Lymphoma

About the Disease
Lymphosarcoma, also known as lymphoma, diffuse, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Lymphosarcoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and Interleukin-13 signaling. The drugs Crofelemer and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid.

Common Targets
TNFRSF9 | JAK3 | CARD8 | G5347 | G114548 | JAK1 | TNFRSF10B | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | IL2RB | TNFAIP8 | CHEK2 | PIK3CG | BIRC2 | G596 | FAM110B | KDR | CRBN | PVT1 | XRCC1 | G6714 | NTRK2 | TEC | NFKB1 | GJB2 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | AURKA | FCGR1A | G1956 | CD248 | DNA-Directed DNA Polymerase Complex | ABL1 | KLRD1 | HDAC10 | CD24 | GSR | IL1B | JAK2 | MALT1 | ASNS | FOLR2 | PLK2 | G6774 | PTPRD | G3569 | MYD88 | G2335 | CDK2 | Serine/Threonine Kinase (nonspecified subtype) | G7015 | TFRC | Tyrosine-Protein Kinases Src (nonspecified subtype) | CSK | MAX | NR1I3 | Tachykinin Receptor (nonspecified subtype) | I-kappa-B-kinase (IKK) complex | HDAC6 | IL2RG | HDAC2 | FGFR2 | CD1A | FSCN1 | BTK | BNC1 | Integrin alphavbeta3 (vitronectin) receptor | AMP-activated protein kinase (AMPK) | IFI44L | HOXA9 | CDK5/p25 | Heat shock protein 90 (nonspecified subtype) | DAB2 | NR1H2 | PRMT5 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | RRM1 | HIF1A | G595 | TSPAN33 | KCND3 | HMOX2 | G1/S-specific cyclin-E (nonspecified subtype) | MIR155 | SLC7A5 | PRKCA | IL2RA | CDK6 | TM2D3 | CHEK1 | IRAK3 | G207 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CCR4 | G1432 | NF-kappaB (NFkB) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | LAG3 | AXL | BMX | LPP | G7099 | NR1H3 | Ribonucleoside-diphosphate reductase | Calcium channel (nonspecified subtype) | Protein kinase C (nonspecified subtype) | UNC13D | HLA class II histocompatibility antigen DR (HLA-DR) | VWA5B1 | TYK2 | G5133 | EED | EML4 | Lipoxygenase (nonspecified subtype) | G598 | BRD2 | PLK3 | RRM2 | CSF1R | CD3 Complex (T Cell Receptor Complex) | PIM3 | TNFRSF18 | TNFSF13B | mTOR complex 1 | G7295 | CLK4 | CDK5 | DHODH | CDK4 | IKZF1 | G29126 | KIT | DCK | TOP1 | G4780 | MAP3K14 | IL3RA | Glutamate Transporter (nonspecified subtype) | CDK9/Cyclin T1 | SHOX2 | PIK3CB | FCRL1 | G7852 | BRCA2 | GART | ARG1 | CACNG8 | CYP1A1 | ICAM1 | MAP2K1 | RHOH | NADH dehydrogenase (Complex I) | REL | IL-2 receptor | HLA-DRB1 | XIAP | FGFR3 | BRD4 | UPF3A | PIK3CD | ZNF503 | NRN1 | DNA Topoisomerase II (nonspecified subtype) | NR1I2 | Adenosine deaminase (nonspecified subtype) | ROS1 | HDAC3 | CDK9 | G673 | G4137 | GABRG3 | ADA | FCRL3 | IRF4 | IL15 | DYRK1A | PDPK1 | CD40 | CD44 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | Chaperone (nonspecified subtype) | TPBG | ID4 | SIRPA | XPO1 | CD52 | ZAP70 | CD38 | Histone acetyltransferase (HAT) (nonspecified subtype) | Integrin alphavbeta5 receptor | NCK1 | Eukaryotic Translation Initiation Factor 4A (eIF-4A) | CD22 | ABCC2 | Interleukin-12 (IL-12) | NTRK3 | IRAK4 | HLA-DRA | ITK | SYK | KLRK1 | LOC105374265 | SEPTIN9 | CEACAM8 | PDGFRB | Pim Kinase (nonspecified subtype) | CDK4/Cyclin D | Na+/K+-ATPase (nonspecified subtype) | G581 | HDAC1 | Reverse transcriptase (Telomerase) | G4170 | MUC1 | FCGR3A | CCNT1 | EZH1 | CDK20 | PRKCD | ITGA5 | PTGS1 | PPARG | CD55 | G4609 | Voltage-Gated Sodium Channel Complex | SLC22A2 | FCRL2 | AKT2 | ACHE | CASP8 | G920 | BIRC3 | NTRK1 | GPD1 | LYPLA1 | Heme Oxygenase (HO) (nonspecified subtype) | CSNK1A1 | Interferon (nonspecified subtype) | G9429 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | Cyclin D (nonspecified subtype) | CD7 | MS4A1 | CD70 | BCL2A1 | G2475 | Pyruvate dehydrogenase kinase (nonspecified subtype) | SYT2 | MME | Polycomb Repressive Complex 2 | RPSA | TNFAIP3 | IRF5 | ZFPM2 | PNP | GSTT1 | CHUK | DAPK1 | G3480 | mTOR complex 2 | FLT4 | G6PC1 | CCND3 | CD59 | CXCL13 | IKZF3 | KIF11 | MMP13 | CYP1A2 | Transforming growth factor beta (nonspecified subtype) | IL1RAP | Sodium channel (nonspecified subtype) | Caspase (nonspecified subtype) | GRM3 | RAD51 | alpha-beta T Cell Receptor Complex (TCR) | FLT1 | G836 | LYPLA2 | FGFR1 | CD3E | HLA-DRB3 | KLRC4-KLRK1 | TNFRSF13C | CDK2/Cyclin A | TGFB2 | G4318 | CLEC16A | BCL2L2 | CCNE1 | BLK | Heat shock protein 70 (nonspecified subtype) | ROR1 | NR3C1 | G7157 | Ikzf1 | TNFRSF17 | BTLA | CLK1 | AP-1 Transcription Factor Complex | FGFR4 | NCR3LG1 | Adenosine receptor (nonspecified subtype) | PIM1 | G4193 | CDK8 | BRD3 | IL2 | POLA1 | ENTPD1 | TNFRSF4 | CXCR2 | Chemokine receptor (nonspecified subtype) | SRSF2 | METAP2 | CDK2/Cyclin E | TIGIT | HAVCR2 | Tubulin | PRKCQ | RALBP1 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | MMP2 | PALB2 | G1786 | MAP2K2 | LRRC32 | CD79B | G5743 | TLR9 | G3082 | PLK4 | ITPKB | NAMPT | Cyclin A (nonspecified subtype) | BCL6 | CTLA4 | TNFRSF8 | CFH | G4233 | TYMS | MUC5AC | HLA-DRB5 | IL-13 receptor | PIK3CA | CD47 | GATA3 | WT1 | CD28 | IRAK1 | CCR5 | CD37 | G2064 | G7124 | ALB | AKT3 | GSPT1 | LGALS1 | STING1 | BIRC5 | DIABLO | FLT3 | DNAH14 | PDGFRA | IL10 | DHFR | MAT2A | HASPIN | PTPRC | NLRP3 Inflammasome | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | CLK2 | TXK | Proteasome Complex | RET | SLC1A2 | MGMT | FCRL5 | KLRB1 | VHL | Interleukin 23 complex (IL-23) | CXCL5 | TOP2A | CD5 | Histone deacetylase (nonspecified subtype) | G2146 | G5243 | CDK1 | CD19 | CDK7 | ASRGL1 | POU2AF1 | PIM2 | CDK19 | AHI1 | IL18 | TNFSF4 | G238 | TRBC1 | HMOX1

Note: If you'd like to get a target analysis report for Lymphoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Lymphoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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