Disease

Peutz-Jeghers Syndrome

About the Disease
Peutz-Jeghers Syndrome, also known as pjs, is related to congenital heart defects, hamartomas of tongue, and polysyndactyly and appendix adenocarcinoma. An important gene associated with Peutz-Jeghers Syndrome is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, cervix and colon, and related phenotypes are multiple lentigines and gastrointestinal carcinoma

Common Targets
G2475 | IL1F10 | FKBP1A | PMS1 | PMS2 | MUTYH | ZAN | ZBTB39 | STK11 | OR4C45 | DSP | SMAD9 | MLH3 | TDG | APBB3 | MMRN1 | APC | SPNS1 | DSPP | AXIN2 | MLH1 | TENM4 | MSH2 | MSH6 | G5728 | OR5D13 | SLX4

疾病靶点研报
Peutz-Jeghers Syndrome

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