NF2 | RECQL4 | H3-3A | SIL1 | CD36 | VIL1 | SHANK1 | AIFM1 | RALYL | DCLRE1B | LRP6 | UTP6 | MUC17 | TPM3 | HSPA4L | MYO15A | HDAC2 | SLC26A1 | BCAM | TENM2 | XYLB | HRG | SDC1 | TOX3 | SMO | PIGM | SEMA6A | NCAN | SGPP2 | EXO5 | SLC9A1 | DNAJB8 | BTBD3 | POLDIP2 | G1026 | MC1R | GUCY2F | FARS2 | ADAMTSL3 | HSD17B2 | LMO7 | MYO7B | ACTL9 | SLC22A1 | BTBD17 | GTSE1 | OR2T1 | LYST | FGF3 | ANXA2R | TEX43 | CCND2 | RGS12 | G29126 | VAV1 | SMG6 | GLI2 | ESPNL | RYR1 | CD3 Complex (T Cell Receptor Complex) | TCF12 | EVI5 | PCDHA3 | PSMD13 | RIPOR2 | CASKIN1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | PCDH18 | ADAMTS13 | MLPH | FAT4 | GPR137C | LYRM4 | PLXNB2 | GPR149 | ZNF358 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CTDNEP1 | CFAP91 | PSMD3 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | MYOM2 | ANP32E | G5728 | KMT2C | C8B | JCAD | NLRP8 | STAC | ZC3H12C | GPR52 | SFTPA1 | SERPINI1 | SH2B1 | KIAA0319L | SUFU | NAT2 | KCNV1 | TRAF4 | Hedgehog Protein (nonspecified subtype) | OR5P2 | TPMT | PAMR1 | TRMU | MLN | CILP | ANXA11 | FLG | SIPA1L1 | PRKCA | XPOT | ZAN | ESX1 | POLE | DDX11 | CCDC107 | C5 | ERICH6B | ITGA8 | TEDC1 | TRMT5 | PRDM15 | KCNA4 | FAN1 | CCDC39 | CNTNAP5 | TTC16 | IDH1 | UAP1L1 | MTBP | OCLN | LY9 | PMS2 | TTLL4 | GLI3 | RASGRF2 | ATP10B | CKAP4 | CCDC169 | NWD1 | TYR | ADCK2 | AP4B1 | ZNF284 | CD180 | ARID2 | OTX2-AS1 | TTC28 | PIK3R1 | GRXCR2 | CILP2 | SF3B1 | CASR | DISC1 | LRRC4B | SPTA1 | DRD2 | DOCK6 | COL9A1 | TCF4 | CDPF1 | DBNDD1 | KIF27 | ZNF513 | RPGRIP1 | NOD2 | IRS4 | ATP10A | COMT | CDK5RAP1 | NAV1 | NUP42 | ANO8 | TF | ANKRD23 | ALPK1 | FMO5 | ACKR1 | SH3TC1 | SLC9A3 | SLC12A9 | HDAC1 | HHATL | ATP6V0A2 | ELP1 | SEMA6B | C9orf152 | CIT | CDKN2B-AS1 | HNRNPU | FGD6 | LACC1 | G4609 | FGA | ZNF444 | VPS72 | KAT6A | ATAD3B | TMEM117 | CDH8 | TMPRSS11E | PIEZO1 | SOX3 | MKS1 | PDPN | KCNK10 | HAPLN3 | TPBG | VWDE | PTCH1 | SOD2 | SLFN5 | G7157 | KLRK1 | ULK4 | GPX1 | CFAP43 | CASP8 | ADA | PRRX1 | ZFP28 | VAX1 | DNAH6 | GAMT | ROBO4 | NPM3 | USP18 | PTPRJ | FOXM1 | PRSS3 | CEP290 | TTC14 | ITGA11 | MAP3K13 | Casein kinase II (CKII) | DTX3L | SMIM2 | FAM193A | IARS1 | SLC4A2 | PKHD1 | ZNF526 | TULP1 | SYBU | BBS5 | GPAM | STAT5 (nonspecified subtype) | CCDC28B | FUCA1 | G9429 | SMURF1 | TFAP2A | GSTT1 | BIN3 | LOXL1 | CSMD1 | CTSZ | SMARCA4 | HRNR | WDR43 | RNMT | PRKCH | XRCC3 | OLIG2 | SLC22A15 | INTS2 | ACHE | PLA2G4D | R3HDM1 | RAD50 | LRRC36 | PCSK7 | UNC13C | ANO2 | PTPRM | C11orf40 | DICER1 | DOCK1 | NRP1 | DNHD1 | GRM8 | UBP1 | CDK17 | Tubulin | DSP | LRRC17 | SIGLEC1 | ACSL6 | PUM2 | ANKRD11 | GSDMB | SMAD2 | NMBR | PRB1 | STT3A | ACVR1 | USP54 | EVX1 | PTPN18 | HAVCR1 | KANK3 | CKAP2 | ARHGEF17 | LINC02693 | AKIP1 | MYOM1 | PNKP | ANKS3 | ADRB1 | LRP1 | PNP | FKBP9 | Mitogen-Activated Protein Kinase (nonspecified subtype) | EPYC | PLEKHG5 | GPAT2 | SORCS2 | KMT2A | G2033 | H3C3 | AMPH | CHUK | ASCL3 | IFNE | SOAT1 | TNS2 | RP1 | AOC1 | ELL3 | KLRC4-KLRK1 | ACOXL | RASSF8 | CCL27 | COL6A1 | PDLIM4 | FGF23 | CHIA | DENND1C | CDC14B | MAPK15 | AMDHD1 | ABCC6 | G2064 | CABP4 | ACSM1 | DCTN1 | MRI1 | TECPR1 | PIK3CA | TDRD6 | FSIP2 | F5 | SI | SLC22A4 | MARS1 | MSRB3 | CXCR6 | COG6 | LPIN2 | DAPK3 | MEFV | NELFA | ZNF235 | USH2A | KDM6B | CLPP | MCHR2 | ANKZF1 | TCHH | NOS3 | Janus Kinase (nonspecified subtype) | IL16 | NEFH | MMP2 | FAM118A | GABRA5 | BSN | KIFC1 | SMN1 | HYDIN | GIN1 | MAN2A2 | PART1 | SLC17A5 | CNGB1 | PLA2R1 | G5243 | CA14 | BLTP3A | PCARE | AHNAK2 | KIR3DL3 | TTN | SPATS2L | PKD1L2 | PTCHD1 | FURIN | PDE5A | UNC80 | POLR1B | VCX | PALB2 | SLC38A10 | KCTD10 | PGF | DKK4 | POLR2D | PRG2 | PYCR2 | LZTS3 | ITGAD | SLC10A2 | CYP2B6 | APOL1 | SCN1B | USE1 | CDAN1 | LRP2 | NGLY1 | ZNF610 | TOP2A | CALR | PLXNB1 | MAGEF1 | C3 | RFX6 | BIRC5 | GBA2 | OR6C4 | IL10 | LINC02843 | AKAP8 | FGD2 | OR52K1 | EPHX1 | TRIM32 | KMT2D | PGGT1B | CDH5 | GSTM1 | FAAP20 | OTC | ARTN | CFTR | CEP350 | SMN2 | TAP1 | TTLL12 | APBA1 | KLKB1 | OR7E24 | MYCN | Histone deacetylase (nonspecified subtype) | CFAP410 | TANGO6 | ARRDC1-AS1 | DCST2 | PEAR1 | CYP1B1 | SH3D21 | USP9X | FMO3 | QRICH2 | VPS13C | TSR1 | COL27A1 | CYP4A11 | NMRK2 | ABO | GRM4 | GSTP1 | WDFY4 | TTC3 | G2146 | PEX6 | POLR2E | IGF2BP2 | COL2A1 | DDX3X | CADPS2 | ADRA1B | MYH7B | G238 | C9orf43 | MTUS2 | VPS28 | FRS2 | OR4S2 | DRD3 | CD276 | CABP1 | ADCY9 | SLC10A4 | TMEM151A | N4BP2 | COPB2 | CD19 | E2F8 | KANK2 | MRTFA | MUC20 | CC2D2A | TUSC1 | HECW2 | KCNH7 | MSH2 | THOC5 | TUBAL3 | CBLB | CDH23 | EMX2 | NLRP12 | INF2 | CTNNB1 | OR6B2 | MLH1 | TXK | PAICS | JAK3 | RAB11FIP5 | RASSF2 | FCRL5 | OR5L1 | CACNA1F | FUT3 | LOC105377046 | JHY | KNDC1 | CD68 | SETD3 | HLA-C | PNLIPRP2 | MFSD6 | PLSCR2 | AOAH | ITGB6 | GOLGA4 | AHRR | ROBO3 | TOGARAM1 | GPR161 | G6714 | G7015 | MAGI2 | OR5M9 | MYBPH | GIGYF2 | GOLGB1 | SYTL2 | ARID3C | YES1 | DNAH10 | ALOX15 | LATS2 | CR2 | WNT4 | TUBB | FMN2 | RAPGEF5 | LLGL2 | RAD51AP2 | MINAR1 | EDC4 | OR51G2 | ZP3 | FHOD3 | INPP5J | CDKL4 | HEXIM2 | EBLN2 | MACROD2 | KDM6A | OSBP2 | OR9G1 | NCOR1 | G7015

Note: If you'd like to get a target analysis report for Medulloblastoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Medulloblastoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Congenital Dyserythropoietic Anemia | Hypoalbuminemia | Facioscapulohumeral Muscular Dystrophy Type 2 | Congenital Sodium Diarrhea | Spastic Paraplegia Type 7 | Schnyder Crystalline Corneal Dystrophy | Fibromyalgia | Subcortical Band Heterotopia | Idiopathic Pulmonary Fibrosis | Crimean-Congo Hemorrhagic Fever | Nephropathy | Crohn's Disease | Systemic Lupus Erythematosus | Smith-Lemli-Opitz Syndrome | Hypogonadism | Geleophysic Dysplasia | Juvenile Myelomonocytic Leukemia | Meier-Gorlin Syndrome | Vitelliform Macular Dystrophy | Muir-Torre Syndrome | Thalassemia | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Cancer, Skin | Seizures-scoliosis-macrocephaly Syndrome | Lattice Corneal Dystrophy Type 1 | Heart Failure | Vitreoretinopathy, Proliferative | Lattice Corneal Dystrophy | Kernicterus | Diabetic Macular Edema | Gastritis, Atrophic | Mucolipidosis Type III | Occipital Neuralgia | Congenital Primary Aphakia | Leigh Syndrome | Leukemia | Hereditary Inclusion Body Myopathy | Meningococcal Infections | Ebstein Anomaly | Acute Coronary Syndrome | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Donnai-Barrow Syndrome | Neurofibromatosis Type 1 | PASLI Disease | Benign Familial Neonatal Convulsions | Pycnodysostosis | Aneurysm, Abdominal Aortic | Azoospermia | Eccrine Porocarcinoma | Opisthorchiasis | Arrhythmogenic Right Ventricular Cardiomyopathy | Angiosarcoma Of The Breast | Tay-Sachs Disease | Bipolar Disorder | Preaxial Polydactyly | Gingivitis | Primary Hyperoxaluria | Mitochondrial DNA Depletion Syndrome 13 | Bullous Pemphigoid | Tinea Versicolor | Down Syndrome | Heimler Syndrome | Lymphedema-distichiasis Syndrome | Arthritis, Gouty | Loeys-Dietz Syndrome | Pyoderma Gangrenosum | Pierpont Syndrome | Congenital Diaphragmatic Hernia | Stroke, Ischemic | Skin Papilloma | Cornelia De Lange Syndrome | Infertility | Pontocerebellar Hypoplasia Type 7 | Coffin-Siris Syndrome | Autism Spectrum Disorders | Hereditary Mixed Polyposis Syndrome | Ectrodactyly | Wagner Disease | Hyperacusis | AIDS Dementia Complex | Pterygium | Distal Spinal Muscular Atrophy | Familial Retinal Arterial Macroaneurysm | Optic Atrophy 2 | Spitz Nevus | Fanconi Syndrome | Congenital Lipoid Adrenal Hyperplasia | Hypertension, Pulmonary | 3-methylcrotonyl-CoA Carboxylase Deficiency | Cholestasis, Intrahepatic | Spondyloepiphyseal Dysplasia Tarda, X-linked | Infantile Nephropathic Cystinosis | Cataplexy | Ocular Albinism Type 1 | Dementia, Vascular | Autonomic Neuropathy | Glutaric Aciduria Type 3 | Hyperkeratosis | Aspartylglycosaminuria | Botulism | Corneal Dystrophy And Perceptive Deafness | Pneumococcal Meningitis | Thyroid Dysgenesis | Hepatitis B, Chronic | Tyrosinemia Type 1 | Spinocerebellar Ataxia Type 20 | Marinesco-Sjogren Syndrome | Glycogen Storage Disease Type 1 | Lymphoproliferative Disease, X-linked | Cardiac Sarcoidosis | Cancer, Prostate | 3C Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Zollinger-Ellison Syndrome | Posterior Polar Cataract | Sarcomatoid Carcinoma Of The Lung | Spinocerebellar Ataxia Type 23 | Varices | Hereditary Neuropathy With Liability To Pressure Palsies | Hidradenitis | Sarcoma, Endometrial Stromal | Otosclerosis | Diarrhea | Lafora Disease | Thanatophoric Dysplasia | Paraganglioma, Carotid Body | Microcephalic Primordial Dwarfism | Long QT Syndrome Type 1 | Exotropia | Congenital Hypofibrinogenemia | Leiomyosarcoma | Pneumonia, Bacterial | Neuromyotonia | Chondrosarcoma | Hereditary Pyropoikilocytosis | N-acetylglutamate Synthase Deficiency | Macular Corneal Dystrophy | Castleman Disease | Alveolar Capillary Dysplasia | Chromosome 5q Deletion Syndrome | Herpes Genitalis | Hemoglobinopathies | Cutaneous T-cell Lymphoma | Hennekam Lymphangiectasia-lymphedema Syndrome | 3-methylglutaconic Aciduria Type I | Farber Disease | Headache | Leri-Weill Dyschondrosteosis | Congenital Ichthyosiform Erythroderma | Congenital Hereditary Endothelial Dystrophy Type I | Congenital Stationary Night Blindness | Autoimmune Polyendocrinopathy Syndrome Type I | Malignant Peripheral Nerve Sheath Tumor | Placenta Previa | Optic Neuropathy | Mood Disorder | Osteogenesis Imperfecta Type V | Emery-Dreifuss Muscular Dystrophy | Tumoral Calcinosis | Influenza | Acne Vulgaris | Cantu Syndrome | Dwarfism | Myelodysplasia | Spondylo-ocular Syndrome | Cardiac Arrest | Aplastic Anemia | Chronic Kidney Disease | Sclerocornea | Sialoadenitis | Homocystinuria | Metabolic Syndrome | DOCK8 Immunodeficiency Syndrome | Pupil Disorders | Adenomyosis | Cranioectodermal Dysplasia | Charcot-Marie-Tooth Disease Axonal Type 2N | Porencephaly | Pneumonia, Viral | Ichthyosis Bullosa Of Siemens | Pseudoachondroplasia | Maple Syrup Urine Disease | Kabuki Syndrome | Acrodysostosis | Pituitary Dwarfism | Distal Myopathy 2 | Nutrition Disorders | Angioimmunoblastic T-cell Lymphoma | Hemimegalencephaly | Ganglioneuroma | Alpha-thalassemia Myelodysplasia Syndrome | Retinal Vasculitis | Hemosiderosis | Cushing Syndrome | Spinocerebellar Ataxia Type 13 | Protein C Deficiency | Craniolenticulosutural Dysplasia | Chondromyxoid Fibroma | Xeroderma Pigmentosum | Combined Pituitary Hormone Deficiency | Cold Agglutinin Disease | Pyruvate Carboxylase Deficiency Disease | Sensorineural Hearing Loss | Blood Protein Disorders | Juvenile Hyaline Fibromatosis | Vaginitis | Sarcosinemia | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Still Disease | Eating Disorder | Hodgkin Lymphoma | Myotonic Disorders | Progressive Myoclonic Epilepsy | Hemorrhagic Disorders | Reticular Dysgenesis | Rhinitis | Dysthymia | Myoclonic Atonic Epilepsy | Waardenburg Syndrome Type 4 | Goldenhar Syndrome | Keratoconjunctivitis | Adenoma, Pituitary | Osteopetrosis | Otitis Externa | Roberts Syndrome | Progressive Familial Intrahepatic Cholestasis Type 3 | Pemphigus Vulgaris | Renpenning Syndrome | Sulfite Oxidase Deficiency | Ileitis | Birk-Barel Syndrome | Open-angle Glaucoma | Spinocerebellar Ataxia Type 12 | Apert Syndrome | Mabry Syndrome | Dysgerminoma | Cramp Fasciculation Syndrome | Bernard-Soulier Syndrome | Congenital Central Hypoventilation Syndrome | Non-Hodgkin Lymphoma | Liver Failure | Congenital Adrenal Hyperplasia | Tuberculosis | Spina Bifida | Renal-hepatic-pancreatic Dysplasia | Birt-Hogg-Dube Syndrome | Narcolepsy | Mitochondrial Cytopathy | Cholesteryl Ester Storage Disease | Acute Anterior Uveitis | Angioedema, Hereditary | Spinocerebellar Ataxia Type 38 | Wolcott-Rallison Syndrome | Autoimmune Disease | Epilepsy, Generalized | Delirium | Alpha-mannosidosis | Hypertrophy | Fraser Syndrome | Adenomatoid Tumor | Inflammatory Linear Verrucous Epidermal Nevus | Tetraplegia | Hypercalcemia | Hypercholesterolemia | Diabetes | Leukocyte Adhesion Deficiency Type 1 | Smith-Magenis Syndrome | Acute Motor Axonal Neuropathy | Renal Tubular Acidosis | Hereditary Folate Malabsorption | Cardiomyopathy, Restrictive | Cerebellar Ataxia, Cayman Type | Microcephaly | Fuchs Heterochromic Iridocyclitis | Pulmonary Sclerosing Hemangioma | Thromboembolism | Christianson Syndrome | Androgen Insensitivity | Non-epidermolytic Palmoplantar Keratoderma | Metaphyseal Chondrodysplasia, Schmid Type | Wolman Disease | Neuromyelitis Optica | Spinocerebellar Ataxia Type 15 | Gestational Trophoblastic Disease | Iron Deficiency Anemia | Adenoma, Villous | Photosensitivity | Chondroma | Hypertension, Renovascular | Alkaptonuria | Thrombocytopenia | Charcot-Marie-Tooth Disease, Type 6 | Distal Myopathy | Alexander Disease | Retinopathy, Diabetic | Stiff-man Syndrome | Bare Lymphocyte Syndrome | Cousin Syndrome | Bronchiolitis | Dyslipidemia | Kaposiform Hemangioendothelioma | Microtia | Meesmann Corneal Dystrophy | Tetanus | Incontinentia Pigmenti | Clouston Hidrotic Ectodermal Dysplasia | Alopecia Areata | Carbonic Anhydrase VA Deficiency | Nestor-Guillermo Progeria Syndrome | Persistent Fetal Circulation | Martsolf Syndrome | 3-hydroxy-3-methylglutaric Aciduria | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Coffin-Lowry Syndrome | Plasma Cell Dyscrasia | Cold-induced Sweating Syndrome | Transthyretin-related Amyloidosis | Ornithine Transcarbamylase Deficiency | Paternal Uniparental Disomy Of Chromosome 14 | Lymphoma, Mantle Cell | Seminoma | Aneurysm, Thoracic Aortic | Oral Lichen Planus | HANAC Syndrome | Poirier-Bienvenu Neurodevelopmental Syndrome | Migraine | Multisystemic Smooth Muscle Dysfunction Syndrome | Polycystic Kidney, Autosomal Dominant | DiGeorge Syndrome | Osteoporosis, Postmenopausal | Goiter | Pemphigus | Dupuytren Disease | Usher Syndrome | Stomatitis | Plasma Cell Leukemia | Polyomavirus Nephropathy | Trimethylaminuria | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Erdheim-Chester Disease | Hemangioendothelioma | Epidermolytic Palmoplantar Keratoderma | Inflammatory Bowel Disease | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Facioscapulohumeral Muscular Dystrophy | Cabezas Syndrome | Meningeal Melanocytoma | Encephalopathy, Glycine | Alcoholism | Chordoma | Dengue Hemorrhagic Fever | Epilepsy | Microvillus Inclusion Disease | Intestinal Tuberculosis | Peters-plus Syndrome | Diabetes Type 1 | Lipodystrophy | Myoclonus-dystonia Syndrome | Carbohydrate Metabolism Disorders | Desmosterolosis | Erectile Dysfunction | Congenital Bile Acid Synthesis Defect | Omenn Syndrome | Kashin-Beck Disease | Acute Tubular Necrosis | Intestinal Hypomagnesemia 1 | Premenstrual Syndrome | Giant Cell Glioblastoma | McKusick Type Metaphyseal Chondrodysplasia | Aceruloplasminemia | Hypermethioninemia | Uterine Leiomyoma | Camurati-Engelmann Disease | LMNA-related Congenital Muscular Dystrophy | Guillain-Barre Syndrome | Vitamin D Deficiency | Multicystic Renal Dysplasia | Leber Hereditary Optic Neuropathy | Gastritis | Paroxysmal Nocturnal Hemoglobinuria | Extramammary Paget's Disease | Basal Ganglia Disease, Biotin-responsive | Meckel-Gruber Syndrome | Hypertensive Retinopathy | Erysipelas | 3-M Syndrome | Optic Nerve Hypoplasia, Bilateral | Chronic Leukemia | Angiosarcoma | Hypogammaglobulinemia | Cri-du-chat Syndrome | Myopathy | Pain | Nicotine Dependence | Familial Exudative Vitreoretinopathy | Blepharitis | Encephalocele | Pericarditis | Chorea-acanthocytosis | GM2-gangliosidosis AB Variant