Disease

Glioblastoma

About the Disease
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

Common Targets
MEDAG | APC | ISL1 | CBLN1 | HLA-DQB1 | CTNNB1 | ADAM32 | GDNF | MYNN | PSMA2 | IDUA | RAB6C | DNA-Directed DNA Polymerase Complex | CLEC2L | MCAM | G472 | PNMT | POLD1 | CYBA | MIR20A | OR5AR1 | ABL1 | HEATR3 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TERF2 | G1956 | G0S2 | H3-3A | JAK2 | NBN | ZMYND10 | DCLRE1B | G3845 | MLH1 | SHANK1 | PDHX | RNF135 | RECQL4 | LMF1 | EDNRA | STN1 | MDM4 | PARP3 | CCDC26 | LDLR | ZBTB16 | ALPL | CORO6 | CNGA3 | STEAP4 | THAP4 | ADGRL4 | H3-3B | SDC1 | EXO5 | CD24 | TCEA3 | B3GNT7 | HOXD8 | FOLR2 | SOCS1 | GNAL | ATG2B | MARVELD2 | FAP | NPTX2 | LIMD1 | PRR15 | PRRT1 | G6774 | CD27 | ONECUT2 | G7015 | NOTCH3 | MEGF10 | AHDC1 | DDX23 | TTC12 | MAP2 | CSK | SRRM3 | TOM1L1 | TFRC | LCLAT1 | KIAA1614 | TBX1 | TUBA4B | MEG3 | G4089 | BTK | HDAC6 | ERCC1 | VAV1 | ARCN1 | SSTR2 | MAP4 | IL13RA2 | SMO | CNTN2 | ME1 | ITGA10 | RYR1 | DGAT1 | GRIN1 | Integrin alphavbeta3 (vitronectin) receptor | LUM | FGFR2 | GHSR | PCDH11X | CYSLTR1 | SFRP2 | CBLN3 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TBR1 | BNC1 | CYTOR | LGALS3 | THRB | VILL | SOST | CCND2 | GSTM5 | NXPH4 | BMP4 | PLA2G4A | OR5P2 | G595 | LRFN5 | SLC16A8 | HIF1A | ADRA1A | NR1H2 | PARP9 | PAMR1 | KMT2C | FAT1 | RAD52 | NLRP5 | RPS6KA3 | DRD4 | SEMA3E | HNRNPA2B1 | KEL | LZTR1 | CDK6 | MYL12A | BCAN | NRAS | SCGB3A1 | HRAS | MIR10B | MIR137 | SLC7A5 | OBSCN | ATRX | GRIA1 | AKAP6 | NEUROD1 | C1QTNF12 | KLHL35 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CNR2 | NF-kappaB (NFkB) | TGFB1 | VEGFC | XRCC2 | TMED7-TICAM2 | AXL | LY6H | LRRC55 | HNRNPF | CLSTN1 | CA1 | FAM229A | HER (erbB) (nonspecified subtype) | G207 | SLC35G2 | MAPK6P2 | TNC | NRG2 | AGT | TAFA1 | GFI1 | HOXD13 | SCD | CD3 Complex (T Cell Receptor Complex) | SLC26A3 | G7099 | G5133 | GRM6 | ISM1 | CSF1R | APLNR | ACSL1 | RAPGEFL1 | NR1H3 | AREG | POLE | KIT | DLGAP3 | G1950 | AP4B1 | ZNF99 | Lipoxygenase (nonspecified subtype) | CDK4 | RBBP4 | ATG5 | RCOR1 | FPR1 | TNFRSF18 | CDKN2B | G29126 | TUBA3D | RAD54B | GLI3 | G5728 | MOG | CYTB | TBX18 | IL4R | KCNS2 | MAOA | TOP1 | IDH1 | G4780 | UNC13A | IPO4 | FZD6 | TUBA3C | G7852 | PMS2 | SPTA1 | TJP1 | GRIA2 | TACC3 | HLA-B | ARID2 | TP73 | ATP5MC2 | DDR2 | MIR375 | CELF5 | MRC1 | G4851 | PDE10A | BCR | BRCA2 | CELF4 | TRPM8 | PIK3R1 | ATG16L1 | NR4A1 | CYP11A1 | HOXA11 | NOD2 | UGT2B4 | IER3 | HLA-DRB1 | LOC145845 | NOTCH4 | HPDL | SPACA6 | EMP3 | HLA-J | MT1M | PHLDB1 | PIK3C2A | CACNG8 | SERPINB1 | CD200 | FGFR3 | COL9A2 | EPHB4 | IQSEC1 | FLOT1 | NKD1 | CNR1 | WIF1 | G673 | HLA-L | SFRP4 | DKK1 | CACNA1C | LYL1 | NFKBIA | ROS1 | LINC02610 | TMEM26 | RTL4 | MAL | EYA4 | CDKN2B-AS1 | PDPN | NDRG2 | CLIC1 | Integrin alpha5beta1 (VLA-5) receptor | PMEL | FABP3 | WDR7 | ROBO4 | DHRSX | CA7 | G4137 | MIR328 | TRPV2 | IL15 | Estrogen receptor (nonspecified subtype) | PXDN | G1029 | ENO1 | NPM2 | PDGFRB | TOX2 | ANGPT2 | ID4 | Integrin alphavbeta5 receptor | EDNRB | TPBG | G142 | PIK3C2B | Histone acetyltransferase (HAT) (nonspecified subtype) | NSD1 | KLRK1 | LAMP1 | MIR21 | WNK2 | INA | ACRBP | DNAH1 | TFAP2A | LRRC31 | SEPTIN9 | TET2 | APBA2 | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | LRRC3B | EPHA3 | RNPC3 | PIKFYVE | CMYA5 | TRPV1 | G4609 | C1orf94 | DPP10 | EFEMP1 | TET1 | RPP25 | ZBED3 | PPARG | ANO2 | PTGS1 | COL1A2 | STK11 | POT1 | TREM2 | TP73-AS1 | LHX5 | SOCS3 | HLA-A | ACTR3C | DCT | RNF39 | PIK3C2G | PTPN1 | SKOR1 | ZNF655 | RHBDF2 | PYCARD | JAG1 | AKT2 | F2 | PRR16 | QPCT | NTRK1 | LOC100287944 | GSK3B | TSPO | AXIN1 | KIF5C | NRP1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | G2475 | GSDMB | KCNIP3 | MTSS1 | KHDRBS2 | ATG4B | CD70 | IL5 | SMARCA4 | DDIT3 | M1AP | SEMA3C | PSMD10 | ARL9 | XRCC3 | ITGA7 | RTEL1 | TES | B3GALT4 | RASGRP2 | MACROD1 | GSTT1 | ACKR3 | AOX1 | LAD1 | ENO2 | NFIL3 | CDH18 | PCDHGA4 | FLT4 | MAML2 | G3480 | RBP1 | NRXN1 | ALS2CL | mTOR complex 2 | HUWE1 | SPEG | PDE4C | POLR3B | NUAK1 | NEFM | G6PC1 | CPQ | NTN1 | BCAT1 | MOXD1 | KIF11 | IL18RAP | IDH2 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | PIK3C3 | CCDC68 | PDLIM4 | COPS5 | HPS1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | KDM1A | FLT1 | ADAM12 | RAVER2 | CLCN3 | LINC00092 | RAD51 | NR2F2 | MCF2L2 | WFDC2 | G7157 | FMOD | NFKBIZ | CD3E | SEMG1 | FGFR1 | KLRC4-KLRK1 | SST | FBP1 | HSD11B2 | MARS1 | PKM | SFRP5 | RASSF10 | LINC01341 | ACTG1 | PROM1 | MSC | HEY1 | AOPEP | SLC4A4 | GJB6 | CHI3L1 | LIF | TGFB2 | DNA topoisomerase (nonspecified subtype) | DGKA | TEK | EPHA2 | AP-1 Transcription Factor Complex | LRRC15 | FGFR4 | DDN | TMEM235 | APEX1 | GJA1 | CLCN5 | Poly [ADP-ribose] polymerase (nonspecified subtype) | TXNRD1 | PRKCB | PVR | RB1 | IRF6 | G4193 | TMEM97 | SCD5 | MYO15B | RBP7 | Integrin alpha7beta1 Receptor | MBP | PLA2R1 | PACS2 | PAX6 | IL12A | DSC3 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | PTH1R | Tubulin | RFX4 | FASLG | CPNE8 | LZTS2 | NIPAL4 | CBLN4 | EPHA5 | TNXB | TPPP3 | EPHA10 | SCN9A | SHH | TAMALIN | TNFRSF4 | CCSER1 | VRK2 | ULK2 | HOXC4 | ZAR1 | PDE4A | SEL1L | GSX2 | MMP8 | TAPBPL | TIGIT | PGF | Integrin alpha-10/beta1 | PIDD1 | ACTA1 | DHX33 | G1786 | ERBB4 | PDHA1 | SEMA3A | HLA-DPB1 | CPEB1 | GRAMD2A | FANCA | CTLA4 | G5743 | NF1 | G3082 | ZNF704 | SELENOP | Integrin alphavbeta1 | GRID2IP | G4233 | WT1 | PIK3CA | CCNI2 | UGT2A3 | CRACR2A | PARP2 | RRAS | PPP1R14A | SLC34A2 | HPSE2 | NT5E | CPLX1 | G7124 | NSUN7 | ATG10 | VAX2 | CRACDL | NID2 | CLHC1 | SMARCB1 | HCAR2 | SFRP1 | IL-13 receptor | ETFA | G367 | G2064 | MUS81 | G672 | EPHX3 | CALCR | FLT3 | ULBP1 | CFTR | ALB | DRC1 | SSTR1 | NBL1 | FYN | SEC31B | RHOD | MYCN | TRPA1 | HTR2A | BST2 | MIF | AKT3 | GNMT | LPCAT2 | BIRC5 | FTO | COL21A1 | HPGDS | GRPR | PPP1R36 | SLC2A3 | PDGFRA | FCHSD1 | DCLRE1A | PTPN11 | GABRA6 | RGMA | C2orf80 | TRAF3IP2 | SERPING1 | IL10 | GSTM1 | OPCML | RET | CX3CR1 | OR5D13 | H3C2 | DKK3 | TOP2A | VHL | CFLAR | MGMT | G5243 | MIR196A2 | G2146 | ALDH1A3 | VTI1A | RHBDF1 | GOLGA3 | AKR7A3 | ALOX5 | IL4 | KIR2DS4 | PLAUR | DLL4 | MICA | PSD | RTEL1-TNFRSF6B | RPL5 | CRIP1 | SNX31 | CD276 | ONECUT1 | COL11A2 | MYADM | ULK1 | SIX3 | CYP19A1 | SCARNA5 | OR5D18 | ADGRA2 | EPAS1 | PPM1D | HOTAIR | G238 | HOXA5 | RAB27B | IL13 | KCNB1 | NEIL3 | G7422 | LRIG1 | CER1 | ANXA2 | EVX2 | RAD54L | SOX2-OT | DKK2 | GSTP1 | STAG2 | HLA-C | ZMIZ1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | MIR199A1 | MYRIP | G5347 | GPR55 | MAGI2 | RAD51B | CMTM2 | GAREM2 | MSH6 | HMOX1 | FAM83F | IDO2 | MIR199A2 | CRBN | SSH3 | PICK1 | MSH2 | OR8K3 | KDR | PIK3CG | H2AC25 | NKAIN2 | TCF7L2 | XRCC1 | YES1

疾病靶点研报
Glioblastoma

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