Leukodystrophies

About the Disease
Leukodystrophy, also known as leukodystrophies, is related to metachromatic leukodystrophy and krabbe disease, and has symptoms including back pain, headache and pain. An important gene associated with Leukodystrophy is EIF2B5 (Eukaryotic Translation Initiation Factor 2B Subunit Epsilon), and among its related pathways/superpathways are Neural Stem Cells and Lineage-specific Markers and Translation factors. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are no effect and no effect

Common Targets
GBA1 | TMEM106B | TUBB4A | AARS1 | AHDC1 | GRIN1 | PMP22 | PAH | LARS2 | IBA57 | GATAD2B | TMEM163 | MCOLN1 | TMEM63A | SDHB | G7015 | HSPD1 | FLNA | MRPS22 | NKX6-2 | MAL | UFM1 | EIF2B3 | SZT2 | EIF2B2 | AARS2 | EIF2B5 | ACER3 | G472 | DHCR24 | ALS2 | APOE | SDHAF1 | AMPD2 | SPATA5L1 | CLCN2 | POLR3B | NDUFS7 | KARS1 | GJC2 | KCNT1 | RMND1 | BRAT1 | GLB1 | NDUFA2 | SOX10 | PYCR2 | EPRS1 | ATF4 | CSF1R | ATRN | DDB1 | DARS1 | POLR3A | DEGS1 | CLDN11 | STXBP1 | GPR17 | POLR1C | CNTNAP1 | RARS1 | HIKESHI

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