Leukodystrophies

About the Disease
Leukodystrophy, also known as leukodystrophies, is related to metachromatic leukodystrophy and krabbe disease, and has symptoms including back pain, headache and pain. An important gene associated with Leukodystrophy is EIF2B5 (Eukaryotic Translation Initiation Factor 2B Subunit Epsilon), and among its related pathways/superpathways are Neural Stem Cells and Lineage-specific Markers and Translation factors. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are no effect and no effect

Common Targets
GBA1 | TMEM106B | TUBB4A | AARS1 | AHDC1 | GRIN1 | PMP22 | PAH | LARS2 | IBA57 | GATAD2B | TMEM163 | MCOLN1 | TMEM63A | SDHB | G7015 | HSPD1 | FLNA | MRPS22 | NKX6-2 | MAL | UFM1 | EIF2B3 | SZT2 | EIF2B2 | AARS2 | EIF2B5 | ACER3 | G472 | DHCR24 | ALS2 | APOE | SDHAF1 | AMPD2 | SPATA5L1 | CLCN2 | POLR3B | NDUFS7 | KARS1 | GJC2 | KCNT1 | RMND1 | BRAT1 | GLB1 | NDUFA2 | SOX10 | PYCR2 | EPRS1 | ATF4 | CSF1R | ATRN | DDB1 | DARS1 | POLR3A | DEGS1 | CLDN11 | STXBP1 | GPR17 | POLR1C | CNTNAP1 | RARS1 | HIKESHI

Note: If you'd like to get a target analysis report for Leukodystrophies, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Leukodystrophies at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Open-angle Glaucoma | Primary Progressive Nonfluent Aphasia | Pyoderma Gangrenosum | Infertility | Corneal Dystrophies, Hereditary | Parvovirus B19 Infection | Basan Syndrome | Sclerosteosis 2 | Acute Tubular Necrosis | Neurofibroma | Usher Syndrome Type III | Progressive Osseous Heteroplasia | Anthrax | Spinocerebellar Ataxia Type 23 | Glaucoma | Familial Isolated Hyperparathyroidism | Sweet Syndrome | PHARC Syndrome | Influenza | Cryptosporidiosis | Ichthyosis, X-linked | Retinal Degeneration | Blepharoconjunctivitis | Diffuse Mesangial Sclerosis | Spinocerebellar Ataxia Type 16 | Pontocerebellar Hypoplasia Type 7 | Ebstein Anomaly | Gangliosidosis, GM1 | Micropenis | Temporal Lobe Epilepsy | Osteomalacia | Wolff-Parkinson-White Syndrome | Nevus | Desmosterolosis | Sarcoidosis, Pulmonary | Pineoblastoma | Insulin Resistance | Spinal And Bulbar Muscular Atrophy | Autonomic Nervous System Disorders | Hypertension, Essential | Renal-hepatic-pancreatic Dysplasia | Tracheal Disorders | Osteogenesis Imperfecta Type VI | Glutaric Aciduria Type 1 | Glycogen Storage Disease Type 1 | Acromesomelic Dysplasia | Nephritis, Interstitial | Gingivitis | Bronchitis, Chronic | Acne Vulgaris | T-cell Leukemia | Succinic Semialdehyde Dehydrogenase Deficiency | Primary Hyperoxaluria Type 1 | Aneurysm, Thoracic Aortic | Juvenile Myelomonocytic Leukemia | Pendred Syndrome | Tuberculosis | Fuchs Heterochromic Iridocyclitis | Craniometaphyseal Dysplasia | Atherosclerosis | Multisystemic Smooth Muscle Dysfunction Syndrome | Oral Lichen Planus | Hepatic Veno-occlusive Disease | Hereditary Hemorrhagic Telangiectasia Type 2 | Thin Basement Membrane Disease | Contact Dermatitis | Multiple Epiphyseal Dysplasia | X-linked Charcot-Marie-Tooth Disease | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Thyroid Dysgenesis | Miyoshi Myopathy | Compartment Syndrome | Alagille Syndrome | Benign Recurrent Intrahepatic Cholestasis 1 | Herpes Simplex Dermatitis | Intracranial Hypertension | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Corneal Edema | Pneumothorax | Medulloblastoma | Congenital Poikiloderma | Yellow Fever | Panuveitis | Aicardi-Goutieres Syndrome | Myelitis | Nephronophthisis | Retinitis Pigmentosa 3 | Congenital Muscular Dystrophy | Facioscapulohumeral Muscular Dystrophy Type 2 | Colitis, Lymphocytic | Christianson Syndrome | Spondylocarpotarsal Synostosis Syndrome | Familial Pheochromocytoma-paraganglioma | Diamond-Blackfan Anemia | Silver-Russell Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Thrombophilia | Cousin Syndrome | Carcinoma, Transitional Cell | Pancreatitis, Chronic | T-cell Chronic Lymphocytic Leukemia | Hereditary Spherocytosis | Tangier Disease | Metabolic Syndrome | Hydronephrosis | Tendinopathy | WAGR Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Mosaic Variegated Aneuploidy Syndrome 2 | Kidney Stones | Gilbert Syndrome | Toxoplasmosis | Peripheral Neuropathy | Chromosome 8q21.11 Deletion Syndrome | Combined Deficiency Of Factor V And Factor VIII | Histiocytic Sarcoma | Amebiasis | Porphyria Cutanea Tarda | Corticobasal Syndrome | Glycogen Storage Disease Type 5 | TARP Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Spinocerebellar Ataxia Type 27 | Thalassemia | Synovitis | Multicystic Renal Dysplasia | D-2-Hydroxyglutaric Aciduria | Gout | Ameloblastic Carcinoma | Palsy, Cerebral | Ollier Disease | Lipid Metabolism Disorders | Progressive Familial Intrahepatic Cholestasis | Diverticulitis | Gray Platelet Syndrome | Colitis, Collagenous | Brachial Plexus Neuropathy | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | GM2-gangliosidosis AB Variant | Spinocerebellar Ataxia Type 2 | Infantile Spasm | Spinocerebellar Ataxia Type 12 | Infertility, Male | Behcet's Disease | Persistent Hyperplastic Primary Vitreous | Hemorrhagic Disorders | Pelvic Inflammatory Disease | Distal Myopathy 2 | Alveolar Capillary Dysplasia | Autosomal Recessive Spastic Paraplegia Type 54 | Chordoma | Proopiomelanocortin Deficiency | Raynaud Phenomenon | Hepatitis, Chronic | Autoimmune Disease | Hodgkin Lymphoma | Tricho-hepato-enteric Syndrome | Esophagitis | Gerstmann-Straussler-Scheinker Syndrome | Retinal Vasculitis | Cutaneous Mastocytosis | Kohlschutter-Tonz Syndrome | Cataract | Primary Carnitine Deficiency | Macrodactyly | Glomerulonephritis | Ganglioglioma | Hypotension, Orthostatic | Porphyria, Variegate | Anuria | Facioscapulohumeral Muscular Dystrophy | Waardenburg Syndrome Type 2 | Cerebrovascular Disorders | Hydrops Fetalis | Anti-glomerular Basement Membrane Disease | Fibrosarcoma | Vitreoretinopathy, Proliferative | Blue Rubber Bleb Nevus Syndrome | Panic Disorder | 3-methylglutaconic Aciduria Type I | Congenital Lipoid Adrenal Hyperplasia | Anemia | Lichen Sclerosus | Cardiomyopathy, Peripartum | Ischemia | Erythrokeratodermia Variabilis | Pseudohypoparathyroidism Type 1C | Zygomycosis | Agammaglobulinemia | Fundus Albipunctatus | Carpal Tunnel Syndrome | Coronary Heart Disease | Distal Spinal Muscular Atrophy | Acute Anterior Uveitis | Multicentric Carpotarsal Osteolysis Syndrome | Mohr-Tranebjaerg Syndrome | Chondrodysplasia Punctata 1, X-linked Recessive | Hemorrhoids | Camptocormia | Congenital Dyserythropoietic Anemia | Sepiapterin Reductase Deficiency | Hypervalinemia | Graft-versus-host Disease | Central Retinal Artery Occlusion | Dysequilibrium Syndrome | Calcium Pyrophosphate Deposition Disease | Dermatitis | Acrodermatitis Enteropathica | Spinocerebellar Ataxia Type 40 | Angelman Syndrome | Kabuki Syndrome | Agnathia-Otocephaly Complex | Cirrhosis | Scoliosis | 3-M Syndrome | Schwartz-Jampel-Aberfeld Syndrome | Crigler-Najjar Syndrome | Stroke, Hemorrhagic | Evans Syndrome | Renal Dysplasia | HANAC Syndrome | Mabry Syndrome | Polycystic Kidney, Autosomal Recessive | Bronchiolitis | Brachydactyly | Multiple Myeloma | Focal Facial Dermal Dysplasia | Liver Failure, Acute Infantile | Dowling-Degos Disease | Angina Pectoris | Progressive Familial Intrahepatic Cholestasis Type 1 | Craniofacial Dysostosis | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Kearns-Sayre Syndrome | Apparent Mineralocorticoid Excess Syndrome | Urticaria | Muscle Wasting | Sponastrime Dysplasia | Bladder Exstrophy | Aphasia | Hoyeraal-Hreidarsson Syndrome | Lewy Body Dementia | Neurotoxicity | Herpes Genitalis | Senior-Loken Syndrome | Inflammatory Bowel Disease | Polymyositis | 5-oxoprolinase Deficiency | Desbuquois Syndrome | Carey-Fineman-Ziter Syndrome | Hypertension, Renovascular | Hyperammonemia | Hyperthyroidism | Dystonia-parkinsonism, X-linked | Familial Retinal Arterial Macroaneurysm | Hypercholesterolemia | Adrenoleukodystrophy, X-linked | Osteoarthritis | Leiomyoma | Gynecomastia | Iron Deficiency Anemia | Spinal Muscular Atrophy Type 2 | Pain | Carbamoyl Phosphate Synthetase I Deficiency | Schnyder Crystalline Corneal Dystrophy | Pulmonary Capillary Hemangiomatosis | Epilepsy Of Infancy With Migrating Focal Seizures | Lymphoma | Hartsfield Syndrome | Polymicrogyria | T-cell Prolymphocytic Leukemia | Nijmegen Breakage Syndrome | Stuve-Wiedemann Syndrome | Hyper IgE Syndrome | Filariasis | Retinitis Pigmentosa | Multiple Sulfatase Deficiency | Narcolepsy | Zollinger-Ellison Syndrome | Epiphyseal Chondrodysplasia, Miura Type | Cold-induced Sweating Syndrome | Sengers Syndrome | Glycogen Storage Disease Type 4 | Spondyloperipheral Dysplasia | Dysgerminoma | Long QT Syndrome Type 1 | Arthritis | Astrocytoma, Anaplastic | Myopathy | Schnitzler Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Renal Hypomagnesemia 3 | Tyrosinemia Type 1 | Chondrosarcoma | Polycystic Kidney, Autosomal Dominant | Bare Lymphocyte Syndrome | Vascular Cognitive Impairment | Cramp Fasciculation Syndrome | Renal Failure | Tremor | Imerslund-Grasbeck Syndrome | Absence Epilepsy | Acute Lymphocytic Leukemia | Stiff-man Syndrome | Huntington's Disease | Eating Disorder | Jaundice, Obstructive | Pneumonia, Mycoplasma | Pulmonary Tuberculosis | Charcot-Marie-Tooth Disease Type 2D | Norrie Disease | Vertigo | Hepatitis | Vascular Calcification | H Syndrome | Glutaric Aciduria Type 2 | Pierson Syndrome | Primary Hyperoxaluria Type 3 | Keratitis | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Spinal Muscular Atrophy | Pneumonia, Bacterial | Asphyxia Neonatorum | Corneal Dystrophy And Perceptive Deafness | Ependymoma | Hennekam Lymphangiectasia-lymphedema Syndrome | Microcephaly, Seizures, And Developmental Delay | Diabetic Nephropathy | CDKL5 Deficiency Disorder | Heart Block | Mitochondrial Myopathy | Neural Tube Defect | Iron Overload | Atelosteogenesis Type 1 | Pseudohypoparathyroidism Type 2 | Polyarteritis Nodosa | Hypokalemia | Diabetes Gestational | Neuroma | Goldenhar Syndrome | Specific Granule Deficiency | Chronic Granulomatous Disease | Onchocerciasis | Learning Disability | Systemic Mastocytosis | Branchiootorenal Syndrome | Familial Hyperaldosteronism | Echinococcosis | Carcinoma, Merkel Cell | Spinal Muscular Atrophy Type 3 | Ophthalmia, Sympathetic | Dementia | Aldosterone Deficiency | Proctitis | Carcinoma, Small Cell | Lipid Storage Myopathy | Heavy Chain Disease | Dystonia Musculorum Deformans | Tumoral Calcinosis | Alcoholism | Corneal Neovascularization | Lissencephaly 2 | Cerebrotendinous Xanthomatosis | Prurigo Nodularis | Polymyalgia Rheumatica | Monilethrix | Headache | Meningococcal Meningitis | Hepatoblastoma | Polycythemia | Arterial Tortuosity Syndrome | X-linked Myotubular Myopathy | Hyperandrogenemia | Hepatic Adenomatosis | Rolandic Epilepsy | Smith-Kingsmore Syndrome | Nance-Horan Syndrome | Familial Advanced Sleep Phase Syndrome | Lennox-Gastaut Syndrome | Diabetes Insipidus | Cervical Dystonia | Renpenning Syndrome | Budd-Chiari Syndrome | Neuronal Ceroid Lipofuscinosis | Glucagonoma | Dystonia | Iron Metabolism Disorders | Epithelial-myoepithelial Carcinoma | Guanidinoacetate Methyltransferase Deficiency | Hepatitis, Alcoholic | Esophagitis, Eosinophilic | Conjunctivitis | Spinocerebellar Ataxia Type 5 | Congenital Dyserythropoietic Anemia Type 4 | Frontometaphyseal Dysplasia | Epidermolysis Bullosa Simplex, Generalized | Fibrillation, Atrial | Duodenal Atresia | Intellectual Disability, Autosomal Dominant 5 | Systemic Lupus Erythematosus