Spinocerebellar Ataxia Type 12

About the Disease
Spinocerebellar Ataxia 12, also known as spinocerebellar ataxia type 12, is related to spinocerebellar ataxia 36 and multiple system atrophy 1, and has symptoms including dysdiadochokinesis and head tremor. An important gene associated with Spinocerebellar Ataxia 12 is PPP2R2B (Protein Phosphatase 2 Regulatory Subunit Bbeta), and among its related pathways/superpathways are Akt Signaling and Dopamine-DARPP32 Feedback onto cAMP Pathway. Affiliated tissues include spinal cord, cerebellum and eye, and related phenotypes are hyperreflexia and cerebellar atrophy

Common Targets
PPP2R2B

Note: If you'd like to get a target analysis report for Spinocerebellar Ataxia Type 12, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spinocerebellar Ataxia Type 12 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pigment Dispersion Syndrome | Extramammary Paget's Disease | Hypercalciuria | Craniofacial Dysostosis | Congenital Hemolytic Anemia | Fetal Akinesia Deformation Sequence | Nephritis, Interstitial | Rift Valley Fever | Diabetes Gestational | Ocular Hypertension | Basal Ganglia Disease | Hypohidrotic Ectodermal Dysplasia | Spinocerebellar Ataxia Type 12 | Paracoccidioidomycosis | Thromboembolism | Malaria | Leber Congenital Amaurosis | Hereditary Folate Malabsorption | Spondylolisthesis | Vaginitis | Aspartylglycosaminuria | Esthesioneuroblastoma | Hypertensive Nephropathy | Ocular Albinism Type 1 | Immunoproliferative Disorders | Plasmacytoma | Retinal Vasculitis | Sandhoff Disease | Mesothelioma, Malignant | Periodic Limb Movement Disorder | Congenital Hereditary Endothelial Dystrophy Type II | Potocki-Shaffer Syndrome | Vertebrobasilar Insufficiency | Bronchiolitis | Lymphoma | Leprosy | Non-epidermolytic Palmoplantar Keratoderma | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Cholangiocarcinoma | Macular Corneal Dystrophy | 3-hydroxy-3-methylglutaric Aciduria | Multifocal Motor Neuropathy | Nager Acrofacial Dysostosis | Subacute Sclerosing Panencephalitis | Congenital Disorders Of Glycosylation | Syncope | Amyotrophic Lateral Sclerosis, Juvenile | Carcinoma, Squamous Cell | Hyperprolactinemia | Hepatic Adenomatosis | Low Phospholipid Associated Cholelithiasis | Hyperthyroidism | Antisocial Personality Disorder | Osteoporosis, Postmenopausal | Renal Tubular Acidosis | Lesch-Nyhan Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Oligoasthenoteratozoospermia | Hoyeraal-Hreidarsson Syndrome | Gastritis, Atrophic | Acrodysostosis | Nicotine Dependence | Mucolipidosis Type II | Arthritis, Psoriatic | Ellis-Van Creveld Syndrome | Seborrheic Dermatitis | Loeys-Dietz Syndrome Type 4 | Chorea-acanthocytosis | Sleep Apnea, Obstructive | Primary Pigmented Nodular Adrenocortical Disease | Congenital Afibrinogenemia | Stomatitis | Measles | Stickler Syndrome | Cryopyrin-associated Periodic Syndromes | Tangier Disease | Alveolar Capillary Dysplasia | Apert Syndrome | Diabetic Encephalopathy | Hypertension | Coronary Artery Disease | Megalencephaly | Wolff-Parkinson-White Syndrome | Perry Syndrome | Chanarin-Dorfman Syndrome | Pseudohypoparathyroidism Type 1C | Leiomyoma | Craniosynostosis | Neuromuscular Disorders | Angiomyolipoma | Blastoma, Pleuropulmonary | Charcot-Marie-Tooth Disease Type 2D | Donnai-Barrow Syndrome | Dyggve-Melchior-Clausen Disease | Familial Hemiplegic Migraine | Mitochondrial DNA Depletion Syndrome | Optic Nerve Hypoplasia, Bilateral | Duchenne Muscular Dystrophy | Cutaneous Mastocytosis | Burn-McKeown Syndrome | Tardive Dyskinesia | Chromosome 5q Deletion Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | HELLP Syndrome | Glutaric Aciduria Type 1 | Cutaneous Angiosarcoma | Biotinidase Deficiency | Corneal Neovascularization | CEDNIK Syndrome | Hyper IgE Syndrome | Focal Cortical Dysplasia Type 2 | Reticular Dysgenesis | Netherton Syndrome | GM2-gangliosidosis AB Variant | Myeloid Leukemia | Papillon-Lefevre Syndrome | Glycogen Storage Disease Type 4 | Adenoma, Pituitary | Esophageal Motility Disorders | Cat Eye Syndrome | X-linked Charcot-Marie-Tooth Disease | Autoimmune Polyendocrine Syndrome | Enterocolitis, Necrotizing | Porencephaly | Retinal Degeneration | Rhinitis | Eclampsia | Myotonic Disorders | Microphthalmia | Endocarditis | Schizencephaly | Polycythemia Vera | Brachial Plexus Neuropathy | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Glomerulonephritis, Membranous | Keratitis | Neuromyelitis Optica | Hepatorenal Syndrome | Seminoma | Leishmaniasis, Cutaneous | Rhizomelic Chondrodysplasia Punctata | Lymphoproliferative Disease, X-linked | Coronary Heart Disease | Stroke, Ischemic | Erythema Nodosum | Peripheral T-cell Lymphoma | Cardiomyopathy, Peripartum | Congenital Myasthenic Syndrome | Persistent Truncus Arteriosus | Angioedema, Hereditary | Familial Cerebral Amyloid Angiopathy | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Gerodermia Osteodysplastica | Hemochromatosis | Nail Disorder, Nonsyndromic Congenital | Miyoshi Myopathy | Congenital Poikiloderma | Lattice Corneal Dystrophy Type 1 | Cartilage Disorders | Pyruvate Decarboxylase Deficiency | Hepatic Steatosis | Bursitis | Porphyria | Ataxia-ocular Apraxia 2 | Hyperkeratosis | Neutrophilia | Primary Cutaneous Amyloidosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Venous Insufficiency | Chronic Granulomatous Disease, X-linked | Carcinoma, Transitional Cell | Acute Coronary Syndrome | Early Infantile Epileptic Encephalopathy 28 | Pseudohermaphroditism | Insulinoma | Autosomal Recessive Bestrophinopathy | Spondylosis | Isovaleric Acidemia | Saethre-Chotzen Syndrome | Adenoma, Pleomorphic | Fucosidosis | Familial Digital Arthropathy-brachydactyly | Chromosome 8q21.11 Deletion Syndrome | Congenital Fiber-type Disproportion Myopathy | Enlarged Vestibular Aqueduct | Inflammatory Myofibroblastic Tumor | X-linked Creatine Transporter Deficiency | Hypersensitivity Pneumonitis | Congenital Myopathy | Cystitis | Familial Exudative Vitreoretinopathy | Anodontia | Peeling Skin Syndrome Type B | Carbonic Anhydrase VA Deficiency | Metaphyseal Chondrodysplasia, Schmid Type | MELAS Syndrome | Carney-Stratakis Syndrome | Diabetes Insipidus | Whipple's Disease | Thyroid Hormone Resistance | Hyperglycemia | Pneumococcal Meningitis | Atrial Septal Defect | Glutaric Aciduria Type 3 | Avian Influenza | Hypertelorism | Hypertension, Renovascular | Nephropathy | Schistosomiasis | Fibrosarcoma | Cold-induced Sweating Syndrome | Arthritis, Gouty | Vascular Calcification | Stroke, Hemorrhagic | Alopecia Totalis | Scleroderma | Multiple Sclerosis | Autosomal Recessive Spastic Paraplegia Type 75 | Pseudomyxoma Peritonei | Erythematotelangiectatic Rosacea | Myelodysplasia | Angina Pectoris | Congenital Mirror Movements | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Ureteropelvic Junction Obstruction | Familial Glucocorticoid Deficiency | Arterial Tortuosity Syndrome | Spitz Nevus | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Chondrodysplasia Punctata 2, X-linked Dominant | Thrombasthenia | Sponastrime Dysplasia | Chronic Neutrophilic Leukemia | Tonsillitis | Congenital Aniridia | Panic Disorder | Osteopetrosis | Progressive Myoclonic Epilepsy | Hyperlipidemia | Ameloblastoma | Neurogenic Bladder | Neurofibroma, Plexiform | Anorectal Malformations | Galactosialidosis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Paternal Uniparental Disomy Of Chromosome 14 | Lyme Disease | Gilbert Syndrome | T-cell Chronic Lymphocytic Leukemia | Anthrax | Otitis Media | Hypogammaglobulinemia | Hermansky-Pudlak Syndrome | Pompe Disease | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Duane Retraction Syndrome | Pemphigus | Iron Deficiency Anemia | Erythromelalgia | Epidermal Nevus Syndrome | Krabbe Disease | Asperger Syndrome | Ependymoma | Congenital Dyserythropoietic Anemia Type 4 | Neurofibromatosis | Spinocerebellar Ataxia Type 8 | Motion Sickness | Combined Deficiency Of Factor V And Factor VIII | Lactose Intolerance | Retinopathy Of Prematurity | Hyperphenylalaninemia | Non-Hodgkin Lymphoma | DNA Ligase IV Deficiency | Carbamoyl Phosphate Synthetase I Deficiency | Lathosterolosis | Language Disorders | Juvenile Hyaline Fibromatosis | Infertility | Idiopathic Pulmonary Fibrosis | Hypoplastic Left Heart Syndrome | Nestor-Guillermo Progeria Syndrome | Pure Red Cell Aplasia | Tyrosinemia Type 1 | Pancreatitis, Chronic | Lymphoma, Mantle Cell | Hypokalemic Periodic Paralysis | Juvenile Polyposis | Nijmegen Breakage Syndrome | Bone Marrow Necrosis | Osteopathia Striata With Cranial Sclerosis | Adenocarcinoma | Osteitis | Plasma Cell Leukemia | H Syndrome | Agoraphobia | Hepatitis C, Chronic | Premature Ejaculation | Cardiofaciocutaneous Syndrome | NGLY1 Deficiency | Pyruvate Kinase Deficiency | Ophthalmia, Sympathetic | Atopy | Waardenburg Syndrome Type 4 | Pleural Tuberculosis | Diffuse Palmoplantar Keratoderma | Osteomyelitis | Huntington's Disease-like 2 | Brooke-Spiegler Syndrome | Gastritis | Gestational Trophoblastic Disease | Autoimmune Hemolytic Anemia | Holt-Oram Syndrome | NDH Syndrome | Patent Ductus Arteriosus | Prolymphocytic Leukemia | Focal Dermal Hypoplasia | Neurodegeneration With Brain Iron Accumulation | Proopiomelanocortin Deficiency | Alpha-mannosidosis | Hepatitis B, Chronic | Hypokalemia | Acute Motor Axonal Neuropathy | Micro Syndrome | Optic Neuropathy, Anterior Ischemic | Osteonecrosis | Hypotension, Orthostatic | Charcot-Marie-Tooth Disease Type 3 | Pulverulent Zonular Cataract | Corneal Dystrophy And Perceptive Deafness | Cutaneous T-cell Lymphoma | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Androgenic Alopecia | Muir-Torre Syndrome | Paraplegia | Osteosarcoma | Exotropia | Hemangioma | Purpura, Thrombotic Thrombocytopenic | Hypertension, Pulmonary | Kabuki Syndrome 2 | Leukocyte Adhesion Deficiency | Primary Progressive Nonfluent Aphasia | Astrocytoma | Williams Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Focal Segmental Glomerulosclerosis | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Hepatitis, Chronic | Retinal Detachment | Cheilitis | Dentinogenesis Imperfecta | Otosclerosis | Treacher Collins Syndrome | Arrhythmogenic Right Ventricular Cardiomyopathy | Spitzoid Melanoma | Aplastic Anemia | Transcobalamin Deficiency | Corneal Ulcer | Aldosteronism | Connective Tissue Disorders | Lymphangiomatosis | Psoriasis | Congenital Dyserythropoietic Anemia Type 1 | Echinococcosis | Nephrocalcinosis | Lupus Erythematosus | Sarcoma, Ewing | Diffuse Mesangial Sclerosis | Xeroderma Pigmentosum Variant Type | Necrotizing Autoimmune Myopathy | Agnathia-Otocephaly Complex | Neurofibromatosis Type 2 | Fibrosis | Tietze Syndrome | Congenital Generalized Lipodystrophy | Polymicrogyria | Epidermolysis Bullosa Dystrophica | Congenital Nephrotic Syndrome | Wagner Disease | Gynecomastia | Kearns-Sayre Syndrome | Early Infantile Epileptic Encephalopathy | Cholelithiasis | Hereditary Hemorrhagic Telangiectasia Type 2 | Yellow Fever | Cyclic Vomiting Syndrome | Meningitis | Ischemia | Primary Ovarian Insufficiency | Frank-ter Haar Syndrome | Recurrent Respiratory Papillomatosis | Parkinsonism | Postaxial Polydactyly | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | C3 Glomerulopathy | Paraganglioma, Carotid Body | Oculocutaneous Albinism Type 4 | Leber Hereditary Optic Neuropathy | Asplenia | Blepharitis