Raynaud Phenomenon

About the Disease
Raynaud Disease, also known as raynaud phenomenon, is related to antisynthetase syndrome and scleroderma, familial progressive, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Raynaud Disease is CENPB (Centromere Protein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Cilostazol and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and heart, and related phenotypes are abnormality of the skeletal system and raynaud phenomenon

Common Targets
Prostanoid Receptor (nonspecified subtype) | PTGES | Calcium channel (nonspecified subtype) | TRPM8 | EPHX2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | ADRA2B | PTGIR | DYRK1A | DGAT2 | G5243 | PPID | NFATC2 | AVPR2 | HPGD | GSK3B | IL10 | OPRD1 | PDE5A | HTR2A | Prostanoid TP receptor (nonspecified subtype) | HRH1 | SFTPD | alpha1-Adrenoceptor (nonspecified subtype) | AGTR2 | NPR1 | CDK1 | Soluble guanylyl cyclase | ADRA2C | OPRM1 | AVPR1A | ACE | Epoxide Hydrolase (nonspecified subtype) | OPRK1

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