Juvenile Myelomonocytic Leukemia

About the Disease
Juvenile Myelomonocytic Leukemia, also known as leukemia, juvenile myelomonocytic, is related to noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia and noonan syndrome 3, and has symptoms including exanthema, fatigue and fever. An important gene associated with Juvenile Myelomonocytic Leukemia is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs homoharringtonine and Aldesleukin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and bone, and related phenotypes are juvenile myelomonocytic leukemia and Decreased viability

Common Targets
MAP2K1 | CDKN2B | AKAP12 | BMP4 | G3845 | TP73 | GM-CSF Receptor (GM-CSF-R) | CHFR | TET2 | RARB | GATA2 | DAPK1 | APC | SETBP1 | NF1 | CALCA | CBL | RASA4 | MGMT | JAK3 | MAP2K2 | PTPN11 | CSF2 | MLH1 | RASSF1 | ZRSR2 | G1029 | CDK1 | NRAS | G5347 | H19 | RRAS | G4780 | CDH13 | DNA Methyltransferase (DNMT) (nonspecified subtype) | IGF2-AS | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | ASXL1 | G2099 | CSF3

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