Depression

About the Disease
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

Common Targets
CSNK1E | KCNH2 | PCDHB17P | TNKS | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | DDC | PLCB4 | CACNA1H | COPS7B | TLR8 | HDAC6 | CEBPE | LINC02310 | HRH3 | HTR3A | SNCA | CDK2 | HDAC2 | REST | GPR139 | TRPC4 | RORC | G3620 | TRAPPC8 | Protein Phosphatase 2A | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | TMEM106B | HTR1F | Prostaglandin EP Receptor (nonspecified subtype) | ERCC1 | CACNA1B | Nicotinic alpha4beta2alpha5 Receptor | PIEZO2 | OTX2 | LOC105377329 | G595 | SLC1A3 | BDNF | GDNF-AS1 | AVPR1A | PTGES | PTPN2 | NF-kappaB (NFkB) | MC1R | ZNF682 | TACR3 | MAD1L1 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | LRRK2 | CACNA2D1 | MTERF2 | PITRM1 | EFR3B | LPAR2 | CACNA2D2 | SLC22A1 | cAMP Phosphodiesterase (nonspecified subtype) | Nicotinic alpha6beta2alpha4beta2beta3 receptor | CST5 | KCNC1 | TGFB1 | PREP | CDK6 | Tyrosine-Protein Kinases Src (nonspecified subtype) | GPR156 | TACR2 | NGFR | ENDOG | GABRA4 | SSTR2 | G207 | PTPRD | Kainate Receptor (GluR) (nonspecified subtype) | KCNA3 | KCNN3 | KISS1 | HOXD9 | SLC18A2 | MKNK2 | GRM5 | NR3C2 | VGLL4 | Nicotinic (alpha4beta2)2alpha4 receptor | CRY2 | GBA1 | L-type voltage-dependent calcium channel complex | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | Voltage-gated K(v) channel (nonspecified subtype) | CA5A | GCHFR | GHSR | RAI1 | CYP2C19 | TEF | PEX5L | KCNQ4 | GRIN2C | Phosphodiesterase IV (PDE4) (nonspecified subtype) | DAO | MYT1L | PDE4B | LOC101927825 | PRKCZ | HABP2 | NOS1 | CEND1 | CDK4 | OPRK1 | TEX264 | GRIN1 | KLHL8 | CHRM4 | Tachykinin Receptor (nonspecified subtype) | Nicotinic (alpha4beta2)2beta2 receptor | MTNR1A | THRB | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | Interleukin-1 (nonspecified subtype) | RARA | OPRM1 | CAVIN3 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | FKBP1A | SLC7A5 | GPR52 | BRF1 | NOS1AP | KCNK18 | KCTD12 | ADRA1A | SRD5A1 | DRD4 | RXFP3 | TGFBRAP1 | KDM5C | PLA2G4A | ACE | Gamma-Aminobutyric acid type B receptor | ARRB2 | GNB3 | GPNMB | NPSR1 | Thyroid hormone receptor (nonspecified subtype) | DAOA | PRKCA | ROCK1 | ADRA2B | NPY1R | CNR2 | LTA | GAL | MORC1 | MGLL | SCN3A | RASGRF1 | EPHX2 | NRG1 | BRINP2 | G1432 | LINC00882 | T-Type Calcium Channel | GRIA1 | G4780 | SIGMAR1 | KCNQ3 | Somatostatin receptor (nonspecified subtype) | PPARA | AVPR1B | MAP2K1 | Calcium channel (nonspecified subtype) | ZNF649 | MUTYH | Alpha-2 Adrenergic receptors (nonspecified subtype) | CA6 | LINC03000 | TRPC5 | HLA-DQB2 | HRH2 | GABRB2 | GABRG2 | PLIN3 | SGK1 | ESR2 | RCL1 | GRM6 | Lipoxygenase (nonspecified subtype) | MAOA | CDK5 | CHRM1 | TYR | PDE1C | KCTD16 | CTNNA2 | DRD2 | APLNR | PDCD4 | KCNC2 | GEMIN4 | GH1 | CACNA1G | RASGRF2 | G142 | LIN28B | ACSS2 | SLC22A3 | ANKK1 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | COMT | TRPM8 | BRD4 | EML2 | PGR | PIK3CD | KEAP1 | SORCS3 | GRIK2 | LOC105373710 | LTB4R2 | GRTP1 | CCKBR | HTR4 | DAOA-AS1 | PDE10A | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | Estrogen receptor (nonspecified subtype) | MC2R | SPECC1L-ADORA2A | GRIN2D | TNFSF11 | HDAC3 | HCRTR1 | MEF2C-AS2 | HMGCR | KCNK2 | SSTR3 | OGG1 | CDPF1 | BST1 | P2RX3 | AGMAT | HTR1A | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | ADORA2B | ARRB1 | SLC6A2 | NFATC2 | GRM2 | ADORA1 | GALR3 | PPP3CC | HDAC1 | G1385 | Alcohol Dehydrogenase (nonspecified subtype) | G23411 | PDE9A | ID3 | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel (nonspecified subtype) | DRD5 | TMEFF2 | MEF2A | MTRR | HTR2B | Neurotrophic Factor (nonspecified subtype) | CNR1 | LEP | IL10RB | alpha-Adrenoceptor (nonspecified subtype) | TRIM39 | alpha-Secretase (nonspecified subtype) | Nicotinic alpha3beta4 Receptor | Chloride channel (nonspecified subtype) | FHIT | CACNG8 | SMPD1 | FZD7 | SLC6A9 | ZCCHC4 | Opioid receptor (nonspecified subtype) | GDF7 | TRPV2 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | CACNA1C | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | NPY2R | NR1I2 | LOC105369441 | DYRK1A | NTRK3 | CRHBP | Adenylate Cyclase (nonspecified subtype) | PPARG | TMPRSS11D | SLC1A6 | GABA(A) receptor | KCNK10 | G5595 | GRM7 | HSD11B1 | PGAM5-KEAP1-NRF2 Complex | CHRNA7 | Nicotinic alpha4beta2 receptor | ADRB3 | G4137 | GRIA3 | CPPED1 | PTGS1 | HTR5A | Melatonin receptor (nonspecified subtype) | CA7 | BRPF3 | GLO1 | AVPR2 | AKTIP | TRPV1 | MTHFD1L | DGCR8 | PPARD | Histone acetyltransferase (HAT) (nonspecified subtype) | BCHE | GABRG3 | MTNR1B | LINGO1 | ADORA2A | ADRA2A | DPP4 | UTS2R | SCN4A | PAOX | PIK3C2B | Casein kinase II (CKII) | G2099 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | B3GLCT | LOC105375983 | G581 | WNK2 | Arrestin (nonspecified subtype) | DYRK3 | SLC45A4 | OXT | FDX2 | PTPN1 | Sphingomyelin phosphodiesterase (nonspecified subtype) | OR10AD1 | G3480 | Pim Kinase (nonspecified subtype) | cAMP-Dependent protein kinase (PKA) | SLC22A2 | PAX5 | LTB | SLC12A7 | LOC107984098 | ADH1B | Tubulin | KCNQ Channels (K(v) 7) (nonspecified subtype) | ACHE | OPRL1 | JAKMIP3 | CES1 | MC3R | SERPINE1 | GSK3B | MMP7 | NPY | FKBP5 | RORA | Voltage-Gated Sodium Channel Complex | F2 | XDH | OTOS | GRIN2A | CSF1 | CD300LF | Orexin receptor (nonspecified subtype) | COPS9 | PRF1 | SUMO3 | SLC6A11 | TSPO | PRL | PYGM | SSTR4 | AXIN1 | PRKCD | CCL14 | NPY5R | G836 | GABRB3 | PLAT | KCNA5 | HCN2 | PLA2G6 | PSORS1C3 | GRIK3 | GRM8 | IL15RA | ADORA3 | TRPC6 | OPRD1 | PCLO | G3630 | FYB1 | PFKP | PTPN5 | Mitogen-Activated Protein Kinase (nonspecified subtype) | MME | SKP2 | G4318 | GABRA1 | NR3C1 | sigma Receptor (nonspecified subtype) | ADRB1 | LIPC | TFAP2C | G7124 | ADCY8 | KCNK3 | SLC6A12 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | FGF10 | BDNF-AS | HCRTR2 | MAST4 | DRD1 | CDH18 | TPH2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G6PC1 | RASGRP2 | Trypsin (nonspecified subtype) | KDM1A | GABBR2 | CHRM3 | NDE1 | NRXN1 | DNAAF5 | G4233 | ASTN1 | DTNBP1 | LOC101928331 | Sodium channel (nonspecified subtype) | PDE4C | beta-Adrenoceptor (nonspecified subtype) | PPP5C | FAAH | CALCRL | LOC105369749 | CYP3A5 | SST | PDE6D | PDE1B | LEPR | CHAT | RXRA | G367 | LINC02210-CRHR1 | KCNQ5 | G5743 | Caspase (nonspecified subtype) | HCG9 | PNPLA2 | ABCC8 | TPPP | ADRA1D | SIK2 | PDE2A | NEUROG3 | LOC101928354 | AP-1 Transcription Factor Complex | ACMSD | NUAK Family SNF1-like Kinase (nonspcified subtype) | Glycine receptor | AMPD3 | GRM3 | IL1A | Dopamine receptor (nonspecified subtype) | G5243 | S100A10 | Transcriptional Enhancer Factor (TEAD) (nonspecified subype) | KCNQ1 | POU3F3 | SCN1A | TDO2 | TPH1 | VDR | CRHR1 | MMP2 | TXNRD1 | MAP2K2 | GPRASP1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | LMNA | G196 | KCNK9 | CDKN1B | L-Type calcium channel (nonspecified subtype) | HTR6 | DGKA | TMEM97 | Vasopressin Receptor (nonspecified subtype) | SLC6A4 | SLC25A40 | ABR | GRM1 | FPR2 | PAX6 | GABRA5 | RBM39 | ADIPOR2 | NEIL1 | PDE5A | SLC6A1 | NQO2 | CHL1 | KCNE2 | Nicotinic alpha4beta4 receptor | IL10 | Adenosine receptor (nonspecified subtype) | G1786 | SLC6A13 | Cannabinoid receptor (nonspecified subtype) | MTHFR | GABRD | DYRK1B | TH | MAPK10 | ROCK2 | HTR1B | SCN9A | SCD5 | PACS2 | MYO15B | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | KDR | SORD | CCKAR | SLC5A1 | PLAU | ADAM6 | THOP1 | GPR83 | RFX4 | KCNS3 | NT5E | HRH1 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | ASIC1 | G1956 | VRK2 | ADRB2 | NMDA receptor | TIMP2 | PDE4A | IFNG | CYP2B6 | Gastric H+/K+-ATPase | DAGLA | GNAS | GAA | NAMPT | GLP2R | PARD3 | SLC24A4 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | TACR1 | PRKCQ | ADAMTS2 | HTR2A | NOS2 | ATXN1 | Histamine Receptor (HR) (nonspecified subtype) | NELL1 | LIPE | VHL | SGIP1 | LOC105378797 | NPAS3 | alpha1-Adrenoceptor (nonspecified subtype) | EGLN1 | TRPA1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | GABRA2 | Histone deacetylase (nonspecified subtype) | SSTR5 | AGER | GAD1 | ZNF577 | MC4R | ABLIM2 | G3146 | alpha-6 beta-2 Nicotinic receptor | G7422 | LOC105376627 | LOC105378800 | Neurotensin receptor (nonspecified subtype) | Arginase (nonspecified subtype) | DNER | NR1D1 | MLF1-DT | STING1 | Nicotinic alpha6beta2beta3 receptor | LIN28B-AS1 | MIF | P2RX7 | GHRHR | Nitric oxide synthase (NOS) (nonspecified subtype) | GSTP1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | DNAJC7 | WNT1 | HPSE2 | Imidazoline I2 receptor (I2) | SSTR1 | FTO | SPOUT1 | HCAR2 | CYP19A1 | MMP14 | HCN1 | IL6R | GRM4 | IRAK1 | Gamma-aminobutyric-acid A receptor, Rho | PPM1A | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | ADRA1B | HTR3D | G238 | PCDHB6 | LOC107985688 | HTR2C | RXFP4 | CRY1 | CSNK1D | KCNN1 | DRD3 | KCNJ10 | DYRK2 | NLN | MTR | FRMD1 | CAVIN2 | GPR39 | CTDP1 | IL4 | Nicotinic alpha3beta2 receptor | Inward Rectifier Potassium Channel (nonspecified subtype) | ALOX5 | CDK1 | PDE1A | KIF1A | APOE | NLRP3 Inflammasome | CRP | FAM135B | GABRA6 | ANPEP | RGMA | Neuronal acetylcholine receptor alpha2beta2 receptor | Protein phosphatase-1 | CRBN | GALR2 | Glutamate Receptor Ionotropic (nonspecified subtype) | PRKCE | GRK2 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | REN | ARF6 | Potassium Channels (nonspecified subtype) | DAGLB | CHRNB2 | CRHR2 | ISL2 | MAOB | OXTR | SLC6A3 | GALR1 | GLP1R | MCHR1 | TAAR1 | Inward Rectifier Potassium Channel (nonspecified subtype) | NMUR2 | HSPA2 | SLC1A2 | KREMEN1 | TMEM161B-DT | Nicotinic alpha3beta2beta3 receptor | CTNND2 | GPR17 | CHRM2 | GPR55 | MAPK8IP1 | Melanocortin receptor (nonspecified subtype) | PTGER2 | IL1B | ODC1 | HTR1D | SVIL | LIPG | RGS4 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | RPS6KA5 | CLOCK | G3569 | G3576 | DUSP1 | NGF | L3MBTL2 | Galanin receptor (nonspecified subtype) | TRPC3 | GRIN2B | G114548 | Vasopressin V1 Receptor (nonspecified subtype) | KCNB1 | MC5R | PDE7A | LOC105379109 | MBOAT1 | G10413 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | KCNQ2 | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | GPR143 | KISS1R | MIR4761 | TRPM3 | GABRA3 | RAB29 | LOC102723838 | NTRK2 | Monoamine oxidase (MAO) (nonspecified subtype) | LHPP | ADRA2C | MIR1307 | GRIK4 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | DLGAP1 | LOC105379232 | SLC29A4 | GSK3A | CGAS | Phosphodiesterase (nonspecified subtype) | OSCAR | PDE4D | KMO | PICK1 | MACROD2 | PCSK1 | PKDREJ | PER2 | Nicotinic alpha1beta1deltagamma Receptor | CCK receptor (nonspecified subtype) | GDNF | HTR7 | SCN2A | NRXN3 | Glutamate Receptor Ionotropic AMPA Receptor | SIRT2

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