Peutz-Jeghers Syndrome

About the Disease
Peutz-Jeghers Syndrome, also known as pjs, is related to congenital heart defects, hamartomas of tongue, and polysyndactyly and appendix adenocarcinoma. An important gene associated with Peutz-Jeghers Syndrome is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, cervix and colon, and related phenotypes are multiple lentigines and gastrointestinal carcinoma

Common Targets
G2475 | IL1F10 | FKBP1A | PMS1 | PMS2 | MUTYH | ZAN | ZBTB39 | STK11 | OR4C45 | DSP | SMAD9 | MLH3 | TDG | APBB3 | MMRN1 | APC | SPNS1 | DSPP | AXIN2 | MLH1 | TENM4 | MSH2 | MSH6 | G5728 | OR5D13 | SLX4

Note: If you'd like to get a target analysis report for Peutz-Jeghers Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Peutz-Jeghers Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Osteogenesis Imperfecta Type II | Hennekam Lymphangiectasia-lymphedema Syndrome | Thrombophilia | Gestational Trophoblastic Disease | Tularemia | Graft-versus-host Disease | DEND Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Waardenburg Syndrome Type 4 | Acne Vulgaris | Acute Motor Axonal Neuropathy | Avian Influenza | Frank-ter Haar Syndrome | Malignant Peripheral Nerve Sheath Tumor | Familial Hemiplegic Migraine | Acne | Neovascular Glaucoma | Hyperammonemia | Mycosis Fungoides | Autism Spectrum Disorders | Carney Triad | Superficial Spreading Melanoma | Fibrodysplasia Ossificans Progressiva | Inflammatory Linear Verrucous Epidermal Nevus | Oligoasthenoteratozoospermia | Sensorineural Hearing Loss | Shwachman-Bodian-Diamond Syndrome | Limb Girdle Muscular Dystrophy | Smith-Magenis Syndrome | Pseudoexfoliation Syndrome | Schizencephaly | Oligospermia | Spinocerebellar Ataxia Type 7 | Metabolic Diseases | Lymphopenia | Eclampsia | Trismus-pseudocamptodactyly Syndrome | Desbuquois Syndrome | Hereditary Xerocytosis | Acanthosis Nigricans | Pneumoconiosis | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Periventricular Nodular Heterotopia | Schamberg Disease | Cataract | Anal Fissure | Deafness, Dystonia, And Cerebral Hypomyelination | Smoldering Myeloma | Hypopituitarism | Ectrodactyly | Narcolepsy | Myotonia | Astrocytoma, Anaplastic | Agammaglobulinemia | Nance-Horan Syndrome | Muscle Wasting | Creatine Deficiency Syndrome Due To AGAT Deficiency | Pulmonary Stenosis | Anti-NMDA Receptor Encephalitis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Acute Myeloid Leukemia | Hereditary Neuropathy With Liability To Pressure Palsies | Celiac Disease | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Waardenburg Syndrome Type 4A | Amenorrhea | Pearson Syndrome | Spastic Paraplegia Type 7 | Progressive Familial Intrahepatic Cholestasis | Larsen Syndrome | Hodgkin Lymphoma | Nasodigitoacoustic Syndrome | GLUT1 Deficiency Syndrome | Loeys-Dietz Syndrome | Sandhoff Disease | Citrullinemia | Seminoma | Congenital Heart Block | Purpura, Thrombotic Thrombocytopenic | Optic Nerve Diseases | CHOPS Syndrome | Congenital Primary Aphakia | Esophageal Motility Disorders | Contact Dermatitis | Combined Malonic And Methylmalonic Acidemia | Macrophagic Myofasciitis | Kohlschutter-Tonz Syndrome | Retinal Vasculitis | Nager Acrofacial Dysostosis | Gastroenteritis, Eosinophilic | Hypermethioninemia | Neuromyelitis Optica | Fatty Aldehyde Dehydrogenase Deficiency | Congenital Hypofibrinogenemia | Carbohydrate Metabolism Disorders | Giant Cell Glioblastoma | Still Disease | Familial Pheochromocytoma-paraganglioma | Skin Papilloma | Obesity | Blomstrand Osteochondrodysplasia | Trichotillomania | Neuromyotonia | Amish Infantile Epilepsy Syndrome | Transthyretin-related Amyloidosis | Ligneous Conjunctivitis | Rheumatoid Arthritis | VACTERL Association | Gangliosidosis | Hyperuricemia | Silver-Russell Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Erythema Multiforme | Diabetes Gestational | Long QT Syndrome Type 1 | Benign Familial Infantile Seizures | Bone Giant Cell Tumor | Epilepsy, Generalized | 3-methylglutaconic Aciduria Type I | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Congenital Stromal Corneal Dystrophy | Galactosemia | DiGeorge Syndrome | Keratoconus | Niemann-Pick Disease, Type C | Blepharoconjunctivitis | Lymphoma, AIDS-related | Primary Sclerosing Cholangitis | Polyradiculopathy | Hypertelorism | Niemann-Pick Disease, Type B | Melnick-Needles Syndrome | Takenouchi-Kosaki Syndrome | Hyperphenylalaninemia | Lentigo | Hereditary Elliptocytosis | Alpers Syndrome | Pontocerebellar Hypoplasia | Primary Cutaneous Amyloidosis | Amelanotic Melanoma | Epilepsy | Chiari Malformation Type I | Chronic Mucocutaneous Candidiasis | Autosomal Recessive Spastic Paraplegia Type 54 | Retinitis Pigmentosa 3 | Malonyl-CoA Decarboxylase Deficiency | Angiomyolipoma | Pneumothorax | Schwannomatosis | Carbonic Anhydrase VA Deficiency | Sclerosing Cholangitis | Crohn's Disease | Diabetes Mellitus, Transient Neonatal | Thin Basement Membrane Disease | Rett Syndrome | Sialoadenitis | Rhabdomyosarcoma, Embryonal | Brachydactyly | Hypertension, Renovascular | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Stroke, Ischemic | Hamartoma | Bartter Syndrome | Von Willebrand Disease | Smith-Kingsmore Syndrome | Cri-du-chat Syndrome | Liebenberg Syndrome | Adenoma, Pleomorphic | Silicosis | Zollinger-Ellison Syndrome | Acrodermatitis | Myasthenia | Blue Nevus | Paroxysmal Kinesigenic Dyskinesia | Scapuloperoneal Spinal Muscular Atrophy | Benign Familial Neonatal Convulsions | Congenital Adrenal Hyperplasia | Wolcott-Rallison Syndrome | Aplasia Cutis Congenita | Hepatitis, Autoimmune | Empyema | Optic Nerve Hypoplasia, Bilateral | Hereditary Spastic Paraplegia | Vitamin D Deficiency | Delirium | Infertility, Male | Oculopharyngeal Muscular Dystrophy | Angioedema, Acquired | Urea Cycle Disorder | Kashin-Beck Disease | Saethre-Chotzen Syndrome | Hypersensitivity Pneumonitis | Pericarditis | Facioscapulohumeral Muscular Dystrophy Type 2 | Hidradenitis | Epidermal Nevus Syndrome | Gastritis | Charcot-Marie-Tooth Disease Type 4 | Trichomegaly | Withdrawal Syndrome | Trichorhinophalangeal Syndrome | Aneurysm, Thoracic Aortic | Glomerulonephritis, Membranoproliferative | Dysmorphophobia | Glycogen Storage Disease Type 0, Muscle | Coffin-Siris Syndrome | Hemophilia | Arthritis, Gouty | Walker-Warburg Syndrome | Obsessive-compulsive Disorder | Stomatitis | Hepatic Veno-occlusive Disease | Primary Lateral Sclerosis | Vogt-Koyanagi-Harada Syndrome | PASLI Disease | Vasculitis | Pyruvate Kinase Deficiency | GNE Myopathy | Paraplegia | Mood Disorder | Congenital Stationary Night Blindness | Cornelia De Lange Syndrome | Diabetic Encephalopathy | Multiple Sclerosis | Intellectual Disability, Autosomal Dominant 5 | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Cold Agglutinin Disease | Myositis, Focal | Asplenia | Best Macular Dystrophy | Thyroiditis, Autoimmune | Mitochondrial Cytopathy | VACTERL/VATER Association | Hepatitis A | Primary Erythromelalgia | Congenital Disorders Of Glycosylation | Double Outlet Right Ventricle | Acute Chest Syndrome | Spinocerebellar Ataxia Type 8 | T-cell Chronic Lymphocytic Leukemia | Lafora Disease | Hepatoblastoma | Retinopathy, Diabetic | Adrenomyeloneuropathy | Growth Hormone Excess | Cryptorchidism | Graves Disease | Prolactinoma | Hepatic Adenomatosis | Common Cold | Cystitis, Interstitial | Cancer, Brain | Optic Neuropathy | HUPRA Syndrome | Encephalopathy | Leber Congenital Amaurosis | Cancer, Prostate | Early Infantile Epileptic Encephalopathy 28 | Gardner Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Chromosome 5q Deletion Syndrome | Blepharo-cheilo-odontic Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | McCune-Albright Syndrome | Strabismus | Giant Axonal Neuropathy | Tuberculous Meningitis | Speech Disorders | Encephalitis, Tick-borne | Stromal Corneal Dystrophy | Sialidosis Type I | Varices | Pachyonychia Congenita | Intestinal Hypomagnesemia 1 | Polyneuropathy | Leukocyte Adhesion Deficiency Type 1 | Diastrophic Dysplasia | Hydrocephalus, Normal Pressure | Methemoglobinemia Type IV | Mast Cell Leukemia | Osteogenesis Imperfecta | Bullous Pemphigoid | Fanconi Syndrome | Acromicric Dysplasia | Wagner Disease | Gerodermia Osteodysplastica | Guillain-Barre Syndrome | Stickler Syndrome | Charcot-Marie-Tooth Disease Type 2E | Language Disorders | Autonomic Nervous System Disorders | Sleep Apnea, Obstructive | Becker Muscular Dystrophy | Parkinson's Disease | 5-oxoprolinase Deficiency | Papilledema | Partington Syndrome | Progressive Familial Intrahepatic Cholestasis Type 1 | Endometriosis | Keratoconjunctivitis | Neutropenia | Microcephalic Primordial Dwarfism | Paronychia | Cutaneous T-cell Lymphoma | Dwarfism | Constipation | Trichothiodystrophy | Fibromuscular Dysplasia | Encephalopathy, Glycine | Myoclonus-dystonia Syndrome | Hypohidrotic Ectodermal Dysplasia | Gastroschisis | Small Lymphocytic Lymphoma | Kaposi Sarcoma | Infertility | Basal Ganglia Cerebrovascular Disease | Osteochondrosis | IMAGe Syndrome | Ebstein Anomaly | Osteosclerosis | Familial Digital Arthropathy-brachydactyly | Acrodermatitis Enteropathica | Spondylo-ocular Syndrome | Bulimia Nervosa | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Spina Bifida | Granular Corneal Dystrophy | Fuchs Dystrophy | Pseudohypoparathyroidism Type 1C | Sengers Syndrome | Acute Leukemia | Placenta Previa | Kabuki Syndrome | WAGR Syndrome | Aldosterone Deficiency | Thymoma, Malignant | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Aphasia | Progressive Encephalopathy-optic Atrophy Syndrome | Portal Vein Thrombosis | Thrombasthenia | Iron Deficiency Anemia | Bronchiolitis | Alveolar Capillary Dysplasia | Neurodevelopmental Disorders | Endometritis | Blepharospasm | Veno-occlusive Disease | Milk Allergy | Mucolipidosis Type II | Cancer, Lung | Priapism | Ocular Hypertension | Pontocerebellar Hypoplasia Type 7 | Choriocarcinoma | Autonomic Neuropathy | Nicotine Addiction | Mumps | Asthma, Exercise-induced | Allan-Herndon-Dudley Syndrome | Presbyopia | AIDS Dementia Complex | Renal Dysplasia | Corneal Dystrophies, Hereditary | Myelitis, Transverse | Pigment Dispersion Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Rhabdoid Tumor | Specific Granule Deficiency | Autism | Pseudo-pseudohypoparathyroidism | Cryptococcal Meningitis | Combined Deficiency Of Factor V And Factor VIII | Anorectal Fistula | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hereditary Mixed Polyposis Syndrome | Follicular Dendritic Cell Sarcoma | Pfeiffer Syndrome | Delayed Sleep Phase Syndrome | Sarcoma, Ewing | Leukodystrophies | Neurofibromatosis Type 2 | Hypertension, Essential | Pseudohypoaldosteronism | Heart Septal Defects | Cluster Headache | Ependymoma | Headache | Oculocutaneous Albinism Type 2 | Alpha-1 Antitrypsin Deficiency | Plasma Cell Dyscrasia | Diabetes Insipidus | Posterior Polar Cataract | Hypertension, Pulmonary | Medium-chain Acyl-CoA Dehydrogenase Deficiency | T-cell Prolymphocytic Leukemia | Subcortical Band Heterotopia | Spinocerebellar Ataxia Type 2 | Anovulation | Ovarian Hyperstimulation Syndrome